专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110251250A1 USE OF DIMIRACETAM IN THE TREATMENT OF CHRONIC PAIN 有权
标题翻译：二甲双胍在治疗慢性疼痛中的应用
公开(公告)号：US20110251250A1
公开(公告)日：2011-10-13
申请号：US13166088
申请日：2011-06-22
申请人： Carlo FARINA , Carla Ghelardini , Paola Petrillo
发明人： Carlo FARINA , Carla Ghelardini , Paola Petrillo
IPC分类号： A61K31/4188 , A61P25/04 , A61P19/02
CPC分类号： A61K31/7068 , A61K31/4188 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The use of dimiracetam in the treatment of chronic pain is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in iatrogenic neuropathies associated with antiviral and chemotherapeutic drug treatments and in painful conditions caused by osteoarthritis. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose. The possibility of treating such debilitating pathologies with a highly effective and essentially non-toxic compound is therefore disclosed.
摘要翻译：公开了使用二拉西坦治疗慢性疼痛。在比以前公开的与其认知增强活性（即改善学习和记忆）相比更高的剂量下，双拉西坦能够完全恢复与慢性疼痛的几种动物模型相关的痛觉过敏或异常性疼痛。二西拉西坦在与抗病毒和化疗药物治疗相关的医源性神经病变以及由骨关节炎引起的疼痛状况下表现出高活性。此外，即使在比最高治疗剂量高10倍的剂量下，二西拉坦也没有毒性。因此公开了用高效和基本上无毒化合物治疗这种衰弱病态的可能性。

2. 发明授权

US07989421B2 Use of dimiracetam in the treatment of chronic pain 有权
标题翻译：使用双拉西坦治疗慢性疼痛
公开(公告)号：US07989421B2
公开(公告)日：2011-08-02
申请号：US12450944
申请日：2008-04-15
申请人： Carlo Farina , Carla Ghelardini , Paola Petrillo
发明人： Carlo Farina , Carla Ghelardini , Paola Petrillo
IPC分类号： A61K31/44 , A61K31/40 , A61P23/00
CPC分类号： A61K31/7068 , A61K31/4188 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The use of dimiracetam in the treatment of chronic pain is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in iatrogenic neuropathies associated with antiviral and chemotherapeutic drug treatments and in painful conditions caused by osteoarthritis. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose. The possibility of treating such debilitating pathologies with a highly effective and essentially non-toxic compound is therefore disclosed.
摘要翻译：公开了使用二拉西坦治疗慢性疼痛。在比以前公开的与其认知增强活性（即改善学习和记忆）相比更高的剂量下，二西拉坦能够完全恢复与慢性疼痛的几种动物模型相关的痛觉过敏或异常性疼痛。二西拉西坦在与抗病毒和化疗药物治疗相关的医源性神经病变以及由骨关节炎引起的疼痛状况下表现出高活性。此外，即使在比最高治疗剂量高10倍的剂量下，二西拉坦也没有毒性。因此公开了用高效和基本上无毒化合物治疗这种衰弱病态的可能性。

3. 发明授权

US07732473B2 Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof 失效
标题翻译：具有推ic作用的化合物及其制备方法，含有它们的药物组合物及其用途
公开(公告)号：US07732473B2
公开(公告)日：2010-06-08
申请号：US12378475
申请日：2009-02-13
申请人： Carlo Farina , Stefania Gagliardi , Carlo Parini , Marisa Martinelli , Carla Ghelardini
发明人： Carlo Farina , Stefania Gagliardi , Carlo Parini , Marisa Martinelli , Carla Ghelardini
IPC分类号： A61K31/4166 , C07D235/00
CPC分类号： C07D487/04
摘要： Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.
摘要翻译：本文描述了具有向异性作用（即保护和刺激脑功能），止痛作用和抗痛觉过敏作用的新型双环芳基咪唑酮; 还描述了其制备方法和包含它们的药物组合物，其可用于治疗认知缺陷和各种类型的疼痛。

