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1. 发明申请

WO2012168836A2 DYNAMIC CONSTRAINING WITH OPTICAL SHAPE SENSING 审中-公开
标题翻译：具有光学形状感应的动态约束
公开(公告)号：WO2012168836A2
公开(公告)日：2012-12-13
申请号：PCT/IB2012052753
申请日：2012-05-31
申请人： KONINKL PHILIPS ELECTRONICS NV , MANZKE ROBERT , T HOOFT GERT WIM , CHAN RAYMOND , DESJARDINS ADRIEN EMMANUEL
发明人： MANZKE ROBERT , T HOOFT GERT WIM , CHAN RAYMOND , DESJARDINS ADRIEN EMMANUEL
IPC分类号： A61B5/107 , A61B5/11 , A61N5/10 , G02B6/02
CPC分类号： A61B5/0536 , A61B5/0064 , A61B5/0073 , A61B5/015 , A61B5/1073 , A61B5/1126 , A61B5/1128 , A61B5/4836 , A61B5/6804 , A61B5/6831 , A61B34/20 , A61B2017/00699 , A61B2034/2051 , A61B2034/2061 , A61B2503/20 , A61B2505/07 , A61N5/1049 , A61N5/1069 , G02B6/022
摘要： A system, device and method for measuring dynamic movement of a subject include a mesh configured to flexibly and snuggly fit over at least a portion of the subject. The mesh includes one or more shape sensing optical fibers disposed therein, and a second feedback modality of measurement that includes sensors or detectors incorporated therein such that the one or more shape sensing optical fibers monitors movement of the sensors or detectors on a subject. A reconstruction module is coupled to the shape sensing fibers to receive feedback signals and interpret dynamic changes in a shape and position of the sensors or detectors based on the feedback signals. The reconstruction module accounts for the dynamic changes to improve a medical activity on the subject.
摘要翻译：用于测量对象的动态移动的系统，装置和方法包括被配置为在受试者的至少一部分上灵活地并且贴合地配合的网。网格包括设置在其中的一个或多个形状感测光纤，以及包括其中并入的传感器或检测器的第二反馈测量模式，使得一个或多个形状感测光纤监测对象上的传感器或检测器的移动。重建模块耦合到形状感测光纤以基于反馈信号接收反馈信号并解释传感器或检测器的形状和位置的动态变化。重建模块考虑到动态变化，以改善该主题的医疗活动。

2. 发明申请

WO2011132109A1 EXTENDING IMAGE INFORMATION 审中-公开
标题翻译：扩展图像信息
公开(公告)号：WO2011132109A1
公开(公告)日：2011-10-27
申请号：PCT/IB2011/051545
申请日：2011-04-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , NACHABÉ, Rami , MIHAJLOVIC, Nenad , DESJARDINS, Adrien, Emmanuel , HORIKX, Jeroen, Jan, Lambertus , VAN DER VOORT, Marjolein
发明人： HENDRIKS, Bernardus, Hendrikus, Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , NACHABÉ, Rami , MIHAJLOVIC, Nenad , DESJARDINS, Adrien, Emmanuel , HORIKX, Jeroen, Jan, Lambertus , VAN DER VOORT, Marjolein
IPC分类号： A61B1/00 , A61B1/06 , A61B1/32 , A61B5/00
CPC分类号： A61B5/0075 , A61B5/0062 , A61B5/0071 , A61B5/0084 , A61B5/6848
摘要： The present invention relates to a system for extending microscopy information, where the microscopy information is image information from a first region (118) of an associated sample, the first region being imaged with an imaging system. The extension of the microscopy information originates from probing a larger second region (116) by photons which are emitted at an exit position (128) and collected at en entry position (130). The exit position and the entry position are spatially separated so that so that average spectral information of photons emitted from the exit position and collected at the entry position, is dependent on the second region (116) of the associated sample, the second region (116) being larger than the first region (118).
摘要翻译：本发明涉及用于扩展显微镜信息的系统，其中显微镜信息是来自相关样品的第一区域（118）的图像信息，第一区域用成像系统成像。显微镜信息的延伸来自于在出口位置（128）处发射并在入口位置（130）收集的光子探测较大的第二区域（116）。出口位置和入口位置在空间上分离，使得从出口位置发射并在入口位置收集的光子的平均光谱信息取决于相关样品的第二区域（116），第二区域（116））大于第一区域（118）。

