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1. 发明专利

IL293502A Recombinant virus, composition comprising the same, and uses thereof 未知
公开(公告)号：IL293502A
公开(公告)日：2022-08-01
申请号：IL29350222
申请日：2022-06-01
申请人： ACADEMIA SINICA , CHI HUEY WONG , CHUNG YI WU
发明人： CHI-HUEY WONG , CHUNG-YI WU
IPC分类号： F27D11/08
摘要： Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.

2. 发明专利

IL266526D0 Recombinant virus, composition comprising the same, and uses thereof 未知
公开(公告)号：IL266526D0
公开(公告)日：2019-07-31
申请号：IL26652619
申请日：2019-05-08
申请人： CHI HUEY WONG , ACADEMIA SINICA , CHUNG YI WU
发明人： CHI-HUEY WONG , CHUNG-YI WU
IPC分类号： F27D20060101
摘要： Immunogenic compositions comprising hemagglutinin (HA) variants and/or neuraminidase (NA) variants, which may be contained in an influenza A virus, and uses thereof for eliciting immune responses against influenza A virus.

3. 发明授权

US10338069B2 Glycan arrays for high throughput screening of viruses 有权
公开(公告)号：US10338069B2
公开(公告)日：2019-07-02
申请号：US14376837
申请日：2011-04-12
申请人： Chi-Huey Wong , Chung-Yi Wu , Chi-Hui Liang , An-Suei Yang
发明人： Chi-Huey Wong , Chung-Yi Wu , Chi-Hui Liang , An-Suei Yang
IPC分类号： G01N33/569 , G01N33/53 , G01N33/543
摘要： Glycan arrays that can detect and distinguish between various sub-types and strains of influenza virus are provided. Methods for using the glycan arrays with assays using nanoparticle amplification technique are disclosed. Sandwich assays using gold nanoparticles conjugated to phage particles comprising influenza virus-specific antibodies for detecting multiple serotypes using a single reaction are provided. Plurality of glycans directed to specific target HA of influenza virus comprises the array. Detector molecules comprising noble metals conjugated to (a) phage display particles expressing antibodies against hemagglutinin and (b) neuraminidase binding agents are disclosed.

4. 发明授权

US10307470B2 Antibody-mediated anti-tumor activity induced by Reishi mushroom polysaccharides 有权
公开(公告)号：US10307470B2
公开(公告)日：2019-06-04
申请号：US14906663
申请日：2014-07-26
申请人： ACADEMIA SINICA , Chi-Huey Wong , Chung-Yi Wu , Hsien-Yeh Hsu , Shih-Fen Liao , Chi-Hui Liang
发明人： Chi-Huey Wong , Chung-Yi Wu , Hsien-Yeh Hsu , Shih-Fen Liao , Chi-Hui Liang
IPC分类号： A61K39/00 , A61K36/074
摘要： Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW=˜35 kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-α-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.

5. 发明授权

US08767494B2 Far end resistance tracking design with near end pre-charge control for faster recovery time 有权
标题翻译：远端电阻跟踪设计，具有近端预充电控制，可实现更快的恢复时间
公开(公告)号：US08767494B2
公开(公告)日：2014-07-01
申请号：US13493118
申请日：2012-06-11
申请人： Chen-Lin Yang , Chung-Yi Wu , Yu-Hao Hsu
发明人： Chen-Lin Yang , Chung-Yi Wu , Yu-Hao Hsu
IPC分类号： G11C7/00 , G11C8/00
CPC分类号： G11C7/12 , G11C7/227 , G11C8/18 , G11C11/413
摘要： A wordline tracking circuit and corresponding method are disclosed, and include a tracking wordline having an impedance characteristic associated therewith that models a row of memory cells in a memory device, wherein the tracking wordline has a near end that receives a wordline pulse signal having a near end rising pulse edge and a near end falling pulse edge. The tracking wordline also has a far end. A tracking cell component is coupled to the far end of the tracking wordline that receives the wordline pulse signal. Lastly, the circuit includes a tracking bitline pre-charge circuit coupled to the tracking cell that is configured to pre-charge a tracking bitline associated with the tracking cell using the near end wordline pulse signal.
摘要翻译：公开了一种字线追踪电路及相应的方法，包括具有与之相关联的阻抗特征的跟踪字线，其对存储器件中的一行存储单元进行建模，其中跟踪字线具有接近具有近似的字线脉冲信号的近端结束上升脉冲沿和近端下降脉冲沿。跟踪字线也有一个远端。跟踪单元组件耦合到接收字线脉冲信号的跟踪字线的远端。最后，电路包括耦合到跟踪单元的跟踪位线预充电电路，其被配置为使用近端字线脉冲信号对与跟踪单元相关联的跟踪位线进行预充电。