4. 发明申请

US20080226718A1 Indole and Azaindole Derivatives For the Treatment of Inflammatory and Autoimmune Diseases 审中-公开
标题翻译：吲哚和Azaindole衍生物治疗炎症和自身免疫性疾病
公开(公告)号：US20080226718A1
公开(公告)日：2008-09-18
申请号：US12091739
申请日：2006-10-25
申请人： Carlo Farina , Gabriela Constantin , Carlo Laudanna , Paola Misiano
发明人： Carlo Farina , Gabriela Constantin , Carlo Laudanna , Paola Misiano
IPC分类号： A61K9/28 , A61K31/404 , A61P17/06 , A61P37/00 , A61P1/00 , A61P19/02 , A61K31/5383
CPC分类号： A61K31/404
摘要： The use is described of compounds of formula (I) wherein A is chosen from a phenyl or a heterocyclic ring with 5 or 6 members containing up to two heteroatoms chosen from nitrogen, oxygen and sulfur, X and Y represent carbon or nitrogen, and R1-R6 are as described in the specification, in the prevention and/or treatment of inflammatory and autoimmune diseases.
摘要翻译：描述了式（I）化合物，其中A选自苯基或杂环，其中5或6个成员含有至多两个选自氮，氧和硫的杂原子，X和Y表示碳或氮，R1 -R6如说明书中所述，在预防和/或治疗炎性和自身免疫疾病中。

5. 发明申请

US20070259882A1 3-SUBSTITUTED QUINOLINE-4-CARBOXAMIDE DERIVATIVES AS NK-3 AND NK-2 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 3-取代的喹啉-4-羧酰胺衍生物作为NK-3和NK-2受体拮抗剂
公开(公告)号：US20070259882A1
公开(公告)日：2007-11-08
申请号：US11768338
申请日：2007-06-26
申请人： Carlo FARINA , Stefania Gagliardi , Giuseppe Giardina , Marisa Martinelli
发明人： Carlo FARINA , Stefania Gagliardi , Giuseppe Giardina , Marisa Martinelli
IPC分类号： A61K31/497 , A61P25/00 , C07D401/00
CPC分类号： C07D215/50 , C07D215/16 , C07D215/52 , C07D401/04 , C07D401/06 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/06 , C07D487/04
摘要： A compound of formula (I) below or a pharmaceutically acceptable salt or solvate thereof:
摘要翻译：下式（I）的化合物或其药学上可接受的盐或溶剂合物：

6. 发明申请

US20060229315A1 3-Substituted Quinoline-4-Carboxamide Derivatives as NK-3 and NK-2 Receptor Antagonists 审中-公开
标题翻译： 3-取代的喹啉-4-羧酰胺衍生物作为NK-3和NK-2受体拮抗剂
公开(公告)号：US20060229315A1
公开(公告)日：2006-10-12
申请号：US11426956
申请日：2006-06-28
申请人： Carlo FARINA , Stefania GAGLIARDI , Giuseppe GIARDINA , Marisa MARTINELLI
发明人： Carlo FARINA , Stefania GAGLIARDI , Giuseppe GIARDINA , Marisa MARTINELLI
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D215/50 , C07D215/16 , C07D215/52 , C07D401/04 , C07D401/06 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/06 , C07D487/04
摘要： A compound of formula (I) below or a pharmaceutically acceptable salt or solvate thereof:
摘要翻译：下式（I）的化合物或其药学上可接受的盐或溶剂合物：

7. 发明申请

US20060161004A1 Novel compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20060161004A1
公开(公告)日：2006-07-20
申请号：US11331623
申请日：2006-01-13
申请人： Carlo Farina , Giuseppe Giardina , Mario Grugni , Guy Marguerite Nadler
发明人： Carlo Farina , Giuseppe Giardina , Mario Grugni , Guy Marguerite Nadler
IPC分类号： A61K31/4709 , C07D401/02
CPC分类号： C07D401/06 , C07D401/14
摘要： Certain compounds of formula (I): or a pharmaceutically acceptable salt or hydrate thereof, a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and composition in medicine.
摘要翻译：某些式（I）化合物：或其药学上可接受的盐或水合物，制备此类化合物的方法，包含这些化合物的药物组合物以及这些化合物和组合物在医药中的用途。