3. 发明申请

WO2011104664A1 INTERVENTIONAL ABLATION DEVICE WITH TISSUE DISCRIMINATING CAPABILITY 审中-公开
标题翻译：具有组织分辨能力的传统解决方案
公开(公告)号：WO2011104664A1
公开(公告)日：2011-09-01
申请号：PCT/IB2011/050727
申请日：2011-02-22
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , NACHABÉ, Rami , BIERHOFF, Waltherus, Cornelis, Jozef , DESJARDINS, Adrien, Emmanuel
发明人： HENDRIKS, Bernardus, Hendrikus, Wilhelmus , LUCASSEN, Gerhardus, Wilhelmus , NACHABÉ, Rami , BIERHOFF, Waltherus, Cornelis, Jozef , DESJARDINS, Adrien, Emmanuel
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B8/0841 , A61B18/02 , A61B2017/00057 , A61B2017/00061 , A61B2017/00084 , A61B2017/00106 , A61B2018/00577 , A61B2034/2063 , A61B2090/378 , G06F19/00
摘要： An interventional ablation device (1) is proposed to comprise an ablation needle (3) with an elongated body(5) and a handle(7). Adjacent to an ablation element (9) provided on the body (5), at least one or preferably two or more sensors(11-21) are provided, preferably at both of opposing sides of the ablation element (9). The ablation device (1) is adapted for detecting physiological information of tissue (27, 29, 31) surrounding an ablation site (33) based on measurement values provided by the sensors. E.g., optical sensors may be used to measure a reflectance spectrum indicating whether the adjacent tissue is healthy tissue (31), tumorous tissue (27) or ablated tissue (29). Using such information, an ablation process may be controlled.
摘要翻译：提出介入消融装置（1）包括具有细长主体（5）和手柄（7）的消融针（3）。设置在主体（5）上的消融元件（9）附近，优选地在消融元件（9）的相对两侧提供至少一个或优选两个或更多个传感器（11-21）。消融装置（1）适于基于由传感器提供的测量值来检测围绕消融部位（33）的组织（27,29,31）的生理信息。例如，光学传感器可用于测量反映光谱，其指示相邻组织是健康组织（31），肿瘤组织（27）还是消融组织（29）。使用这种信息，可以控制消融过程。

4. 发明申请

WO2011004288A1 VISUALIZATION OF PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：生理参数的可视化
公开(公告)号：WO2011004288A1
公开(公告)日：2011-01-13
申请号：PCT/IB2010/052955
申请日：2010-06-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NACHABÉ, Rami , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , BABIC, Drazenko , BRAUN, Augustinus, Laurentius , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, Emmanuel , MIHAJLOVIC, Nenad , HARBERS, Rik
发明人： NACHABÉ, Rami , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , BABIC, Drazenko , BRAUN, Augustinus, Laurentius , VAN DER VOORT, Marjolein , DESJARDINS, Adrien, Emmanuel , MIHAJLOVIC, Nenad , HARBERS, Rik
IPC分类号： A61B6/12 , A61B19/00
CPC分类号： A61B6/12 , A61B1/00147 , A61B5/065 , A61B6/463 , A61B6/5247 , A61B8/463 , A61B34/20 , A61B2034/256 , A61B2090/365 , G06F19/00
摘要： The invention relates to a medical imaging apparatus for providing information about an object. The invention further relates to a method for providing information about an object. In order to improve the preparation and the visual reception of information relating to an object during medical interventions, a medical imaging apparatus for providing information about an object is provided that comprises an image acquisition device an interventional device, a processing device and a display device. The image acquisition device detects object data from at least one region of interest of an object and provides the object data to the processing device. The interventional device detects physiological parameters of the object depending on the position of a predetermined area of the interventional device in relation to the object and provides the physiological parameters to the processing device. Further, the processing device transforms at least a part of the object data into image data and converts the physiological parameters into physiological data. The processing device then modifies at least one image parameter of the image data depending on the physiological data and thereby transforms the image data into modified live image data which is provided to the display device displaying a modified live image.
摘要翻译：本发明涉及一种用于提供关于物体的信息的医学成像设备。本发明还涉及一种用于提供关于对象的信息的方法。为了改善在医疗干预期间与物体有关的信息的准备和视觉接收，提供了一种用于提供关于物体的信息的医学成像装置，其包括图像获取装置，介入装置，处理装置和显示装置。图像获取装置从对象的至少一个感兴趣区域检测对象数据，并将对象数据提供给处理装置。介入装置根据介入装置相对于物体的预定区域的位置来检测物体的生理参数，并将生理参数提供给处理装置。此外，处理装置将至少一部分对象数据变换为图像数据，并将生理参数转换为生理数据。处理装置然后根据生理数据修改图像数据的至少一个图像参数，从而将图像数据变换为提供给显示修改的实时图像的显示装置的修改的实况图像数据。

