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1. 发明申请

WO2003080869A2 STORING AND DETECTING NUCLEIC ACID ADMINISTERED TO A SOLID CARRIER 审中-公开
标题翻译：储存和检测核酸的固体载体
公开(公告)号：WO2003080869A2
公开(公告)日：2003-10-02
申请号：PCT/NL2003/000491
申请日：2003-07-03
申请人： PRIMAGEN HOLDING B.V. , DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
发明人： DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/703 , C12Q2545/114 , C12Q2565/518
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 µl , more preferably at least 250 µl of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.
摘要翻译：本发明提供了用于检测至少一种样品中感兴趣的核酸的方法，包括将所述样品施用至能够至少部分吸收所述样品的固体载体，干燥所述载体，提供在将所述载体的至少一个代表性部分与核酸分离溶液接触，从而从所述载体中提取代表性量的所述核酸，并检测所述代表性量的所述核酸。采用本发明的方法，诸如体液样本的样本稳定在可从服用部位（例如当地医院或欠发达国家的实验室）运送并被发送到通过正常的物流手段在世界其他地方的服务测试实验室。优选地，将至少100微升，更优选至少250微升的样品施用于所述载体，以检测目标核酸的低滴度。还提供了用于检测，鉴定和/或定量样品中感兴趣的核酸的部分试剂盒，其包含能够至少部分吸收所述样品的固体载体和核酸分离溶液。

2. 发明申请

WO2003080869A3 STORING AND DETECTING NUCLEIC ACID ADMINISTERED TO A SOLID CARRIER 审中-公开
公开(公告)号：WO2003080869A3
公开(公告)日：2003-10-02
申请号：PCT/NL2003/000491
申请日：2003-07-03
申请人： PRIMAGEN HOLDING B.V. , DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
发明人： DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 µl , more preferably at least 250 µl of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.

3. 发明申请

WO2006038797A1 USE OF STATIN OR PRECURSOR THEREOF FOR THE TREATMENT OF HIV INFECTIONS 审中-公开
标题翻译：使用抗生素或其前体治疗艾滋病毒感染
公开(公告)号：WO2006038797A1
公开(公告)日：2006-04-13
申请号：PCT/NL2005/000714
申请日：2005-10-04
申请人： PRIMAGEN HOLDING B.V. , DE BAAR, Marinus, Petrus , PAXTON, William, Anderson , POLLAKIS, Georgios
发明人： DE BAAR, Marinus, Petrus , PAXTON, William, Anderson , POLLAKIS, Georgios
IPC分类号： A61K31/366 , A61P31/18
CPC分类号： A61K31/366
摘要： The invention relates to a new use of statins. It was found that statins are capable of reducing human immunodeficiency virus (HIV) infection of cells that are normally susceptible to HIV-infection. Provided are pharmaceuticals, methods and uses of a statin in the treatment of infections.
摘要翻译：本发明涉及他汀类药物的新用途。发现他汀类能够减少通常易感染艾滋病毒的细胞的人体免疫缺陷病毒（HIV）感染。提供他汀类药物治疗感染的药物，方法和用途。

4. 发明申请

WO2005003392A3 HMG COENZYME A REDUCTASE INHIBITORS AFFECT THE MITOCHONDRIAL DNA CONTENT OF CELLS 审中-公开
公开(公告)号：WO2005003392A3
公开(公告)日：2005-01-13
申请号：PCT/NL2004/000468
申请日：2004-07-01
申请人： PRIMAGEN HOLDING B.V. , VAN GEMEN, Bob , DE BAAR, Marinus, Petrus
发明人： VAN GEMEN, Bob , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
摘要： Statins are widely used for the treatment of high cholesterol levels. In the present invention the effect of statins on mitochondrial nucleic acid and the activation state of mitochondria is used in methods for determining whether a subject is at risk of developing side effects of statin treatment, methods for the treatment of a clinical symptom associated with reduced mitochondrial function. Further provided are kits and the like comprising a means for the detection of mitochondrial nucleic acid, or the activation of a mitochondrion for use in a method mentioned above.

5. 发明授权

EP1427860B1 STORING AND QUANTIFYING NUCLEIC ACID ADMINISTERED TO A SOLID CARRIER 有权
标题翻译：存储并固定在载体应用NUCLEIC定量
公开(公告)号：EP1427860B1
公开(公告)日：2009-06-17
申请号：EP03738785.9
申请日：2003-07-03
申请人： PrimaGen Holding B.V.
发明人： DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/703 , C12Q2545/114 , C12Q2565/518
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 µl , more preferably at least 250 µl of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.

6. 发明公开

EP1639134A2 HMG COENZYME A REDUCTASE INHIBITORS AFFECT THE MITOCHONDRIAL DNA CONTENT OF CELLS 审中-公开
标题翻译： HMG-CoA还原酶的抑制剂AFFECT细胞线粒体的DNA含量
公开(公告)号：EP1639134A2
公开(公告)日：2006-03-29
申请号：EP04748698.0
申请日：2004-07-01
申请人： PrimaGen Holding B.V.
发明人： VAN GEMEN, Bob , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q2600/16
摘要： Statins are widely used for the treatment of high cholesterol levels. In the present invention the effect of statins on mitochondrial nucleic acid and the activation state of mitochondria is used in methods for determining whether a subject is at risk of developing side effects of statin treatment, methods for the treatment of a clinical symptom associated with reduced mitochondrial function. Further provided are kits and the like comprising a means for the detection of mitochondrial nucleic acid, or the activation of a mitochondrion for use in a method mentioned above.

7. 发明公开

EP1427860A2 STORING AND DETECTING NUCLEIC ACID ADMINISTERED TO A SOLID CARRIER 有权
标题翻译：存储并固定在载体应用NUCLEIC定量
公开(公告)号：EP1427860A2
公开(公告)日：2004-06-16
申请号：EP03738785.9
申请日：2003-07-03
申请人： PrimaGen Holding B.V.
发明人： DE ROOIJ, Esther, Regina , DE BAAR, Marinus, Petrus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/703 , C12Q2545/114 , C12Q2565/518
摘要： The invention provides a method for detecting a nucleic acid of interest in at least one sample, comprising administering said sample to a solid carrier capable of at least in part absorbing said sample, drying said carrier, providing at least a representative part of said carrier to a nucleic acid isolation solution so that a representative amount of said nucleic acid is extracted from said carrier, and detecting said representative amount of said nucleic acid. With a method of the invention a sample, such as a body fluid sample, is stabilized in such a way that it can be shipped from the site of taking (for instance local hospital or lab in a less-developed country) and be sent to a service testing laboratory elsewhere in the world by normal logistics means. Preferably at least 100 µl , more preferably at least 250 µl of sample is administered to said carrier, in order to detect low titers of nucleic acid of interest. A kit of parts for detecting, identifying and/or quantifying a nucleic acid of interest in a sample, comprising a solid carrier capable of at least in part absorbing said sample, and a nucleic acid isolation solution, is also herewith provided.

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