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1. 发明授权

US5062203A Method of making a flexible membrane circuit tester 失效
公开(公告)号：US5062203A
公开(公告)日：1991-11-05
申请号：US658805
申请日：1991-02-22
申请人： Brian S. Miller , David R. Kaplan
发明人： Brian S. Miller , David R. Kaplan
IPC分类号： G01R31/312
CPC分类号： G01R31/312 , Y10T29/49165
摘要： A pattern of electrodes, with electrical lead lines to the electrodes, arearried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.

2. 发明授权

US5055776A Flexible membrane circuit tester 失效
标题翻译：柔性膜电路测试仪
公开(公告)号：US5055776A
公开(公告)日：1991-10-08
申请号：US551370
申请日：1990-07-10
申请人： Brian S. Miller , David R. Kaplan
发明人： Brian S. Miller , David R. Kaplan
IPC分类号： G01R31/312
CPC分类号： G01R31/312
摘要： A pattern of electrodes, with electrical lead lines to the electrodes, arearried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.
摘要翻译：具有电极引线的电极图案由安装在框架上的薄膜承载。该图案对应于要测试的电路上的测试点图案。导线穿过框架上的边缘连接器。为了测试电路，膜通过空气压力被压在测试点上，使得在电极和测试点之间发生电容耦合。

3. 发明授权

US5079501A Flexible membrane circuit tester 失效
标题翻译：柔性膜电路测试仪
公开(公告)号：US5079501A
公开(公告)日：1992-01-07
申请号：US658804
申请日：1991-02-22
申请人： Brian S. Miller , David R. Kaplan
发明人： Brian S. Miller , David R. Kaplan
IPC分类号： G01R31/312
CPC分类号： G01R31/312
摘要： A pattern of electrodes, with electrical lead lines to the electrodes, arearried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.
摘要翻译：具有电极引线的电极图案由安装在框架上的薄膜承载。该图案对应于要测试的电路上的测试点图案。导线穿过框架上的边缘连接器。为了测试电路，膜通过空气压力被压在测试点上，使得在电极和测试点之间发生电容耦合。

4. 发明授权

US5072176A Flexible membrane circuit tester 失效
公开(公告)号：US5072176A
公开(公告)日：1991-12-10
申请号：US658807
申请日：1991-02-22
申请人： Brian S. Miller , David R. Kaplan
发明人： Brian S. Miller , David R. Kaplan
IPC分类号： G01R31/312
CPC分类号： G01R31/312
摘要： A pattern of electrodes, with electrical lead lines to the electrodes, arearried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.

5. 发明授权

US5062204A Method of making a flexible membrane circuit tester 失效
标题翻译：制造柔性膜电路测试仪的方法
公开(公告)号：US5062204A
公开(公告)日：1991-11-05
申请号：US658803
申请日：1991-02-22
申请人： Brian S. Miller , David R. Kaplan
发明人： Brian S. Miller , David R. Kaplan
IPC分类号： G01R31/312
CPC分类号： G01R31/312 , Y10T29/49165
摘要： A pattern of electrodes, with electrical lead lines to the electrodes, arearried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.
摘要翻译：具有电极引线的电极图案由安装在框架上的薄膜承载。该图案对应于要测试的电路上的测试点图案。导线穿过框架上的边缘连接器。为了测试电路，膜通过空气压力被压在测试点上，使得在电极和测试点之间发生电容耦合。

6. 发明授权

US5046239A Method of making a flexible membrane circuit tester 失效
公开(公告)号：US5046239A
公开(公告)日：1991-09-10
申请号：US658806
申请日：1991-02-22
申请人： Brian S. Miller , David R. Kaplan
发明人： Brian S. Miller , David R. Kaplan
IPC分类号： G01R31/312
CPC分类号： G01R31/312 , Y10T29/49165
摘要： A pattern of electrodes, with electrical lead lines to the electrodes, arearried by a thin-film membrane mounted on a frame. The pattern corresponds to a test point pattern on a circuit to be tested. The lead lines go to edge connectors on the frame. In order to test a circuit, the membrane is pushed against the test points by air pressure, such that capacitive coupling occurs between the electrodes and the test points.

