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2. 发明授权

US6150407A Methods for inhibiting angiogenesis 失效
标题翻译：抑制血管发生的方法
公开(公告)号：US6150407A
公开(公告)日：2000-11-21
申请号：US274813
申请日：1999-03-22
申请人： Daniel Tuse , Charles Hiebert , Keith R. Laderoute , Nahid Waleh
发明人： Daniel Tuse , Charles Hiebert , Keith R. Laderoute , Nahid Waleh
IPC分类号： A61K9/127 , A61K31/192 , A61K31/235 , A61K39/00 , A61K47/48 , A61P9/10 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , A61K31/19 , A61K31/24
CPC分类号： A61K39/0011 , A61K31/192
摘要： The present invention relates to methods for effectively inhibiting unwanted angiogenesis. More particularly, this invention relates to methods of treating diseases that show unwanted angiogenesis and to delivering anti-angiogenic activity to a mammal. In other aspects this invention relates to methods of reducing the level of tumor necrosis factor .alpha..
摘要翻译：本发明涉及有效抑制不想要的血管发生的方法。更具体地说，本发明涉及治疗显示出不想要的血管生成并向哺乳动物递送抗血管生成活性的疾病的方法。在其它方面，本发明涉及降低肿瘤坏死因子α水平的方法。

3. 发明授权

US4678658A Aerosol germicide and dye 失效
标题翻译：气溶胶杀菌剂和染料
公开(公告)号：US4678658A
公开(公告)日：1987-07-07
申请号：US935236
申请日：1986-11-26
申请人： Irene Casey , Daniel Tuse
发明人： Irene Casey , Daniel Tuse
IPC分类号： A01N25/06 , A61L2/22 , A61L9/14 , C11D3/40 , C11D9/44 , A61K9/12 , A01N25/00 , A61K7/46 , A61K7/50
CPC分类号： C11D3/40 , A01N25/06 , A61L2/22 , A61L9/14 , C11D9/444
摘要： An aerosol spray for use in disinfecting a surface for personal use, such as a public restroom facility or telephone. The composition and delivery of the composition provides for the placement of a spray of disinfectant which includes a dye. The dye disappears as the spray effects the germicidal activity of the disinfectant. The composition is also rapidly drying, so that the dye disappears as well as the disinfecting composition leaving the surface dry.
摘要翻译：用于消毒用于个人使用的表面的气溶胶喷雾剂，例如公共厕所设施或电话。组合物的组成和输送提供了包括染料的消毒剂喷雾的放置。当喷雾影响消毒剂的杀菌活性时，染料消失。组合物也快速干燥，使得染料消失以及消除组合物使表面干燥。

4. 发明申请

US20060029612A1 Prevention and treatment of recurrent respiratory papillomatosis 审中-公开
标题翻译：预防和治疗复发性呼吸道乳头状瘤病
公开(公告)号：US20060029612A1
公开(公告)日：2006-02-09
申请号：US11107575
申请日：2005-04-15
申请人： Kenneth Palmer , Daniel Tuse , Stephen Reinl , Mark Smith , Gregory Pogue
发明人： Kenneth Palmer , Daniel Tuse , Stephen Reinl , Mark Smith , Gregory Pogue
IPC分类号： A61K39/12
CPC分类号： C12N15/8258 , A61K39/12 , A61K2039/5258 , C12N2710/20034
摘要： Juvenile-onset recurrent respiratory papillomatosis is treated using active vaccination or passive immune therapy of neutralizing antibodies against HPV L2 neutralizing epitopes.
摘要翻译：使用针对HPV L2中和表位的中和抗体的主动接种或被动免疫治疗来治疗少年复发性呼吸道乳头状瘤病。

