专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110251250A1 USE OF DIMIRACETAM IN THE TREATMENT OF CHRONIC PAIN 有权
标题翻译：二甲双胍在治疗慢性疼痛中的应用
公开(公告)号：US20110251250A1
公开(公告)日：2011-10-13
申请号：US13166088
申请日：2011-06-22
申请人： Carlo FARINA , Carla Ghelardini , Paola Petrillo
发明人： Carlo FARINA , Carla Ghelardini , Paola Petrillo
IPC分类号： A61K31/4188 , A61P25/04 , A61P19/02
CPC分类号： A61K31/7068 , A61K31/4188 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The use of dimiracetam in the treatment of chronic pain is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in iatrogenic neuropathies associated with antiviral and chemotherapeutic drug treatments and in painful conditions caused by osteoarthritis. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose. The possibility of treating such debilitating pathologies with a highly effective and essentially non-toxic compound is therefore disclosed.
摘要翻译：公开了使用二拉西坦治疗慢性疼痛。在比以前公开的与其认知增强活性（即改善学习和记忆）相比更高的剂量下，双拉西坦能够完全恢复与慢性疼痛的几种动物模型相关的痛觉过敏或异常性疼痛。二西拉西坦在与抗病毒和化疗药物治疗相关的医源性神经病变以及由骨关节炎引起的疼痛状况下表现出高活性。此外，即使在比最高治疗剂量高10倍的剂量下，二西拉坦也没有毒性。因此公开了用高效和基本上无毒化合物治疗这种衰弱病态的可能性。

2. 发明授权

US07989421B2 Use of dimiracetam in the treatment of chronic pain 有权
标题翻译：使用双拉西坦治疗慢性疼痛
公开(公告)号：US07989421B2
公开(公告)日：2011-08-02
申请号：US12450944
申请日：2008-04-15
申请人： Carlo Farina , Carla Ghelardini , Paola Petrillo
发明人： Carlo Farina , Carla Ghelardini , Paola Petrillo
IPC分类号： A61K31/44 , A61K31/40 , A61P23/00
CPC分类号： A61K31/7068 , A61K31/4188 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The use of dimiracetam in the treatment of chronic pain is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in iatrogenic neuropathies associated with antiviral and chemotherapeutic drug treatments and in painful conditions caused by osteoarthritis. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose. The possibility of treating such debilitating pathologies with a highly effective and essentially non-toxic compound is therefore disclosed.
摘要翻译：公开了使用二拉西坦治疗慢性疼痛。在比以前公开的与其认知增强活性（即改善学习和记忆）相比更高的剂量下，二西拉坦能够完全恢复与慢性疼痛的几种动物模型相关的痛觉过敏或异常性疼痛。二西拉西坦在与抗病毒和化疗药物治疗相关的医源性神经病变以及由骨关节炎引起的疼痛状况下表现出高活性。此外，即使在比最高治疗剂量高10倍的剂量下，二西拉坦也没有毒性。因此公开了用高效和基本上无毒化合物治疗这种衰弱病态的可能性。

3. 发明申请

US20100129469A1 USE OF DIMIRACETAM IN THE TREATMENT OF CHRONIC PAIN 有权
标题翻译：二甲双胍在治疗慢性疼痛中的应用
公开(公告)号：US20100129469A1
公开(公告)日：2010-05-27
申请号：US12450944
申请日：2008-04-15
申请人： Carlo Farina , Carla Ghelardini , Paola Petrillo
发明人： Carlo Farina , Carla Ghelardini , Paola Petrillo
IPC分类号： A61K33/24 , A61K31/4188 , A61K31/437 , C07D487/04 , A61P25/02 , A61P25/00
CPC分类号： A61K31/7068 , A61K31/4188 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The use of dimiracetam in the treatment of chronic pain is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in iatrogenic neuropathies associated with antiviral and chemotherapeutic drug treatments and in painful conditions caused by osteoarthritis. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose. The possibility of treating such debilitating pathologies with a highly effective and essentially non-toxic compound is therefore disclosed.
摘要翻译：公开了使用二拉西坦治疗慢性疼痛。在比以前公开的与其认知增强活性（即改善学习和记忆）相比更高的剂量下，二西拉坦能够完全恢复与慢性疼痛的几种动物模型相关的痛觉过敏或异常性疼痛。二西拉西坦在与抗病毒和化疗药物治疗相关的医源性神经病变以及由骨关节炎引起的疼痛状况下表现出高活性。此外，即使在比最高治疗剂量高10倍的剂量下，二西拉坦也没有毒性。因此公开了用高效和基本上无毒化合物治疗这种衰弱病态的可能性。