8. 发明授权

US06903117B2 Indole derivatives for the treatment of osteoporosis 失效
标题翻译：吲哚衍生物用于治疗骨质疏松症
公开(公告)号：US06903117B2
公开(公告)日：2005-06-07
申请号：US10300332
申请日：2002-11-20
申请人： Carlo Farina , Stefania Gagliardi , Guy Marguerite Marie Gerard Nadler
发明人： Carlo Farina , Stefania Gagliardi , Guy Marguerite Marie Gerard Nadler
IPC分类号： B82B1/00 , C07D209/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D451/02 , C07D451/04 , C07D455/02 , C07D471/04 , C07D471/08 , C07D471/16 , A61K31/454
CPC分类号： C07D451/02 , C07D209/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D451/04 , C07D455/02 , C07D471/04 , C07D471/08
摘要： A compound of formula (I): or a salt thereof, or a solvate thereof, wherein Ra represents a group R5 which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a): wherein X represents a hydroxy or an alkoxy group wherein the alkyl group may be substitued or unsubstituted or X represents a group NRsRt wherein Rs and Rt each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or Rs and Rt together with the nitrogen to which they are attached form a heterocyclic group; R1 represents an alkyl or a substituted or unsubstituted aryl group; and R2, R3 and R4 each independently represent hydrogen, alkyl, aryl or substituted aryl; R6 and R7 each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R6 and R7 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; and R8 represents hydrogen, hydroxy, alkynoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalky, carbalkoxyalkyl, carbamoyl or aminosulphonyl; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.
摘要翻译：式（I）化合物或其盐或其溶剂合物，其中R a表示R 5基团，其为氢，烷基或任选取代的芳基，R b表示式（a ）：其中X表示羟基或烷氧基，其中烷基可以被取代或未被取代，或X表示基团NR 1 R t R 3和R 3各自独立地表示氢，烷基，取代的烷基，任选取代的烯基，任选取代的芳基，任选取代的芳烷基，任选取代的杂环基或任选取代的杂环基烷基，和它们所连接的氮一起形成杂环基; R 1表示烷基或取代或未取代的芳基; 和R 2，R 3和R 4各自独立地表示氢，烷基，芳基或取代的芳基; R 6和R 7各自独立地表示氢，羟基，氨基，烷氧基，任选取代的芳氧基，任选取代的苄氧基，烷基氨基，二烷基氨基，卤素，三氟甲基，三氟甲氧基，硝基，烷基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基或R 6和R 7一起代表亚甲二氧基，羰基二氧基或羰基二氨基; R 8表示氢，羟基，炔酰基，烷基，氨基烷基，羟基烷基，羧基，烷氧基烷基，氨基甲酰基或氨基磺酰基; 制备这种化合物的方法，含有这种化合物的药物组合物和这种化合物在医药中的用途。

