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1. 发明专利

IL223983A Heterocyclic alkynyl benzene compounds, medicinal compositions comprising them and uses thereof 未知
公开(公告)号：IL223983A
公开(公告)日：2017-11-30
申请号：IL22398312
申请日：2012-12-27
申请人： KE DING , DEPING WANG , DUANQING PEI , ZHANG ZHANG , KUN LUO , YUBING FENG , MENGJUE SHEN , GUANGZHOU HEALTHQUEST PHARMA CO LTD , GUANGZHOU INST BIOMED & HEALTH
发明人： KE DING , DEPING WANG , DUANQING PEI , ZHANG ZHANG , KUN LUO , YUBING FENG , MENGJUE SHEN
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec.

2. 发明专利

AU2094101A Leukolysin/mmp25/mt6-mmp 未知
公开(公告)号：AU2094101A
公开(公告)日：2001-06-18
申请号：AU2094101
申请日：2000-12-13
申请人： UNIV MINNESOTA , DUANQING PEI
发明人： PEI DUANQING
IPC分类号： A61K38/00 , A61K39/00 , C12N9/64 , C12N9/00

3. 发明授权

US09163217B2 Method for increasing the efficiency of inducing pluripotent stem cells 有权
标题翻译：提高多能干细胞诱导效率的方法
公开(公告)号：US09163217B2
公开(公告)日：2015-10-20
申请号：US13808596
申请日：2012-03-31
申请人： Duanqing Pei , Tao Wang
发明人： Duanqing Pei , Tao Wang
IPC分类号： C12N15/00 , C12N5/0775 , C12N5/074
CPC分类号： C12N5/0662 , C12N5/0696 , C12N2500/38 , C12N2501/602 , C12N2501/72 , C12N2506/13 , C12N2510/00
摘要： The present invention relates to a method for increasing the efficiency of inducing pluripotent stem cells by utilizing genes Jhdm1b and Jhdm1a that modify histone. By utilizing Jhdm1b, Jhdm1a, and a stem cell inducing factor, the present invention increases the efficiency of inducing pluripotent stem cells and increases the quality of induced pluripotent stem cells. The stem cell inducing factor is a combination of Oct4 and Klf4, or a combination of Sox2, Oct4, and Klf4, or a combination of Oct4 and Sox2, and Oct4 alone. The method further comprises exposing the cells to vitamin C, which further increases the efficiency of inducing pluripotent stem cells as compared with the case where no vitamin C is used. By using less stem cell reducing factors, the method of the present invention reduces the potential carcinogenicity, obtains a high inducing efficiency, and provides high-quality induced pluripotent stem cells capable of germ-line transmission.
摘要翻译：本发明涉及通过使用修饰组蛋白的基因Jhdm1b和Jhdm1a来提高诱导多能干细胞的效率的方法。通过利用Jhdm1b，Jhdm1a和干细胞诱导因子，本发明增加诱导多能干细胞的效率并增加诱导多能干细胞的质量。干细胞诱导因子是Oct4和Klf4的组合，或Sox2，Oct4和Klf4的组合，或Oct4和Sox2以及Oct4的组合。该方法还包括将细胞暴露于维生素C，与不使用维生素C的情况相比，这进一步增加诱导多能干细胞的效率。通过使用较少的干细胞减少因子，本发明的方法降低潜在致癌性，获得高诱导效率，并提供能够进行种系传播的高质量诱导多能干细胞。

4. 发明申请

US20120100568A1 SERUM-FREE MEDIUM FOR INDUCING PLURIPOTENT STEM CELLS QUICKLY WITH HIGH EFFICIENCY AND METHOD USING THEREOF 审中-公开
标题翻译：用于高效率诱导肺癌干细胞的无血清培养基及其使用方法
公开(公告)号：US20120100568A1
公开(公告)日：2012-04-26
申请号：US13265553
申请日：2009-09-30
申请人： Duanqing Pei , Jiekai Chen , Jing Liu
发明人： Duanqing Pei , Jiekai Chen , Jing Liu
IPC分类号： C12N5/071 , C12Q1/02
CPC分类号： C12N5/0696 , C12N2500/90 , C12N2501/115 , C12N2501/235
摘要： A serum-free medium for inducing and reprogramming somatic cells into induced pluripotent stem cells (iPS) quickly with high efficiency, and the method using thereof for inducing and reprogramming somatic cells without feeder are provided, wherein the rate and efficiency of whole process of inducing and reprogramming are greatly improved. The uses of the medium in inducing pluripotent stem cells, and the uses in the method for screening compounds, especially in the method for high throughput screening compounds are further provided.
摘要翻译：提供了一种无血清培养基，以高效率快速诱导和重编程体细胞进入诱导多能干细胞（iPS），并提供了其用于诱导和重编程体细胞而无饲养的方法，其中诱导全过程的速率和效率并且重新编程得到很大的改善。进一步提供介质诱导多能干细胞的用途，以及用于筛选化合物的方法，特别是在高通量筛选化合物的方法中的用途。

