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1. 发明申请

US20080286161A1 Methods and Devices for Performing Chemical Reactions on a Solid Support 有权
标题翻译：在固体支持物上进行化学反应的方法和装置
公开(公告)号：US20080286161A1
公开(公告)日：2008-11-20
申请号：US12109653
申请日：2008-04-25
申请人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Worl , Andrzej Maczuszenko
发明人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Worl , Andrzej Maczuszenko
IPC分类号： B01L3/00
CPC分类号： B01L9/527 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L9/523 , B01L2200/025 , B01L2200/0689 , B01L2300/0636 , B01L2300/0877 , B01L2300/1827 , B01L2300/1844 , C12Q1/6827
摘要： Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top of the substrate. The reaction containment member includes one or more cavities that form chambers directly above one or more target locations on the surface of the substrate. The chambers can be used to conduct biochemical processes directly over the substrate, as well as to perform thermal cycling of material contained inside the chamber using a heating element disposed directly on the substrate. The substrate assembly is preferably used in combination with a processing machine that dispenses materials into the chambers and that conducts biochemical reactions of materials contained within the chambers, without requiring the substrate assembly to be moved from one location to another location during the processes.
摘要翻译：提供了用于在基板上直接进行生物化学处理的装置和方法。基板组件包括可拆卸地将基板支撑在固定位置的盒，以及可移除地位于基板顶部上的反应容纳构件。反应容纳构件包括一个或多个空腔，其在衬底表面上的一个或多个目标位置上直接形成腔室。这些腔室可以用于直接在衬底上进行生物化学过程，并且使用直接设置在衬底上的加热元件来对包含在腔室内的材料进行热循环。衬底组件优选地与加工机器组合使用，该加工机器将材料分配到室中并且在室内进行包含的材料的生化反应，而不需要在工艺期间将衬底组件从一个位置移动到另一个位置。

2. 发明授权

US08088573B2 Methods and devices for performing chemical reactions on a solid support 有权
标题翻译：在固体支持物上进行化学反应的方法和装置
公开(公告)号：US08088573B2
公开(公告)日：2012-01-03
申请号：US12109653
申请日：2008-04-25
申请人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Worl , Andrzej Maczuszenko
发明人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Worl , Andrzej Maczuszenko
IPC分类号： C12Q1/68 , C12M3/00 , C12M1/36
CPC分类号： B01L9/527 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L9/523 , B01L2200/025 , B01L2200/0689 , B01L2300/0636 , B01L2300/0877 , B01L2300/1827 , B01L2300/1844 , C12Q1/6827
摘要： Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top of the substrate. The reaction containment member includes one or more cavities that form chambers directly above one or more target locations on the surface of the substrate. The chambers can be used to conduct biochemical processes directly over the substrate, as well as to perform thermal cycling of material contained inside the chamber using a heating element disposed directly on the substrate. The substrate assembly is preferably used in combination with a processing machine that dispenses materials into the chambers and that conducts biochemical reactions of materials contained within the chambers, without requiring the substrate assembly to be moved from one location to another location during the processes.
摘要翻译：提供了用于在基板上直接进行生物化学处理的装置和方法。基板组件包括可拆卸地将基板支撑在固定位置的盒，以及可移除地位于基板顶部上的反应容纳构件。反应容纳构件包括一个或多个空腔，其在衬底表面上的一个或多个目标位置上直接形成腔室。这些腔室可以用于直接在衬底上进行生物化学过程，并且使用直接设置在衬底上的加热元件来对包含在腔室内的材料进行热循环。衬底组件优选地与加工机器组合使用，该加工机器将材料分配到室中并且在室内进行包含的材料的生化反应，而不需要在工艺期间将衬底组件从一个位置移动到另一位置。

