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1. 发明申请

US20110281853A1 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ATRIAL FIBRILLATION 审中-公开
标题翻译：用于治疗或预防ATRIAL FIBRILLATION的组合物和方法
公开(公告)号：US20110281853A1
公开(公告)日：2011-11-17
申请号：US13106618
申请日：2011-05-12
申请人： Rishi Arora , David E. Zembower
发明人： Rishi Arora , David E. Zembower
IPC分类号： A61K31/551 , A61K31/135 , A61K31/404 , A61K31/22 , A61K31/5377 , A61K31/18 , A61K31/24 , A61K31/16 , A61K31/165 , A61K31/352 , A61K31/437 , A61K31/44 , A61K31/522 , A61K31/215 , A61K31/445 , A61K31/4725 , A61K31/4025 , A61K31/4545 , A61P9/06 , A61K31/47
CPC分类号： A61K31/46 , A61K31/132 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/22 , A61K31/24 , A61K31/352 , A61K31/4025 , A61K31/404 , A61K31/437 , A61K31/44 , A61K31/445 , A61K31/4545 , A61K31/47 , A61K31/4725 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K2300/00
摘要： The present invention provides compositions and methods for treating or preventing atrial fibrillation (AF). In particular, the present invention provides administration of muscarinic receptor antagonists (e.g., M2-selective muscarinic receptor blockers), administered alone or in combination with other therapeutic agents (e.g., beta-adrenergic receptor blockers) to treat and/or prevent atrial fibrillation.
摘要翻译：本发明提供了治疗或预防房颤（AF）的组合物和方法。特别地，本发明提供了单独施用或与其它治疗剂（例如β-肾上腺素能受体阻断剂）组合施用毒蕈碱受体拮抗剂（例如，M2选择性毒蕈碱受体阻断剂）以治疗和/或预防心房颤动。

2. 发明授权

US07265112B2 Small molecule modulators of hepatocyte growth factor (scatter factor) activity 有权
标题翻译：肝细胞生长因子（分散因子）活性的小分子调节剂
公开(公告)号：US07265112B2
公开(公告)日：2007-09-04
申请号：US11025373
申请日：2004-12-29
申请人： David E. Zembower , David A. Eiznhamer
发明人： David E. Zembower , David A. Eiznhamer
IPC分类号： A61K31/4155 , A61K31/5377 , C07D231/12 , C07D413/14
CPC分类号： C07D231/12 , A61K31/4155 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.
摘要翻译：本发明提供具有式（I）的化合物及其药学上可接受的衍生物，其中R 1，R 2和B如本文中所述的类别和亚类所述，并且还提供其药物组合物及其用于治疗其中HGF / SF或其活性或其激动剂或拮抗剂具有治疗有用作用的许多病症或疾病中的任何一种的方法。

3. 发明授权

US07250437B2 Small molecule modulators of hepatocyte growth factor (scatter factor) activity 有权
公开(公告)号：US07250437B2
公开(公告)日：2007-07-31
申请号：US11024615
申请日：2004-12-29
申请人： David E. Zembower , David A. Eiznhamer
发明人： David E. Zembower , David A. Eiznhamer
IPC分类号： A61K31/415 , A61K31/4155 , C07D231/12
CPC分类号： C07D231/12 , A61K31/4155 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14
摘要： The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.

