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1. 发明申请

US20160106909A1 Apparatus for Simultaneous Multiple Medicament Administration 审中-公开
标题翻译：同时多药治疗仪器
公开(公告)号：US20160106909A1
公开(公告)日：2016-04-21
申请号：US14897651
申请日：2014-06-11
申请人： UMC UTRECHT HOLDING BV
发明人： Brechtje Riphagen , Anna Monica Dori Egenie Timmerman , Joris Emanuel Nicolaas Jaspers , Lucas Alphonsus Maria Evers , Richard Leonard Maria Schoffelen , Jan Willem Marinus Mijers , Ronald van Dijk , Daniel van den Hoorn
IPC分类号： A61M5/14 , A61M5/145 , A61M5/38
CPC分类号： A61M5/1408 , A61M5/145 , A61M5/16877 , A61M5/385 , A61M39/105 , A61M2205/7536 , A61M2207/00
摘要： The invention relates to an apparatus and a method for simultaneous multiple medicine administration. The apparatus according to the invention comprises a housing in which at least two entry chambers and a collecting point are formed, wherein each entry chamber communicates with the collecting point via a flow path respectively and wherein in each flow path at least one penetration member is arranged, which causes a decrease in pressure downstream to the penetration member with respect to the pressure upstream to the penetration member. According to the method of the invention the independency of flow rates is eliminated irrespective of the equipment that is used, wherein a fluid is fed to a collecting point via separate flow paths and at least one penetration member is arranged within each flow path causing a decrease in pressure downstream to the penetration member with respect to the pressure upstream to the penetration member.
摘要翻译：本发明涉及一种用于同时多次给药的装置和方法。根据本发明的装置包括壳体，其中形成有至少两个进入室和收集点，其中每个入口室分别经由流动路径与收集点连通，并且其中在每个流动路径中布置有至少一个穿透构件，这导致相对于穿透构件上游的压力，穿透构件下游的压力降低。根据本发明的方法，消除了流量的独立性，而与使用的设备无关，其中流体经由分离的流动路径被供给到收集点，并且至少一个穿透构件被布置在每个流动路径内，导致减少相对于穿透构件上游的压力，在穿透构件的下游压力。

2. 发明申请

US20180036480A1 Device for Administration of Fluid Medicaments 审中-公开
公开(公告)号：US20180036480A1
公开(公告)日：2018-02-08
申请号：US15551602
申请日：2015-02-19
申请人： UMC Utrecht Holding BV
发明人： Brechtje Riphagen , Lucas Alphonsus Maria Evers , Jan Willem Marinus Mijers , Lex Alexander Franciscus Van Rossum
IPC分类号： A61M5/165 , A61M5/168 , A61L31/04 , A61M39/22 , A61M5/38 , A61L31/14 , A61M5/14 , A61M39/24
CPC分类号： A61M5/165 , A61L31/048 , A61L31/14 , A61M5/1408 , A61M5/1412 , A61M5/16827 , A61M5/385 , A61M39/223 , A61M39/24 , A61M2005/1652 , A61M2205/0216 , A61M2205/3306 , A61M2205/584 , A61M2205/75
摘要： A device 2 for the administration of fluids to a human or animal body comprising a housing 3 with a first inlet 28, at least one second inlet 29, 30, one outlet 31 and a collecting point, wherein the first inlet 28 communicates with the collecting point through a first channel and the outlet 31 communicates with the collecting point. The second inlet 29, 30 communicates with the collecting point or an indicator chamber 24, 25 through a second channel 21, 22 in which a valve 26, 27 is arranged, the valve 26, 27 being adjustable between a first position and a second position, wherein, in the first position of the valve 26, 27, the second channel 26, 27 communicates with the indicator chamber 24, 25 and, in the second position of the valve 26, 27, the second channel 21, 22 communicates with the collecting point.