3. 发明授权

US07364897B2 Methods and devices for performing chemical reactions on a solid support 有权
标题翻译：在固体支持物上进行化学反应的方法和装置
公开(公告)号：US07364897B2
公开(公告)日：2008-04-29
申请号：US10412801
申请日：2003-04-11
申请人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Wörl , Andrzej Maczuszenko
发明人： Paul Heaney , Chao Lin , David Opalsky , Phillip Bruce, III , Charles Griswold , Sheila A. Walker , Ralf Wörl , Andrzej Maczuszenko
IPC分类号： C12M1/34 , C12M3/00 , C12M1/22
CPC分类号： B01L9/527 , B01L3/5025 , B01L3/502707 , B01L3/502715 , B01L3/50851 , B01L7/52 , B01L9/523 , B01L2200/025 , B01L2200/0689 , B01L2300/0636 , B01L2300/0877 , B01L2300/1827 , B01L2300/1844 , C12Q1/6827
摘要： Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position, and a reaction containment member that is removably located on top of the substrate. The reaction containment member includes one or more cavities that form chambers directly above one or more target locations on the surface of the substrate. The chambers can be used to conduct biochemical processes directly over the substrate, as well as to perform thermal cycling of material contained inside the chamber using a heating element disposed directly on the substrate. The substrate assembly is preferably used in combination with a processing machine that dispenses materials into the chambers and that conducts biochemical reactions of materials contained within the chambers, without requiring the substrate assembly to be moved from one location to another location during the processes.
摘要翻译：提供了用于在基板上直接进行生物化学处理的装置和方法。基板组件包括可拆卸地将基板支撑在固定位置的盒，以及可移除地位于基板顶部上的反应容纳构件。反应容纳构件包括一个或多个空腔，其在衬底表面上的一个或多个目标位置上直接形成腔室。这些腔室可以用于直接在衬底上进行生物化学过程，并且使用直接设置在衬底上的加热元件来对包含在腔室内的材料进行热循环。衬底组件优选地与加工机器组合使用，该加工机器将材料分配到室中并且在室内进行包含的材料的生化反应，而不需要在工艺期间将衬底组件从一个位置移动到另一位置。

4. 发明申请

US20060024841A1 Method and apparatus for delivery of submicroliter volumes onto a substrate 审中-公开
公开(公告)号：US20060024841A1
公开(公告)日：2006-02-02
申请号：US11243113
申请日：2005-10-04
申请人： Xian-Wei Yao , Chao Lin , Paul Heaney , Thomas Becker , Aaron Hanson , Michael Willis
发明人： Xian-Wei Yao , Chao Lin , Paul Heaney , Thomas Becker , Aaron Hanson , Michael Willis
IPC分类号： G01N1/10 , G01D15/04
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00619 , B01J2219/00659 , B01J2219/00677 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , B01J2219/00725 , B01L3/0244 , B01L3/0248 , B01L2200/0657 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N1/10 , G01N35/0099 , G01N35/028 , G01N35/10 , G01N35/1016 , G01N35/1065 , G01N2035/00158 , G01N2035/1037 , Y10T436/11 , Y10T436/112499 , Y10T436/119163 , Y10T436/24 , Y10T436/2575
摘要： A slotted pin tool, a delivery system containing the pin tool, a substrate for use in the system and methods using the pin tool and system are provided. The slotted pin tool contains a plurality of pins having slotted ends designed to fit around each loci of material deposited on a surface, such as a microarray, without contacting any of the deposited material. Sample is delivered by contacting the pin tool with the surface; the amount delivered is proportional to the velocity of the pin tool as it contacts the surface or the velocity of the liquid when movement of the pin is halted.

5. 发明授权

US5908755A Sequential step method for sequencing and identifying polynucleotides 失效
标题翻译：用于测序和鉴定多核苷酸的顺序步骤
公开(公告)号：US5908755A
公开(公告)日：1999-06-01
申请号：US950709
申请日：1997-10-15
申请人： Rajan Kumar , Paul Heaney
发明人： Rajan Kumar , Paul Heaney
IPC分类号： C12N15/09 , C12Q1/68 , G06F17/30 , C12P19/34 , G01N33/48
CPC分类号： C12Q1/6869 , Y10T436/143333
摘要： In one aspect, described are methods of sequencing of polynucleotides using a sequential step procedure. The methods of the invention begin with the provision of a single-stranded polynucleotide template that is annealed with a primer, forming a template-primer complex. The methods of the invention can provide for adding discrete nucleotides by a polymerase to the template-primer complex, where the added nucleotides can be labeled. The methods of the invention can involve the identification of a polynucleotide or polynucleotides having a contiguous non-redundant string or a superimposed non-redundant string pattern. The detection of the presence of a non-redundant contiguous string can be used, for example, to identify a particular gene. Alternatively, for example, if the non-redundant contiguous string is not unique to a particular gene, the string can be used to form a DNA library that can then be searched, for example, with a second string. Similarly, a superimposed non-redundant string pattern can be used, for example, to identify a gene or to search a DNA library. Such strings can be used, for example, in annealing reactions and in computer searches of a database having a catalog of sequenced polynucleotides.
摘要翻译：在一个方面，描述了使用顺序步骤程序测序多核苷酸的方法。本发明的方法开始于提供与引物退火的单链多核苷酸模板，形成模板引物复合物。本发明的方法可以提供通过聚合酶将离散的核苷酸加入到模板 - 引物复合物中，其中加入的核苷酸可被标记。本发明的方法可以涉及鉴定具有连续非冗余字符串或叠加的非冗余字符串模式的多核苷酸或多核苷酸。例如，可以使用非冗余连续字符串的存在的检测来鉴定特定基因。或者，例如，如果非冗余连续字符串对于特定基因不是唯一的，则该字符串可以用于形成DNA文库，然后可以例如用第二个字符串来搜索。类似地，可以使用叠加的非冗余字符串模式，例如识别基因或搜索DNA文库。这样的串可用于例如退火反应和计算机搜索具有测序多核苷酸目录的数据库。

