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1. 发明授权

US06984759B2 Process for the preparation of perfluoropolyethers having aldehyde, alcohol, amine end groups by catalytic reduction 失效
标题翻译：通过催化还原制备具有醛，醇，胺端基的全氟聚醚的方法
公开(公告)号：US06984759B2
公开(公告)日：2006-01-10
申请号：US10630698
申请日：2003-07-31
申请人： Antonella Di Meo , Rosaldo Picozzi , Claudio Tonelli
发明人： Antonella Di Meo , Rosaldo Picozzi , Claudio Tonelli
IPC分类号： C07C209/00 , C07C209/44 , C07C45/00 , C07C41/18
CPC分类号： C08G65/322 , C08G65/007 , C08G65/226 , C08G65/323 , C08G65/3255 , C08G65/329
摘要： Process for the perfluoropolyether preparation having reactive end groups —CH2NH2, —CHO, —CH2OH, by reduction of the corresponding perfluoropolyethers having —CN, —COCl, —CHO end groups by using gaseous hydrogen in the presence of a catalyst constituted by Pd, Rh, or Ru, supported on solid metal fluorides, at a temperature from 20° C. to 150° C. and under a pressure between 1 and 50 atm.
摘要翻译：通过还原相应的全氟聚醚，具有反应性端基-CH 2 NH 2，-CHO，-CH 2 OH的全氟聚醚制备方法在由固体金属氟化物负载的Pd，Rh或Ru构成的催化剂存在下，在20℃至150℃的温度下，通过使用气态氢，具有-CN，-COCl，-CHO端基和在1和50大气压之间。

2. 发明申请

US20100240930A1 Process for the manufacture of polyol perfluoropolyether derivative 有权
标题翻译：制备多元醇全氟聚醚衍生物的方法
公开(公告)号：US20100240930A1
公开(公告)日：2010-09-23
申请号：US12681151
申请日：2008-10-03
申请人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti , Antonella DI Meo
发明人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti , Antonella DI Meo
IPC分类号： C07C41/26
CPC分类号： C07C41/26 , C07C43/126 , C08G65/007 , C08G65/22 , C08G65/2639 , C08G65/3312 , C10M2211/063
摘要： A process for the manufacture of a polyol (per)fluoropolyether derivative, comprising: 1. reacting at least one triol having two protected hydroxyl functions and a free hydroxyl group with an activating agent, to yield an activated protected triol; 2. reacting the activated protected triol with a functional (per)fluoropolyether derivative of formula: T2-O—Rf-T1, wherein: Rf represents a fluoropolyoxyalkene chain which is a fluorocarbon segment comprising ether linkages in main chain; T1 and T2, equal to or different from each other, are independently selected from non-functional groups of formula: —CF3, —CF2—CF3, —CF2Cl, —CF2CF2Cl, —CF2—COF, —COF: and functional hydroxyl groups comprising at least one hydroxyl group, with the provisio that at least one of T1 and T2 is a functional hydroxyl group as above detailed to yield a protected polyol (per)fluoropolyether derivative; and 3. deprotecting the protected polyol (per)fluoropolyether derivative to yield the polyol (per)fluoropolyether derivative.
摘要翻译：一种制备多元醇（全）氟代聚醚衍生物的方法，包括：使至少一种具有两个保护的羟基官能团和游离羟基的三醇与活化剂反应，得到活化的保护的三醇; 2.使活化的受保护的三醇与式T2-O-Rf-T1的功能性（全）氟聚醚衍生物反应，其中：Rf代表氟代聚氧亚烷基链，其是在主链中包含醚键的氟碳链段; T1和T2彼此相同或不同，独立地选自式-CF 3，-CF 2 -CF 3，-CF 2 Cl，-CF 2 CF 2 Cl，-CF 2 -CFF，-COF的非官能团：和包含至少一个羟基，条件是T1和T2中的至少一个是如上详述的官能羟基，得到受保护的多元醇（全）氟聚醚衍生物; 和3.将保护的多元醇（全）氟聚醚衍生物脱保护，得到多元醇（全）氟聚醚衍生物。

