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1. 发明授权

US08846671B2 Heterocyclic alkynyl benzene compounds and medical compositions and uses thereof 有权
标题翻译：杂环炔基苯化合物及其组合物及其用途
公开(公告)号：US08846671B2
公开(公告)日：2014-09-30
申请号：US13807678
申请日：2011-06-03
申请人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
发明人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
IPC分类号： A61K31/535 , C07D401/00
CPC分类号： C07D487/04 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04
摘要： The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec.
摘要翻译：式（I）的杂环炔基苯化合物，其药学上可接受的盐和立体异构体，以及用于制备用于预防或治疗肿瘤的药物的应用。这些化合物可以克服临床上对Gleevec的抵抗力。

2. 发明申请

US20130196985A1 HETEROCYCLIC ALKYNYL BENZENE COMPOUNDS AND MEDICAL COMPOSITIONS AND USES THEREOF 有权
标题翻译：杂环烷基苯并噻唑化合物及其组合物及其用途
公开(公告)号：US20130196985A1
公开(公告)日：2013-08-01
申请号：US13807678
申请日：2011-06-03
申请人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
发明人： Ke Ding , Deping Wang , Duanqing Pei , Zhang Zhang , Mengjie Shen , Kun Luo , Yubing Feng
IPC分类号： C07D487/04 , C07D471/04 , C07D401/12 , C07D403/12 , C07D401/14
CPC分类号： C07D487/04 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04
摘要： The heterocyclic alkynyl benzene compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in preparing drugs for preventing or treating tumors. The compounds can overcome the clinically induced resistance against Gleevec.
摘要翻译：式（I）的杂环炔基苯化合物，其药学上可接受的盐和立体异构体，以及用于制备用于预防或治疗肿瘤的药物的应用。这些化合物可以克服临床上对Gleevec的抵抗力。

3. 发明授权

US09807604B2 Area-based location privacy management 有权
公开(公告)号：US09807604B2
公开(公告)日：2017-10-31
申请号：US14129641
申请日：2013-07-19
申请人： INTEL CORPORATION , Xiaoyong Pan , Justin Lipman , Yuhuan Huang , Yong Jiang , Ke Ding , Dzinh J. Nguyen , Robert A. Colby
发明人： Xiaoyong Pan , Justin Lipman , Yuhuan Huang , Yong Jiang , Ke Ding , Dzinh J. Nguyen , Robert A. Colby
IPC分类号： H04W12/02 , H04W4/02 , H04W12/08 , H04B17/318 , H04W72/12 , H04W88/08
CPC分类号： H04W12/02 , H04B17/318 , H04W4/02 , H04W4/025 , H04W12/08 , H04W72/1247 , H04W88/08
摘要： Technologies for location privacy management include a mobile computing device to determine whether an application is authorized to obtain the location of the mobile computing device based on a determined location and location access policy of the mobile computing device. The location access policy includes policy rules that identify whether the application is authorized to obtain the location of the mobile computing device. If the mobile computing device determines that the application is not authorized to obtain the location of the mobile computing device, the mobile computing device blocks the application from obtaining the location.

4. 发明授权

US09110674B1 Systems and methods for dynamic power management and performance adjustment of media playing 有权
标题翻译：用于动态电源管理和媒体播放性能调整的系统和方法
公开(公告)号：US09110674B1
公开(公告)日：2015-08-18
申请号：US13486537
申请日：2012-06-01
申请人： Yao Cui , Yi Wang , Ke Ding
发明人： Yao Cui , Yi Wang , Ke Ding
IPC分类号： G06T1/20 , G06F9/38 , G06F9/48
CPC分类号： G06F9/38 , G06F1/3203 , G06F1/3206 , G06F1/324 , G06F1/329 , G06F9/4893 , G06F9/5083 , G06F9/5094 , G06F2209/5022 , Y02D10/126 , Y02D10/22 , Y02D10/24
摘要： System and methods are provided for dynamic performance adjustment of a media playing pipeline. For example, the media playing pipeline includes one or more components synchronized for media playing. A reference component in the media playing pipeline is selected, the reference component having a component performance level. A pipeline performance level of the media playing pipeline is determined. When the pipeline performance level is higher than a threshold, the component performance level of the reference component is adjusted to decrease the pipeline performance level. When the pipeline performance level is lower than the threshold, the component performance level of the reference component is adjusted to increase the pipeline performance level.
摘要翻译：提供系统和方法用于媒体播放管道的动态性能调整。例如，媒体播放管线包括为媒体播放而同步的一个或多个组件。选择媒体播放管道中的参考组件，参考组件具有组件性能级别。确定媒体播放管道的管道性能级别。当管道性能水平高于阈值时，调整参考部件的部件性能水平以降低管道性能水平。当管道性能水平低于阈值时，调整参考部件的部件性能水平，提高管道性能水平。