4. 发明授权

US06399654B1 Biflavanoids and derivatives thereof as antiviral agents 失效
标题翻译：双变种及其衍生物作为抗病毒剂
公开(公告)号：US06399654B1
公开(公告)日：2002-06-04
申请号：US09060839
申请日：1998-04-15
申请人： Yuh-Meei Lin , David E. Zembower , Michael T. Flavin , Ralph Schure , Geng-Xian Zhao
发明人： Yuh-Meei Lin , David E. Zembower , Michael T. Flavin , Ralph Schure , Geng-Xian Zhao
IPC分类号： A61K3135
CPC分类号： A61K38/19 , A61K31/35 , A61K31/352 , A61K31/47 , A61K31/55 , A61K31/70 , A61K31/7048 , A61K38/212 , A61K45/06 , C07D311/30 , C07D311/32 , A61K38/20 , A61K2300/00
摘要： Substantially purified antiviral biflavanoids robustaflavone, hinokiflavone, amentoflavone, agathisflavone, volkensiflavone, morelloflavone, rhusflavanone, succedaneaflavanone, GB-1a, and GB-2a are provided. Antiviral biflavanoid derivatives and salt forms thereof, e.g., robustaflavone tetrasulfate potassium salt, and methods for preparing the same are also disclosed. Pharmaceutical compositions which include the antiviral biflavanoids, derivatives or salts thereof are also provided alone or in combination with at least one antiviral agent such as 3TC. Also disclosed is an improved method for obtaining substantially pure robustaflavone from plant material. The biflavanoid compounds, derivatives or salts thereof of the invention may be used in a method for treating and/or preventing viral infections caused by viral agents such as influenza, e.g., influenza A and B; hepatitis, e.g., hepatitis B; human immunodeficiency virus, e.g., HIV-1; Herpes viruses (HSV-1 and HSV-2); Varicella Zoster virus (VZV); and measles. For instance, semi-synthetic hexa-O-acetate and hexa-O-methyl ether derivatives of robustaflavone have been found to be effective in a method for treating or preventing hepatitis B viral infections. Compositions which include these robustaflavone derivatives along with methods for preparing and using the same are also provided. These compositions may be used alone or in combination with at least one antiviral agent such as 3TC.
摘要翻译：提供了大量纯化的抗病毒双歧杆菌强壮黄酮，桧醇酮，黄酮黄酮，恶灵素，伏安芬酮，多氟黄酮，黄豆酮，琥珀醛缩酮，GB-1a和GB-2a。还公开了抗病毒双变异构物衍生物及其盐形式，例如耐久性黄酮四硫酸钾钾盐及其制备方法。包括抗病毒双弗来菌素，其衍生物或盐的药物组合物也单独提供或与至少一种抗病毒剂如3TC组合提供。还公开了一种用于从植物材料获得基本上纯的健壮的黄豆黄酮的改进方法。本发明的双叉子化合物，其衍生物或盐可用于治疗和/或预防由病毒药物如流感引起的病毒感染的方法，例如流感A和B; 肝炎，例如乙型肝炎; 人类免疫缺陷病毒，例如HIV-1; 疱疹病毒（HSV-1和HSV-2）; 水痘带状疱疹病毒（VZV）; 和麻疹。例如，已经发现健康黄酮的半合成六-O-乙酸酯和六-O-甲基醚衍生物在治疗或预防乙型肝炎病毒感染的方法中是有效的。还提供了包括这些耐久性黄酮衍生物的组合物以及其制备和使用方法。这些组合物可以单独使用或与至少一种抗病毒剂如3TC组合使用。

5. 发明授权

US07579483B2 Process for preparing 7-(acryloyl)indoles 失效
标题翻译：制备7-（丙烯酰）吲哚的方法
公开(公告)号：US07579483B2
公开(公告)日：2009-08-25
申请号：US11748858
申请日：2007-05-15
申请人： Jasbir Singh , Siead I. Zegar , David E. Zembower , Christopher J. Tokar , Livia A. Enache , Wayne E. Zeller
发明人： Jasbir Singh , Siead I. Zegar , David E. Zembower , Christopher J. Tokar , Livia A. Enache , Wayne E. Zeller
IPC分类号： C07D409/02 , C07D209/08
CPC分类号： C07D409/12 , C07D209/08
摘要： The present invention involves a process for preparing substituted indoles, such as DTSI involving two sequential cross-coupling reactions.
摘要翻译：本发明涉及制备取代的吲哚的方法，例如涉及两个顺序的交叉偶联反应的DTSI。

6. 发明授权

US06605596B2 Indolocarbazole anticancer agents and methods of using them 失效
标题翻译：吲哚并咔唑抗癌剂及其使用方法
公开(公告)号：US06605596B2
公开(公告)日：2003-08-12
申请号：US10057260
申请日：2001-10-29
申请人： David E. Zembower , Yongping Xie , Yasheen Zhou
发明人： David E. Zembower , Yongping Xie , Yasheen Zhou
IPC分类号： A61K3170
CPC分类号： C07H19/04 , C07H19/044
摘要： The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of the following general formulas that inhibit topoisomerase I activity
摘要翻译：本发明涉及抗肿瘤化合物，组合物和方法。特别地，本发明涉及抑制拓扑异构酶I活性的以下通式的吲哚咔唑类似物

7. 发明申请

US20120093885A1 THERAPEUTIC VESICLES 审中-公开
标题翻译：治疗药物
公开(公告)号：US20120093885A1
公开(公告)日：2012-04-19
申请号：US13276142
申请日：2011-10-18
申请人： Susmita Sahoo , Douglas W. Losordo , David E. Zembower
发明人： Susmita Sahoo , Douglas W. Losordo , David E. Zembower
IPC分类号： A61K35/12 , A61P9/00 , A61P9/10 , A61P1/04 , A61P7/02 , A61P9/04 , A61P19/00 , A61P25/28 , A61P3/10 , A61P25/16 , A61P17/02 , A61P25/00 , A61P7/00 , C12N5/074 , A61K9/00
CPC分类号： A61K35/51 , A61K38/1774
摘要： The present technology provides compositions of vesicles, uses of vesicles, and methods relating to vesicles. For example, provided herein are vesicles derived from stem cells for use in regenerative therapies.
摘要翻译：本技术提供囊泡的组合物，囊泡的用途和与囊泡相关的方法。例如，本文提供的是来自用于再生治疗的干细胞的囊泡。