5. 发明申请

WO2012164481A1 SYSTEM FOR DISTRIBUTED BLOOD FLOW MEASUREMENT 审中-公开
标题翻译：分布式血液流量测量系统
公开(公告)号：WO2012164481A1
公开(公告)日：2012-12-06
申请号：PCT/IB2012/052665
申请日：2012-05-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , 'T HOOFT, Gert, Wim , DESJARDINS, Adrien, Emmanuel , BARLEY, Maya, Ella , CHAN, Raymond
发明人： 'T HOOFT, Gert, Wim , DESJARDINS, Adrien, Emmanuel , BARLEY, Maya, Ella , CHAN, Raymond
IPC分类号： A61B5/026 , A61B5/028 , G01F1/688
CPC分类号： A61B5/0261 , A61B5/028 , A61B5/6852 , A61B2562/0233 , G01F1/6884
摘要： A medical system for minimally-invasive measurement of blood flow in an artery(AT). An interventional device (IVD) with an optical fiber (FB) comprising a plurality of temperature-sensitive optical sensor segments, e.g. Fiber Bragg Gratings, spatially distributed along its longitudinal extension is configured for insertion into an artery (AT). A temperature changer (TC) is arranged in the IVD to introduce a local change in temperature (ΔT) of a bolus of blood in the artery, to allow thermal tracking over time with the optical fiber (FB). A measurement unit (MU) with a laser light source (LS) delivers light to the optical fiber (FB) and receives light reflected from the optical fiber (FB) and generates a corresponding time varying output signal. A first algorithm (A1) translates this time varying output signal into a set of temperatures corresponding to temperatures at respective positions along the optical fiber (FB). A second algorithm (A2) calculates a measure of blood flow (BF) at respective positions along the optical fiber (FB) in accordance with a temporal behavior of said set of temperatures. Such system can be used to quickly scan an artery for diagnosing stenotic regions without the need for pullbacks or injection of toxic liquids. A good spatial resolution of the blood flow measurement can be obtained in real-time.
摘要翻译：用于动脉（AT）血流量微创测量的医疗系统。具有光纤（FB）的介入装置（IVD），其包括多个温度敏感的光学传感器段，例如，沿着其纵向延伸部空间分布的光纤布拉格光栅被配置成插入到动脉（AT）中。在IVD中布置了温度变换器（TC），以引入动脉中的血块的局部温度变化（ΔT），以允许随着光纤（FB）随时间的热跟踪。具有激光光源（LS）的测量单元（MU）向光纤（FB）传送光并接收从光纤（FB）反射的光并产生相应的时变输出信号。第一算法（A1）将该时变输出信号转换成对应于沿着光纤（FB）的相应位置处的温度的一组温度。第二算法（A2）根据所述一组温度的时间特性计算沿着光纤（FB）的各个位置处的血流量（BF）的测量。这种系统可用于快速扫描动脉以诊断狭窄区域，而不需要回吸或注射有毒液体。可以实时获得血流测量的良好的空间分辨率。

6. 发明申请

WO2012123869A2 DEVICE FOR OPTICAL NERVE LOCALIZATION AND OPTICAL NERVE STIMULATION 审中-公开
标题翻译：用于光神经定位和光学神经刺激的装置
公开(公告)号：WO2012123869A2
公开(公告)日：2012-09-20
申请号：PCT/IB2012/051111
申请日：2012-03-09
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , LUCASSEN, Gerhardus, Wilhelmus , KANAGASABAPATHI, Thirukumaran, Thangaraj , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , BIERHOFF, Waltherus, Cornelis, Jozef , DESJARDINS, Adrien, Emmanuel , KLEWER, Jasper , ROGGEVEEN, Stephan, Adriaan , VAN DER VOORT, Marjolein
发明人： LUCASSEN, Gerhardus, Wilhelmus , KANAGASABAPATHI, Thirukumaran, Thangaraj , HENDRIKS, Bernardus, Hendrikus, Wilhelmus , BIERHOFF, Waltherus, Cornelis, Jozef , DESJARDINS, Adrien, Emmanuel , KLEWER, Jasper , ROGGEVEEN, Stephan, Adriaan , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/4893 , A61B5/0068 , A61B5/0075 , A61B5/0077 , A61B5/0082 , A61N5/0622 , A61N2005/063 , A61N2005/0651 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/067
摘要： The invention relates to identification and stimulation of nerve tissues, and more in particular to a method, apparatus and probe for optical nerve localization and optical nerve stimulation. The invention combines in a single apparatus the localization and the verification of the presence of nerve tissue by optical stimulation. The stimulation is detected by monitoring the variations based on thermal sensitive spectroscopic features of light scattering from the area of the stimulated nervous tissue.
摘要翻译：本发明涉及神经组织的鉴别和刺激，更具体地涉及光学神经定位和光学神经刺激的方法，装置和探针。本发明通过光学刺激在单个装置中组合定位和验证神经组织的存在。通过基于来自刺激的神经组织的区域的光散射的热敏光谱特征监测变化来检测刺激。

