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1. 发明申请

WO2006062389A2 MITOCHONDRION BOUND NUCLEIC ACID FOR DETERMINING A HEALTH STATUS OF AN INDIVIDUAL 审中-公开
标题翻译：用于确定个体健康状况的MITOCHONDRION BOUND NUCLEIC ACID
公开(公告)号：WO2006062389A2
公开(公告)日：2006-06-15
申请号：PCT/NL2005/000771
申请日：2005-10-28
申请人： PRIMAGEN HOLDING B.V. , UMC UTRECHT HOLDING B.V. , PENNING, Maarten Tjerk , MAAS, Henriette Catharina Gerarda Irene Martina , DE BAAR, Marinus Petrus , VOEST, Emile Eugene
发明人： PENNING, Maarten Tjerk , MAAS, Henriette Catharina Gerarda Irene Martina , DE BAAR, Marinus Petrus , VOEST, Emile Eugene
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6865 , C12Q2545/101
摘要： The invention describes means and methods for determining mitochondrion bound nucleic acid and describes the use thereof in diagnostics. Preferable cell free mitochondrion bound nucleic acid is determined.
摘要翻译：本发明描述了用于确定线粒体结合核酸的方法和方法，并描述了其在诊断中的用途。测定优选的无细胞线粒体结合核酸。

2. 发明申请

WO2006038797A1 USE OF STATIN OR PRECURSOR THEREOF FOR THE TREATMENT OF HIV INFECTIONS 审中-公开
标题翻译：使用抗生素或其前体治疗艾滋病毒感染
公开(公告)号：WO2006038797A1
公开(公告)日：2006-04-13
申请号：PCT/NL2005/000714
申请日：2005-10-04
申请人： PRIMAGEN HOLDING B.V. , DE BAAR, Marinus, Petrus , PAXTON, William, Anderson , POLLAKIS, Georgios
发明人： DE BAAR, Marinus, Petrus , PAXTON, William, Anderson , POLLAKIS, Georgios
IPC分类号： A61K31/366 , A61P31/18
CPC分类号： A61K31/366
摘要： The invention relates to a new use of statins. It was found that statins are capable of reducing human immunodeficiency virus (HIV) infection of cells that are normally susceptible to HIV-infection. Provided are pharmaceuticals, methods and uses of a statin in the treatment of infections.
摘要翻译：本发明涉及他汀类药物的新用途。发现他汀类能够减少通常易感染艾滋病毒的细胞的人体免疫缺陷病毒（HIV）感染。提供他汀类药物治疗感染的药物，方法和用途。

3. 发明申请

WO2005003392A3 HMG COENZYME A REDUCTASE INHIBITORS AFFECT THE MITOCHONDRIAL DNA CONTENT OF CELLS 审中-公开
公开(公告)号：WO2005003392A3
公开(公告)日：2005-01-13
申请号：PCT/NL2004/000468
申请日：2004-07-01
申请人： PRIMAGEN HOLDING B.V. , VAN GEMEN, Bob , DE BAAR, Marinus, Petrus
发明人： VAN GEMEN, Bob , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
摘要： Statins are widely used for the treatment of high cholesterol levels. In the present invention the effect of statins on mitochondrial nucleic acid and the activation state of mitochondria is used in methods for determining whether a subject is at risk of developing side effects of statin treatment, methods for the treatment of a clinical symptom associated with reduced mitochondrial function. Further provided are kits and the like comprising a means for the detection of mitochondrial nucleic acid, or the activation of a mitochondrion for use in a method mentioned above.

