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1. 发明授权

US08662392B2 System and method for tracking items during a process 有权
标题翻译：一个进程跟踪物品的系统和方法
公开(公告)号：US08662392B2
公开(公告)日：2014-03-04
申请号：US13293529
申请日：2011-11-10
申请人： Norbert D. Hagen , David Opalsky
发明人： Norbert D. Hagen , David Opalsky
IPC分类号： G06F17/00
CPC分类号： G06Q10/087 , G01N35/00732 , G01N2035/00752 , G01N2035/00782 , G01N2035/00801 , G01N2035/00831 , G01N2035/00841
摘要： A system and method for tracking items during a process employs a rack configured to hold one or more receptacles. Each receptacle includes a machine-readable label providing information regarding the receptacle, and each receptacle-receiving position of the rack has associated therewith a machine-readable label identifying the receptacle receiving location. The rack also includes a memory element to which electronic data may be written. A label reading device reads the machine-readable label on each receptacle and the position-indicating, machine-readable labels on the rack. Information obtained from the machine-readable labels is written to the memory element, so that for subsequent processing of the receptacles carried on the rack, information relating to each of the receptacles can be obtained by reading the information written to the memory element. A tamper prevention element provides an indication of whether the rack may have been tampered with after data is written to the memory element.
摘要翻译：用于在过程中跟踪物品的系统和方法采用配置成容纳一个或多个容器的架子。每个插座包括提供关于插座的信息的机器可读标签，并且机架的每个插座接收位置具有标识容器接收位置的机器可读标签。机架还包括可以写入电子数据的存储元件。标签读取装置读取每个插座上的机器可读标签和机架上的位置指示机器可读标签。从机器可读标签获得的信息被写入存储元件，因此为了随后处理在机架上承载的插座，可以通过读取写入存储元件的信息来获得与每个插座有关的信息。防篡改元件提供了在将数据写入存储器元件之后机架是否可能被篡改的指示。

2. 发明授权

US08088573B2 Methods and devices for performing chemical reactions on a solid support 有权
标题翻译：在固体支持物上进行化学反应的方法和装置
公开(公告)号：US08088573B2
公开(公告)日：2012-01-03
申请号：US12109653
申请日：2008-04-25
申请人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Worl , Andrzej Maczuszenko
发明人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Worl , Andrzej Maczuszenko
IPC分类号： C12Q1/68 , C12M3/00 , C12M1/36
CPC分类号： B01L9/527 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L9/523 , B01L2200/025 , B01L2200/0689 , B01L2300/0636 , B01L2300/0877 , B01L2300/1827 , B01L2300/1844 , C12Q1/6827
摘要： Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top of the substrate. The reaction containment member includes one or more cavities that form chambers directly above one or more target locations on the surface of the substrate. The chambers can be used to conduct biochemical processes directly over the substrate, as well as to perform thermal cycling of material contained inside the chamber using a heating element disposed directly on the substrate. The substrate assembly is preferably used in combination with a processing machine that dispenses materials into the chambers and that conducts biochemical reactions of materials contained within the chambers, without requiring the substrate assembly to be moved from one location to another location during the processes.
摘要翻译：提供了用于在基板上直接进行生物化学处理的装置和方法。基板组件包括可拆卸地将基板支撑在固定位置的盒，以及可移除地位于基板顶部上的反应容纳构件。反应容纳构件包括一个或多个空腔，其在衬底表面上的一个或多个目标位置上直接形成腔室。这些腔室可以用于直接在衬底上进行生物化学过程，并且使用直接设置在衬底上的加热元件来对包含在腔室内的材料进行热循环。衬底组件优选地与加工机器组合使用，该加工机器将材料分配到室中并且在室内进行包含的材料的生化反应，而不需要在工艺期间将衬底组件从一个位置移动到另一位置。

3. 发明申请

US20100240136A1 APPARATUS AND METHOD FOR ASSAYING COAGULATION IN FLUID SAMPLES 有权
公开(公告)号：US20100240136A1
公开(公告)日：2010-09-23
申请号：US12785257
申请日：2010-05-21
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： G01N33/86
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.