3. 发明授权

US07161030B2 Hydrofluoroethers having at least one hydrogenated-OCFX'CH3 end group wherein X′=F, CF3 and their preparation process 失效
标题翻译：具有至少一个氢化OCFX'CH3端基的氢氟醚，其中X'= F，CF 3及其制备方法
公开(公告)号：US07161030B2
公开(公告)日：2007-01-09
申请号：US10630697
申请日：2003-07-31
申请人： Rosaldo Picozzi , Antonella Di Meo , Claudio Tonelli
发明人： Rosaldo Picozzi , Antonella Di Meo , Claudio Tonelli
IPC分类号： C07C51/58 , C07C41/18 , C07C45/41 , C07C53/15
CPC分类号： C07C43/137 , C07C43/126 , C07C43/315 , C07C59/135 , C08G65/007 , C08G65/226 , C08G65/322
摘要： Hydrofluoroethers of formula: T-CFX′—O—Rf—CFX-T′ (II) wherein: T=CH3; X, X′, equal to or different from each other, are selected between F, CF3; T00′=F, Cl, H, C1–C3 perfluoroalkyl, CH3, CH2OH, COCl, CHO, CO2H; Rf is a perfluoroalkylene or a perfluoropolyoxyalkylene and respective preparation process by reduction with hydrogen in the presence of a platinum catalyst supported on metal fluorides of the corresponding compounds with at least one —COCl end group.
摘要翻译：下式的氢氟醚：<？in-line-formula description =“In-line formula”end =“lead”？> T-CFX'-ORF-CFX-T'（II） in-line-formula description =“In-line Formulas”end =“tail”？>其中：T = CH 3 3; X，X'彼此相等或不同，在F，CF 3 3之间选择; T00'= F，Cl，H，C 1 -C 3全氟烷基，CH 3，CH 2 OH ，COCl，CHO，CO 2 H; R f是全氟亚烷基或全氟聚氧化烯，以及各自的制备方法，通过在负载在相应化合物的金属氟化物上的铂催化剂存在下用氢还原至少一个-COCl端基。

4. 发明授权

US08513471B2 Process for the manufacture of polyol perfluoropolyether derivative 有权
标题翻译：制备多元醇全氟聚醚衍生物的方法
公开(公告)号：US08513471B2
公开(公告)日：2013-08-20
申请号：US12681151
申请日：2008-10-03
申请人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti , Antonella Di Meo
发明人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti , Antonella Di Meo
IPC分类号： C07C41/26 , C07C43/12
CPC分类号： C07C41/26 , C07C43/126 , C08G65/007 , C08G65/22 , C08G65/2639 , C08G65/3312 , C10M2211/063
摘要： A process for the manufacture of a polyol (per)fluoropolyether derivative comprising: 1. reacting at least one triol having two protected hydroxyl functions and a free hydroxyl group with an activating agent, to yield an activated protected triol; 2. reacting the activated protected triol with a functional (per)fluoropolyether derivative of formula: T2-O—Rf-T1, wherein: Rf represents a fluoropolyoxyalkene chain which is a fluorocarbon segment comprising ether linkages in main chain; T1 and T2, equal to or different from each other, are independently selected from non-functional groups of formula: —CF3, —CF2—CF3, —CF2Cl, —CF2CF2Cl, —CF2—COF, —COF: and functional hydroxyl groups comprising at least one hydroxyl group, with the provisio that at least one of T1 and T2 is a functional hydroxyl group as above detailed to yield a protected polyol (per)fluoropolyether derivative; and 3. deprotecting the protected polyol (per)fluoropolyether derivative to yield the polyol (per)fluoropolyether derivative.
摘要翻译：制备多元醇（全）氟聚醚衍生物的方法，包括：1.使具有两个被保护的羟基官能团和游离羟基的至少一种三醇与活化剂反应，得到活化的保护的三醇; 2.使活化的受保护的三醇与式T2-O-Rf-T1的功能性（全）氟聚醚衍生物反应，其中：Rf代表氟代聚氧亚烷基链，其是在主链中包含醚键的氟碳链段; T1和T2彼此相同或不同，独立地选自式-CF 3，-CF 2 -CF 3，-CF 2 Cl，-CF 2 CF 2 Cl，-CF 2 -CFF，-COF的非官能团：和包含至少一个羟基，条件是T1和T2中的至少一个是如上详述的官能羟基，得到受保护的多元醇（全）氟聚醚衍生物; 和3.将保护的多元醇（全）氟聚醚衍生物脱保护，得到多元醇（全）氟聚醚衍生物。

