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1. 发明授权

US09345806B2 Manufacture of medical implants 有权
标题翻译：医疗植入物的制造
公开(公告)号：US09345806B2
公开(公告)日：2016-05-24
申请号：US12303348
申请日：2007-06-07
申请人： Claudio Tonelli , Piero Gavezotti , Ritalba Lamendola
发明人： Claudio Tonelli , Piero Gavezotti , Ritalba Lamendola
IPC分类号： A61L27/14 , A61L28/00 , A61L29/04 , A61L31/04
CPC分类号： A61L27/14 , A61L28/0026 , A61L29/049 , A61L31/04
摘要： The invention pertains to a process for the manufacture cola medical implant, said process comprising: reacting a mixture of non functional, monofunctional, and bifunctional perfluoropolyethers comprising hydroxyl terminal groups, wherein the average functionality is of at least 1.97 [mixture (M)] with suitable reactants for producing a thermoplastic elastomer; moulding the so-obtained thermoplastic elastomer for yielding at least a part of the medical implant. It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.
摘要翻译：本发明涉及制造可乐医用植入物的方法，所述方法包括：使包含羟基端基的非官能，单官能和双功能全氟聚醚的混合物反应，其中平均官能度为至少1.97 [混合物（M）]与用于生产热塑性弹性体的合适的反应物; 模制如此获得的热塑性弹性体以产生医用植入物的至少一部分。已经令人惊奇地发现，通过使用具有高官能度的全氟聚醚的混合物，有利地可以通过从其中模制热塑性弹性体来制造具有改善的生物相容性并且被降低的生物流体的化学品提取的医用植入物。

2. 发明授权

US08304515B2 Process for the purification of polyol PFPE derivative 有权
标题翻译：多元醇PFPE衍生物的纯化方法
公开(公告)号：US08304515B2
公开(公告)日：2012-11-06
申请号：US12921844
申请日：2009-03-13
申请人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti
发明人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti
IPC分类号： C08F6/00
CPC分类号： C08G65/30 , C08G65/007 , C08G65/22 , C08G65/24
摘要： A process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO—CH2—CH(OH)—CH2—O—CH2—CF2—O—Rf—CF2—CH2O—CH2—CH(OH)—CH2OH, wherein Rf represents a fluoropolyoxyalkene chain (chain Rf), from a mixture (M) of hydroxyl (per)fluoropolyether derivatives, said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain Rf terminated with at least one end group of formula: —CF2CH2OH; —CF2CH2O—CH(OH)—CH2—O—CH2—CH(OH)—CH2OH; said process comprising: step 1: reacting the mixture (M) with ketones and/or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal/acetal derivatives, so as to yield a protected mixture (P); step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture (Pf); step 3: fractional distillation of the mixture (Pf) so as to isolate the cyclic acetal/ketal derivatives of tetraol (T); and step 4: hydrolyzing the acetal/ketal derivatives of tetraol (T) so as to recover pure tetraol (T).
摘要翻译：一种用于纯化式（I）的四醇PFPE衍生物[四醇（T））的方法：HO-CH 2 -CH（OH）-CH 2 -O-CH 2 -CF 2 -O-Rf-CF 2 -CH 2 O-CH 2 -CH （OH）-CH 2 OH，其中Rf表示氟代聚氧亚烷基链（链Rf），由羟基（全）含氟聚醚衍生物的混合物（M），所述混合物包含所述四醇（T）和至少一种羟基（全）氟聚醚[PFPE （OH）]，其包含用至少一个具有下列结构的端基终止的链Rf：-CF 2 CH 2 OH; -CF 2 CH 2 O-CH（OH）-CH 2 -O-CH 2 -CH（OH）-CH 2 OH; 所述方法包括：步骤1：使混合物（M）与酮和/或醛反应，以便通过形成相应的环缩酮/缩醛衍生物来选择性保护连位碳原子上的羟基，从而产生受保护的混合物（P ）; 步骤2：使混合物（P）的残余羟基与合适的官能化试剂反应，从而获得功能化的保护的混合物（Pf）; 步骤3：分馏混合物（Pf），以分离四醇（T）的环状缩醛/缩酮衍生物; 和步骤4：水解四醇（T）的缩醛/缩酮衍生物以回收纯四醇（T）。

