专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008086462A3 AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS 审中-公开
公开(公告)号：WO2008086462A3
公开(公告)日：2008-07-17
申请号：PCT/US2008/050728
申请日：2008-01-10
申请人： WYETH , VENKATESAN, Aranapakam, M. , DEHNHARDT, Christoph , CHEN, Zecheng , SANTOS, Osvaldo, Dos , SANTOS, Efren, Delos , CURRAN, Kevin , AYRAL-KALOUSTIAN, Semiramis , CHEN, Lei
发明人： VENKATESAN, Aranapakam, M. , DEHNHARDT, Christoph , CHEN, Zecheng , SANTOS, Osvaldo, Dos , SANTOS, Efren, Delos , CURRAN, Kevin , AYRAL-KALOUSTIAN, Semiramis , CHEN, Lei
IPC分类号： C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , A61K31/517 , A61P35/00
摘要： The present invention relates to amino-substituted quinazoline derivatives as inhibitors of β-catenin/tcf-4 pathway, which can be useful in the treatment of cancer; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.

2. 发明申请

WO2021178263A1 HUMAN-LIKE HEAVY CHAIN ANTIBODY VARIABLE DOMAIN (VHH) DISPLAY LIBRARIES 审中-公开
公开(公告)号：WO2021178263A1
公开(公告)日：2021-09-10
申请号：PCT/US2021/020180
申请日：2021-03-01
申请人： MERCK SHARP & DOHME CORP. , CHEN, Lei , CHEN, Ming-Tang , HSIEH, Chung-Ming , SEVY, Alexander Mario
发明人： CHEN, Lei , CHEN, Ming-Tang , HSIEH, Chung-Ming , SEVY, Alexander Mario
IPC分类号： C12N15/12 , C12N15/62 , C12N15/10 , C07K19/00
摘要： Heavy chain antibody variable domain (VHH) display libraries are described comprising human-like VHH comprising three synthetically generated complementarity determining region (CDR) areas in which the amino acids at each of positions 44 and 45 or positions 37, 44, 45, and 47comprise the amino acid at the corresponding position of a Camelid VHH, wherein the amino acid positions are according to Kabat numbering. Human-like VHHs identified using these libraries may be useful for the manufacture of therapeutics for treating diseases and disorders.

3. 发明申请

WO2019010603A1 A CONDITION BASED ENERGY SMART AIR CIRCULATION SYSTEM 审中-公开
公开(公告)号：WO2019010603A1
公开(公告)日：2019-01-17
申请号：PCT/CN2017/092336
申请日：2017-07-10
申请人： CARRIER CORPORATION , CHEN, Lei
发明人： CHEN, Lei , ZHAO, Jianwei , WEN, Sanming , MCKINNEY, Peter Johannes
IPC分类号： F24F11/00
摘要： A method for improving the effectiveness of a building air circulation system having motorized blower and a contamination filter. The method including predicting a cost of operation of the system over an operational duration based on at least electricity consumption of the motor (115), and an operational cost to operate the filter (148), predicting a cost of maintenance of the system over the operational duration based on at least one of, a condition of the filter (148), a cost of a filter (148), a cost of labor to clean or replace the filter (148), and an effectiveness of the filter (148) over the operational duration, and balancing the cost of operation of the circulation system versus the cost of maintenance of the circulation system over the duration to recommend at least one of a filter use/bypass schedule, a filter maintenance schedule, and a fresh air input schedule satisfying an operation objective and an operational constraint.

