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1. 发明申请

US20160231319A1 METHOD OF ENHANCING HEMATOPOIETIC CELL TRANSPLANTATION 审中-公开
标题翻译：增强血细胞移植的方法
公开(公告)号：US20160231319A1
公开(公告)日：2016-08-11
申请号：US14788171
申请日：2015-06-30
申请人： David R. KAPLAN
发明人： David R. KAPLAN
IPC分类号： G01N33/569 , A61K35/28 , C12Q1/68
CPC分类号： A61K35/28 , A61K2035/124 , C12Q1/6876 , C12Q1/6883 , C12Q2600/158 , G01N33/5005 , G01N2333/47 , G01N2333/82 , G01N2333/91205 , G01N2333/948 , G01N2800/245
摘要： The invention relates to a method for enhancing the transplantation of hematopoietic cells to supplement or fully reconstitute the hematopoietic system, such as in myeloablated patients or patients otherwise deficient in hematopoietic cells. The method involves administering CD34+ cells having enhanced expression of one or more of AML-1, MYSM1, Hif1a, Profilin-1, phospho-GSK-3beta, SKP2, cbx7, Bmi-1, TCF1, Musashi-2, or FLI1 at levels that provide desirable therapeutically effective amounts of self-renewal of the administered cells and desirable therapeutically effective amounts of differentiation of the administered cells into the various progeny cells of the hematopoietic system (i.e., therapeutically effective amounts of hematopoietic reconstitution). To provide such cells to a subject, the invention relates to detecting such cells prior to or during treatment to ascertain whether such cells are present in clinically-relevant amounts. It may also relate to treating a subject so as to provide clinically-relevant numbers of such cells, as with specific mobilization agents.
摘要翻译：本发明涉及一种用于增强造血细胞移植以补充或完全重建造血系统的方法，例如在骨髓瘤患者或另外缺乏造血细胞的患者中。该方法包括给予具有增强的AML-1，MYSM1，Hif1a，Profilin-1，phospho-GSK-3beta，SKP2，cbx7，Bmi-1，TCF1，Musashi-2或FLI1中的一种或多种的表达的CD34 + 其提供所需治疗有效量的所施用细胞的自我更新和所需的治疗有效量的施用细胞分化成造血系统的各种后代细胞（即，治疗有效量的造血重建）。为了向受试者提供这样的细胞，本发明涉及在治疗之前或期间检测这样的细胞，以确定这些细胞是否以临床相关的量存在。它还可以涉及治疗受试者以提供临床相关数量的这种细胞，如与特定动员剂一样。

2. 发明授权

US5471055A Focal plane array test facility 失效
标题翻译：焦平面阵列测试设备
公开(公告)号：US5471055A
公开(公告)日：1995-11-28
申请号：US68341
申请日：1993-05-28
申请人： Christopher R. Costanzo , David R. Kaplan , Khoa V. Dang
发明人： Christopher R. Costanzo , David R. Kaplan , Khoa V. Dang
IPC分类号： G01D18/00 , G01J5/52
CPC分类号： G01D18/00 , G01J5/522
摘要： A test system for completely characterizing all known types of infrared andar-infrared detector arrays for FLIR imagers, which utilizes a number of different radiation sources, array supports, radiation filters, and radiation stops all remotely controlled and positioned by a computer which performs the test, sorts the data collected the results and presents it in a variety of formats. Also an automatic test method for characterizing infrared detectors using remote controlled radiation sources and dewar mounting devices under computer control.
摘要翻译：用于完全表征用于FLIR成像器的所有已知类型的红外和远红外检测器阵列的测试系统，其利用多个不同的辐射源，阵列支架，辐射过滤器和辐射停止所有远程控制和定位的计算机执行测试，对收集的结果进行排序，并以各种格式呈现。还有一种用于在计算机控制下使用遥控辐射源和杜瓦瓶装置来表征红外探测器的自动测试方法。