7. 发明申请

WO2012101532A1 OPTICAL SENSING FOR RELATIVE TRACKING OF ENDOSCOPES 审中-公开
标题翻译：光学感应相关跟踪内镜
公开(公告)号：WO2012101532A1
公开(公告)日：2012-08-02
申请号：PCT/IB2012/050112
申请日：2012-01-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DESJARDINS, Adrien Emmanuel , 'T HOOFT, Gert Wim , BARLEY, Maya Ella , GUTIERREZ, Luis Felipe , CHAN, Raymond , MANZKE, Robert
发明人： DESJARDINS, Adrien Emmanuel , 'T HOOFT, Gert Wim , BARLEY, Maya Ella , GUTIERREZ, Luis Felipe , CHAN, Raymond , MANZKE, Robert
IPC分类号： A61B1/00 , A61B1/012 , A61B1/267 , G02B23/24 , A61M25/01 , A61B19/00 , A61B17/34
CPC分类号： A61B1/0125 , A61B1/00135 , A61B1/00154 , A61B1/018 , A61B1/267 , A61B1/2676 , A61B5/064 , A61B5/065 , A61B2034/2061 , A61B2090/0811 , A61M2025/0166 , G02B23/2423 , G02B23/2476
摘要： A telescopic endoscope employing a primary endoscope (30, 50) having a instrument channel, a miniature secondary endoscope (40, 60) deployed within the instrument channel of the primary endoscope (30, 50), and an endoscope tracker including one or more sensors (32, 61) and one or markers (41, 52) for sensing any portion of the miniature secondary endoscope (40, 60) extending from a distal end of the instrument channel of the primary endoscope (30, 50).
摘要翻译：使用具有仪器通道的主内窥镜（30,50）的伸缩式内窥镜，配置在主内窥镜（30,50）的仪器通道内的微型二次内窥镜（40,60），以及内窥镜跟踪器，其包括一个或多个传感器（32,61）和一个或标记物（41,42），用于感测从主内窥镜（30,50）的仪器通道的远端延伸的微型二次内窥镜（40,60）的任何部分。

8. 发明申请

WO2012056386A1 ADAPTIVE IMAGING AND FRAME RATE OPTIMIZING BASED ON REAL-TIME SHAPE SENSING OF MEDICAL INSTRUMENTS 审中-公开
标题翻译：基于医疗仪器实时形状检测的自适应成像和帧速率优化
公开(公告)号：WO2012056386A1
公开(公告)日：2012-05-03
申请号：PCT/IB2011/054728
申请日：2011-10-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , CHAN, Raymond , WANG, Jinnan , DESJARDINS, Adrien, Emmanuel , GUTIERREZ, Luis, Felipe , BARLEY, Maya, Ella , 't HOOFT, Gert, Wim
发明人： CHAN, Raymond , WANG, Jinnan , DESJARDINS, Adrien, Emmanuel , GUTIERREZ, Luis, Felipe , BARLEY, Maya, Ella , 't HOOFT, Gert, Wim
IPC分类号： A61B19/00
CPC分类号： A61B6/488 , A61B5/055 , A61B5/066 , A61B6/03 , A61B6/12 , A61B6/486 , A61B6/487 , A61B6/504 , A61B6/5229 , A61B6/54 , A61B6/542 , A61B34/20 , A61B2017/00075 , A61B2034/2051 , A61B2034/2061
摘要： A system and method for adaptive imaging include a shape sensing system (115, 117) coupled to an interventional device (102) to measure spatial characteristics of the interventional device in a subject. An image module (130) is configured to receive the spatial characteristics and generate one or more control signals in accordance with the spatial characteristics. An imaging device (110) is configured to image the subject in accordance with the control signals.
摘要翻译：用于自适应成像的系统和方法包括耦合到介入装置（102）以测量受试者中介入装置的空间特征的形状感测系统（115,117）。图像模块（130）被配置为接收空间特性并根据空间特性产生一个或多个控制信号。成像装置（110）被配置为根据控制信号对被摄体进行成像。