4. 发明申请

WO2014110706A1 THIOPHENE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：噻吩取代的四环化合物及其用于治疗病毒性疾病的方法
公开(公告)号：WO2014110706A1
公开(公告)日：2014-07-24
申请号：PCT/CN2013/001677
申请日：2013-12-31
申请人： MERCK SHARP & DOHME CORP. , TONG, Ling , YU, Wensheng , KOZLOWSKI, Joseph A. , CHEN, Lei , SELYUTIN, Oleg , KIM, Seong Heon , DWYER, Michael , HU, Bin , ZHONG, Bin , WAI, Dahai , HAO, Jinglai , SHEN, Changmao , LEI, Zhixin , WANG, Weijun
发明人： TONG, Ling , YU, Wensheng , KOZLOWSKI, Joseph A. , CHEN, Lei , SELYUTIN, Oleg , KIM, Seong Heon , DWYER, Michael , HU, Bin , ZHONG, Bin , WAI, Dahai , HAO, Jinglai , SHEN, Changmao , LEI, Zhixin , WANG, Weijun
IPC分类号： C07D498/04 , C07D409/14 , A61K31/5365 , A61P31/14
CPC分类号： C07D498/04 , A61K31/4985 , A61K31/5365 , A61K31/7056 , A61K31/7072 , A61K38/005 , A61K38/212 , A61K45/06 , C07D519/00 , Y02A50/385 , Y02A50/389 , A61K2300/00
摘要： Thiophene-substituted tetracyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A, A', R 2 , R 3 , R 4 and R 5 are as defined herein. The compositions comprising at least one thiophene-substituted tetracyclic compound, and methods of using the thiophene-substituted tetracyclic compounds for treating or preventing HCV infection in a patient are also provided.
摘要翻译：式（I）的噻吩取代的四环化合物及其药学上可接受的盐，其中A，A'，R 2，R 3，R 4和R 5如本文所定义。还提供了包含至少一种噻吩取代的四环化合物的组合物，以及使用噻吩取代的四环化合物治疗或预防患者HCV感染的方法。

5. 发明申请

WO2014110705A9 HETEROCYCLE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开
公开(公告)号：WO2014110705A9
公开(公告)日：2014-07-24
申请号：PCT/CN2013/001676
申请日：2013-12-31
申请人： MERCK SHARP & DOHME CORP. , YU, Wensheng , TONG, Ling , KOZLOWSKI, Joseph A. , SELYUTIN, Oleg , CHEN, Lei , KIM, Jae-Hun , SHA, Deyou , RIZVI, Razia , SHANKAR, Bandarpalle , HU, Bin , ZHONG, Bin , WAI, Dahai , HAO, Jinglai , WEI, Wei , JI, Tao , ZAN, Shuai
发明人： YU, Wensheng , TONG, Ling , KOZLOWSKI, Joseph A. , SELYUTIN, Oleg , CHEN, Lei , KIM, Jae-Hun , SHA, Deyou , RIZVI, Razia , SHANKAR, Bandarpalle , HU, Bin , ZHONG, Bin , WAI, Dahai , HAO, Jinglai , WEI, Wei , JI, Tao , ZAN, Shuai
IPC分类号： C07D498/04 , C07D409/14 , A61K31/5365 , A61P31/14
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A', R 2 R 3 , R 4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.

6. 发明申请

WO2013052041A1 GAS SENSOR 审中-公开
标题翻译：气体传感器
公开(公告)号：WO2013052041A1
公开(公告)日：2013-04-11
申请号：PCT/US2011/054855
申请日：2011-10-05
申请人： UTC FIRE & SECURITY CORPORATION , CHEN, Lei , YANG, Zhiwei , YAMANIS, Jean , ZAFIRIS, Georgios S. , SANGIOVANNI, Joseph J.
发明人： CHEN, Lei , YANG, Zhiwei , YAMANIS, Jean , ZAFIRIS, Georgios S. , SANGIOVANNI, Joseph J.
IPC分类号： G01N27/333 , G01N27/30
CPC分类号： G01N27/407 , G01N27/40 , G01N27/404 , G01N27/4074 , G01N27/413
摘要： A membrane electrode assembly for a gas sensor is described that includes a membrane disposed between a sensing electrode and a counter electrode. The membrane is a polymer membrane, such as an ionomer, having an ionic liquid retained therein.
摘要翻译：描述了一种用于气体传感器的膜电极组件，其包括设置在感测电极和对电极之间的膜。膜是聚合物膜，例如离聚物，其中保留有离子液体。