9. 发明授权

US6025390A Heteroaromatic pentadienoic acid derivatives useful as inhibitors of bone resorption 失效
标题翻译：可用作骨吸收抑制剂的杂芳族戊二烯酸衍生物
公开(公告)号：US6025390A
公开(公告)日：2000-02-15
申请号：US214689
申请日：1999-06-23
申请人： Carlo Farina , Stefania Gagliardi , Guy Marguerite Marie Gerard Nadler , Michel Jean Roger Martin
发明人： Carlo Farina , Stefania Gagliardi , Guy Marguerite Marie Gerard Nadler , Michel Jean Roger Martin
IPC分类号： A61K31/343 , A61K31/381 , A61K31/4525 , A61K31/4535 , A61K31/47 , A61P19/10 , C07D215/12 , C07D307/80 , C07D333/60 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , A61K31/34 , A61K31/38 , A61K31/445 , C07D215/00 , C07D401/00
CPC分类号： C07D405/06 , C07D215/12 , C07D307/80 , C07D333/60 , C07D409/06
摘要： A compound of formula (I) or a salt thereof, or a solvate thereof, ##STR1## wherein: R.sub.1 represents an alkyl group or a substituted or unsubstituted aryl group; R.sub.2, R.sub.3 and R.sub.4 each independently represent hydrogen, alkyl, aryl or substituted aryl; R.sub.5 and R.sub.6 each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R.sub.5 and R.sub.6 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; X represents a hydroxy or an alkoxy group wherein the alkyl group may be substituted or unsubstituted or X represents a group NR.sub.S R.sub.t wherein R.sub.S and R.sub.t each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or R.sub.S and R.sub.t together with the nitrogen to which they are attached form a heterocyclic group; and Y represents O or S and Z represents CH, CH.dbd.CH or N; or Y represents NR.sub.7 wherein R.sub.7 represents hydrogen, hydroxy, alkanoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamoyl or aminosulphonyl and Z represents CH.dbd.CH or N; a pharmaceutical composition containing such a compound, a process for preparing such a compound and the use of such a compound in medicine.
摘要翻译： PCT No.PCT / EP97 / 03709 Sec。 371日期1999年6月23日第 102（e）1999年6月23日PCT 1997年7月7日PCT公布。出版物WO98 / 01436 日期1998年1月15日A式（I）化合物或其盐或其溶剂化物，其中：R1表示烷基或取代或未取代的芳基; R2，R3和R4各自独立地表示氢，烷基，芳基或取代的芳基; R5和R6各自独立地表示氢，羟基，氨基，烷氧基，任选取代的芳氧基，任选取代的苄氧基，烷基氨基，二烷基氨基，卤素，三氟甲基，三氟甲氧基，硝基，烷基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基或R5和R6一起代表亚甲二氧基，羰基二氧基或羰基二氨基; X表示羟基或烷氧基，其中烷基可以是取代或未取代的或X表示NRSRt基团，其中RS和Rt各自独立地表示氢，烷基，取代的烷基，任选取代的烯基，任选取代的芳基，任选取代的芳基烷基，任选取代的杂环基或任选取代的杂环基烷基，或RS和R R与它们所连接的氮一起形成杂环基; Y表示O或S，Z表示CH，CH = CH或N; 或Y表示NR 7，其中R 7表示氢，羟基，烷酰基，烷基，氨基烷基，羟基烷基，羧基烷基，烷氧基烷基，氨基甲酰基或氨基磺酰基，Z表示CH = CH或N; 含有这种化合物的药物组合物，这种化合物的制备方法和这种化合物在医药中的应用。

10. 发明授权

US5082939A Pyridazine derivatives 失效
标题翻译：哒嗪衍生物
公开(公告)号：US5082939A
公开(公告)日：1992-01-21
申请号：US384947
申请日：1989-07-25
申请人： Carlo Farina , Mario Pinza , Alberto Cerri , Francesco Parravicini
发明人： Carlo Farina , Mario Pinza , Alberto Cerri , Francesco Parravicini
IPC分类号： C07D237/22
CPC分类号： C07D237/22
摘要： A novel process for preparing alkoxyalkylidenehydrazinopyridazine derivatives which comprises reducing a novel alkoxytriphenylmethylazopyridazine derivative, removing the triphenylmethyl group and reacting with an aldehyde or ketone derivative.A specific compound produced by this process is 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-6-isopropylidenehydrazinopyridazine.
摘要翻译：制备烷氧基亚烷基肼哒嗪衍生物的新方法，包括还原新的烷氧基三苯基甲基偶氮哒嗪衍生物，除去三苯基甲基并与醛或酮衍生物反应。通过该方法制备的具体化合物是3- [3 - [[2-（3,4-二甲氧基苯基）乙基]氨基] -2-羟基丙氧基] -6-异丙基亚肼基哒嗪。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式