4. 发明授权

US07973066B2 Pyrrolo[1,2-A]imidazoledione effective in the treatment of peripheral neurotoxicity induced by chemotherapeutic agents 失效
标题翻译：吡咯并[1,2-A]咪唑二酮有效治疗由化疗药物引起的周围神经毒性
公开(公告)号：US07973066B2
公开(公告)日：2011-07-05
申请号：US12312575
申请日：2007-11-14
申请人： Carlo Farina , Carla Ghelardini , Paola Petrillo
发明人： Carlo Farina , Carla Ghelardini , Paola Petrillo
IPC分类号： A61K31/4166 , C07D235/00
CPC分类号： A61K31/4188 , C07D487/04
摘要： The use of a compound of formula (I), is disclosed in treating and/or preventing 5 chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.
摘要翻译：公开了式（I）化合物在治疗和/或预防5种化学疗法诱发的周围神经毒性（CIPN）中的应用。本发明包括其中式（I）化合物与抗癌剂混合存在的药物组合物。还提供了具有减少的CIPN相关副作用的改进的抗癌治疗。

5. 发明授权

US08222241B2 Use of dimiracetam in the treatment of chronic pain 有权
标题翻译：使用双拉西坦治疗慢性疼痛
公开(公告)号：US08222241B2
公开(公告)日：2012-07-17
申请号：US13166088
申请日：2011-06-22
申请人： Carlo Farina , Carla Ghelardini , Paola Petrillo
发明人： Carlo Farina , Carla Ghelardini , Paola Petrillo
IPC分类号： A61K31/44 , A61K31/40 , A61P23/00
CPC分类号： A61K31/7068 , A61K31/4188 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The use of dimiracetam in the treatment of chronic pain is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in iatrogenic neuropathies associated with antiviral and chemotherapeutic drug treatments and in painful conditions caused by osteoarthritis. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose. The possibility of treating such debilitating pathologies with a highly effective and essentially non-toxic compound is therefore disclosed.
摘要翻译：公开了使用二拉西坦治疗慢性疼痛。在比以前公开的与其认知增强活性（即改善学习和记忆）相比更高的剂量下，二西拉坦能够完全恢复与慢性疼痛的几种动物模型相关的痛觉过敏或异常性疼痛。二西拉西坦在与抗病毒和化疗药物治疗相关的医源性神经病变以及由骨关节炎引起的疼痛状况下表现出高活性。此外，即使在比最高治疗剂量高10倍的剂量下，二西拉坦也没有毒性。因此公开了用高效和基本上无毒化合物治疗这种衰弱病态的可能性。

6. 发明申请

US20100062077A1 PYRROLO[1,2-A]IMIDAZOLEDIONE EFFECTIVE IN THE TREATMENT OF PERIPHERAL NEUROTOXICITY INDUCED BY CHEMOTHERAPEUTIC AGENTS 失效
标题翻译：治疗由化疗药物引起的外周神经毒性的PYRROLO [1,2-A]咪达拉灭有效
公开(公告)号：US20100062077A1
公开(公告)日：2010-03-11
申请号：US12312575
申请日：2007-11-14
申请人： Carlo Farina , Carla Ghelardini , Paola Petrillo
发明人： Carlo Farina , Carla Ghelardini , Paola Petrillo
IPC分类号： A61K31/4188 , A61K33/24 , A61K31/4745 , A61P25/02
CPC分类号： A61K31/4188 , C07D487/04
摘要： The use of a compound of formula (I), is disclosed in treating and/or preventing 5 chemotherapy-induced peripheral neurotoxicity (CIPN). The invention includes pharmaceutical compositions wherein the compound of formula (I) is present in a mixture with anticancer agents. An improved anticancer treatment with reduced CIPN-related side effects is also provided.
摘要翻译：公开了式（I）化合物在治疗和/或预防5种化学疗法诱发的周围神经毒性（CIPN）中的应用。本发明包括其中式（I）化合物与抗癌剂混合存在的药物组合物。还提供了具有减少的CIPN相关副作用的改进的抗癌治疗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式