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1. 发明申请

WO2010002954A1 (2-ARYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)MORPHOLINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开
标题翻译：（2-ARYL-7H-吡咯并[2,3-D]嘧啶-4-基）吗啉化合物，它们作为MTOR激酶和PI3激酶抑制剂使用，以及它们的合成
公开(公告)号：WO2010002954A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/049342
申请日：2009-07-01
申请人： WYETH , CHEN, Zecheng , VENKATESAN, Aranapakam, M. , ZASK, Arie , VERHEIJEN, Jeroen, C. , AYRAL-KALOUSTIAN, Semiramis , MANSOUR, Tarek, S. , CURRAN, Kevin, J.
发明人： CHEN, Zecheng , VENKATESAN, Aranapakam, M. , ZASK, Arie , VERHEIJEN, Jeroen, C. , AYRAL-KALOUSTIAN, Semiramis , MANSOUR, Tarek, S. , CURRAN, Kevin, J.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention relates to 2-aryl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)morpholine compounds of the Formula (I): or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译：本发明涉及式（I）的2-芳基-7H-吡咯并[2,3-d]嘧啶-4-基）吗啉化合物或其药学上可接受的盐，其中组分变量如本文所定义，组合物包括化合物，以及制备和使用该化合物的方法。

2. 发明申请

WO2009143313A1 TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS 审中-公开
标题翻译： TRIAZINE化合物作为P13激酶和MT抑制剂
公开(公告)号：WO2009143313A1
公开(公告)日：2009-11-26
申请号：PCT/US2009/044774
申请日：2009-05-21
申请人： WYETH , VENKATESAN, Aranapakam, M. , CHEN, Zecheng , DEHNHARDT, Christoph, M. , DOS SANTOS, Osvaldo , DELOS SANTOS, Efren Guillermo , ZASK, Arie , VERHEIJEN, Jeroen, C. , KAPLAN, Joshua, Aaron , RICHARD, David, J. , AYRAL-KALOUSTIAN, Semiramis , MANSOUR, Tarek, S. , GOPALSAMY, Ariamala , CURRAN, Kevin, J. , SHI, Mengxiao
发明人： VENKATESAN, Aranapakam, M. , CHEN, Zecheng , DEHNHARDT, Christoph, M. , DOS SANTOS, Osvaldo , DELOS SANTOS, Efren Guillermo , ZASK, Arie , VERHEIJEN, Jeroen, C. , KAPLAN, Joshua, Aaron , RICHARD, David, J. , AYRAL-KALOUSTIAN, Semiramis , MANSOUR, Tarek, S. , GOPALSAMY, Ariamala , CURRAN, Kevin, J. , SHI, Mengxiao
IPC分类号： C07D498/08 , A61K31/53 , A61P35/00
CPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08
摘要： Compounds of formula I (I) wherein: R 1 is (II) or (III); and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
摘要翻译：式I（I）的化合物，其中：R 1是（II）或（III）; 并且R 2，R 4和R 6-9在本文中定义，及其药学上可接受的盐和酯。这些化合物抑制PI3激酶和mTOR，并可用于治疗PI3激酶和mTOR介导的疾病，如多种癌症。公开了制备和使用本发明化合物的方法。还公开了含有本发明化合物的各种组合物。

3. 发明申请

WO2008115974A2 PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS 审中-公开
标题翻译：吡唑并嘧啶类似物及其作为MTOR激酶和PI3激酶抑制剂的用途
公开(公告)号：WO2008115974A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/057467
申请日：2008-03-19
申请人： WYETH , ZASK, Arie , NOWAK, Pawel, Wojciech , VERHEIJEN, Jeroen , CURRAN, Kevin, J. , KAPLAN, Joshua , MALWITZ, David , BURSAVICH, Matthew Gregory , COLE, Derek, Cecil , AYRAL-KALOUSTIAN, Semiramis , YU, Ker , RICHARD, David, James , LEFEVER, Mark
发明人： ZASK, Arie , NOWAK, Pawel, Wojciech , VERHEIJEN, Jeroen , CURRAN, Kevin, J. , KAPLAN, Joshua , MALWITZ, David , BURSAVICH, Matthew Gregory , COLE, Derek, Cecil , AYRAL-KALOUSTIAN, Semiramis , YU, Ker , RICHARD, David, James , LEFEVER, Mark
CPC分类号： C07D487/04
摘要： The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR -related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K -related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.
摘要翻译：本发明涉及吡唑并嘧啶类似物，制备吡唑并嘧啶类似物的方法，包含吡唑并嘧啶类似物的组合物，以及用于治疗mTOR相关病症的方法，所述方法包括向有需要的受试者施用有效量的吡唑并嘧啶模拟。本发明还涉及治疗与PI3K相关的病症，包括向有需要的受试者施用有效量的吡唑并嘧啶类似物。

