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1. 发明授权

US09102627B2 Processes for preparing 3-benzazepines 有权
标题翻译：制备3-苯并氮杂的方法
公开(公告)号：US09102627B2
公开(公告)日：2015-08-11
申请号：US13619788
申请日：2012-09-14
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61K31/55 , C07D223/16 , C07D401/02 , C07D403/02 , C07C209/50 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C17/16 , C07C25/06 , C07C209/74 , C07C211/27
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
摘要翻译：本发明提供了用于制备3-苯并氮杂及其盐的方法和中间体，其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病如肥胖症。

2. 发明授权

US08481535B2 Crystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor 有权
公开(公告)号：US08481535B2
公开(公告)日：2013-07-09
申请号：US12301212
申请日：2007-05-17
申请人： Tawfik Gharbaoui , Dipanjan Sengupta , Ashwin M. Krishnan , Nainesh Shah , Ryan M. Hart , Mark Macias , Edward A. Lally , Jonathan Duffield
发明人： Tawfik Gharbaoui , Dipanjan Sengupta , Ashwin M. Krishnan , Nainesh Shah , Ryan M. Hart , Mark Macias , Edward A. Lally , Jonathan Duffield
IPC分类号： A61K31/5377 , A61K31/496 , C07D295/185 , C07D403/12
CPC分类号： C07D231/12
摘要： The present invention relates to processes for preparing phenyl-pyrazoles of Formula (I) and salts and pharmaceutical compositions thereof, useful as modulators of 5-HT2A serotonin receptor activity. The present invention also relates to intermediates used in the processes, and their preparation. The present invention also relates to crystalline forms of 5-HT2A serotonin receptor modulators, compositions thereof and methods of using the same.

3. 发明申请

US20050020560A1 Chlorins processing fused ring systems useful as photoselective compounds for photodynamic therapy 有权
标题翻译：用于光动力学治疗的紫杉烷加工稠环系统可用作光选择性化合物
公开(公告)号：US20050020560A1
公开(公告)日：2005-01-27
申请号：US10922974
申请日：2004-08-23
申请人： Byron Robinson , Dipanjan Sengupta , Avinash Phadke
发明人： Byron Robinson , Dipanjan Sengupta , Avinash Phadke
IPC分类号： A61K41/00 , C07D487/22 , A61K31/555
CPC分类号： C07D487/22 , A61K41/0057 , A61K41/0071
摘要： The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.
摘要翻译：本发明提供了用于光动力学治疗和化合物本身的具有环状环系的萘并氯和其他二氢卟酚的制备方法。制造萘并二氢黄汞化合物的方法包括将内消旋 - （2'-羟甲基）苯基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉前体的化合物与足够温度的至少一种酸催化剂接触，足够的时间产生所需的转化。类似地，具有环状环系的二氢卟酚可以由诸如中 - （2'-羟甲基）芳基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉的化合物制备。本文所述的方法提供用于合成具有环状环系的萘并氯和二氢卟酚的新途径。

4. 发明授权

US06794505B1 Chlorins possessing fused ring systems useful as photoselective compounds for photodynamic therapy 有权
标题翻译：具有可用作光动力治疗的光选择性化合物的稠环体系的二氢卟酚
公开(公告)号：US06794505B1
公开(公告)日：2004-09-21
申请号：US09538980
申请日：2000-03-30
申请人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
发明人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
IPC分类号： C07D48722
CPC分类号： C07D487/22 , A61K41/0057 , A61K41/0071
摘要： The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.
摘要翻译：本发明提供了用于光动力学治疗和化合物本身的具有环状环系的萘并氯和其他二氢卟酚的制备方法。制造萘并二氢黄汞化合物的方法包括将内消旋 - （2'-羟甲基）苯基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉前体的化合物与足够温度的至少一种酸催化剂接触，足够的时间产生所需的转化。类似地，具有环状环系的二氢卟酚可以由诸如中 - （2'-羟甲基）芳基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉的化合物制备。本文所述的方法提供用于合成具有环状环系的萘并氯和二氢卟酚的新途径。

5. 发明授权

US08946207B2 Processes for preparing 3-benzazepines 有权
公开(公告)号：US08946207B2
公开(公告)日：2015-02-03
申请号：US13619773
申请日：2012-09-14
申请人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Ulrich Weigl , Heidedore Jlsabeth Rey-Papina
发明人： Beverly L. Wolgast , Charles A. Gilson, III , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61K31/55 , C07D223/16 , C07C209/50 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C17/16 , C07C25/06 , C07C209/74 , C07C211/27
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.

6. 发明授权

US08853419B2 Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof 有权
标题翻译：（R）-2-（7-（4-环戊基-3-（三氟甲基）苄氧基）-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基）乙酸及其盐的制备方法
公开(公告)号：US08853419B2
公开(公告)日：2014-10-07
申请号：US13575458
申请日：2011-01-27
申请人： Antonio Garrido Montalban , Daniel J. Buzard , John A. DeMattei , Tawfik Gharbaoui , Stephen R. Johannsen , Ashwin M. Krishnan , Young Mi Khulman , You-An Ma , Michael John Martinelli , Suzanne Michiko Sato , Dipanjan Sengupta
发明人： Antonio Garrido Montalban , Daniel J. Buzard , John A. DeMattei , Tawfik Gharbaoui , Stephen R. Johannsen , Ashwin M. Krishnan , Young Mi Khulman , You-An Ma , Michael John Martinelli , Suzanne Michiko Sato , Dipanjan Sengupta
IPC分类号： C07D209/80 , A61K31/403 , C07D209/94
CPC分类号： C12P17/10 , C07B2200/13 , C07C17/278 , C07D209/80 , C07D209/88 , C07D209/94 , C07D295/155
摘要： The present invention relates to processes and intermediates useful in the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis).
摘要翻译：本发明涉及可用于制备（R）-2-（7-（4-环戊基-3-（三氟甲基）苄氧基）-1,2,3,4-四氢环戊二烯并[b]吲哚-3 - 基）乙酸及其盐，可用于治疗S1P1受体相关疾病的S1P1受体调节剂，例如由淋巴细胞介导的疾病和病症，移植排斥反应，自身免疫性疾病和病症，炎性疾病和病症（例如急性和慢性炎性病症），癌症和特征在于血管完整性的潜在缺陷或与血管发生相关的病症，例如可能是病理性的（例如，可能发生在炎症，肿瘤发展和动脉粥样硬化）。