3. 发明授权

US5242687A Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells 失效
标题翻译：使用携带CD8的抗原呈递细胞减少涉及T细胞的细胞免疫反应的方法
公开(公告)号：US5242687A
公开(公告)日：1993-09-07
申请号：US691475
申请日：1991-04-25
申请人： Mark L. Tykocinski , David R. Kaplan
发明人： Mark L. Tykocinski , David R. Kaplan
IPC分类号： A61K35/28 , A61K38/11 , A61K38/17 , A61K39/00 , C07K14/705 , C12N15/866
CPC分类号： C12N15/86 , C07K14/705 , C07K14/70517 , A61K2039/5154 , A61K2039/5156 , C12N2710/14143 , Y10S514/885 , Y10S530/866 , Y10S530/868
摘要： Specific and nonspecific immunomodulation, enhancement of cellular engraftment, and modulation of nonimmune cells are achieved by using various membrane-binding and soluble CD8 compositions.
摘要翻译：通过使用各种膜结合和可溶性CD8组合物来实现特异性和非特异性免疫调节，细胞移植的增强和非免疫细胞的调节。

4. 发明申请

US20100105574A1 CANCER STEM CELLS AND USES THEREOF 审中-公开
标题翻译：癌细胞及其用途
公开(公告)号：US20100105574A1
公开(公告)日：2010-04-29
申请号：US12608310
申请日：2009-10-29
申请人： Leon M. Hansford , Kristen M. Smith , Alessandro Datti , Freda M. Miller , David R. Kaplan
发明人： Leon M. Hansford , Kristen M. Smith , Alessandro Datti , Freda M. Miller , David R. Kaplan
IPC分类号： C40B30/06
CPC分类号： C12N5/0695 , A61K31/444 , A61K31/4745 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/56 , A61K31/704 , A61K31/7048 , C12N2503/02 , G01N33/5011 , G01N33/5058
摘要： Disclosed are enriched preparations of neuroblastoma tumor initiating cells (NB TICs). The NB TICs are capable of self-renewal, initiating neuroblastoma tumor growth in vivo and are capable of being passaged in high frequency. These NB TICs have chromosomal abnormalities and are capable of giving rise to secondary tumor spheres. Methods are also disclosed for preparing the enriched preparations of NB TICs, such as from neuroblastoma tumor tissue and metastasized bone marrow. Also disclosed are methods of screening candidate substances to identify therapeutic agents for the treatment of neuroblastoma. Methods are also provided for screening a sample for neuroblastoma, as well as for screening a sample to identify the stage of neuroblastoma present. Kits are also provided for selecting appropriate anti-neuroblastoma compounds for a patient, and utilize isolated compositions of the patients' neuroblastoma tumor initiating cells. In this manner, a customized medicinal profile for the patient may be devised.
摘要翻译：公开了神经母细胞瘤肿瘤起始细胞（NB TIC）的富集制剂。 NB TIC能够自我更新，在体内启动神经母细胞瘤肿瘤生长，并能够以高频率传播。这些NB TIC具有染色体异常，并且能够产生继发性肿瘤球。还公开了制备NB TIC的富集制剂的方法，例如来自神经母细胞瘤肿瘤组织和转移的骨髓。还公开了筛选候选物质以鉴定用于治疗神经母细胞瘤的治疗剂的方法。还提供了用于筛选神经母细胞瘤样品的方法，以及用于筛选样品以鉴定存在的神经母细胞瘤的阶段。还提供试剂盒用于为患者选择合适的抗神经母细胞瘤化合物，并利用患者的神经母细胞瘤肿瘤起始细胞的分离组合物。以这种方式，可以设计用于患者的定制药物轮廓。