3. 发明申请

WO2014198411A2 APPARATUS FOR SIMULTANEOUS MULTIPLE MEDICAMENT ADMINISTRATION 审中-公开
标题翻译：同时使用多种药物管理的装置
公开(公告)号：WO2014198411A2
公开(公告)日：2014-12-18
申请号：PCT/EP2014001582
申请日：2014-06-11
申请人： UMC UTRECHT HOLDING BV
发明人： RIPHAGEN BRECHTJE , TIMMERMANN ANNA MONICA DORI EGENIE , JASPERS JORIS EMANUEL NOCILAAS , EVERS LUCAS ALPHONSUS MARIA , SCHOFFELEN RICHARD LEONARD MARIA , MIJERS JAN WILLEM MARINUS , VAN DIJK RONALD , VAN DEN HOORN DANIEL
CPC分类号： A61M5/1408 , A61M5/145 , A61M5/16877 , A61M5/385 , A61M39/105 , A61M2205/7536 , A61M2207/00
摘要： The invention relates to an apparatus and a method for simultaneous multiple medicine administration. Apparatus and systems for simultaneous multiple medicine administration of prior art have the disadvantage of medicine flow rates being dependent on each other i.e. changing a particular flow rate leads to a change in the other flow rates. Moreover, the changed flow rate does not reach a set value in a short period of time but fluctuates around the set value for an undesired long period of time. This results in a wrong dosage of all medicines, if the flow rate of one medicine is adjusted, and can cause a serious damage to a patient since some medicine have a very narrow therapeutic range of safety. The apparatus according to the invention eliminates this disadvantage and provides an almost exact dosage when administering multiple medicines simultaneously. The apparatus according to the invention comprises a housing in which at least two entry chambers and a collecting point are formed, wherein each entry chamber communicates with the collecting point via a flow path respectively and wherein in each flow path at least one penetration member is arranged, which causes a decrease in pressure downstream the penetration member with respect to the pressure upstream the penetration member. According to the method of the invention the independency of flow rates is eliminated irrespective of the equipment that is used, wherein a fluid is fed to a collecting point via separate flow paths and at least one penetration member is arranged within each flow path causing a decrease in pressure downstream the penetration member with respect to the pressure upstream the penetration member. The fluids eventually converge at the collecting point.
摘要翻译：本发明涉及一种用于同时多次给药的装置和方法。用于同时多次给药现有技术的装置和系统具有药物流速相互依赖的缺点，即改变特定流速导致其它流量的变化。此外，改变的流量在短时间段内没有达到设定值，而在不期望的长时间段内在设定值附近波动。如果调整一种药物的流量，则可能导致所有药物的剂量不正确，并且可能对患者造成严重损害，因为一些药物具有非常窄的治疗安全范围。根据本发明的装置消除了这种缺点并且在同时施用多种药物时提供了几乎精确的剂量。根据本发明的装置包括壳体，其中形成有至少两个进入室和收集点，其中每个进入室分别经由流动路径与收集点连通，并且其中在每个流动路径中布置有至少一个穿透构件，其导致穿透构件相对于穿透构件上游的压力下游的压力降低。根据本发明的方法，消除了流量的独立性，而与使用的设备无关，其中流体经由分离的流动路径被供给到收集点，并且至少一个穿透构件被布置在每个流动路径内，导致减少穿透构件相对于穿透构件上游的压力下游的压力。流体最终在收集点收敛。

4. 发明申请

WO2013093812A3 A RAPID QUANTITATIVE ASSAY TO MEASURE CFTR FUNCTION IN A PRIMARY INTESTINAL CULTURE MODEL 审中-公开
标题翻译：快速定量测定一次性肠内培养模型CFTR功能
公开(公告)号：WO2013093812A3
公开(公告)日：2013-09-19
申请号：PCT/IB2012057497
申请日：2012-12-19
申请人： UMC UTRECHT HOLDING BV
发明人： BEEKMAN JEFFREY MATTHIJN , DEKKERS JOHANNA FLORENTIA , VAN DER ENT CORNELIS KORSTIAAN , CLEVERS JOHANNES CAROLUS
IPC分类号： G01N33/50 , C12N5/00
CPC分类号： G01N33/5082 , G01N33/5026 , G01N2500/10 , G01N2800/26 , G01N2800/347 , G01N2800/382 , G01N2800/52
摘要： The invention relates to an assay for diagnosing a disease or affliction that affects fluid uptake or secretion or for studying the effectiveness of one or more drugs for treating the disease or affliction, wherein the assay comprises measuring swelling of one or more organoids.
摘要翻译：本发明涉及用于诊断影响流体摄取或分泌的疾病或病痛或用于研究一种或多种药物用于治疗疾病或病痛的有效性的测定，其中所述测定包括测量一种或多种类器官的肿胀。