5. 发明授权

US08144997B1 Method for enhanced image decoding 有权
标题翻译：增强图像解码方法
公开(公告)号：US08144997B1
公开(公告)日：2012-03-27
申请号：US11949544
申请日：2007-12-03
申请人： Ke Ding
发明人： Ke Ding
IPC分类号： G06K9/36 , H04N7/12
CPC分类号： H04N19/59 , H04N19/162 , H04N19/17 , H04N19/176 , H04N19/44 , H04N19/46 , H04N19/48 , H04N19/60 , H04N19/85
摘要： A method of processing an image includes the steps of receiving selection of the first region of interest (ROI) of an image, processing the first image data related to the first ROI, displaying the first image ROI based on the first image data, receiving selection of the second ROI of the image, which at least partially overlapping the first ROI, processing the second image data related to a portion of the second ROI that does not overlap the first ROI, combining the processed second image data with the processed first image data that overlaps the second ROI, and displaying the second image ROI based on the combined processed second image data and the processed first data.
摘要翻译：处理图像的方法包括以下步骤：接收图像的第一感兴趣区域（ROI）的选择，处理与第一ROI相关的第一图像数据，基于第一图像数据显示第一图像ROI，接收选择所述图像的第二ROI与所述第一ROI至少部分重叠，处理与不与所述第一ROI重叠的所述第二ROI的一部分相关的所述第二图像数据，将所处理的第二图像数据与所处理的第一图像数据所述第二ROI与所述第二ROI重叠，并且基于所述组合处理的第二图像数据和所处理的第一数据显示所述第二图像ROI。

6. 发明申请

US20110218196A1 COMPOUNDS OF ESTROGEN-RELATED RECEPTOR MODULATORS AND THE USES THEREOF 有权
标题翻译：雌激素相关受体调节剂的化合物及其用途
公开(公告)号：US20110218196A1
公开(公告)日：2011-09-08
申请号：US13054664
申请日：2009-03-06
申请人： Ke Ding , Chiwai Wong , Lijie Peng , Zhanfang Kang , Xi Zhou
发明人： Ke Ding , Chiwai Wong , Lijie Peng , Zhanfang Kang , Xi Zhou
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/519 , A61P3/00 , A61P3/10 , A61P3/04 , A61P3/08 , A61P3/06
CPC分类号： C07D471/04
摘要： The compounds according to formula (VIII), their pharmaceutically acceptable acid or base addition salts, and the uses thereof. These compounds and their pharmaceutically acceptable acid or base addition salts can be used for preparing medicaments for modulating estrogen related receptors (ERR), and treating metabolic diseases, such as high blood fat, fatty liver, hyperglycemia, diabetes, obesity. The substituents of the formula are defined in the description.
摘要翻译：根据式（VIII）的化合物，其药学上可接受的酸或碱加成盐及其用途。这些化合物及其药学上可接受的酸或碱加成盐可用于制备用于调节雌激素相关受体（ERR）的药物，以及治疗诸如高血脂，脂肪肝，高血糖症，糖尿病，肥胖症等代谢疾病。式的取代基在说明书中定义。