4. 发明申请

US20120221252A1 SYSTEMS AND METHODS FOR DISTINGUISHING OPTICAL SIGNALS OF DIFFERENT MODULATION FREQUENCIES IN AN OPTICAL SIGNAL DETECTOR 有权
标题翻译：用于在光信号检测器中分辨不同调制频率的光学信号的系统和方法
公开(公告)号：US20120221252A1
公开(公告)日：2012-08-30
申请号：US13404437
申请日：2012-02-24
申请人： Robert E. HEINZ , Dennis NEWELL , David OPALSKY , Jason RHUBOTTOM
发明人： Robert E. HEINZ , Dennis NEWELL , David OPALSKY , Jason RHUBOTTOM
IPC分类号： G06F19/10
CPC分类号： G01N21/6486 , G01N21/6428
摘要： Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal.
摘要翻译：用于检测光信号的系统和方法，以及用于鉴别由背景信号和其它光学噪声的相关联激励信号激发的发射部分发射的光信号，并采用数字技术确定检测到的具有调制频率的光信号的部分对应于相关激励信号的调制。

5. 发明申请

US20080286161A1 Methods and Devices for Performing Chemical Reactions on a Solid Support 有权
标题翻译：在固体支持物上进行化学反应的方法和装置
公开(公告)号：US20080286161A1
公开(公告)日：2008-11-20
申请号：US12109653
申请日：2008-04-25
申请人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Worl , Andrzej Maczuszenko
发明人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Worl , Andrzej Maczuszenko
IPC分类号： B01L3/00
CPC分类号： B01L9/527 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L9/523 , B01L2200/025 , B01L2200/0689 , B01L2300/0636 , B01L2300/0877 , B01L2300/1827 , B01L2300/1844 , C12Q1/6827
摘要： Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top of the substrate. The reaction containment member includes one or more cavities that form chambers directly above one or more target locations on the surface of the substrate. The chambers can be used to conduct biochemical processes directly over the substrate, as well as to perform thermal cycling of material contained inside the chamber using a heating element disposed directly on the substrate. The substrate assembly is preferably used in combination with a processing machine that dispenses materials into the chambers and that conducts biochemical reactions of materials contained within the chambers, without requiring the substrate assembly to be moved from one location to another location during the processes.
摘要翻译：提供了用于在基板上直接进行生物化学处理的装置和方法。基板组件包括可拆卸地将基板支撑在固定位置的盒，以及可移除地位于基板顶部上的反应容纳构件。反应容纳构件包括一个或多个空腔，其在衬底表面上的一个或多个目标位置上直接形成腔室。这些腔室可以用于直接在衬底上进行生物化学过程，并且使用直接设置在衬底上的加热元件来对包含在腔室内的材料进行热循环。衬底组件优选地与加工机器组合使用，该加工机器将材料分配到室中并且在室内进行包含的材料的生化反应，而不需要在工艺期间将衬底组件从一个位置移动到另一个位置。

6. 发明授权

US08718948B2 Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector 有权
标题翻译：用于区分光信号检测器中不同调制频率的光信号的系统和方法
公开(公告)号：US08718948B2
公开(公告)日：2014-05-06
申请号：US13404437
申请日：2012-02-24
申请人： Robert E. Heinz , Dennis Newell , David Opalsky , Jason Rhubottom
发明人： Robert E. Heinz , Dennis Newell , David Opalsky , Jason Rhubottom
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： G01N21/6486 , G01N21/6428
摘要： Systems and method for detecting optical signals, and for discriminating optical signals emitted by an emission moiety that is excited by an associated excitation signal from background signals and other optical noise, employing digital techniques for determining the portion of a detected optical signal having a modulation frequency corresponding to a modulation of the associated excitation signal.
摘要翻译：用于检测光信号的系统和方法，以及用于鉴别由背景信号和其它光学噪声的相关联激励信号激发的发射部分发射的光信号，并采用数字技术确定检测到的具有调制频率的光信号的部分对应于相关激励信号的调制。