5. 发明申请

US20070106092A1 Hydrofluoroethers having at least one hydrogenated -OCFX'CH3 end group wherein X'=F, CF3 and their preparation process 审中-公开
标题翻译：具有至少一个氢化的-OCFX'CH3端基的氢氟醚，其中X'= F，CF 3及其制备方法
公开(公告)号：US20070106092A1
公开(公告)日：2007-05-10
申请号：US11588325
申请日：2006-10-27
申请人： Rosaldo Picozzi , Antonella Di Meo , Claudio Tonelli
发明人： Rosaldo Picozzi , Antonella Di Meo , Claudio Tonelli
IPC分类号： C07C59/10 , C07C47/02 , C07C51/58
CPC分类号： C07C43/137 , C07C43/126 , C07C43/315 , C07C59/135 , C08G65/007 , C08G65/226 , C08G65/322
摘要： Hydrofluoroethers of formula: T-CFX′—O—Rf—CFX-T′ (II) wherein: T=CH3; X, X′, equal to or different from each other, are selected between F, CF3; T′=F, Cl, H, C1—C3 perfluoroalkyl, CH3, CH20H, COC1, CHO, CO2H; Rf is a perfluoroalkylene or a perfluoropolyoxyalkylene and respective preparation process by reduction with hydrogen in the presence of a platinum catalyst supported on metal fluorides of the corresponding compounds with at least one —COCl end group.
摘要翻译：下式的氢氟醚：<？in-line-formula description =“In-line formula”end =“lead”？> T-CFX'-ORF-CFX-T'（II） in-line-formula description =“In-line Formulas”end =“tail”？>其中：T = CH 3 3; X，X'彼此相等或不同，在F，CF 3 3之间选择; T'= F，Cl，H，C 1 -C 3全氟烷基，CH 3，CH 2 OH COC 1，CHO，CO 2 H; R f是全氟亚烷基或全氟聚氧化烯，以及各自的制备方法，通过在负载在相应化合物的金属氟化物上的铂催化剂存在下用氢还原至少一个-COCl端基。

6. 发明授权

US06919479B2 Process for the preparation of perfluoropolyethers acyl-fluoride ended by reduction of the corresponding peroxidic perfluoropolyethers 失效
标题翻译：制备全氟聚醚酰氟的方法是通过还原相应的过氧化全氟聚醚来终止
公开(公告)号：US06919479B2
公开(公告)日：2005-07-19
申请号：US10631862
申请日：2003-08-01
申请人： Antonella Di Meo , Rosaldo Picozzi , Claudio Tonelli
发明人： Antonella Di Meo , Rosaldo Picozzi , Claudio Tonelli
IPC分类号： C07C51/62 , C07B61/00 , C07C59/135 , C08G65/00 , C08G65/22 , C08G65/322 , C07C51/09
CPC分类号： C08G65/226 , C08G65/007 , C08G65/322
摘要： A process for the preparation of perfluoropolyethers of formula: T-CFX′—O—Rf—CFX—COF (I) wherein: T=COF, F, C1-C3 perfluoroalkyl; X, X′=—F, —CF3; Rf=—(C2F4O)m(CF2CF(CF3)O)n(CF2O)p(CF(CF3)O)q—, the sum n+m+p+q ranges from 2 to 200, by reduction with hydrogen of the corresponding peroxidic perfluoropolyethers, in the presence of a catalyst formed by metals of the VIII group supported on metal fluorides, at a temperture from 20° C. to 140° C., and at a pressure between 1 and 50 atm.
摘要翻译：一种制备式的全氟聚醚的方法：<？in-line-formula description =“In-line formula”end =“lead”？> T-CFX'-ORF-CFX-COF （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中：T = COF，F，C 1 -C 3，全氟烷基 X，X'= -F，-CF 3 3; （CF 2）2 - （C 2 H 4）（CF 2） CF（CF 3）O）n（CF 2 O）p（CF 3 CF 3）通过在相应的过氧化全氟聚醚的氢还原的情况下，在由下述催化剂形成的催化剂的存在下，n + m + p + q的和n + m + p + q在2至200的范围内， VIII族的金属在金属氟化物上负载，温度为20℃至140℃，压力为1至50atm。

