专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06794505B1 Chlorins possessing fused ring systems useful as photoselective compounds for photodynamic therapy 有权
标题翻译：具有可用作光动力治疗的光选择性化合物的稠环体系的二氢卟酚
公开(公告)号：US06794505B1
公开(公告)日：2004-09-21
申请号：US09538980
申请日：2000-03-30
申请人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
发明人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
IPC分类号： C07D48722
CPC分类号： C07D487/22 , A61K41/0057 , A61K41/0071
摘要： The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.
摘要翻译：本发明提供了用于光动力学治疗和化合物本身的具有环状环系的萘并氯和其他二氢卟酚的制备方法。制造萘并二氢黄汞化合物的方法包括将内消旋 - （2'-羟甲基）苯基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉前体的化合物与足够温度的至少一种酸催化剂接触，足够的时间产生所需的转化。类似地，具有环状环系的二氢卟酚可以由诸如中 - （2'-羟甲基）芳基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉的化合物制备。本文所述的方法提供用于合成具有环状环系的萘并氯和二氢卟酚的新途径。

2. 发明申请

US20080275232A1 CHLORINS POSSESSING FUSED RING SYSTEMS USEFUL AS PHOTOSELECTIVE COMPOUNDS FOR PHOTODYNAMIC THERAPY 审中-公开
标题翻译：适用于光化学治疗的化合物的氯林定点熔化系统
公开(公告)号：US20080275232A1
公开(公告)日：2008-11-06
申请号：US12147208
申请日：2008-06-26
申请人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
发明人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
IPC分类号： C07D487/22
CPC分类号： C07D487/22 , A61K41/0057 , A61K41/0071
摘要： The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.
摘要翻译：本发明提供了用于光动力学治疗和化合物本身的具有环状环系的萘并氯和其他二氢卟酚的制备方法。制造萘并二氢黄汞化合物的方法包括将内消旋 - （2'-羟甲基）苯基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉前体的化合物与足够温度的至少一种酸催化剂接触，足够的时间产生所需的转化。类似地，具有环状环系的二氢卟酚可以由诸如中 - （2'-羟甲基）芳基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉的化合物制备。本文所述的方法提供用于合成具有环状环系的萘并氯和二氢卟酚的新途径。

3. 发明授权

US07521551B2 Chlorins possessing fused ring systems useful as photoselective compounds for photodynamic therapy 有权
标题翻译：具有可用作光动力治疗的光选择性化合物的稠环体系的二氢卟酚
公开(公告)号：US07521551B2
公开(公告)日：2009-04-21
申请号：US10922974
申请日：2004-08-23
申请人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
发明人： Byron C. Robinson , Dipanjan Sengupta , Avinash Phadke
IPC分类号： C07B47/00
CPC分类号： C07D487/22 , A61K41/0057 , A61K41/0071
摘要： The present invention provides a process of preparation of naphthochlorins and other chlorins with annelated ring systems useful for photodynamic therapy and the compounds themselves. The method for producing naphthochlorin compounds include contacting compounds such as meso-(2′-hydroxymethyl)phenyl porphyrin or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin precursors with at least one acid catalyst at sufficient temperature for a sufficient time to yield the desired conversion. In a similar manner chlorins possessing annelated ring systems may be made from compounds such as meso-(2′-hydroxymethyl)aryl porphyrins or meso-(2′-N,N,N-trialkylaminomethyl)phenyl porphyrin. The procedures described herein provide new routes for synthesizing naphthochlorins and chlorins with annelated ring systems.
摘要翻译：本发明提供了用于光动力学治疗和化合物本身的具有环状环系的萘并氯和其他二氢卟酚的制备方法。制造萘并二氢黄汞化合物的方法包括将内消旋 - （2'-羟甲基）苯基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉前体的化合物与足够温度的至少一种酸催化剂接触，足够的时间产生所需的转化。类似地，具有环状环系的二氢卟酚可以由诸如中 - （2'-羟甲基）芳基卟啉或中 - （2-N，N，N-三烷基氨基甲基）苯基卟啉的化合物制备。本文所述的方法提供用于合成具有环状环系的萘并氯和二氢卟酚的新途径。