7. 发明申请

US20110159079A1 High Delivery Rates for Lipid Based Drug Formulations, and Methods of Treatment Thereof 审中-公开
标题翻译：基于脂质药物制剂的高递送率及其治疗方法
公开(公告)号：US20110159079A1
公开(公告)日：2011-06-30
申请号：US12983659
申请日：2011-01-03
申请人： Zhili Li , Lawrence T. Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
发明人： Zhili Li , Lawrence T. Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
IPC分类号： A61K9/127 , A61K47/44 , A61P31/00 , A61P11/00
CPC分类号： A61K9/0078 , A61K9/127 , A61K9/1617 , A61K9/5015 , A61K9/5123 , A61K31/7034 , A61K31/7036 , Y02A50/406 , Y02A50/473
摘要： Provided is a method of preparing lipid based drug formulations with low lipid/drug ratios using coacervation techniques. Also provided are methods of delivering such lipid based drug formulations at high delivery rates, and methods of treating patients with pulmonary diseases comprising administering such lipid based drug formulations.
摘要翻译：提供了使用凝聚技术制备具有低脂/药物比例的基于脂质的药物制剂的方法。还提供了以高递送速率递送这种基于脂质的药物制剂的方法，以及治疗患有肺部疾病的患者的方法，包括施用这种基于脂质的药物制剂。

8. 发明授权

US07718189B2 Sustained release of antiinfectives 有权
标题翻译：持续释放抗感染药
公开(公告)号：US07718189B2
公开(公告)日：2010-05-18
申请号：US11185448
申请日：2005-07-19
申请人： Lawrence T. Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
发明人： Lawrence T. Boni , Brian S. Miller , Vladimir Malinin , Xingong Li
IPC分类号： A61K9/127
CPC分类号： A61K47/28 , A61K9/0078 , A61K9/127 , A61K9/1277 , A61K31/407 , A61K31/4709 , A61K31/496 , A61K31/545 , A61K31/7036 , A61K31/704 , A61K45/06 , Y02A50/473
摘要： Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 μm. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1:1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.
摘要翻译：提供基本上不含阴离子脂质的脂质抗感染制剂，其脂质与抗感染比为约1:1至约4:1，平均平均直径小于约1μm。还提供了制备包含输注方法的脂质抗感染制剂的方法。还提供了脂质抗感染制剂，其中通过在线融合方法制备的脂质与药物的比例为约1:1或更低，约0.75:1或更低，或约0.50:1或更低。本发明还涉及治疗患有肺部感染的患者的方法，其包括向患者施用治疗有效量的本发明的抗脂质抗感染药物。本发明还涉及一种治疗患者囊性纤维化的方法，其包括向患者施用治疗有效量的本发明的抗脂质抗感染制剂。

9. 发明授权

US4573627A Indium bump hybrid bonding method and system 失效
标题翻译：铟凸块混合键合方法及系统
公开(公告)号：US4573627A
公开(公告)日：1986-03-04
申请号：US684223
申请日：1984-12-20
申请人： Brian S. Miller , Aubrey J. Dunn
发明人： Brian S. Miller , Aubrey J. Dunn
IPC分类号： B23K20/02 , H01L21/98 , B23K20/00 , B23K31/02
CPC分类号： H01L25/50 , B23K20/02 , H01L2924/0002
摘要： In order to ensure total bonding together of two-dimensional arrays of inm bumps on circuit boards, additional bumps are placed on each board in a triangular pattern which contains the array of that board. Opposing sets of thrusters are used to move the boards and their bumps toward each other, after the arrays are aligned with the boards juxtaposed and substantially parallel to each other. As corresponding sets of additional bumps touch each other, the set of thrusters moving the boards at those points hold their positions, until all sets of additional bumps are in touch; all of the thrusters of at least one board are then simultaneously energized until a predetermined pressure is achieved between the boards.
摘要翻译：为了确保电路板上的铟凸块的二维阵列的全部结合在一起，附加的凸块以包含该板的阵列的三角形图案放置在每个板上。在将阵列与彼此并置并且基本上彼此平行的板对准之后，相反的推进器组被用于将板和它们的凸起朝向彼此移动。当相应的附加凸块相互接触时，在那些位置移动板的推进器组保持它们的位置，直到所有的附加凸块组合在一起; 然后至少一个板的所有推进器同时通电，直到板之间达到预定的压力。

10. 发明申请

US20100068257A1 Sustained Release of Antiinfectives 审中-公开
标题翻译：持续释放抗感染药
公开(公告)号：US20100068257A1
公开(公告)日：2010-03-18
申请号：US12424177
申请日：2009-04-15
申请人： Lawrence T. Boni , Brian S. Miller
发明人： Lawrence T. Boni , Brian S. Miller
IPC分类号： A61K9/127 , A61K31/70 , A61P11/00
摘要： Provided, among other things, is a method of treating or ameliorating pulmonary infection in a cystic fibrosis patient comprising pulmonary administration of an effective amount of a liposomal/complexed antiinfective to the patient, wherein the (i) administrated amount is 50% or less of the comparative free drug amount, or (ii) the dosing is once a day or less, or (iii) both.
摘要翻译：提供了一种治疗或改善囊性纤维化患者肺部感染的方法，包括向患者肺部施用有效量的脂质体/复合抗感染药，其中（i）给药量为50％或更少比较游离药物量，或（ii）给药是每天一次或更少，或（iii）两者。

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