5. 发明申请

WO2009121848A9 USE OF PSEUDOMONAS AERUGINOSA ALKALINE PROTEASE (APRA) AND INHIBITORS THEREOF IN MEDICINE AND AGRICULTURE 审中-公开
标题翻译： PSEUDOMONAS AERUGINOSA碱性蛋白酶（APRA）及其在医药和农业中的抑制剂的使用
公开(公告)号：WO2009121848A9
公开(公告)日：2009-11-26
申请号：PCT/EP2009053758
申请日：2009-03-30
申请人： UMC UTRECHT HOLDING BV , BARDOEL BART WILLEM , VAN DER ENT SJOERD , PIETERSE CORNELIS MARINUS JOZE , VAN KESSEL CORNELIS PETRUS MAR , VAN STRIJP JOHANNES ANTONIUS G
发明人： BARDOEL BART WILLEM , VAN DER ENT SJOERD , PIETERSE CORNELIS MARINUS JOZEF , VAN KESSEL CORNELIS PETRUS MARIA , VAN STRIJP JOHANNES ANTONIUS GERARDUS
CPC分类号： A61K38/55 , A61K39/00 , C12N15/8281
摘要： The invention relates to an inhibitor of Pseudomonas aeruginosa alkaline protease for use in the treatment or prevention of infectious diseases in humans, animals and plants. The treatment suitably comprises inhibiting the interference of Pseudomonas aeruginosa alkaline protease with a microbial molecule that is recognized by receptors involved in innate immunity, in particular flagellin. The receptors involved in innate immunity are Toll-like receptors, in particular the Toll-like receptor 5 (TLR5), or the flagellin locus 2 (FLS2) receptor.
摘要翻译：本发明涉及铜绿假单胞菌碱性蛋白酶抑制剂，用于治疗或预防人，动物和植物中的感染性疾病。治疗适当地包括抑制绿脓假单胞菌碱性蛋白酶与涉及先天免疫的受体识别的微生物分子的干扰，特别是鞭毛蛋白。参与先天免疫的受体是Toll样受体，特别是Toll样受体5（TLR5）或鞭毛蛋白基因座2（FLS2）受体。

6. 发明申请

WO2007144198B1 FPLR-1 INHIBITORS FOR USE IN DISEASES INVOLVING AMYLOID-INDUCED INFLAMMATORY EVENTS (FLIPR AND FLIPR-LIKE) AND IMMUNECOMPLEX-MEDIATED DISEASES 审中-公开
标题翻译： FPLR-1抑制剂用于涉及淀粉样变性炎症事件（FLIPR和FLIPR样）和免疫介导的疾病的疾病
公开(公告)号：WO2007144198B1
公开(公告)日：2008-07-17
申请号：PCT/EP2007005340
申请日：2007-06-18
申请人： UMC UTRECHT HOLDING BV , VAN KESSEL CORNELIS PETRUS MAR , VAN STRIJP JOHANNES ANTONIUS G
发明人： VAN KESSEL CORNELIS PETRUS MAR , VAN STRIJP JOHANNES ANTONIUS G
IPC分类号： C07K14/31
CPC分类号： C07K14/31 , A61K38/00
摘要： The present invention relates to a FPLR-1 inhibitor selected from the group consisting of FLIPr having the amino acid sequence MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKESDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIKVVKNGEIDSIYWD; FLIPr-like having the amino acid sequence MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERADKLIKEADEKNEHYKGKTVEDLYVIAKKMGKGNTIAVVKIKDGGKNGYYTFDITRPLEEHRKNIPVVKNGEIDSITWY; fragments of a) or b) having FPLR-1 inhibitory activity; homologues of a), b) or c) having FPLR-1 inhibitory activity; or derivatives of a), b), c) or d) having FPLR-1 inhibitory activity.
摘要翻译：本发明涉及选自下组的FPLR-1抑制剂：具有氨基酸序列MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERIDKLMKESDKNLTPYKAETVNDLYLIVKKLSQGDVKKAVVRIKDGGPRDYYTFDLTRPLEENRKNIKVVKNGEIDSIYWD的FLIPr; FLIPr样具有氨基酸序列MKKNITKTIIASTVIAAGLLTQTNDAKAFFSYEWKGLEIAKNLADQAKKDDERADKLIKEADEKNEHYKGKTVEDLYVIAKKMGKGNTIAVVKIKDGGKNGYYTFDITRPLEEHRKNIPVVKNGEIDSITWY; a）或b）的片段具有FPLR-1抑制活性; a），b）或c）具有FPLR-1抑制活性的同系物; 或具有FPLR-1抑制活性的a），b），c）或d）的衍生物。