4. 发明申请

WO2008086462A3 AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS 审中-公开
公开(公告)号：WO2008086462A3
公开(公告)日：2008-07-17
申请号：PCT/US2008/050728
申请日：2008-01-10
申请人： WYETH , VENKATESAN, Aranapakam, M. , DEHNHARDT, Christoph , CHEN, Zecheng , SANTOS, Osvaldo, Dos , SANTOS, Efren, Delos , CURRAN, Kevin , AYRAL-KALOUSTIAN, Semiramis , CHEN, Lei
发明人： VENKATESAN, Aranapakam, M. , DEHNHARDT, Christoph , CHEN, Zecheng , SANTOS, Osvaldo, Dos , SANTOS, Efren, Delos , CURRAN, Kevin , AYRAL-KALOUSTIAN, Semiramis , CHEN, Lei
IPC分类号： C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , A61K31/517 , A61P35/00
摘要： The present invention relates to amino-substituted quinazoline derivatives as inhibitors of β-catenin/tcf-4 pathway, which can be useful in the treatment of cancer; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.

5. 发明申请

WO2010133691A3 A SYSTEM AND METHOD FOR STREAMING MUSIC REPAIR AND ERROR CONCEALMENT 审中-公开
标题翻译：用于流动音乐修复和错误隐藏的系统和方法
公开(公告)号：WO2010133691A3
公开(公告)日：2011-01-20
申请号：PCT/EP2010057014
申请日：2010-05-20
申请人： UNIV ULSTER , DOHERTY JONATHAN PAUL , CURRAN KEVIN , MCKEVITT PAUL
发明人： DOHERTY JONATHAN PAUL , CURRAN KEVIN , MCKEVITT PAUL
IPC分类号： G10L19/02 , G10L19/00 , G10L19/005 , G10L19/14 , G10L19/16
CPC分类号： G10L19/005 , G10L19/167
摘要： A method is provided for analysing the self-similarity of an audio file. The method involves obtaining the audio spectrum envelope data of an audio file to be analysed; performing a clustering operation on the spectrum envelope data to produce a clustered set of data; for a first portion of the clustered data, performing a string matching operation on at least one other portion of the clustered data; and based on the results of the string matching operation, determining the at least one other portion of the clustered data most similar to said first portion of the clustered data. There is also provided a method of repairing an audio stream received over a network using similarity data to replace damaged or missing portions of data with similar "good" portions of data.
摘要翻译：提供了一种用于分析音频文件的自相似性的方法。该方法涉及获得要分析的音频文件的音频频谱包络数据; 对频谱包络数据执行聚类操作以产生一组聚集的数据; 对于所述聚类数据的第一部分，对所述聚集数据的至少一个其他部分执行字符串匹配操作; 并且基于所述字符串匹配操作的结果，确定与所述聚集数据的所述第一部分最相似的所述聚类数据的所述至少一个其他部分。还提供了一种使用相似性数据来修复通过网络接收的音频流的方法，以用类似的“良好”数据部分替换数据的损坏或丢失部分。