6. 发明授权

US5872623A Massively parallel detection 失效
标题翻译：大规模并行检测
公开(公告)号：US5872623A
公开(公告)日：1999-02-16
申请号：US721427
申请日：1996-09-26
申请人： Paul J. Stabile , David Norman Ludington , Pamela Kay York , Arye Rosen , Satyam Choudary Cherukuri , Peter John Zanzucchi , Paul Heaney
发明人： Paul J. Stabile , David Norman Ludington , Pamela Kay York , Arye Rosen , Satyam Choudary Cherukuri , Peter John Zanzucchi , Paul Heaney
IPC分类号： B01L3/00 , C40B60/14 , G01N21/25 , G01N21/00
CPC分类号： G01N21/255 , B01L3/5085 , B01J2219/00317 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , B01L2300/0654 , B01L2300/0803 , B01L2300/0819 , C40B60/14
摘要： The invention provides apparatuses for detecting light from, for example, closely spaced detection sites. In one embodiment, the invention provides an apparatus for measuring the amount of light emitted from or transmitted through two or more detection sites of a first set of detection sites on a planar substrate while spatially resolving the measurements for each detection site of the first set, the apparatus comprising: for each detection site of the first set, an addressable source of a light beam directed to that detection site at a first angle; and an array detector comprising a plurality of light responsive pixels, wherein for each detection site of the first set there is at least one light responsive pixel that receives light emitted from or transmitted through that detection site at a second angle that can be the same as the first angle.
摘要翻译：本发明提供了用于检测来自例如紧密间隔的检测位置的光的装置。在一个实施例中，本发明提供了一种用于测量从平面基板上的第一组检测位置的两个或更多个检测位点发射或透射的光的量的装置，同时空间地分辨第一组的每个检测位点的测量值，该装置包括：对于第一组的每个检测部位，以第一角度指向该检测部位的光束的寻址源; 以及阵列检测器，其包括多个光响应像素，其中对于第一组的每个检测位置，存在至少一个光响应像素，其接收以第二角度发射或透过该检测部位的光，该第二角度可以与第一个角度

7. 发明授权

US5854684A Massively parallel detection 失效
标题翻译：大规模并行检测
公开(公告)号：US5854684A
公开(公告)日：1998-12-29
申请号：US721432
申请日：1996-09-26
申请人： Paul J. Stabile , David Norman Ludington , Pamela Kay York , Arye Rosen , Satyam Choudary Cherukuri , Peter John Zanzucchi , Paul Heaney
发明人： Paul J. Stabile , David Norman Ludington , Pamela Kay York , Arye Rosen , Satyam Choudary Cherukuri , Peter John Zanzucchi , Paul Heaney
IPC分类号： B01L3/00 , C40B60/14 , G01N21/25 , G01N21/00
CPC分类号： B01L3/5085 , G01N21/253 , B01J2219/00317 , B01J2219/00434 , B01J2219/00448 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00707 , B01L2300/0654 , B01L2300/0803 , B01L2300/0819 , C40B60/14
摘要： The invention provides apparatuses for detecting light from, for example, closely spaced detection sites. In one embodiment, the invention provides an apparatus for measuring the amount of light emitted from a first set of two or more detection sites on a planar substrate while spatially resolving the measurements from each first set detection site, the apparatus comprising: a source of a light beam directed towards the planar substrate at a first angle; one or more lenses for focusing light emitted or reflected from each of the first set detection sites and having a second angle having an angle offset from the first angle, onto a unique area of an array detector; and the array detector comprising a plurality of light responsive pixels, wherein for each first detection site there is at least one light responsive pixel that receives light emitted or reflected from that detection site and substantially no cross-talk from another detection site, and wherein substantially none of the light from the light source intersects with the array detector.
摘要翻译：本发明提供了用于检测来自例如紧密间隔的检测位置的光的装置。在一个实施例中，本发明提供了一种用于测量从平面基板上的第一组两个或更多个检测位置发射的光量的装置，同时在空间上分辨来自每个第一组检测位置的测量值，该装置包括：以第一角度朝向平面基板的光束; 一个或多个透镜，用于将从第一组检测位置中的每一个发射或反射的光聚焦并且具有与第一角度偏移的第二角度到阵列检测器的唯一区域上; 并且所述阵列检测器包括多个光响应像素，其中对于每个第一检测位置，存在至少一个光响应像素，其接收从该检测位点发射或反射的光，并且基本上不从另一检测位点进行串扰，并且其中基本上来自光源的光都不与阵列检测器相交。

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