6. 发明授权

US08680020B2 Glycan arrays on PTFE-like aluminum coated glass slides and related methods 有权
标题翻译：聚四氟乙烯涂覆玻璃载片上的糖阵列及相关方法
公开(公告)号：US08680020B2
公开(公告)日：2014-03-25
申请号：US12503797
申请日：2009-07-15
申请人： Chi-Huey Wong , Chung-Yi Wu , Susan Y. Tseng
发明人： Chi-Huey Wong , Chung-Yi Wu , Susan Y. Tseng
IPC分类号： C40B40/12 , C40B20/04
CPC分类号： G01N33/553 , C40B40/12 , C40B50/14 , G01N33/582 , G01N2333/942 , G01N2400/10 , H01J49/40
摘要： Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.
摘要翻译：镀铝玻璃片提供了一种新的聚糖阵列平台。具体来说，铝涂层玻璃片增加了基于荧光的测定方法的灵敏度。另外，铝涂层玻璃载玻片允许碳水化合物的质谱分析，并提供一个检查纤维素酶活性的平台。 ACG载玻片的独特性质包括：1）表面上的金属氧化物层可以活化，用于接枝有机化合物如改性寡糖; 2）表面保持导电，并且接枝的寡糖可以通过质谱法和碳水化合物结合测定同时表征; 和3）在结合分析中，载玻片比透明玻片更敏感。

7. 发明申请

US20120328646A1 Globo H and Related Anti-Cancer Vaccines with Novel Glycolipid Adjuvants 有权
标题翻译： Globo H和相关抗癌疫苗与新型糖脂佐剂
公开(公告)号：US20120328646A1
公开(公告)日：2012-12-27
申请号：US13568510
申请日：2012-08-07
申请人： Chi-Huey Wong , Chung-Yi Wu , Alice L. Yu , John Yu
发明人： Chi-Huey Wong , Chung-Yi Wu , Alice L. Yu , John Yu
IPC分类号： A61K39/385 , A61P35/00 , C07K14/33 , C07K14/00 , C07K14/34
CPC分类号： A61K39/0011 , A61K2039/55511 , A61K2039/6037 , A61K2039/6081 , A61K2039/627 , C12N15/1137 , C12N2310/14
摘要： An immunogenic composition containing a glycan conjugate including a carrier protein, and a glycan including Globo H, an immunogenic fragment thereof, or stage-specific embryonic antigen-4 (SSEA-4), wherein the glycan is conjugated with the carrier protein through a linker.
摘要翻译：含有载体蛋白的聚糖缀合物和包含Globo H，其免疫原性片段或阶段特异性胚胎抗原-4（SSEA-4）的聚糖的免疫原性组合物，其中所述聚糖通过接头与载体蛋白质缀合。