5. 发明申请

US20090036387A1 NOVEL CHEMICAL ENTITIES AFFECTING NEUROBLASTOMA TUMOR-INITIATING CELLS 审中-公开
标题翻译：影响NEUROBLASTOMA肿瘤发生细胞的新化合物
公开(公告)号：US20090036387A1
公开(公告)日：2009-02-05
申请号：US12206963
申请日：2008-09-09
申请人： DAVID R. KAPLAN , Kristen M. Smith , Alessandro Datti
发明人： DAVID R. KAPLAN , Kristen M. Smith , Alessandro Datti
IPC分类号： A61K31/7048 , C12N5/00 , A61K31/473 , A61K31/52 , A61K31/395 , A61K31/435 , A61K31/44 , A61K31/7068 , A61K31/58 , A61P35/00 , A61K31/704 , A61K31/495 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/56 , A61K31/4425 , A61K31/14 , A61K31/34 , A61K31/122
CPC分类号： C12N5/0695 , A61K31/444 , A61K31/4745 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/56 , A61K31/704 , A61K31/7048 , C12N2503/02 , G01N33/5011 , G01N33/5058
摘要： Disclosed are neuroblastoma tumor-initiating cell inhibiting compositions comprising chemical entities capable of affecting neuroblastoma tumor-initiating cells. Pharmaceutical preparations that include these chemical entities are also provided for the treatment of neuroblastoma. These pharmaceutical preparations are suitable for the treatment of humans, and are particularly suited for the treatment of children of 12 years of age or younger having neuroblastoma. The compositions and pharmaceutical preparations posses reduced normal cell cytotoxicity. The compositions and pharmaceutical preparations may be used alone or together with other conventional neuroblastoma preparations as part of a clinical regimen in the treatment and management of neuroblastoma.
摘要翻译：公开了包含能够影响神经母细胞瘤肿瘤起始细胞的化学实体的神经母细胞瘤肿瘤起始细胞抑制组合物。包括这些化学实体的药物制剂也用于治疗神经母细胞瘤。这些药物制剂适用于人类的治疗，特别适用于治疗12岁或以下神经母细胞瘤的儿童。组合物和药物制剂具有降低的正常细胞毒性。组合物和药物制剂可以单独使用或与其它常规神经母细胞瘤制剂一起使用，作为神经母细胞瘤的治疗和治疗的临床方案的一部分。

6. 发明申请

US20080038770A1 Cancer Stem Cells And Uses Thereof 失效
标题翻译：癌干细胞及其用途
公开(公告)号：US20080038770A1
公开(公告)日：2008-02-14
申请号：US11562798
申请日：2006-11-22
申请人： Loen M. Hansford , Kristen M. Smith , Alessandro Datti , Freda M. Miller , David R. Kaplan
发明人： Loen M. Hansford , Kristen M. Smith , Alessandro Datti , Freda M. Miller , David R. Kaplan
IPC分类号： C12Q1/20 , C12M1/14 , C40B30/06 , C12N5/08
CPC分类号： C12N5/0695 , A61K31/444 , A61K31/4745 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/56 , A61K31/704 , A61K31/7048 , C12N2503/02 , G01N33/5011 , G01N33/5058
摘要： Disclosed are enriched preparations of neuroblastoma tumor initiating cells (NB TICs). The NB TICs are capable of self-renewal, initiating neuroblastoma tumor growth in vivo and are capable of being passaged in high frequency. These NB TICs have chromosomal abnormalities and are capable of giving rise to secondary tumor spheres. Methods are also disclosed for preparing the enriched preparations of NB TICs, such as from neuroblastoma tumor tissue and metastasized bone marrow. Also disclosed are methods of screening candidate substances to identify therapeutic agents for the treatment of neuroblastoma. Methods are also provided for screening a sample for neuroblastoma, as well as for screening a sample to identify the stage of neuroblastoma present. Kits are also provided for selecting appropriate anti-neuroblastoma compounds for a patient, and utilize isolated compositions of the patients' neuroblastoma tumor initiating cells. In this manner, a customized medicinal profile for the patient may be devised.
摘要翻译：公开了神经母细胞瘤肿瘤起始细胞（NB TIC）的富集制剂。 NB TIC能够自我更新，在体内启动神经母细胞瘤肿瘤生长，并能够以高频率传播。这些NB TIC具有染色体异常，并且能够产生继发性肿瘤球。还公开了制备NB TIC的富集制剂的方法，例如来自神经母细胞瘤肿瘤组织和转移的骨髓。还公开了筛选候选物质以鉴定用于治疗神经母细胞瘤的治疗剂的方法。还提供了用于筛选神经母细胞瘤样品的方法，以及用于筛选样品以鉴定存在的神经母细胞瘤的阶段。还提供试剂盒用于为患者选择合适的抗神经母细胞瘤化合物，并利用患者的神经母细胞瘤肿瘤起始细胞的分离组合物。以这种方式，可以设计用于患者的定制药物轮廓。