3. 发明申请

US20110003968A1 Process for the purification of polyol PFPE derivative 有权
标题翻译：多元醇PFPE衍生物的纯化方法
公开(公告)号：US20110003968A1
公开(公告)日：2011-01-06
申请号：US12921844
申请日：2009-03-13
申请人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti
发明人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti
IPC分类号： C08F6/28
CPC分类号： C08G65/30 , C08G65/007 , C08G65/22 , C08G65/24
摘要： A process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO—CH2—CH(OH)—CH2—O—CH2—CF2—O—Rf—CF2—CH2O—CH2—CH(OH)—CH2OH, wherein Rf represents a fluoropolyoxyalkene chain (chain Rf), from a mixture (M) of hydroxyl (per)fluoropolyether derivatives, said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain Rf terminated with at least one end group of formula: —CF2CH2OH; —CF2CH2O—CH(OH)—CH2—O—CH2—CH(OH)—CH2OH; said process comprising: step 1: reacting the mixture (M) with ketones and/or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal/acetal derivatives, so as to yield a protected mixture (P); step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture (Pf); step 3: fractional distillation of the mixture (Pf) so as to isolate the cyclic acetal/ketal derivatives of tetraol (T); and step 4: hydrolyzing the acetal/ketal derivatives of tetraol (T) so as to recover pure tetraol (T).
摘要翻译：一种用于纯化式（I）的四醇PFPE衍生物[四醇（T））的方法：HO-CH 2 -CH（OH）-CH 2 -O-CH 2 -CF 2 -O-Rf-CF 2 -CH 2 O-CH 2 -CH （OH）-CH 2 OH，其中Rf表示氟代聚氧亚烷基链（链Rf），由羟基（全）氟代聚醚衍生物的混合物（M），所述混合物包含所述四醇（T）和至少一种羟基（全）氟聚醚[PFPE （OH）]，其包含用至少一个具有下列结构的端基终止的链Rf：-CF 2 CH 2 OH; -CF 2 CH 2 O-CH（OH）-CH 2 -O-CH 2 -CH（OH）-CH 2 OH; 所述方法包括：步骤1：使混合物（M）与酮和/或醛反应，以便通过形成相应的环缩酮/缩醛衍生物来选择性保护连位碳原子上的羟基，从而产生受保护的混合物（P ）; 步骤2：使混合物（P）的残余羟基与合适的官能化试剂反应，从而获得功能化的保护的混合物（Pf）; 步骤3：分馏混合物（Pf），以分离四醇（T）的环状缩醛/缩酮衍生物; 和步骤4：水解四醇（T）的缩醛/缩酮衍生物以回收纯四醇（T）。

4. 发明申请

US20100197869A1 Aromatic hydrogenated polymers containing fluorine 有权
标题翻译：含氟的芳香族氢化聚合物
公开(公告)号：US20100197869A1
公开(公告)日：2010-08-05
申请号：US12669019
申请日：2008-07-16
申请人： Claudio Tonelli
发明人： Claudio Tonelli
IPC分类号： C08G69/48 , C08G63/91 , C08G18/00 , C08G73/10 , C08G16/00 , C08G65/48 , C08G75/14 , C08G75/20
CPC分类号： C08G63/916 , C08G63/672 , C08G63/6826 , C08G65/007 , C08G69/26 , C08G69/28 , C08G69/40 , C08G69/42 , C08G69/48 , C08G2650/48 , C08L67/00 , C08L71/02 , C08L77/00 , C08L81/02 , C08L2666/14 , C08L2666/22
摘要： Aromatic hydrogenated polymers comprising perfluoropolyether (PIPE) chains bonded to the aromatic rings to form sequences randomly distributed in the polymer structure, having the formula (I): (T1-CF2O—Rf—CF2)n-T3 in which: n is an integer from 1 to 10; T1 is an aromatic group of the backbone of the hydrogenated polymer, or alternatively condensed aromatic groups; T3 may be equal to T1, or alternatively a functional group —COOH or —COF; Rf is a (per)fluoropolyoxyalkylene chain, in which the starting hydrogenated aromatic polymers are obtained by polycondensation, stepwise polyaddition or polyaddition of cyclic monomers in which the ring is formed by at least 3 atoms.
摘要翻译：芳族氢化聚合物，其包含与芳香环结合的全氟聚醚（PIPE）链，以形成随机分布在聚合物结构中的序列，具有式（I）：（T1-CF2O-Rf-CF2）n-T3，其中：n是整数从1到10; T1是氢化聚合物的骨架的芳族基团，或者可选地是稠合芳族基团; T3可以等于T1，或者可以是官能团-COOH或-COF; Rf是（全）氟聚氧亚烷基链，其中起始氢化芳族聚合物通过环状单体的缩聚，逐步加聚或加聚获得，其中环由至少3个原子形成。