9. 发明申请

WO2011048509A1 OPTICAL SENSING - ENABLED INTERVENTIONAL INSTRUMENTS FOR RAPID DISTRIBUTED MEASUREMENTS OF BIOPHYSICAL PARAMETERS 审中-公开
标题翻译：光学感应 - 用于生物物理参数快速分布测量的传统仪器
公开(公告)号：WO2011048509A1
公开(公告)日：2011-04-28
申请号：PCT/IB2010/053845
申请日：2010-08-26
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , CHAN, Raymond , BARLEY, Maya, Ella , DESJARDINS, Adrien, Emmanuel , SHECHTER, Guy , 'T HOOFT, Gert
发明人： CHAN, Raymond , BARLEY, Maya, Ella , DESJARDINS, Adrien, Emmanuel , SHECHTER, Guy , 'T HOOFT, Gert
IPC分类号： A61B19/00
CPC分类号： A61B1/00165 , A61B1/005 , A61B34/20 , A61B90/06 , A61B2017/00022
摘要： An interventional instrument, system and method include an elongated flexible member (100) having one or more segmented sections (101) disposed longitudinally. An optical fiber (104) is disposed internally in the flexible member. A plurality of optical sensors (102) are coupled to the optical fiber and distributed along a length of the flexible member such that the optical sensors are positioned to monitor parameters simultaneously at different positions or at different data sources along the flexible member to provide distributed sensing.
摘要翻译：介入仪器，系统和方法包括具有纵向设置的一个或多个分段部分（101）的细长柔性构件（100）。光纤（104）设置在柔性部件的内部。多个光学传感器（102）耦合到光纤并且沿柔性部件的长度分布，使得光学传感器被定位成沿着柔性部件在不同位置或不同数据源处同时监测参数以提供分布式感测。

10. 发明申请

WO2012123869A3 DEVICE FOR OPTICAL NERVE LOCALIZATION AND OPTICAL NERVE STIMULATION 审中-公开
标题翻译：用于光学神经定位和光学神经刺激的装置
公开(公告)号：WO2012123869A3
公开(公告)日：2013-01-17
申请号：PCT/IB2012051111
申请日：2012-03-09
申请人： KONINKL PHILIPS ELECTRONICS NV , LUCASSEN GERHARDUS WILHELMUS , KANAGASABAPATHI THIRUKUMARAN THANGARAJ , HENDRIKS BERNARDUS HENDRIKUS WILHELMUS , BIERHOFF WALTHERUS CORNELIS JOZEF , DESJARDINS ADRIEN EMMANUEL , KLEWER JASPER , ROGGEVEEN STEPHAN ADRIAAN , VAN DER VOORT MARJOLEIN
发明人： LUCASSEN GERHARDUS WILHELMUS , KANAGASABAPATHI THIRUKUMARAN THANGARAJ , HENDRIKS BERNARDUS HENDRIKUS WILHELMUS , BIERHOFF WALTHERUS CORNELIS JOZEF , DESJARDINS ADRIEN EMMANUEL , KLEWER JASPER , ROGGEVEEN STEPHAN ADRIAAN , VAN DER VOORT MARJOLEIN
IPC分类号： A61B5/00
CPC分类号： A61B5/4893 , A61B5/0068 , A61B5/0075 , A61B5/0077 , A61B5/0082 , A61N5/0622 , A61N2005/063 , A61N2005/0651 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/067
摘要： The invention relates to identification and stimulation of nerve tissues, and more in particular to a method, apparatus and probe for optical nerve localization and optical nerve stimulation. The invention combines in a single apparatus the localization and the verification of the presence of nerve tissue by optical stimulation. The stimulation is detected by monitoring the variations based on thermal sensitive spectroscopic features of light scattering from the area of the stimulated nervous tissue.
摘要翻译：本发明涉及神经组织的识别和刺激，并且更具体地涉及用于光学神经定位和光学神经刺激的方法，设备和探针。本发明在单个装置中通过光学刺激将神经组织的定位和验证结合起来。通过监测基于刺激的神经组织的区域的光散射的热敏光谱特征的变化来检测刺激。

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