7. 发明申请

WO2012041014A1 TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION 审中-公开
标题翻译：用于治疗乙型肝炎病毒感染的四环吲哚类衍生物
公开(公告)号：WO2012041014A1
公开(公告)日：2012-04-05
申请号：PCT/CN2011/001638
申请日：2011-09-28
申请人： MERCK SHARP & DOHME CORP. , KOZLOWSKI, Joseph A. , ROSENBLUM, Stuart B. , COBURN, Craig A. , SHANKAR, Bandarpalle, B. , ANILKUMAR, G., Nair , CHEN, Lei , DWYER, Michael, P. , JIANG, Yueheng , KEERTIKAR, Kartik, M. , LAVEY, Brian, J. , SELYUTIN, Oleg, B. , TONG, Ling , WONG, Michael , YANG, De-Yi , YU, Wensheng , ZHOU, Guowei , WU, Hao , HU, Bin , ZHONG, Bin , SUN, Fei , JI, Tao , SHEN, Changmao , RIZVI, Razia , ZENG, Qingbei
发明人： KOZLOWSKI, Joseph A. , ROSENBLUM, Stuart B. , COBURN, Craig A. , SHANKAR, Bandarpalle, B. , ANILKUMAR, G., Nair , CHEN, Lei , DWYER, Michael, P. , JIANG, Yueheng , KEERTIKAR, Kartik, M. , LAVEY, Brian, J. , SELYUTIN, Oleg, B. , TONG, Ling , WONG, Michael , YANG, De-Yi , YU, Wensheng , ZHOU, Guowei , WU, Hao , HU, Bin , ZHONG, Bin , SUN, Fei , JI, Tao , SHEN, Changmao , RIZVI, Razia , ZENG, Qingbei
IPC分类号： C07D498/04 , C07D487/04 , C07D471/04 , A61K31/5365 , A61K31/4985 , A61K31/437 , A61P31/14
CPC分类号： C07D498/04 , A61K31/437 , A61K31/4985 , A61K31/5365 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： Tetracyclic indole derivatives of formula (I), pharmaceutically acceptable salts and the pharmaceutical compositions thereof are provided, wherein A, A', G, R 1 , R 15 , U, V, V, W, W, X, X', Y, Y' are as defined in the invention. Use of these derivatives for treating hepatitis C virus (HCV) infection is also provided.
摘要翻译：其中A，A'，G，R 1，R 15，U，V，V，W，W，X，X'，Y，Y的化合物 '如本发明所定义。还提供了这些衍生物用于治疗丙型肝炎病毒（HCV）感染的用途。

8. 发明申请

WO2010019123A1 MANAGEMENT OF POWER FROM MULTIPLE SOURCES IN AN ELEVATOR POWER SYSTEM 审中-公开
标题翻译：电力系统中多个电源的功率管理
公开(公告)号：WO2010019123A1
公开(公告)日：2010-02-18
申请号：PCT/US2008/009780
申请日：2008-08-15
申请人： OTIS ELEVATOR COMPANY , OGGIANU, Stella, M. , THORNTON, Robert, K. , BLASKO, Vladimir , VERONESI, William, A. , CHEN, Lei , MARVIN, Daryl, J.
发明人： OGGIANU, Stella, M. , THORNTON, Robert, K. , BLASKO, Vladimir , VERONESI, William, A. , CHEN, Lei , MARVIN, Daryl, J.
IPC分类号： B66B1/30
CPC分类号： B66B1/302
摘要： Power exchange is managed between an elevator hoist motor (12), a primary power supply (20), and an energy storage system (32). A power distribution ratio is set that establishes a proportion of elevator hoist motor demand addressed by the primary power supply. The power exchanged between the hoist motor, the primary power supply, and the energy storage system is then controlled such that the primary power supply exchanges power with the elevator hoist motor according to the power distribution ratio.
摘要翻译：在电梯起重电动机（12），主电源（20）和能量存储系统（32）之间管理电力交换。设定配电比率，其设定由主电源寻址的电梯起重机电动机需求的比例。然后，控制升降马达，主电源和能量存储系统之间交换的电力，使得主电源根据配电比与电梯起重马达交换电力。