5. 发明申请

US20130302893A1 METHOD FOR INCREASING THE EFFICIENCY OF INDUCING PLURIPOTENT STEM CELLS 有权
标题翻译：增加诱导大脑干细胞效率的方法
公开(公告)号：US20130302893A1
公开(公告)日：2013-11-14
申请号：US13808596
申请日：2012-03-31
申请人： Duanqing Pei , Tao Wang
发明人： Duanqing Pei , Tao Wang
IPC分类号： C12N5/0775
CPC分类号： C12N5/0662 , C12N5/0696 , C12N2500/38 , C12N2501/602 , C12N2501/72 , C12N2506/13 , C12N2510/00
摘要： The present invention relates to a method for increasing the efficiency of inducing pluripotent stem cells, and more particularly, to a method for increasing the efficiency of inducing pluripotent stem cells by utilizing genes Jhdm1b and Jhdm1a that modify histone. By utilizing Jhdm1b, Jhdm1a, and a stem cell inducing factor, the present invention increases the efficiency of inducing pluripotent stem cells and increases the quality of induced pluripotent stem cells. The stem cell inducing factor is a combination of Oct4 and Klf4, or a combination of Sox2, Oct4, and Klf4, or a combination of Oct4 and Sox2, and Oct4 alone. The method of the present invention further comprises exposing the cells to vitamin C, which further increases the efficiency of inducing pluripotent stem cells as compared with the case where no vitamin C is used. By using less stem cell reducing factors, the method of the present invention reduces the potential carcinogenicity, obtains a high inducing efficiency, and provides high-quality induced pluripotent stem cells capable of germ-line transmission.
摘要翻译：本发明涉及提高多能干细胞诱导效率的方法，更具体地说，涉及通过利用修饰组蛋白的基因Jhdm1b和Jhdm1a来提高诱导多能干细胞的效率的方法。通过利用Jhdm1b，Jhdm1a和干细胞诱导因子，本发明增加诱导多能干细胞的效率并增加诱导多能干细胞的质量。干细胞诱导因子是Oct4和Klf4的组合，或Sox2，Oct4和Klf4的组合，或Oct4和Sox2以及Oct4的组合。本发明的方法还包括将细胞暴露于维生素C，与不使用维生素C的情况相比，这进一步增加诱导多能干细胞的效率。通过使用较少的干细胞减少因子，本发明的方法降低潜在致癌性，获得高诱导效率，并提供能够进行种系传播的高质量诱导多能干细胞。

6. 发明申请

US20130196985A1 HETEROCYCLIC ALKYNYL BENZENE COMPOUNDS AND MEDICAL COMPOSITIONS AND USES THEREOF 有权
标题翻译：杂环烷基苯并噻唑化合物及其组合物及其用途
公开(公告)号：US20130196985A1
公开(公告)日：2013-08-01
申请号：US13807678
申请日：2011-06-03
申请人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
发明人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
IPC分类号： C07D487/04 , C07D471/04 , C07D401/12 , C07D403/12 , C07D401/14
CPC分类号： C07D487/04 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04
摘要： The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec.
摘要翻译：式（I）的杂环炔基苯化合物，其药学上可接受的盐和立体异构体，以及用于制备用于预防或治疗肿瘤的药物的应用。这些化合物可以克服临床上对Gleevec的抵抗力。

7. 发明授权

US08846671B2 Heterocyclic alkynyl benzene compounds and medical compositions and uses thereof 有权
标题翻译：杂环炔基苯化合物及其组合物及其用途
公开(公告)号：US08846671B2
公开(公告)日：2014-09-30
申请号：US13807678
申请日：2011-06-03
申请人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
发明人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
IPC分类号： A61K31/535 , C07D401/00
CPC分类号： C07D487/04 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04
摘要： The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec.
摘要翻译：式（I）的杂环炔基苯化合物，其药学上可接受的盐和立体异构体，以及用于制备用于预防或治疗肿瘤的药物的应用。这些化合物可以克服临床上对Gleevec的抵抗力。