7. 发明申请

US20060247305A1 Chromen-4-one inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof 审中-公开
标题翻译：抗凋亡Bcl-2家族成员的色素-4-酮抑制剂及其用途
公开(公告)号：US20060247305A1
公开(公告)日：2006-11-02
申请号：US11373898
申请日：2006-03-13
申请人： Shaomeng Wang , Ke Ding , Guozhi Tang , Zaneta Nikolovska-Coleska , Renxio Wang , Chao-Yie Yang
发明人： Shaomeng Wang , Ke Ding , Guozhi Tang , Zaneta Nikolovska-Coleska , Renxio Wang , Chao-Yie Yang
IPC分类号： A61K31/353 , C07D405/14
CPC分类号： C07D311/22 , C07D311/36 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D495/04
摘要： The invention relates to small molecules which function as inhibitors of anti-apoptotic Bcl-2 family member proteins (e.g., Bcl-2 and Bcl-xL). The invention also relates to the use of these compounds for inducing apoptotic cell death and sensitizing cells to the induction of apoptotic cell death.
摘要翻译：本发明涉及作为抗凋亡Bcl-2家族成员蛋白（例如Bcl-2和Bcl-xL）的抑制剂的小分子。本发明还涉及这些化合物用于诱导凋亡细胞死亡和使细胞对诱导凋亡性细胞死亡致敏的用途。

8. 发明授权

US09803982B2 Heading estimation for determining a user's location 有权
公开(公告)号：US09803982B2
公开(公告)日：2017-10-31
申请号：US14426604
申请日：2014-04-28
申请人： INTEL CORPORATION , Ke Han , Ke Ding , Jingyi Ma , Yuhuan Huang
发明人： Ke Han , Ke Ding , Jingyi Ma , Yuhuan Huang
IPC分类号： G01C21/16
CPC分类号： G01C21/16
摘要： Technologies for determining a user's location by a mobile computing device include detecting, based on sensed inertial characteristics of the mobile computing device, that a user of the mobile computing device has taken a physical step in a direction. The mobile computing device determines a directional heading of the mobile computing device in the direction and a variation of an orientation of the mobile computing device relative to a previous orientation of the mobile computing device at a previous physical step of the user based on the sensed inertial characteristics. The mobile computing device further applies a Kalman filter to determine a heading of the user based on the determined directional heading of the mobile computing device and the variation of the orientation and determines an estimated location of the user based on the user's determined heading, an estimated step length of the user, and a previous location of the user at the previous physical step.

9. 发明申请

US20140296216A1 PYRIMIDO[4,5-D]PYRIMIDINYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：吡咯二酮[4,5-D]吡啶化合物，药物组合物及其用途
公开(公告)号：US20140296216A1
公开(公告)日：2014-10-02
申请号：US14125304
申请日：2011-12-21
申请人： Ke Ding , Shaohua Chang , Shilin Xu , Lianwen Zhang , Zhengchao Tu , Jian Ding , Meiyu Geng , Yi Chen
发明人： Ke Ding , Shaohua Chang , Shilin Xu , Lianwen Zhang , Zhengchao Tu , Jian Ding , Meiyu Geng , Yi Chen
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/551
摘要： A compound of formula (I) or (II) and use of the compound in the preparation of drugs for treating cancer are disclosed. The study shows that the compounds can inhibit the growth of many kinds of tumor cells, can be used for targeting epidermal growth factor receptor (EGFR), and particularly can inhibit tumor cells with single or multiple mutations of EGFR (T790M). Therefore, the compound can be used as EGFR inhibitor to treat cancer and has a relatively large application value.
摘要翻译：公开了式（I）或（II）的化合物和该化合物在制备用于治疗癌症的药物中的用途。该研究表明，该化合物可抑制多种肿瘤细胞的生长，可用于靶向表皮生长因子受体（EGFR），特别是可以单独或多次EGFR（T790M）突变抑制肿瘤细胞。因此，该化合物可用作EGFR抑制剂治疗癌症，具有较大的应用价值。

10. 发明申请

US20100273799A1 SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF 有权
标题翻译： MDM2的小分子抑制剂及其用途
公开(公告)号：US20100273799A1
公开(公告)日：2010-10-28
申请号：US12822829
申请日：2010-06-24
申请人： Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
发明人： Shaomeng Wang , Ke Ding , Yipin Lu , Zaneta Nikolovska-Coleska , Su Qiu , Guoping Wang , Dongguang Qin , Sanjeev Kumar
IPC分类号： A61K31/5377 , A61K31/407 , A61P35/00 , C07D487/10 , C07D401/14 , A61K31/496 , C07D413/14 , C12N5/02
CPC分类号： C07D209/54 , C07D487/10 , C07D491/10
摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
摘要翻译：本发明涉及作为p53和MDM2相互作用抑制剂的小分子。本发明还涉及这些化合物用于抑制细胞生长，诱导细胞死亡，诱导细胞周期停滞和/或使细胞对附加试剂敏感的用途。

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