4. 发明授权

US5973141A Method for the demethoxycarbonylation of porphyrinic compounds such as pheophorbides 失效
标题翻译：卟啉化合物如脱镁叶绿体的脱甲氧羰基化方法
公开(公告)号：US5973141A
公开(公告)日：1999-10-26
申请号：US188017
申请日：1998-11-27
申请人： Byron C. Robinson , Avinash S. Phadke , Shwn-Ji Susie Hwang Lee , Dipanjan Sengupta
发明人： Byron C. Robinson , Avinash S. Phadke , Shwn-Ji Susie Hwang Lee , Dipanjan Sengupta
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： An improved method for the demethoxycarbonylation of porphyrinic compounds such as pheophorbides involving reacting the starting porphyrinic compound with a high boiling point solvent to which a selected amount of water has been added.
摘要翻译：卟啉化合物如偏硼酸脱甲氧基羰基化的改进方法，包括使起始卟啉化合物与加入了选定量的水的高沸点溶剂反应。

5. 发明授权

US06906050B2 Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and MRI diagnosis 失效
标题翻译：取代卟啉和azaporphyrin衍生物及其在光动力疗法，放射成像和MRI诊断中的应用
公开(公告)号：US06906050B2
公开(公告)日：2005-06-14
申请号：US10159580
申请日：2002-05-31
申请人： Byron C. Robinson
发明人： Byron C. Robinson
IPC分类号： A61K47/48 , A61K49/10 , A61K51/04 , C07D487/22 , A61K31/33 , A61K31/555 , A61K31/695
CPC分类号： C07D487/22 , A61K47/546 , A61K49/085 , A61K49/10 , A61K49/106 , A61K51/0451 , A61K51/0485 , A61K51/0497
摘要： Substituted porphyrin and azaporphyrin deviations with various substitutents in the 12- and 17-positions of the porphyrin skeleton as pharmaceutical agents for use in photodynamic therapy, MRI diagnosis, and radiodiagnostics.
摘要翻译：卟啉骨架的12位和17位的各种取代基的取代卟啉和氮杂卟啉偏差作为用于光动力学治疗，MRI诊断和放射诊断的药物。

6. 发明授权

US06605606B1 Solid forms of tin ethyl etiopurpurin and processes for producing such forms 有权
标题翻译：锡乙基硫脲的固体形式及其制备方法
公开(公告)号：US06605606B1
公开(公告)日：2003-08-12
申请号：US09633105
申请日：2000-08-04
申请人： G. Patrick Stahly , Barbara A. Garcia , Byron C. Robinson
发明人： G. Patrick Stahly , Barbara A. Garcia , Byron C. Robinson
IPC分类号： C07D48722
CPC分类号： C07D487/22 , A61K31/409 , A61K33/24
摘要： Solid forms of tin ethyl etiopurpurin (SnET2), including crystalline form I, crystalline Form II, disordered Form II, and an amorphous form are disclosed. Also disclosed are the 1,2-dichloroethane solvate of SnET2 and the N,N-dimethylformamide solvate of SnET2. These solid forms of SnET2 are useful as pharmaceuticals that exhibit pharmacological activity when irradiated with light and thus are useful in photodynamic therapy. Also disclosed are methods for making these solid forms of SnET2 and pharmaceuticals including these solid forms of SnET2.
摘要翻译：公开了固体形式的锡乙基血浆素（SnET2），包括晶型I，晶型II，无序形式II和无定形形式。还公开了SnET2的1,2-二氯乙烷溶剂化物和SnET2的N，N-二甲基甲酰胺溶剂合物。这些固体形式的SnET2可用作在用光照射时表现出药理活性的药物，因此可用于光动力学治疗。还公开了制备这些固体形式的SnET2的方法和包括这些固体形式的SnET2的药物。