7. 发明授权

US08304515B2 Process for the purification of polyol PFPE derivative 有权
标题翻译：多元醇PFPE衍生物的纯化方法
公开(公告)号：US08304515B2
公开(公告)日：2012-11-06
申请号：US12921844
申请日：2009-03-13
申请人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti
发明人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti
IPC分类号： C08F6/00
CPC分类号： C08G65/30 , C08G65/007 , C08G65/22 , C08G65/24
摘要： A process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO—CH2—CH(OH)—CH2—O—CH2—CF2—O—Rf—CF2—CH2O—CH2—CH(OH)—CH2OH, wherein Rf represents a fluoropolyoxyalkene chain (chain Rf), from a mixture (M) of hydroxyl (per)fluoropolyether derivatives, said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain Rf terminated with at least one end group of formula: —CF2CH2OH; —CF2CH2O—CH(OH)—CH2—O—CH2—CH(OH)—CH2OH; said process comprising: step 1: reacting the mixture (M) with ketones and/or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal/acetal derivatives, so as to yield a protected mixture (P); step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture (Pf); step 3: fractional distillation of the mixture (Pf) so as to isolate the cyclic acetal/ketal derivatives of tetraol (T); and step 4: hydrolyzing the acetal/ketal derivatives of tetraol (T) so as to recover pure tetraol (T).
摘要翻译：一种用于纯化式（I）的四醇PFPE衍生物[四醇（T））的方法：HO-CH 2 -CH（OH）-CH 2 -O-CH 2 -CF 2 -O-Rf-CF 2 -CH 2 O-CH 2 -CH （OH）-CH 2 OH，其中Rf表示氟代聚氧亚烷基链（链Rf），由羟基（全）含氟聚醚衍生物的混合物（M），所述混合物包含所述四醇（T）和至少一种羟基（全）氟聚醚[PFPE （OH）]，其包含用至少一个具有下列结构的端基终止的链Rf：-CF 2 CH 2 OH; -CF 2 CH 2 O-CH（OH）-CH 2 -O-CH 2 -CH（OH）-CH 2 OH; 所述方法包括：步骤1：使混合物（M）与酮和/或醛反应，以便通过形成相应的环缩酮/缩醛衍生物来选择性保护连位碳原子上的羟基，从而产生受保护的混合物（P ）; 步骤2：使混合物（P）的残余羟基与合适的官能化试剂反应，从而获得功能化的保护的混合物（Pf）; 步骤3：分馏混合物（Pf），以分离四醇（T）的环状缩醛/缩酮衍生物; 和步骤4：水解四醇（T）的缩醛/缩酮衍生物以回收纯四醇（T）。

8. 发明申请

US20110003968A1 Process for the purification of polyol PFPE derivative 有权
标题翻译：多元醇PFPE衍生物的纯化方法
公开(公告)号：US20110003968A1
公开(公告)日：2011-01-06
申请号：US12921844
申请日：2009-03-13
申请人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti
发明人： Claudio Tonelli , Graziano Giuseppe Vezzulli , Rosaldo Picozzi , Piero Gavezotti
IPC分类号： C08F6/28
CPC分类号： C08G65/30 , C08G65/007 , C08G65/22 , C08G65/24
摘要： A process for the purification of a tetraol PFPE derivative [tetraol (T)] of formula (I): HO—CH2—CH(OH)—CH2—O—CH2—CF2—O—Rf—CF2—CH2O—CH2—CH(OH)—CH2OH, wherein Rf represents a fluoropolyoxyalkene chain (chain Rf), from a mixture (M) of hydroxyl (per)fluoropolyether derivatives, said mixture comprising said tetraol (T) and at least one hydroxyl (per)fluoropolyether [PFPE (OH)] comprising a chain Rf terminated with at least one end group of formula: —CF2CH2OH; —CF2CH2O—CH(OH)—CH2—O—CH2—CH(OH)—CH2OH; said process comprising: step 1: reacting the mixture (M) with ketones and/or aldehydes so as to selectively protect couples of hydroxyl groups on vicinal carbon atoms by forming corresponding cyclic ketal/acetal derivatives, so as to yield a protected mixture (P); step 2: reacting residual hydroxyl groups of the mixture (P) with suitable functionalizing agents enabling substantial volatility modification, so as to obtain a functionalized protected mixture (Pf); step 3: fractional distillation of the mixture (Pf) so as to isolate the cyclic acetal/ketal derivatives of tetraol (T); and step 4: hydrolyzing the acetal/ketal derivatives of tetraol (T) so as to recover pure tetraol (T).
摘要翻译：一种用于纯化式（I）的四醇PFPE衍生物[四醇（T））的方法：HO-CH 2 -CH（OH）-CH 2 -O-CH 2 -CF 2 -O-Rf-CF 2 -CH 2 O-CH 2 -CH （OH）-CH 2 OH，其中Rf表示氟代聚氧亚烷基链（链Rf），由羟基（全）氟代聚醚衍生物的混合物（M），所述混合物包含所述四醇（T）和至少一种羟基（全）氟聚醚[PFPE （OH）]，其包含用至少一个具有下列结构的端基终止的链Rf：-CF 2 CH 2 OH; -CF 2 CH 2 O-CH（OH）-CH 2 -O-CH 2 -CH（OH）-CH 2 OH; 所述方法包括：步骤1：使混合物（M）与酮和/或醛反应，以便通过形成相应的环缩酮/缩醛衍生物来选择性保护连位碳原子上的羟基，从而产生受保护的混合物（P ）; 步骤2：使混合物（P）的残余羟基与合适的官能化试剂反应，从而获得功能化的保护的混合物（Pf）; 步骤3：分馏混合物（Pf），以分离四醇（T）的环状缩醛/缩酮衍生物; 和步骤4：水解四醇（T）的缩醛/缩酮衍生物以回收纯四醇（T）。