5. 发明申请

US20070249983A1 Machine for extracorporeal blood treatment coupled to a support element 有权
标题翻译：用于体外血液处理的机器耦合到支撑元件
公开(公告)号：US20070249983A1
公开(公告)日：2007-10-25
申请号：US11808068
申请日：2007-06-06
申请人： Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Annalisa Delnevo , Francesco Ribolzi , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
发明人： Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Annalisa Delnevo , Francesco Ribolzi , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
IPC分类号： A61M1/14
CPC分类号： A61M1/16 , A61M1/1643 , A61M1/34 , A61M1/3413 , A61M1/3434 , A61M1/3437 , A61M1/3451 , A61M1/3465 , A61M2205/126 , A61M2205/3331 , A61M2205/3334 , A61M2205/3393 , Y10T137/877
摘要： The invention relates to support element (4) comprising a main body (6) having a front wall (25) and a peripheral wall (32) projecting away from the front wall. The front wall and the peripheral wall define a housing compartment (33) designed to receive a fluid distribution circuitry cooperating with a treatment unit for defining an integrated blood treatment module.
摘要翻译：本发明涉及包括主体（6）的支撑元件（4），所述主体（6）具有前壁（25）和远离前壁突出的周壁（32）。前壁和周边壁限定了一个外壳隔室（33），设计成容纳与治疗单元配合的流体分配电路，用于定义一个集成的血液处理模块。

6. 发明申请

US20070181483A1 Integrated blood treatment module and extracorporeal blood treatment apparatus 有权
标题翻译：综合血液处理模块和体外血液处理仪
公开(公告)号：US20070181483A1
公开(公告)日：2007-08-09
申请号：US11783165
申请日：2007-04-06
申请人： Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Annalisa Delnevo , Francesco Ribolzi , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
发明人： Claudio Tonelli , Vincenzo Baraldi , Massimo Zaccarelli , Annalisa Delnevo , Francesco Ribolzi , Jacques Chevallet , Jacques Duchamp , Aziz Aberkane , Gabriel Meyssonnier , Dominique Pouchoulin
IPC分类号： B01D63/00
CPC分类号： A61M1/3621 , A61M2205/126 , A61M2205/128
摘要： The invention relates to an integrated blood treatment module (1) comprising a support element (4) and a fluid distribution circuitry associated thereto; the distribution circuitry comprises at least a blood line (44), a portion of which is secured to the support element and defines with the latter at least a U-shaped tube length (44a) designed to cooperate, when in use, with a respective pump (3a). There are then further fluid lines (45, 48, 50, 51) fastened to the support element and defining each at least a U-shaped tube length (45a, 48a, 50a, 51a) with respect to said element and each designed to cooperate, when in use, with a respective pump (3b, 3c, 3d, 3e). The support element has a first zone (274) in which the portion of the blood line is secured, and at least a second zone (275) opposite said first zone, to which all the corresponding further tube lengths are fastened.
摘要翻译：本发明涉及一种集成血液处理模块（1），其包括支撑元件（4）和与其相关联的流体分配电路; 分配电路包括至少一条血液线（44），其一部分固定在支撑元件上，并且与血管线固定在至少一个U形管长度（44a）上，U形管长度（44a）在使用时与相应的泵（3a）。然后将另外的流体管线（45,48,50,51）固定到支撑元件并且限定每个至少U形管长度（45a，48a，50a，51a）相对于所述元件和每个设计用于在使用时与相应的泵（3b，3c，3d，3e）配合。所述支撑元件具有第一区域（274），其中所述血液线的所述部分被固定，以及至少第二区域（275），所述第二区域与所述第一区域相对，所有相应的另外的管段被紧固到所述第二区域。