8. 发明申请

US20110098309A1 METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS 审中-公开
标题翻译：使用丙烯酸酯化合物抑制淀粉酶-β可扩散配体形成的方法
公开(公告)号：US20110098309A1
公开(公告)日：2011-04-28
申请号：US12668174
申请日：2008-07-11
申请人： Gary Charles Look , Lauri Schultz , Alexandre Mikhaylovich Polozov , Nikhil Bhagat , Jian Wang , David E. Zembower , William F. Goure , Todd Pray , Grant A. Krafft
发明人： Gary Charles Look , Lauri Schultz , Alexandre Mikhaylovich Polozov , Nikhil Bhagat , Jian Wang , David E. Zembower , William F. Goure , Todd Pray , Grant A. Krafft
IPC分类号： A61K31/4965 , C12N5/071 , A61K31/16 , A61K31/343 , A61K31/341 , A61K31/381 , A61K31/40 , C07C233/00 , C07D333/56 , C07D333/22 , C07D207/30 , C07D241/04 , C07D307/02 , A61P25/28
CPC分类号： A61K9/02 , A61K9/0019 , A61K9/0075 , A61K9/0095 , A61K9/10 , A61K9/146 , A61K9/2054 , A61K9/2059 , A61K31/381 , A61K31/41 , A61K31/415 , C12N5/0619 , C12N2501/999
摘要： Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers from amyloid β1-42 monomers using acylhydrazide compounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers using acylhydrazide compounds.
摘要翻译：公开的是使用酰肼化合物来抑制，调节和/或调节来自淀粉样蛋白和1-42单体的可溶性，球状，非纤维状，神经毒性淀粉样蛋白和β-葡聚糖1-42寡聚体的形成的方法。还公开了治疗患有与使用酰肼化合物形成可溶性，球状，非纤维状，神经毒性淀粉样蛋白和β-葡聚糖1-42寡聚物相关的疾病的患者的方法。

9. 发明授权

US07648978B2 Small molecule modulators of cytokine activity 有权
标题翻译：细胞因子活性的小分子调节剂
公开(公告)号：US07648978B2
公开(公告)日：2010-01-19
申请号：US11238285
申请日：2005-09-28
申请人： David E. Zembower , Jasbir Singh , Rama K. Mishra
发明人： David E. Zembower , Jasbir Singh , Rama K. Mishra
IPC分类号： A61P25/00 , A61K31/55 , C07D403/02
CPC分类号： C07D401/10 , C07D237/32 , C07D401/14 , C07D403/10 , C07D403/14
摘要： The present invention provides compounds having formula (I) or (II): and pharmaceutically acceptable derivatives thereof, wherein m, p, R1, R2, R3 and R4 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of diseases, disorders or conditions associated with HGF/SF or other cytokine activity.
摘要翻译：本发明提供具有式（I）或（II）的化合物及其药学上可接受的衍生物，其中m，p，R 1，R 2，R 3和R 4如本文中一般和本领域和亚类所述，并另外提供其药物组合物及其用于治疗与HGF / SF或其他细胞因子活性相关的许多疾病，病症或病症中的任何一种的方法。

10. 发明申请

US20070270594A1 PROCESS FOR PREPARING 7-(ACRYLOYL)INDOLES 失效
标题翻译：制备7-（丙烯酸）吲哚的方法
公开(公告)号：US20070270594A1
公开(公告)日：2007-11-22
申请号：US11748858
申请日：2007-05-15
申请人： Jasbir Singh , Siead I. Zegar , David E. Zembower , Christopher J. Tokar , Livia A. Enache , Wayne E. Zeller
发明人： Jasbir Singh , Siead I. Zegar , David E. Zembower , Christopher J. Tokar , Livia A. Enache , Wayne E. Zeller
IPC分类号： C07D409/02
CPC分类号： C07D409/12 , C07D209/08
摘要： The present invention involves a process for preparing substituted indoles, such as DTSI involving two sequential cross-coupling reactions.
摘要翻译：本发明涉及制备取代的吲哚的方法，例如涉及两个顺序的交叉偶联反应的DTSI。

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