5. 发明申请

US20060018900A1 Self antigen vaccines for treating B-cell lymphomas and other cancers 审中-公开
标题翻译：用于治疗B细胞淋巴瘤和其他癌症的自身抗原疫苗
公开(公告)号：US20060018900A1
公开(公告)日：2006-01-26
申请号：US11209592
申请日：2005-08-22
申请人： Alison McCormick , Daniel Tuse , Stephen Reinl , John Lindbo , Thomas Turpen
发明人： Alison McCormick , Daniel Tuse , Stephen Reinl , John Lindbo , Thomas Turpen
IPC分类号： A61K39/395 , A61K48/00 , C40B40/08
CPC分类号： C07K16/00 , A61K2039/505 , A61K2039/55522 , A61K2039/5555 , A61K2039/55577 , C07K2317/13 , C07K2317/21 , C07K2317/622 , C12N15/8242 , C12N15/8258
摘要： A polypeptide self-antigen useful in a tumor-specific vaccine mimics one or more epitopes of an antigen uniquely expressed by cells of the tumor. The polypeptide is preferably produced in a plant that has been transformed or transfected with nucleic acid encoding the polypeptide and is obtainable from the plant in correctly folded, preferably soluble form without a need for denaturation and renaturation. This plant-produced polypeptide is immunogenic without a need for exogenous adjuvants or other immunostimulatory materials. The polypeptide is preferably an scFv molecule that bears the idiotype of the surface immunoglobulin of a non-Hodgkin's (or B cell) lymphoma. Upon administration to a subject with lymphoma, the plant-produced, tumor-unique scFv polypeptide induces an idiotype-specific antibody or cell-mediated immune response against the lymphoma.
摘要翻译：可用于肿瘤特异性疫苗的多肽自身抗原模拟由肿瘤细胞唯一表达的抗原的一个或多个表位。多肽优选在已经用编码多肽的核酸转化或转染的植物中产生，并且可以以正确折叠，优选可溶形式从植物获得，而不需要变性和复性。该植物产生的多肽是免疫原性的，不需要外源性佐剂或其他免疫刺激材料。多肽优选是具有非霍奇金（或B细胞）淋巴瘤的表面免疫球蛋白的独特型的scFv分子。当给予具有淋巴瘤的受试者时，植物产生的肿瘤独特的scFv多肽诱导针对淋巴瘤的独特型特异性抗体或细胞介导的免疫应答。

6. 发明授权

US06433012B1 Method for inhibiting inflammatory disease 失效
标题翻译：抑制炎性疾病的方法
公开(公告)号：US06433012B1
公开(公告)日：2002-08-13
申请号：US09656144
申请日：2000-09-06
申请人： Daniel Tuse , Charles Hiebert , Keith R. Laderoute , Nahid Waleh
发明人： Daniel Tuse , Charles Hiebert , Keith R. Laderoute , Nahid Waleh
IPC分类号： A61K3112
CPC分类号： A61K31/235 , A61K31/192 , A61K31/565 , A61K39/0011
摘要： The present invention relates to methods for effectively inhibiting inflammatory diseases, such as Crohn's disease and ulcerative colitis. In other aspects, this invention relates to methods of reducing or inhibiting granulomas.
摘要翻译：本发明涉及有效抑制炎性疾病如克罗恩病和溃疡性结肠炎的方法。在其它方面，本发明涉及减少或抑制肉芽肿的方法。

7. 发明申请

US20070249000A1 METHOD FOR DIAGNOSING A PERSON HAVING B-CELL PATHOLOGIES 审中-公开
标题翻译：用于诊断患有B细胞病毒的人的方法
公开(公告)号：US20070249000A1
公开(公告)日：2007-10-25
申请号：US11740272
申请日：2007-04-25
申请人： Daniel Tuse , Kevin Dawson , William Haddon , Earl White , Wasyl Malyj
发明人： Daniel Tuse , Kevin Dawson , William Haddon , Earl White , Wasyl Malyj
IPC分类号： G01N33/574 , G01N33/50
CPC分类号： G01N33/57407
摘要： Described is a method for diagnosing a person having or being at risk of developing certain B-cell pathologies, including Sjögren's Syndrome and non-Hodgkin's lymphoma, and excluding patients with symptoms similar to Sjögren's Syndrome but with a different etiology, comprising the following steps: providing a sample of a body fluid or tissue from said person, said sample containing a mixture of unknown proteins, protein fragments or peptides; analyzing said samples with mass spectrometry to generate a m/z (mass to charge ratio) spectrogram for each sample; comparing whether the patient's sample contains m/z values that are characteristic of a Sjögren's Syndrome reference database derived from the analysis and cataloguing of multiple patient spectrograms; and determining whether said patient either has or does not have Sjögren's Syndrome on the basis of this comparative analysis.
摘要翻译：描述了一种用于诊断具有或具有发展某些B细胞病变的风险的人的方法，包括Sjögren综合征和非霍奇金淋巴瘤，并且排除具有与Sjögren综合征相似但具有不同病因的患者，包括以下步骤：提供来自所述人的体液或组织的样品，所述样品含有未知蛋白质，蛋白质片段或肽的混合物; 通过质谱分析所述样品以产生每个样品的m / z（质荷比）谱图; 比较患者样本是否包含源自多个患者谱图分析和编目的Sjögren综合征参考数据库特征的m / z值; 并且基于该比较分析确定所述患者是否具有或不具有Sjögren综合征。