7. 发明授权

US07161030B2 Hydrofluoroethers having at least one hydrogenated-OCFX'CH3 end group wherein X′=F, CF3 and their preparation process 失效
标题翻译：具有至少一个氢化OCFX'CH3端基的氢氟醚，其中X'= F，CF 3及其制备方法
公开(公告)号：US07161030B2
公开(公告)日：2007-01-09
申请号：US10630697
申请日：2003-07-31
申请人： Rosaldo Picozzi , Antonella Di Meo , Claudio Tonelli
发明人： Rosaldo Picozzi , Antonella Di Meo , Claudio Tonelli
IPC分类号： C07C51/58 , C07C41/18 , C07C45/41 , C07C53/15
CPC分类号： C07C43/137 , C07C43/126 , C07C43/315 , C07C59/135 , C08G65/007 , C08G65/226 , C08G65/322
摘要： Hydrofluoroethers of formula: T-CFX′—O—Rf—CFX-T′ (II) wherein: T=CH3; X, X′, equal to or different from each other, are selected between F, CF3; T00′=F, Cl, H, C1–C3 perfluoroalkyl, CH3, CH2OH, COCl, CHO, CO2H; Rf is a perfluoroalkylene or a perfluoropolyoxyalkylene and respective preparation process by reduction with hydrogen in the presence of a platinum catalyst supported on metal fluorides of the corresponding compounds with at least one —COCl end group.
摘要翻译：下式的氢氟醚：<？in-line-formula description =“In-line formula”end =“lead”？> T-CFX'-ORF-CFX-T'（II） in-line-formula description =“In-line Formulas”end =“tail”？>其中：T = CH 3 3; X，X'彼此相等或不同，在F，CF 3 3之间选择; T00'= F，Cl，H，C 1 -C 3全氟烷基，CH 3，CH 2 OH ，COCl，CHO，CO 2 H; R f是全氟亚烷基或全氟聚氧化烯，以及各自的制备方法，通过在负载在相应化合物的金属氟化物上的铂催化剂存在下用氢还原至少一个-COCl端基。

8. 发明授权

US06509509B2 Process for the preparation of perfluoropolyoxyalkylenes with hydroxyl end groups 失效
标题翻译：用羟基端基制备全氟聚氧化烯的方法
公开(公告)号：US06509509B2
公开(公告)日：2003-01-21
申请号：US09750101
申请日：2000-12-29
申请人： Claudio Tonelli , Antonio Russo , Ezio Strepparola
发明人： Claudio Tonelli , Antonio Russo , Ezio Strepparola
IPC分类号： C07C4311
CPC分类号： C08G65/324 , C08G65/007
摘要： A process for preparing perfluoropolyoxyalkylenes with hydroxyl end groups having structure: T1—CFW1—O—Rf—CFW2—T2 (I) wherein: T1, T2, are selected from —CH2OH, —F, —CF3, —CF2CF3 with the proviso that at least one of T1 and T2 is —CH2OH; W1 and W2 are selected from F, CF3; Rf is a perfluoropolyoxyalkylene chain having a number average molecular weight 500-10,000 comprising one or more units of the type —CF2CF2O—, —CF2O—, —C3F6O—, —CF2(CF2)zCF2O— (z=1,2); —CR4R5CF2CF2O— with R4 and R5 selected from H, Cl, perfluoroalkyl group; said process comprising the following steps: a) adding an ester precursor having structure (I) and T1, T2 end groups selected from —F, —CF3, —CF2CF3, —COOR (R=linear or branched alkyl group having a number of C atoms from 1 to 5), with the proviso that at least one of T1 and T2 is —COOR, in a reaction mixture formed by: an inert or protic reaction solvent; a reducing agent selected from metal hydrides; an unreactive organic base with respect to the ester; b) hydrolysis of the product obtained in step a) for obtaining the compounds of structure (I) with at least a —CH2OH end group.
摘要翻译：制备具有以下结构的羟基端基的全氟聚氧化烯的方法：其中：T1，T2选自-CH2OH，-F，-CF3，-CF2CF3，条件是T1和T2中的至少一个为-CH2OH; W1和W2 选自F，CF 3; Rf是数均分子量为500-10,000的全氟聚氧亚烷基链，其包含一种或多种-CF 2 CF 2 O-，-CF 2 O-，-C 3 F 6 O-，-CF 2（CF 2）z CF 2 O-（z = 1,2）; -CR4R5CF2CF2O-，其中R4和R5选自H，Cl，全氟烷基; 所述方法包括以下步骤：a）加入具有结构（I）和T1的酯前体，T2端基选自-F，-CF 3，-CF 2 CF 3，-COOR（R =直链或支链烷基，其数目为C 原子从1至5），条件是至少一个T1和T2是-COOR，在由惰性或质子反应溶剂形成的反应混合物中;还原剂选自金属氢化物;非反应性有机碱，相对于酯化; b）在步骤a）中获得的产物的水解，得到至少具有-CH 2 OH端基的结构（I）化合物。