4. 发明申请

WO2005003392A2 HMG COENZYME A REDUCTASE INHIBITORS AFFECT THE MITOCHONDRIAL DNA CONTENT OF CELLS 审中-公开
标题翻译： HMG COENZYME一种还原酶抑制剂影响细胞的MITOCHONDRIAL DNA含量
公开(公告)号：WO2005003392A2
公开(公告)日：2005-01-13
申请号：PCT/NL2004000468
申请日：2004-07-01
申请人： PRIMAGEN HOLDING BV , VAN GEMEN BOB , DE BAAR MARINUS PETRUS
发明人： VAN GEMEN BOB , DE BAAR MARINUS PETRUS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2600/16
摘要： Statins are widely used for the treatment of high cholesterol levels. In the present invention the effect of statins on mitochondrial nucleic acid and the activation state of mitochondria is used in methods for determining whether a subject is at risk of developing side effects of statin treatment, methods for the treatment of a clinical symptom associated with reduced mitochondrial function. Further provided are kits and the like comprising a means for the detection of mitochondrial nucleic acid, or the activation of a mitochondrion for use in a method mentioned above.
摘要翻译：他汀类药物广泛用于治疗高胆固醇水平。在本发明中，他汀类药物对线粒体核酸和线粒体活化状态的影响用于确定受试者是否处于发展他汀类药物治疗副作用的风险的方法中，用于治疗与线粒体降低相关的临床症状的方法功能。进一步提供的试剂盒等包括用于检测线粒体核酸的方法或用于上述方法中的线粒体的活化。

5. 发明申请

WO2006062389A3 METHODS USING MITOCHONDRIAL NUCLEIC ACID FOR DETERMINING A HEALTH STATUS OF AN INDIVIDUAL 审中-公开
标题翻译：使用麻醉核酸测定个体健康状况的方法
公开(公告)号：WO2006062389A3
公开(公告)日：2006-10-19
申请号：PCT/NL2005000771
申请日：2005-10-28
申请人： PRIMAGEN HOLDING BV , UMC UTRECHT HOLDING BV , PENNING MAARTEN TJERK , MAAS HENRIETTE CATHARINA GERAR , DE BAAR MARINUS PETRUS , VOEST EMILE EUGENE
发明人： PENNING MAARTEN TJERK , MAAS HENRIETTE CATHARINA GERAR , DE BAAR MARINUS PETRUS , VOEST EMILE EUGENE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12Q1/6865 , C12Q2545/101
摘要： The invention describes means and methods for determining mitochondrion bound nucleic acid and describes the use thereof in diagnostics. Preferable cell free mitochondrion bound nucleic acid is determined.
摘要翻译：本发明描述了用于确定线粒体结合核酸的方法和方法，并描述了其在诊断中的用途。测定优选的无细胞线粒体结合核酸。

6. 发明申请

WO2003080869A2 STORING AND DETECTING NUCLEIC ACID ADMINISTERED TO A SOLID CARRIER 审中-公开
标题翻译：储存和检测核酸的固体载体
公开(公告)号：WO2003080869A2
公开(公告)日：2003-10-02
申请号：PCT/NL2003/000491
申请日：2003-07-03
申请人： PRIMAGEN HOLDING B.V. , DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
发明人： DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/703 , C12Q2545/114 , C12Q2565/518
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 µl , more preferably at least 250 µl of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.
摘要翻译：本发明提供了用于检测至少一种样品中感兴趣的核酸的方法，包括将所述样品施用至能够至少部分吸收所述样品的固体载体，干燥所述载体，提供在将所述载体的至少一个代表性部分与核酸分离溶液接触，从而从所述载体中提取代表性量的所述核酸，并检测所述代表性量的所述核酸。采用本发明的方法，诸如体液样本的样本稳定在可从服用部位（例如当地医院或欠发达国家的实验室）运送并被发送到通过正常的物流手段在世界其他地方的服务测试实验室。优选地，将至少100微升，更优选至少250微升的样品施用于所述载体，以检测目标核酸的低滴度。还提供了用于检测，鉴定和/或定量样品中感兴趣的核酸的部分试剂盒，其包含能够至少部分吸收所述样品的固体载体和核酸分离溶液。

7. 发明申请

WO2003080869A3 STORING AND DETECTING NUCLEIC ACID ADMINISTERED TO A SOLID CARRIER 审中-公开
公开(公告)号：WO2003080869A3
公开(公告)日：2003-10-02
申请号：PCT/NL2003/000491
申请日：2003-07-03
申请人： PRIMAGEN HOLDING B.V. , DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
发明人： DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 µl , more preferably at least 250 µl of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.

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