7. 发明授权

US06828109B2 Methods for detecting an analyte of interest using catalyzed reporter deposition of tyramide 有权
标题翻译：使用催化报道沉积酪胺来检测感兴趣分析物的方法
公开(公告)号：US06828109B2
公开(公告)日：2004-12-07
申请号：US09738049
申请日：2000-12-15
申请人： David R. Kaplan
发明人： David R. Kaplan
IPC分类号： G01N3353
CPC分类号： G01N33/56972 , G01N2001/302
摘要： The present invention relates to methods of staining cells for flow cytometry, using catalyzed reporter deposition and amplification staining. A catalyzed reporter deposition or an analyte dependent enzyme activation system is described for detecting and/or quantitating an analyte of interest in or on a cell by flow cytometry. Also described are compositions for use in catalyzed reporter deposition methods that can be used to reduce background staining, and thereby enhance peak signal separation between histograms obtained from cells stained with control immunoglobulin versus cells stained with immunoglobulin specific for an analyte of interest, in catalyzed deposition methods.
摘要翻译：本发明涉及使用催化报道沉淀和扩增染色染色细胞的流式细胞术的方法。描述了催化的报告沉积或分析物依赖性酶活化系统，用于通过流式细胞术检测和/或定量细胞中或细胞上的目标分析物。还描述了用于催化报道沉积方法的组合物，其可用于减少背景染色，从而增强从对照免疫球蛋白染色的细胞获得的直方图与感兴趣的分析物的免疫球蛋白染色的催化沉积中的峰信号分离方法。

8. 发明授权

US5817471A Trk tyrosine kinase receptor is the physiological receptor for nerve growth factor 失效
标题翻译： Trk酪氨酸激酶受体是神经生长因子的生理受体
公开(公告)号：US5817471A
公开(公告)日：1998-10-06
申请号：US480553
申请日：1995-06-07
申请人： David R. Kaplan , Luis F. Parada
发明人： David R. Kaplan , Luis F. Parada
IPC分类号： A61K38/00 , C07K14/48 , C07K14/71 , G01N33/564 , G01N33/68 , G01N33/567
CPC分类号： C07K14/71 , C07K14/48 , G01N33/564 , G01N33/6872 , A61K38/00 , G01N2333/48 , G01N2333/9121
摘要： The present invention relates to a complex comprising nerve growth factor (NGF) and trk-proto-oncogene protein. The present invention also relates to methods for detecting the presence of NGF and trk-proto-oncogene receptor. The present invention further relates to methods that can be used in diagnostics and therapeutics for neurodegenerative diseases such as Alzheimer's and Huntington's by detecting NGF-trk receptor pairs and the phosphorylation of trk protein.
摘要翻译：本发明涉及包含神经生长因子（NGF）和trk-原癌基因蛋白质的复合物。本发明还涉及用于检测NGF和trk-原癌基因受体的存在的方法。本发明还涉及通过检测NGF-trk受体对和trk蛋白的磷酸化可以用于诊断和治疗神经变性疾病如阿尔茨海默氏症和亨廷顿舞蹈症的方法。

9. 发明授权

US5601828A CD8 derivatives and methods of use for cellular modulation and enhancement of cellular engraftment 失效
标题翻译： CD8衍生物和用于细胞调节和增强细胞移植的方法
公开(公告)号：US5601828A
公开(公告)日：1997-02-11
申请号：US112005
申请日：1993-08-24
申请人： Mark L. Tykocinski , David R. Kaplan
发明人： Mark L. Tykocinski , David R. Kaplan
IPC分类号： A61K35/28 , A61K38/11 , A61K38/17 , A61K39/00 , C07K14/705 , C12N15/866 , A61K45/00
CPC分类号： C12N15/86 , C07K14/705 , C07K14/70517 , A61K2039/5154 , A61K2039/5156 , A61K38/00 , C07K2319/00 , C12N2710/14143 , Y10S530/868
摘要： Specific and nonspecific immunomodulation, enhancement of cellular engraftment, and modulation of nonimmune cells are achieved by using various membrane-binding and soluble CD8 compositions.
摘要翻译：通过使用各种膜结合和可溶性CD8组合物来实现特异性和非特异性免疫调节，细胞移植的增强和非免疫细胞的调节。

10. 发明授权

US5062203A Method of making a flexible membrane circuit tester 失效
公开(公告)号：US5062203A
公开(公告)日：1991-11-05
申请号：US658805
申请日：1991-02-22
申请人： Brian S. Miller , David R. Kaplan
发明人： Brian S. Miller , David R. Kaplan
IPC分类号： G01R31/312
CPC分类号： G01R31/312 , Y10T29/49165
摘要： A pattern of electrodes, with electrical lead lines to the electrodes, arearried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.

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