8. 发明申请

US20130040390A1 CULTURE MEDIUM SUPPLEMENT AND USE THEREOF 审中-公开
标题翻译：文化媒介补充及其使用
公开(公告)号：US20130040390A1
公开(公告)日：2013-02-14
申请号：US13263865
申请日：2010-07-29
申请人： Duanqing Pei , Jiekai Chen , Jing Liu
发明人： Duanqing Pei , Jiekai Chen , Jing Liu
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , C12N2500/38 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/33 , C12N2501/603 , C12N2501/727 , C12N2501/999 , C12N2506/1307 , C12N2510/00
摘要： The present invention provides a chemically defined culture system, by which induced pluripotent stem (iPS) cells are obtained with high efficiency. The culture medium supplement of the present invention includes vitamin C and a glycogen synthase kinase-3 inhibitor; another culture medium supplement of the present invention further includes, in addition to vitamin C and the glycogen synthase kinase-3 inhibitor, vitamin B12, insulin, a receptor tyrosine kinase, and an anti-oxidant; and the culture medium supplement of the present invention may further be a mixture of the above two culture medium supplements with a serum replacement cell growth promoter. The present invention further provides a complete culture medium for iPS cells, which is formed by one or more of a basal culture medium, serum, and a serum replacement supplement, and the above culture medium supplements, or formed only by the above culture medium supplements and a basal culture medium. The culture system of the present invention is a chemically defined culture system free of serum and contamination from animal source, by which the iPS cells are obtained with high efficiency. The culture system maintains the growth and proliferation of the cells in conversion of somatic cells to iPS cells in absence of feeder cells, significantly accelerates the iPS cell induction process, and greatly improves the induction efficiency of somatic cells into iPS cells.
摘要翻译：本发明提供一种化学上定义的培养系统，通过该培养系统以高效率获得诱导的多能干细胞（iPS）细胞。本发明的培养基补充剂包括维生素C和糖原合酶激酶-3抑制剂; 除了维生素C和糖原合酶激酶-3抑制剂之外，本发明的另一种培养基补充剂还包括维生素B12，胰岛素，受体酪氨酸激酶和抗氧化剂; 并且本发明的培养基补充物还可以是上述两种培养基补充物与血清替代细胞生长促进剂的混合物。本发明还提供一种用于iPS细胞的完整培养基，其由一种或多种基础培养基，血清和血清替代物补充剂形成，并且上述培养基补充剂或仅由上述培养基补充剂形成和基础培养基。本发明的培养系统是不含动物源的血清和污染的化学上定义的培养系统，通过该培养系统以高效率获得iPS细胞。培养体系保持细胞在不存在饲养细胞时体细胞转化为iPS细胞的生长和增殖，显着加速iPS细胞诱导过程，并大大提高体细胞诱导iPS细胞的诱导效率。

9. 发明授权

US09926532B2 Method of generating induced pluripotent stem cells and differentiated cells 有权
公开(公告)号：US09926532B2
公开(公告)日：2018-03-27
申请号：US13997976
申请日：2011-12-23
申请人： Miguel Esteban , Johannes Grillari , Regina Grillari , Duanqing Pei , Ting Zhou
发明人： Miguel Esteban , Johannes Grillari , Regina Grillari , Duanqing Pei , Ting Zhou
IPC分类号： C12N5/00 , C12N5/02 , C12N5/074 , C12N5/0789
CPC分类号： C12N5/0696 , C12N5/0647
摘要： Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells.

10. 发明申请

US20130323782A1 METHOD OF GENERATING INDUCED PLURIPOTENT STEM CELLS AND DIFFERENTIATED CELLS 有权
标题翻译：产生诱导型干细胞和差异细胞的方法
公开(公告)号：US20130323782A1
公开(公告)日：2013-12-05
申请号：US13997976
申请日：2011-12-23
申请人： Miguel Esteban , Johannes Grillari , Regina Grillari , Duanqing Pei , Ting Zhou
发明人： Miguel Esteban , Johannes Grillari , Regina Grillari , Duanqing Pei , Ting Zhou
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , C12N5/0647
摘要： Methods for generating iPSCs and differentiated cells of interest by reprogramming donor cells that have been obtained in a non-invasive manner. In particular, the donor cells are exfoliated epithelial urine cells. The differentiated cells can be obtained by differentiation of the reprogrammed iPSCs or by direct reprogramming the urine cells.
摘要翻译：通过重新编程以非侵入性方式获得的供体细胞产生iPSC和分化细胞的方法。特别地，供体细胞是脱落的上皮细胞。分化的细胞可以通过重新编程的iPSC的分化或通过直接重新编程尿细胞获得。

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