9. 发明授权

US07132574B2 Preparation of perfluoropolyethers having at least one —CH2OH or —CH(CF3)OH end group 有权
标题翻译：具有至少一个-CH 2 OH或-CH（CF 3）OH端基的全氟聚醚的制备
公开(公告)号：US07132574B2
公开(公告)日：2006-11-07
申请号：US10840404
申请日：2004-05-07
申请人： Rosaldo Picozzi , Claudio Tonelli
发明人： Rosaldo Picozzi , Claudio Tonelli
IPC分类号： C07C41/18
CPC分类号： C08G65/322 , B01J21/18 , B01J23/462 , B01J23/464 , C08G65/007
摘要： A process for preparing perfluoropolyethers having at least one —CH2OH or —CH(CF3)OH end group by reaction of the corresponding pefluoropolyethers having at least one carboxylic —COOH or ketonic —(CF3)C═O end group with gaseous hydrogen, between 80° C. and 140° C., in the presence of hydrogenation catalysts.
摘要翻译：通过相应的具有至少一个羧酸-COOH的聚氟醚的反应制备具有至少一个-CH 2 OH或-CH（CF 3 OH）OH端基的全氟聚醚的方法或者在80℃至140℃之间，在氢化催化剂的存在下，使用气态氢的酮 - （CF 3 N 3）CO端基。

10. 发明申请

US20100227983A1 Manufacture of medical implants 有权
标题翻译：医疗植入物的制造
公开(公告)号：US20100227983A1
公开(公告)日：2010-09-09
申请号：US12303348
申请日：2007-06-07
申请人： Claudio Tonelli , Piero Gavezotti , Ritalba Lamendola
发明人： Claudio Tonelli , Piero Gavezotti , Ritalba Lamendola
IPC分类号： C08G63/91 , C08G65/34 , C08G71/04
CPC分类号： A61L27/14 , A61L28/0026 , A61L29/049 , A61L31/04
摘要： The invention pertains to a process for the manufacture cola medical implant, said process comprising: reacting a mixture of non functional, monofunctional, and bifunctional perfluoropolyethers comprising hydroxyl terminal groups, wherein the average functionality is of at least 1.97 [mixture (M)] with suitable reactants for producing a thermoplastic elastomer; moulding the so-obtained thermoplastic elastomer for yielding at least a part of the medical implant. It has been surprisingly found that by using a mixture of perfluoropolyethers having high functionality, it is advantageously possible to manufacture, by moulding thermoplastic elastomers therefrom, medical implants which exhibit improved biocompatibility and which are submitted to reduced chemicals extraction by biological fluids.
摘要翻译：本发明涉及制造可乐医用植入物的方法，所述方法包括：使包含羟基端基的非官能，单官能和双功能全氟聚醚的混合物反应，其中平均官能度为至少1.97 [混合物（M）]与用于生产热塑性弹性体的合适的反应物; 模制如此获得的热塑性弹性体以产生医用植入物的至少一部分。已经令人惊奇地发现，通过使用具有高官能度的全氟聚醚的混合物，有利地可以通过从其中模制热塑性弹性体来制造具有改善的生物相容性并且被生物流体减少的化学品提取的医用植入物。

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