7. 发明申请

WO2007052067A2 VON WILLEBRAND FACTOR (VWF) BINDING PEPTIDES 审中-公开
标题翻译： VON WILLEBRAND因子（VWF）绑定肽
公开(公告)号：WO2007052067A2
公开(公告)日：2007-05-10
申请号：PCT/GB2006/004160
申请日：2006-11-07
申请人： CAMBRIDGE ENTERPRISE LIMITED , UMC UTRECHT HOLDING BV , FARNDALE, Richard , RAYNAL, Nicolas , LISMAN, Johannes , DE GROOT, Philip
发明人： FARNDALE, Richard , RAYNAL, Nicolas , LISMAN, Johannes , DE GROOT, Philip
IPC分类号： C07K14/78 , C07K16/18
CPC分类号： C07K16/36 , A61K38/00 , C07K14/78 , C07K2317/76 , G01N33/6893 , G01N2500/02 , G01N2800/222
摘要： This invention relates to short triple-helical collagen peptides that are recognised by VWF A3 domain and which consist of the sequence N 1 RGX 3 X 4 GX 5 X 6 GX 7 N 2 , wherein; X 3 is any amino acid except G, X 4 is O or P, X 5 is any amino acid except G or A, X 6 is any amino acid except G, X 7 is any amino acid except G or A, and; N1 and N2 are amino acid sequences consisting, independently, of 0 to 10 amino acid residues. Peptides described herein may be useful in the treatment of thrombosis and the diagnosis of bleeding disorders, as well as in the construction of synthetic collagens.
摘要翻译：本发明涉及由VWF A3结构域识别的短序列三螺旋胶原肽，其由序列N 1，R 3，X 3，X 4， GX 5 X 6，GX 7 N 2 N，其中; X 3是除G以外的任何氨基酸，X 4是O或P，X 5是除G或A之外的任何氨基酸，X < 除了G以外，除了G以外，除了G或A以外，任何氨基酸除外。 N1和N2是独立地由0至10个氨基酸残基组成的氨基酸序列。本文所述的肽可用于治疗血栓形成和出血性疾病的诊断，以及合成胶原的构建。

8. 发明申请

WO2016093700A3 IMMUNOGLOBULIN-LIKE MOLECULES DIRECTED AGAINST FIBRONECTIN-EDA 审中-公开
标题翻译：免疫球蛋白样分子靶向抗纤维蛋白原-EDA
公开(公告)号：WO2016093700A3
公开(公告)日：2016-12-22
申请号：PCT/NL2015050860
申请日：2015-12-11
申请人： UMC UTRECHT HOLDING BV
发明人： ARSLAN FATIH
IPC分类号： C07K16/18 , A61P9/10
CPC分类号： C07K16/18 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/34
摘要： The present invention is concerned with immunoglobulin (Ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression of adverse cardiac remodelling and conditions resulting from or relating to pressure-overload, such as heart failure, aneurysm formation and remote myocardial fibrosis and for use in improving angiogenesis, preferably after ischemic injury. The invention also provides nucleic acid molecules encoding said Ig-like molecules, vectors comprising same, and host cells comprising same.
摘要翻译：本发明涉及免疫球蛋白（Ig）样分子或其片段，用于治疗，预防或预防不良心脏重塑的进展和由压力超负荷引起的或与压力超负荷相关的病症，例如心力衰竭，动脉瘤形成和远端心肌纤维化并用于改善血管生成，优选在缺血性损伤后。本发明还提供了编码所述Ig样分子的核酸分子，包含其的载体以及包含其的宿主细胞。