9. 发明授权

US5959058A Coatings based on fluoropolyethers 失效
标题翻译：基于含氟聚醚的涂料
公开(公告)号：US5959058A
公开(公告)日：1999-09-28
申请号：US613518
申请日：1996-03-11
申请人： Claudio Tonelli , Massimo Scicchitano , Stefano Turri
发明人： Claudio Tonelli , Massimo Scicchitano , Stefano Turri
IPC分类号： C08G18/50 , C08G18/71 , C08G18/80 , C08G59/30 , C08G65/00 , C09D171/00 , C09D171/02 , C07C43/12
CPC分类号： C08G65/007 , C08G18/5015 , C08G18/71 , C08G18/718 , C08G18/8025 , C08G59/30 , C09D171/02
摘要： Use of fluorinated polymers based on fluoropolyethers for the preparation of crosslinkable high dry formulations comprising a fluorinated part R.sub.F and optionally an hydrogenated part R.sub.H, not containing groups capable of linking by means of hydrogen bonds to basic acceptors, an hydrogenated part Rh.sub.1 and Rh.sub.2, wherein Rh.sub.1 is equal to or different from Rh.sub.2, and Rh.sub.1 and/or Rh.sub.2 being linking bonds containing at least a functional group capable of linking by means of hydrogen bonds with basic acceptors, the bonds joining the fluorinated part to the hydrogenated part being of ether C--O simple type, the terminals T'.sub.a and T" being such as to render the structure mono-, bi- or polyfunctional, and subsequent crosslinking of the fluorinated polymer, the monofunctional products being always in admixture with a resin having even a higher functionality than the described type; the preferred fluorinated products have the formula:T"--(Rh.sub.2).sub.y (R.sub.H).sub.x --R.sub.F --(R.sub.H).sub.x --(Rh.sub.1).sub.y' T'.sub.a
摘要翻译：使用基于氟聚醚的氟化聚合物制备可交联的高干制剂，其包含氟化部分RF和任选的氢化部分RH，不含能够通过氢键与碱性受体连接的基团，氢化部分Rh1和Rh2，其中 Rh1等于或不同于Rh2，并且Rh1和/或Rh2是至少含有能够通过氢键与碱性受体连接的官能团的连接键，将氟化部分连接到氢化部分上的键为醚CO 简单型，终端T'a和T“使得结构单，双或多官能并随后交联氟化聚合物，单官能产品总是与甚至具有更高官能度的树脂混合比所描述的类型; 优选的氟化产物具有下式：T“ - （Rh 2）y（RH）x-RF-（RH）x-（Rh1）y'T'a

10. 发明授权

US5910614A Process for preparing perfluoropolyethers 失效
标题翻译：制备全氟聚醚的方法
公开(公告)号：US5910614A
公开(公告)日：1999-06-08
申请号：US903060
申请日：1997-07-30
申请人： Stefano Turri , Claudio Tonelli , Carlo Pogliani
发明人： Stefano Turri , Claudio Tonelli , Carlo Pogliani
IPC分类号： C08G65/32 , C08G65/00 , C08G65/30 , C07C43/11 , B01D16/08
CPC分类号： C08G65/30 , C08G65/007
摘要： Separation process of bifunctional macromolecules having hydroxylic termination from non functional and/or monofunctional macromolecules having hydroxylic termination contained in admixture in perfluoropolyoxyalkylenes (I) comprising the following phases:addition of the macromer (I) to a suspension of stationary phase in polar solvent, said stationary phase being formed by a compound containing sites and/or active groups, capable of establishing bonds or interactions of polar type, or hydrogen bonds, with the hydroxylic terminals of the perfluoropolyoxyalkylenes contained in the mixture of formula (I), the macromer/stationary phase ratio ranging from 2/3 to 1/1 w/w; solvent/(stationary phase+macromer) ratio ranging from 0.8/1 to 1.5/1 v/w; evaporation of the solvent, until obtainment of an incoherent and dry powder;first extraction with low polarity fluorinated solvent and separation of the phases by filtering;second extraction of the stationary phase with polar hydrogenated solvent, and separation of the phases by filtering;the macromer fraction having high bifunctionality degree being obtained by concentration of the liquid phase after second extraction, i.e. after removal of the solvent.
摘要翻译：具有羟基终止的具有羟基终止的羟基终止的双官能大分子的分离过程包含在包含以下相的全氟聚氧化烯（I）中的混合物中：将大分子单体（I）加入极性溶剂中的固定相的悬浮液，所述固定相由含有位点和/或活性基团的化合物形成，其能够与式（I）的混合物中所含的全氟聚氧化烯的羟基末端，大分子单体/固定体形成极性型或氢键的键或相互作用相位比范围为2/3至1/1 w / w; 溶剂/（固定相+大分子单体）比率范围为0.8 / 1至1.5 / 1v / w; 蒸发溶剂，直到得到非相干和干粉; 首先用低极性氟化溶剂萃取并通过过滤分离相; 用极性氢化溶剂二次萃取固定相，通过过滤分离相; 通过第二次萃取后的液相浓缩，即除去溶剂后，获得具有高双官能度的大分子单体馏分。

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