6. 发明申请

WO2010133691A2 A SYSTEM AND METHOD FOR STREAMING MUSIC REPAIR AND ERROR CONCEALMENT 审中-公开
标题翻译：用于流动音乐修复和错误隐藏的系统和方法
公开(公告)号：WO2010133691A2
公开(公告)日：2010-11-25
申请号：PCT/EP2010/057014
申请日：2010-05-20
申请人： UNIVERSITY OF ULSTER , DOHERTY, Jonathan, Paul , CURRAN, Kevin , MCKEVITT, Paul
发明人： DOHERTY, Jonathan, Paul , CURRAN, Kevin , MCKEVITT, Paul
IPC分类号： G10L19/02
CPC分类号： G10L19/005 , G10L19/167
摘要： A method is provided for analysing the self-similarity of an audio file. The method involves obtaining the audio spectrum envelope data of an audio file to be analysed; performing a clustering operation on the spectrum envelope data to produce a clustered set of data; for a first portion of the clustered data, performing a string matching operation on at least one other portion of the clustered data; and based on the results of the string matching operation, determining the at least one other portion of the clustered data most similar to said first portion of the clustered data. There is also provided a method of repairing an audio stream received over a network using similarity data to replace damaged or missing portions of data with similar "good" portions of data.
摘要翻译：提供了一种用于分析音频文件的自相似性的方法。该方法涉及获得要分析的音频文件的音频频谱包络数据; 对频谱包络数据执行聚类操作以产生一组聚集的数据; 对于所述聚类数据的第一部分，对所述聚集数据的至少一个其他部分执行字符串匹配操作; 并且基于所述字符串匹配操作的结果，确定与所述聚集数据的所述第一部分最相似的所述聚类数据的所述至少一个其他部分。还提供了一种使用相似性数据来修复通过网络接收的音频流的方法，以用类似的“良好”数据部分来代替数据的损坏或丢失部分。

7. 发明申请

WO2010046104A2 AN ENCRYPTION METHOD 审中-公开
标题翻译：加密方法
公开(公告)号：WO2010046104A2
公开(公告)日：2010-04-29
申请号：PCT/EP2009007555
申请日：2009-10-22
申请人： UNIV ULSTER , CHEDDAD ABBAS , CONDELL JOAN , CURRAN KEVIN , MCKEVITT PAUL
发明人： CHEDDAD ABBAS , CONDELL JOAN , CURRAN KEVIN , MCKEVITT PAUL
IPC分类号： H04L9/20 , G06F21/60 , G06F21/64 , G06K19/06
CPC分类号： G06F21/602 , G06F21/64 , H04L9/0656 , H04N1/4486 , H04N2201/3236
摘要： There is described a method of encrypting a set of 2D input data, preferably image data. The method comprises obtaining the hash value of a password and re-sizing the hash value to fir the size of the 2D input data. The re-sized data is transformed using an irreversible transform, and the output of the transform is then used to encode the 2D data.
摘要翻译：描述了一种对一组2D输入数据进行加密的方法，优选地是图像数据。该方法包括获得密码的哈希值并重新调整哈希值以缩小2D输入数据的大小。使用不可逆变换来变换大小的数据，然后使用变换的输出来对2D数据进行编码。

8. 发明申请

WO2009143317A1 TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS 审中-公开
标题翻译： TRIAZINE化合物作为P13激酶和MT抑制剂
公开(公告)号：WO2009143317A1
公开(公告)日：2009-11-26
申请号：PCT/US2009/044784
申请日：2009-05-21
申请人： WYETH , VENKATESAN, Aranapakam M , CHEN, Zecheng , DEHNHARDT, Christoph M , DOS SANTOS, Osvaldo , DELOS SANTOS, Efren G , ZASK, Arie , VERHEIJEN, Jeroen C , KAPLAN, Joshua A , RICHARD, David J , AYRAL-KALOUSTIAN, Semiramis , MANSOUR, Tarek S , GOPALSAMY, Ariamala , CURRAN, Kevin J , SHI, Mengxiao
发明人： VENKATESAN, Aranapakam M , CHEN, Zecheng , DEHNHARDT, Christoph M , DOS SANTOS, Osvaldo , DELOS SANTOS, Efren G , ZASK, Arie , VERHEIJEN, Jeroen C , KAPLAN, Joshua A , RICHARD, David J , AYRAL-KALOUSTIAN, Semiramis , MANSOUR, Tarek S , GOPALSAMY, Ariamala , CURRAN, Kevin J , SHI, Mengxiao
IPC分类号： C07D498/08 , A61K31/53 , A61P35/00
CPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D451/06 , C07D453/02 , C07D491/113 , C07D498/08
摘要： Compounds of formula (I) wherein: R 1 is and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
摘要翻译：式（I）的化合物，其中：R1是和R2，R4和R6-9在本文中定义，及其药学上可接受的盐和酯。这些化合物抑制PI3激酶和mTOR，并可用于治疗PI3激酶和mTOR介导的疾病，如多种癌症。公开了制备和使用本发明化合物的方法。还公开了含有本发明化合物的各种组合物。