8. 发明授权

US5385832A Method for obtaining highly pure beta 1,3-glucan from euglena 失效
标题翻译：从美洲狮获得高纯度β1,3-葡聚糖的方法
公开(公告)号：US5385832A
公开(公告)日：1995-01-31
申请号：US34609
申请日：1993-03-22
申请人： Daniel Tuse , Leticia Marquez , Leslie A. Hokama
发明人： Daniel Tuse , Leticia Marquez , Leslie A. Hokama
IPC分类号： A61K31/715 , A61P37/00 , C08B37/00 , C12P19/04 , C12R1/89 , A01G7/00 , D06M16/00
CPC分类号： C12P19/04 , A61K31/715 , Y10S435/946
摘要： Substantially pure, pyrogen-free beta-1,3-glucan is produced by cultivating Euglena cells in a defined growth medium and under specified conditions that provide a cell mass comprising 70% to 90% beta-1,3-glucan on a dry weight basis, separating the cell mass from the supernatant, extracting the cell mass with methanol and chloroform, acid-washing the extracted cell mass, and washing the acid-treated material with water.
摘要翻译：通过在确定的生长培养基中和在提供包含70％至90％的β-1,3-葡聚糖的细胞质量的特定条件下干燥产生基本上纯的无热原的β-1,3-葡聚糖将细胞质量与上清液分离，用甲醇和氯仿萃取细胞质量，对提取的细胞团进行酸洗，并用水洗涤酸处理物质。

9. 发明授权

US5344471A Plant root coatings 失效
标题翻译：植物根系涂层
公开(公告)号：US5344471A
公开(公告)日：1994-09-06
申请号：US432690
申请日：1989-11-07
申请人： Daniel Tuse , Leslie A. Hokama , Carrie R. Foss , Jacqueline A. Tefft
发明人： Daniel Tuse , Leslie A. Hokama , Carrie R. Foss , Jacqueline A. Tefft
IPC分类号： A01G7/00 , A01C1/06 , A01N25/00 , A01N25/02 , A01N25/04 , A01N25/10 , A01N25/34 , A01N63/00 , C05F11/08 , A01H5/00
CPC分类号： C05F11/08 , A01C1/06
摘要： Non-phytotoxic roots coating compositions comprising a polymer, VAM propagules, and a fungicide that selectively inhibits pathogenic fungi are provided. Also provided are methods of coating plant roots with the aforesaid composition and plants comprising roots coated with a polymer containing VAM propagules and a fungicide.In an alternative approach, the roots are first rolled in a dried polymer composition and then dipped in a suspension of VAM propagules, or attached to a film which is a dried polymer containing a spore suspension.
摘要翻译：提供了包含聚合物，VAM增殖物和选择性抑制致病真菌的杀真菌剂的非植物毒性根涂料组合物。还提供了使用上述组合物涂覆植物根的方法，以及包含用含有VAM增殖物和杀真菌剂的聚合物涂覆的根的植物的方法。在另一种方法中，根部首先在干燥的聚合物组合物中卷起，然后浸入VAM繁殖体的悬浮液中，或连接到膜上，该膜是含有孢子悬浮液的干燥聚合物。

10. 发明授权

US5084386A Production of beta-1,3-glucan in Euglena 失效
标题翻译：在EUGLENA生产β-1,3葡萄糖
公开(公告)号：US5084386A
公开(公告)日：1992-01-28
申请号：US332502
申请日：1989-03-31
申请人： Daniel Tuse , Leticia Marquez , Leslie A. Hokama
发明人： Daniel Tuse , Leticia Marquez , Leslie A. Hokama
IPC分类号： A61K31/715 , A61P37/00 , C08B37/00 , C12P19/04 , C12R1/89
CPC分类号： C12P19/04 , A61K31/715 , Y10S435/946
摘要： Substantially pure, pyrogen-free beta-1,3-glucan is produced by cultivating Euglena cells in a defined growth medium and under specified conditions that provide a cell mass comprising 70% to 90% beta-1,3-glucan on a dry weight basis, separating the cell mass from the super-natant, extracting the cell mass with methanol and chloroform, acid-washing the extracted cell mass, and washing the acid-treated material with water.
摘要翻译：通过在确定的生长培养基中和在提供包含70％至90％的β-1,3-葡聚糖的细胞质量的特定条件下干燥产生基本上纯的无热原的β-1,3-葡聚糖将细胞质量与超级细胞分离，用甲醇和氯仿萃取细胞质量，对提取的细胞团进行酸洗，并用水洗涤酸处理物质。

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