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1. 发明申请

US20100105574A1 CANCER STEM CELLS AND USES THEREOF 审中-公开
标题翻译：癌细胞及其用途
公开(公告)号：US20100105574A1
公开(公告)日：2010-04-29
申请号：US12608310
申请日：2009-10-29
申请人： Leon M. Hansford , Kristen M. Smith , Alessandro Datti , Freda M. Miller , David R. Kaplan
发明人： Leon M. Hansford , Kristen M. Smith , Alessandro Datti , Freda M. Miller , David R. Kaplan
IPC分类号： C40B30/06
CPC分类号： C12N5/0695 , A61K31/444 , A61K31/4745 , A61K31/519 , A61K31/522 , A61K31/53 , A61K31/56 , A61K31/704 , A61K31/7048 , C12N2503/02 , G01N33/5011 , G01N33/5058
摘要： Disclosed are enriched preparations of neuroblastoma tumor initiating cells (NB TICs). The NB TICs are capable of self-renewal, initiating neuroblastoma tumor growth in vivo and are capable of being passaged in high frequency. These NB TICs have chromosomal abnormalities and are capable of giving rise to secondary tumor spheres. Methods are also disclosed for preparing the enriched preparations of NB TICs, such as from neuroblastoma tumor tissue and metastasized bone marrow. Also disclosed are methods of screening candidate substances to identify therapeutic agents for the treatment of neuroblastoma. Methods are also provided for screening a sample for neuroblastoma, as well as for screening a sample to identify the stage of neuroblastoma present. Kits are also provided for selecting appropriate anti-neuroblastoma compounds for a patient, and utilize isolated compositions of the patients' neuroblastoma tumor initiating cells. In this manner, a customized medicinal profile for the patient may be devised.
摘要翻译：公开了神经母细胞瘤肿瘤起始细胞（NB TIC）的富集制剂。 NB TIC能够自我更新，在体内启动神经母细胞瘤肿瘤生长，并能够以高频率传播。这些NB TIC具有染色体异常，并且能够产生继发性肿瘤球。还公开了制备NB TIC的富集制剂的方法，例如来自神经母细胞瘤肿瘤组织和转移的骨髓。还公开了筛选候选物质以鉴定用于治疗神经母细胞瘤的治疗剂的方法。还提供了用于筛选神经母细胞瘤样品的方法，以及用于筛选样品以鉴定存在的神经母细胞瘤的阶段。还提供试剂盒用于为患者选择合适的抗神经母细胞瘤化合物，并利用患者的神经母细胞瘤肿瘤起始细胞的分离组合物。以这种方式，可以设计用于患者的定制药物轮廓。

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