7. 发明申请

US20120128451A1 METHOD AND APPARATUS FOR EFFECTING TRANSFER OF REACTION RECEPTACLES IN AN INSTRUMENT FOR MULTI-STEP ANALYTICAL PROCEDURES 有权
标题翻译：用于多步骤分析程序的仪器中反应接头的转移的方法和装置
公开(公告)号：US20120128451A1
公开(公告)日：2012-05-24
申请号：US13320746
申请日：2010-05-17
申请人： Norbert D. Hagen , Byron J. Knight , David Opalsky , Jason F. Rhubottom , Olaf Hörger , Heiko Sayer , Harald Thahedl , Stefan Habrich
发明人： Norbert D. Hagen , Byron J. Knight , David Opalsky , Jason F. Rhubottom , Olaf Hörger , Heiko Sayer , Harald Thahedl , Stefan Habrich
IPC分类号： B65G47/00
CPC分类号： B65G47/901 , G01N35/026 , G01N35/04 , G01N2035/0413 , G01N2035/0422 , G01N2035/0484
摘要： Systems for effecting transfer of reaction receptacles between modules of an instrument for performing multi-step analytical procedures and for adjusting for variations in the positions of such modules includes a receptacle carrier supported on a track on which the carrier translates between different modules located adjacent to the track. The carrier includes a receptacle distribution head supported on a receptacle carrier carriage. The distribution head includes a receptacle moving mechanism adapted to move receptacles into and out of the distribution head and into and out of a module. The carriage is engaged with the track and adapted for translation along the track. Drive systems effect powered translation of the carriage, powered elevation and rotation of the distribution head, and powered movement of receptacles into and out of the distribution head. A transfer position locating system automatically determines a receptacle transfer position of the receptacle carrier with respect to each module.
摘要翻译：用于在仪器的模块之间进行反应容器的传送以用于执行多步骤分析程序并用于调整这些模块的位置变化的系统包括支撑在轨道上的插座载体，载体在载体上在不同模块之间平移，跟踪。托架包括支撑在插座托架上的插座分配头。分配头包括容纳移动机构，其适于将容器移入和移出分配头并进出模块。滑架与轨道接合并适应轨道的翻译。驱动系统影响滑架的动力翻转，分配头的动力升降和旋转，以及插座进出分配头的动力运动。传送位置定位系统自动确定插座托架相对于每个模块的插座传送位置。

8. 发明授权

US07977106B2 Method for assaying coagulation in fluid samples 有权
公开(公告)号：US07977106B2
公开(公告)日：2011-07-12
申请号：US12785191
申请日：2010-05-21
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej Maczuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： G01N33/86
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.

9. 发明授权

US07923256B2 Method for assaying coagulation in fluid samples 有权
标题翻译：测定流体样品中凝血的方法
公开(公告)号：US07923256B2
公开(公告)日：2011-04-12
申请号：US12785257
申请日：2010-05-21
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： G01N33/86
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
摘要翻译：本发明是用于患者侧的一次性药筒，用于对新鲜全血或血液衍生物样品进行传统的凝血测定。与电子分析仪一起使用的墨盒允许将流体样品计量并与激活凝血级联的试剂定量混合。还提供了用于凝血酶的人造底物，其作用导致凝块形成。随后使用也容纳在药筒内的微制造传感器检测凝块形成，其中电化学地检测合成基质上凝血酶反应的产物。

10. 发明申请

US20100240067A1 APPARATUS AND METHOD FOR ASSAYING COAGULATION IN FLUID SAMPLES 有权
标题翻译：用于测定流体样品中凝集的装置和方法
公开(公告)号：US20100240067A1
公开(公告)日：2010-09-23
申请号：US12785191
申请日：2010-05-21
申请人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
发明人： Cindra A. Widrig Opalsky , David Opalsky , Andrzej MacZuszenko , Imants R. Lauks , Rhonda J. Cheadle
IPC分类号： G01N33/573
CPC分类号： C12Q1/56 , G01N33/86 , Y10T436/11 , Y10T436/2575
摘要： This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
摘要翻译：本发明是用于患者侧的一次性药筒，用于对新鲜全血或血液衍生物样品进行传统的凝血测定。与电子分析仪一起使用的墨盒允许将流体样品计量并与激活凝血级联的试剂定量混合。还提供了用于凝血酶的人造底物，其作用导致凝块形成。随后使用也容纳在药筒内的微制造传感器检测凝块形成，其中电化学地检测合成基质上凝血酶反应的产物。

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