9. 发明申请

WO2008115974A3 PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS 审中-公开
标题翻译：吡唑并嘧啶类似物及其作为MTOR激酶和PI3激酶抑制剂的用途
公开(公告)号：WO2008115974A3
公开(公告)日：2008-12-18
申请号：PCT/US2008057467
申请日：2008-03-19
申请人： WYETH CORP , ZASK ARIE , NOWAK PAWEL WOJCIECH , VERHEIJEN JEROEN , CURRAN KEVIN J , KAPLAN JOSHUA , MALWITZ DAVID , BURSAVICH MATTHEW GREGORY , COLE DEREK CECIL , AYRAL-KALOUSTIAN SEMIRAMIS , YU KER , RICHARD DAVID JAMES , LEFEVER MARK
发明人： ZASK ARIE , NOWAK PAWEL WOJCIECH , VERHEIJEN JEROEN , CURRAN KEVIN J , KAPLAN JOSHUA , MALWITZ DAVID , BURSAVICH MATTHEW GREGORY , COLE DEREK CECIL , AYRAL-KALOUSTIAN SEMIRAMIS , YU KER , RICHARD DAVID JAMES , LEFEVER MARK
IPC分类号： C07D487/04 , A61K31/519 , A61P3/10 , A61P29/00 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR -related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K -related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.
摘要翻译：本发明涉及吡唑并嘧啶类似物，制备吡唑并嘧啶类似物的方法，包含吡唑并嘧啶类似物的组合物和治疗mTOR相关病症的方法，包括向有需要的受试者施用有效量的吡唑并嘧啶类似物。本发明还涉及治疗PI3K相关疾病，包括向有需要的受试者施用有效量的吡唑并嘧啶类似物。

10. 发明申请

WO2008051244A3 ANTHRANILIC ACID DERIVATIVES USEFUL IN TREATING INFECTION WITH HEPATITIS C VIRUS 审中-公开
标题翻译：用于治疗乙型肝炎病毒感染的抗坏血酸衍生物
公开(公告)号：WO2008051244A3
公开(公告)日：2008-07-17
申请号：PCT/US2006045950
申请日：2006-12-01
申请人： WYETH CORP , BLOOM JONATHAN DAVID , INSAF SHABANA , NITTOLI THOMAS , SUTHERLAND ALAN GORDON , CURRAN KEVIN J , WHELESS KAREN
发明人： BLOOM JONATHAN DAVID , INSAF SHABANA , NITTOLI THOMAS , SUTHERLAND ALAN GORDON , CURRAN KEVIN J , WHELESS KAREN
IPC分类号： C07D317/66 , A61K31/36 , A61P31/12 , C07C235/24 , C07C237/04 , C07C251/48
CPC分类号： C07D317/66 , C07C235/24 , C07C237/04 , C07C251/48 , C07C317/36
摘要： The present invention is directed to compounds of formula (I): wherein R 1 is selected from the group consisting of -C(O)R and (a), wherein R 6 and R 7 are independently selected from H, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or aryl, any of which may be optionally substituted, G is selected from H or hydroxyl, Y is O, NH or S, X is selected from the group consisting of H, halo, alkyl, cycloalkyl, perfluoroalkyl, alkoxy, alkylthio, amino, alkylamino, dialkylamino, and CN, and n is 0, 1, 2 or 3, or a prodrug, a pharmaceutically acceptable salt, or a pharmaceutically active metabolite thereof. This invention is also directed to compositions containing compounds of the invention and methods of using both the inventive compounds and compositions thereof to treat or prevent Hepatitis C virus infection, or to inhibit replication of a Hepatitis C virus.
摘要翻译：本发明涉及式（I）的化合物：其中R 1选自-C（O）R和（a），其中R 6 = 和R 7独立地选自H，烷基，环烷基，杂环烷基，杂芳基或芳基，其中任何一个可以任选被取代，G选自H或羟基，Y是O，NH或S ，X选自H，卤素，烷基，环烷基，全氟烷基，烷氧基，烷硫基，氨基，烷基氨基，二烷基氨基和CN，n为0,1,2或3，或前药，药学上可接受的盐或其药物活性代谢物。本发明还涉及含有本发明化合物的组合物和使用本发明化合物及其组合物治疗或预防丙型肝炎病毒感染或抑制丙型肝炎病毒复制的方法。

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