7. 发明申请

US20130178620A1 PROCESSES FOR PREPARING 3-BENZAZEPINES 有权
标题翻译：制备3-苯并嗪的方法
公开(公告)号：US20130178620A1
公开(公告)日：2013-07-11
申请号：US13619773
申请日：2012-09-14
申请人： Beverly L. Wolgast , CHARLES A. GILSON, III , SHELLEY AYTES , SCOTT A. ESTRADA , DIPANJAN SENGUPTA , BRIAN SMITH , MAX REY , ULRICH WEIGL , HEIDEDORE JLSABETH REY-PAPINA
发明人： Beverly L. Wolgast , CHARLES A. GILSON, III , SHELLEY AYTES , SCOTT A. ESTRADA , DIPANJAN SENGUPTA , BRIAN SMITH , MAX REY , ULRICH WEIGL
IPC分类号： C07D223/16 , C07C17/16 , C07C211/27 , C07C213/02 , C07C209/74 , C07C215/08 , C07C25/06
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
摘要翻译：本发明提供了用于制备3-苯并氮杂及其盐的方法和中间体，其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病如肥胖症。

8. 发明申请

US20080275232A1 CHLORINS POSSESSING FUSED RING SYSTEMS USEFUL AS PHOTOSELECTIVE COMPOUNDS FOR PHOTODYNAMIC THERAPY 审中-公开
标题翻译：适用于光化学治疗的化合物的氯林定点熔化系统
公开(公告)号：US20080275232A1
公开(公告)日：2008-11-06
申请号：US12147208
申请日：2008-06-26
申请人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
发明人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
IPC分类号： C07D487/22
CPC分类号： C07D487/22 , A61K41/0057 , A61K41/0071
摘要： The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.
摘要翻译：本发明提供了用于光动力学治疗和化合物本身的具有环状环系的萘并氯和其他二氢卟酚的制备方法。制造萘并二氢黄汞化合物的方法包括将内消旋 - （2'-羟甲基）苯基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉前体的化合物与足够温度的至少一种酸催化剂接触，足够的时间产生所需的转化。类似地，具有环状环系的二氢卟酚可以由诸如中 - （2'-羟甲基）芳基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉的化合物制备。本文所述的方法提供用于合成具有环状环系的萘并氯和二氢卟酚的新途径。

9. 发明申请

US20080045502A1 Processes for Preparing 3-Benzazepines 有权
标题翻译：制备3-苯并氮杂的方法
公开(公告)号：US20080045502A1
公开(公告)日：2008-02-21
申请号：US10560953
申请日：2004-06-16
申请人： Beverly L. Wolgast , Charles A. Gilson , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
发明人： Beverly L. Wolgast , Charles A. Gilson , Shelley Aytes , Scott A. Estrada , Dipanjan Sengupta , Brian Smith , Max Rey , Ulrich Weigl
IPC分类号： A61K31/55 , A61P3/04 , C07C213/00 , C07C215/28 , C07D223/16
CPC分类号： C07D223/16 , C07C17/16 , C07C25/06 , C07C59/255 , C07C209/50 , C07C209/74 , C07C211/27 , C07C211/29 , C07C213/02 , C07C215/08 , C07C231/02 , C07C233/13
摘要： The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT) receptor agonists for the treatment of, for example, central nervous system disorders such as obesity.
摘要翻译：本发明提供了用于制备3-苯并氮杂及其盐的方法和中间体，其可用作5-羟色胺（5-HT）受体激动剂，用于治疗例如中枢神经系统疾病如肥胖症。

10. 发明授权

US08655112B2 Method and apparatus for an improved workflow for digital image editing 有权
标题翻译：用于数字图像编辑的改进工作流程的方法和装置
公开(公告)号：US08655112B2
公开(公告)日：2014-02-18
申请号：US13492367
申请日：2012-06-08
申请人： Swarnima Bansal , Dipanjan Sengupta
发明人： Swarnima Bansal , Dipanjan Sengupta
IPC分类号： G06K9/03
CPC分类号： G06T11/60
摘要： A method and apparatus for an improved workflow for digital image editing is disclosed. The method comprises accessing a file containing a plurality of effects to apply to an image; merging a plurality of visible layers of the image to create a merged layer; applying the plurality of effects to the merged layer; installing a layer mask on the merged layer; and applying a plurality of user strokes made during an image editing process to the installed layer mask.
摘要翻译：公开了一种用于数字图像编辑的改进工作流程的方法和装置。该方法包括访问包含多个效果的文件以应用于图像; 合并图像的多个可见层以创建合并图层; 将多个效果应用于合并层; 在合并图层上安装图层蒙版; 以及将在图像编辑处理期间产生的多个用户笔画应用于所安装的图层蒙版。

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