9. 发明申请

WO2010008759A2 APPARATUS, METHOD AND COMPUTER-READABLE MEDIUM FOR TESTING A PANEL OF INTERFEROMETRIC MODULATORS 审中-公开
标题翻译：用于测试干涉仪调制器面板的装置，方法和计算机可读介质
公开(公告)号：WO2010008759A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/047847
申请日：2009-06-18
申请人： QUALCOMM MEMS TECHNOLOGIES, INC. , NACHMAN, Ramez , CHEN, Lei , YU, Tao
发明人： NACHMAN, Ramez , CHEN, Lei , YU, Tao
IPC分类号： G01R27/28 , G01R31/14
CPC分类号： G02B26/001 , B81C99/0045 , G01R31/302
摘要： In some embodiments, each interferometric modulator has a stiction threshold voltage. If a voltage above the stiction threshold voltage is applied to the interferometric modulator, the interferometric modulator enters a stiction state permanently, i.e., becomes "stuck," and the interferometric modulator becomes inoperable. Disclosed are apparatuses, methods and computer-readable media for testing a panel of interferometric modulators. A ramped voltage waveform is applied to a plurality of interferometric modulators of the panel. In response to applying the ramped voltage, the stiction threshold voltage is identified. At or above this voltage, the number of stuck interferometric modulators in the panel reaches or exceeds a first threshold number, for example, 50% of the total number of the interferometric modulators constituting the panel. The embodiments can be used to establish stiction benchmark for panel manufacturing processes, to collect data for generating statistical distribution, etc.
摘要翻译：在一些实施例中，每个干涉式调制器具有静态阈值电压。如果高于静态阈值电压的电压被施加到干涉式调制器，则干涉式调制器永久地进入静态状态，即变得“卡住”，并且干涉式调制器变得不可操作。公开了用于测试一组干涉式调制器的装置，方法和计算机可读介质。斜坡电压波形被施加到面板的多个干涉式调制器。响应于施加斜坡电压，识别出静态阈值电压。在该电压以上时，面板中的卡住的干涉式调制器的数量达到或超过第一阈值数，例如构成面板的干涉式调制器总数的50％。这些实施例可以用于建立面板制造过程的静态基准，收集用于生成统计分布的数据等。

10. 发明申请

WO2009100376A2 ANTIGENIC CLOAKING AND ITS USE 审中-公开
标题翻译：抗原克隆及其使用
公开(公告)号：WO2009100376A2
公开(公告)日：2009-08-13
申请号：PCT/US2009/033457
申请日：2009-02-06
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES , UNIVERSITY OF WASHINGTON , UNIVERSITY OF ALABAMA AT BIRMINGHAM , KWONG, Peter, D. , NABEL, Gary, J. , SHAW, George , SCHIEF, William , YANG, Zhi-yong , ZHOU, Tongqing , CHEN, Lei , KWON, Young Do
发明人： KWONG, Peter, D. , NABEL, Gary, J. , SHAW, George , SCHIEF, William , YANG, Zhi-yong , ZHOU, Tongqing , CHEN, Lei , KWON, Young Do
IPC分类号： A61K39/21 , C12N15/49 , G06F19/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/545 , A61K2039/55566 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134 , G06F19/16 , G06F19/18
摘要： Disclosed are antigens that include a target epitope that is defined by atomic coordinates of those amino acids of the antigen that contact an antibody of interest that specifically binds the antigen. The disclosed antigens have between about 10% and about 90% of surface exposed amino acid residues located exterior of the target epitope substituted as compared to a wild- type antigen and less than about 10% of the non-surface exposed amino acid residues substituted as compared to a wild-type antigen. Also disclosed are nucleic acids encoding these antigens and methods of producing these antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a human immunodeficiency type 1 (HIV-I) infection in a subject.
摘要翻译：公开的是包含由与抗原特异性结合的目的抗体接触的抗原的那些氨基酸的原子坐标定义的靶表位的抗原。与野生型抗原相比，所公开的抗原具有位于目标表位外部的表面暴露的氨基酸残基的约10％至约90％，并且少于约10％的非表面暴露的氨基酸残基被取代为与野生型抗原相比。还公开了编码这些抗原的核酸和产生这些抗原的方法。还公开了在受试者中产生免疫应答的方法。在一些实施方案中，该方法是用于治疗或预防受试者中的人类免疫缺陷1型（HIV-1）感染的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式