7. 发明申请

US20080200478A1 ANTINEOPLASTIC AND CURCUMIN DERIVATIVES AND METHODS OF PREPARATION AND USE 失效
标题翻译：抗生素和曲霉素衍生物及其制备和使用方法
公开(公告)号：US20080200478A1
公开(公告)日：2008-08-21
申请号：US11926261
申请日：2007-10-29
申请人： Byron C. Robinson
发明人： Byron C. Robinson
IPC分类号： A61K31/12 , C07C49/105 , C07D239/06 , C07D231/12 , A61K31/505 , A61K31/415 , A61P35/00
CPC分类号： C07D239/20 , C07D231/12 , C07D405/04
摘要： This invention comprises antineoplastic curcumin derivatives and methods of preparation and use thereof. Particular reference is made to the following isomeric compounds wherein R1, R2, and R3 are selected from the group consisting of H, OH, OCH3, and COOH.
摘要翻译：本发明包括抗肿瘤姜黄素衍生物及其制备和使用方法。特别提及以下异构体化合物，其中R 1，R 2和R 3选自H，OH，OCH 3和COOH。

8. 发明授权

US06827926B2 Metallotetrapyrrolic photosensitizing agents for use in photodynamic therapy 失效
标题翻译：用于光动力疗法的金属四吡咯光敏剂
公开(公告)号：US06827926B2
公开(公告)日：2004-12-07
申请号：US10159005
申请日：2002-05-31
申请人： Byron C. Robinson , Ian M. Leitch , Stephanie Greene , Steve Rychnovsky
发明人： Byron C. Robinson , Ian M. Leitch , Stephanie Greene , Steve Rychnovsky
IPC分类号： A61K31409
CPC分类号： A61K49/0036 , A61K41/0071
摘要： Metallotetrapyrrolic compounds having photherapeutic properties useful in photodetection and phototherapy of target issues, particularly porphyrins and azaporphyrins that including gallium in the central pyrrolic core. Also disclosed are methods of using metallotetrapyrrolic compounds for the treatment or detection of cardiovascular disease.
摘要翻译：具有可用于目标问题的光电检测和光疗法的光电特性的金属四吡咯化合物，特别是在中心吡咯核心中包括镓的卟啉和氮杂卟啉。还公开了使用金属四吡咯化合物来治疗或检测心血管疾病的方法。

9. 发明授权

US06462192B2 Processes for large scale production of tetrapyrroles 有权
公开(公告)号：US06462192B2
公开(公告)日：2002-10-08
申请号：US09767140
申请日：2001-01-23
申请人： Byron C. Robinson , Barbara A. Garcia
发明人： Byron C. Robinson , Barbara A. Garcia
IPC分类号： C07D48722
CPC分类号： C07D487/22 , A61K41/0071
摘要： Processes for the large scale production of tetrapyrrolic compounds useful as photosensitizers in photodynamic therapy, such as meso-formyl porphyrins, meso-acrylate porphyrins, purpurins and benzochlorins. In particular, tin ethyl etiopurpurin (SnET2) and the intermediates necessary for its production without chromatography are disclosed.

10. 发明授权

US06444194B1 Indium photosensitizers for PDT 失效
标题翻译：铟光敏剂PDT
公开(公告)号：US06444194B1
公开(公告)日：2002-09-03
申请号：US09308884
申请日：1999-05-26
申请人： Byron C. Robinson , Avinash S. Phadke
发明人： Byron C. Robinson , Avinash S. Phadke
IPC分类号： A61K31409
CPC分类号： A61K31/555
摘要： The invention disclosed herein involves a phototherapeutic pyrrolic core complexed with a non-radioactive Indium atom. Complexation of Indium by the pyrrolic core forms a metalopyrrolic compound which influences enables these compounds to localize at target sites a phototherapy. Such functionally aids in both detection and phototherapy of disease sites, or provides functionality that binds to site specific receptors of a target area such that the therapy is improved.
摘要翻译：本文公开的本发明涉及与非放射性铟原子络合的光治疗性吡咯核。通过吡咯核形成铟的络合物形成金属吡咯化合物，其影响使得这些化合物能够在靶位点定位光疗。这样在功能上有助于疾病部位的检测和光疗，或提供结合目标区域的位点特异性受体的功能，使得治疗得到改善。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式