9. 发明申请

WO2016131463A1 DEVICE FOR ADMINISTRATION OF FLUID MEDICAMENTS 审中-公开
标题翻译：流体药物管理设备
公开(公告)号：WO2016131463A1
公开(公告)日：2016-08-25
申请号：PCT/EP2015/000365
申请日：2015-02-19
申请人： UMC UTRECHT HOLDING BV
发明人： RIPHAGEN, Brechtje , EVERS, Lucas Alphonsus Maria , MIJERS, Jan Willem Marinus , VAN ROSSUM, Lex Alexander Franciscus
IPC分类号： A61M5/14 , A61M5/168 , A61M39/24 , A61M5/165 , A61M39/22
CPC分类号： A61M5/165 , A61L31/048 , A61L31/14 , A61M5/1408 , A61M5/1412 , A61M5/16827 , A61M5/385 , A61M39/223 , A61M39/24 , A61M2005/1652 , A61M2205/0216 , A61M2205/3306 , A61M2205/584 , A61M2205/75
摘要： The present invention relates to a device (2) for the administration of fluids to a human or animal body comprising a housing (3) with a first inlet (28), at least one second inlet (29, 30), one outlet (31) and a collecting point, wherein the first inlet (28) communicates with the collecting point through a first channel and the outlet (31) communicates with the collecting point. The device is characterized in that the second inlet (29, 30) communicates with the collecting point or an indicator chamber (24, 25) through a second channel (21, 22) in which a valve (26, 27) is arranged, the valve (26, 27) being adjustable between a first position and a second position, wherein, in the first position of the valve (26, 27), the second channel (26, 27) communicates with the indicator chamber (24, 25) and, in the second position of the valve (26, 27), the second channel (21, 22) communicates with the collecting point. With the device (2) according to the invention, flow rate irregularities are eliminated (over shoot) or at least minimized (time delay, flow rate fluctuations due to changing flow rates), such that the device (2) allows for a more precise dosage.
摘要翻译：本发明涉及一种用于向人体或动物体施用流体的装置（2），其包括具有第一入口（28）的壳体（3），至少一个第二入口（29,30），一个出口（31））和收集点，其中第一入口（28）通过第一通道与收集点连通，并且出口（31）与收集点连通。该装置的特征在于，第二入口（29,30）通过其中布置有阀（26,27）的第二通道（21,22）与收集点或指示器室（24,25）连通，阀（26,27）可在第一位置和第二位置之间调节，其中在阀（26,27）的第一位置，第二通道（26,27）与指示器室（24,25）连通，并且在阀（26,27）的第二位置，第二通道（21,22）与收集点连通。利用根据本发明的装置（2），流量不均匀性被消除（过度射击）或至少最小化（时间延迟，由于流量变化引起的流量波动），使得装置（2）允许更精确剂量。

10. 发明申请

WO2014198411A3 APPARATUS FOR SIMULTANEOUS MULTIPLE MEDICAMENT ADMINISTRATION 审中-公开
公开(公告)号：WO2014198411A3
公开(公告)日：2014-12-18
申请号：PCT/EP2014/001582
申请日：2014-06-11
申请人： UMC UTRECHT HOLDING BV
发明人： RIPHAGEN, Brechtje , TIMMERMANN, Anna, Monica, Dori, Egenie , JASPERS, Joris, Emanuel, Nocilaas , EVERS, Lucas, Alphonsus, Maria , SCHOFFELEN, Richard, Leonard, Maria , MIJERS, Jan, Willem, Marinus , VAN DIJK, Ronald , VAN DEN HOORN, Daniel
IPC分类号： A61M39/10 , A61M5/14
摘要： The invention relates to an apparatus and a method for simultaneous multiple medicine administration. The apparatus according to the invention comprises a housing (2) in which at least two entry chambers (9, 21) and a collecting point (22, 44) are formed, wherein each entry chamber communicates with the collecting point via a flow path respectively and wherein in each flow path at least one penetration member is arranged, which causes a decrease in pressure downstream the penetration member with respect to the pressure upstream the penetration member. According to the method of the invention the independency of flow rates is eliminated irrespective of the equipment that is used, wherein a fluid is fed to a collecting point via separate flow paths and at least one penetration member is arranged within each flow path causing a decrease in pressure downstream the penetration member with respect to the pressure upstream the penetration member. The fluids eventually converge at the collecting point.

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