8. 发明授权

US08279684B2 Method for extending word-line pulses 有权
标题翻译：扩展字线脉冲的方法
公开(公告)号：US08279684B2
公开(公告)日：2012-10-02
申请号：US12842189
申请日：2010-07-23
申请人： Hsu-Shun Chen , Cheng Hung Lee , Hong-Chen Cheng , Chung-Yi Wu
发明人： Hsu-Shun Chen , Cheng Hung Lee , Hong-Chen Cheng , Chung-Yi Wu
IPC分类号： G11C7/00
CPC分类号： G11C8/08 , G11C11/413
摘要： An integrated circuit includes a positive power supply node, a current tracking circuit, and a current mirroring circuit including a plurality of current paths coupled in parallel. The currents of the plurality of current paths mirror a current of the current tracking circuit. The current mirroring circuit is configured to turn off the plurality of current paths one-by-one in response to a reduction in a positive power supply voltage on the positive power supply node. The integrated circuit further includes a charging node receiving a summation current of the plurality of current paths, wherein a voltage on the charging node is configured to increase through a charging of the summation current.
摘要翻译：集成电路包括正电源节点，电流跟踪电路和包括并联耦合的多个电流路径的电流镜像电路。多个电流通路的电流反映了电流跟踪电路的电流。电流镜像电路被配置为响应于正电源节点上的正电源电压的减小而逐个关闭多个电流路径。集成电路还包括接收多个电流路径的求和电流的充电节点，其中充电节点上的电压被配置为通过对和电流的充电而增加。

9. 发明申请

US20120195139A1 MULTI-POWER DOMAIN DESIGN 有权
标题翻译：多功能域设计
公开(公告)号：US20120195139A1
公开(公告)日：2012-08-02
申请号：US13443619
申请日：2012-04-10
申请人： Hsu-Shun CHEN , Cheng Hung LEE , Chung-Ji LU , Hong-Chen CHENG , Chung-Yi WU , Chih-Chieh CHIU
发明人： Hsu-Shun CHEN , Cheng Hung LEE , Chung-Ji LU , Hong-Chen CHENG , Chung-Yi WU , Chih-Chieh CHIU
IPC分类号： G11C7/00 , G11C5/14
CPC分类号： G11C7/1048 , G11C5/14
摘要： In some embodiments related to a memory array, a sense amplifier (SA) uses a first power supply, e.g., voltage VDDA, while other circuitry, e.g., signal output logic, uses a second power supply, e.g., voltage VDDB. Various embodiments place the SA and a pair of transferring devices at a local IO row, and a voltage keeper at the main IO section of the same memory array. The SA, the transferring devices, and the voltage keeper, when appropriate, operate together so that the data logic of the circuitry provided by voltage VDDB is the same as the data logic of the circuitry provided by voltage VDDA.
摘要翻译：在与存储器阵列相关的一些实施例中，读出放大器（SA）使用第一电源，例如电压VDDA，而其它电路（例如，信号输出逻辑）使用第二电源，例如电压VDDB。各种实施例将SA和一对传送装置放置在本地IO行上，并将电压保持器放置在同一存储器阵列的主IO部分。 SA，传输装置和电压保持器在适当的情况下一起工作，使得由电压VDDB提供的电路的数据逻辑与由电压VDDA提供的电路的数据逻辑相同。

10. 发明申请

US20110090753A1 POWER MANAGEMENT 有权
标题翻译：能源管理
公开(公告)号：US20110090753A1
公开(公告)日：2011-04-21
申请号：US12885826
申请日：2010-09-20
申请人： Cheng Hung LEE , Chung-Yi WU , Hsu-Shun CHEN , Chung-Ji LU
发明人： Cheng Hung LEE , Chung-Yi WU , Hsu-Shun CHEN , Chung-Ji LU
IPC分类号： G11C5/14
CPC分类号： G11C11/413
摘要： An SRAM includes circuitry configured for the SRAM to operate at different operation modes using different voltage levels wherein the voltage level and thus the supply current leakage is regulated based on the operation mode. For example, the SRAM, in a normal operation mode, consumes power as other SRAMs. In a deep sleep mode the supply voltage (e.g., VDDI) for the bit cell in the SRAM macro is lowered by about 20-40% of the SRAM supply voltage (e.g., VDD), sufficient to retain the data in the bit cell. When access to the SRAM is not needed, the SRAM operates in the sleep mode, consuming little or no power.
摘要翻译： SRAM包括被配置用于使用不同的电压电平在不同的操作模式下工作的电路，其中基于操作模式调节电压电平和因此的电流泄漏。例如，在正常工作模式下，SRAM将作为其他SRAM消耗电力。在深度睡眠模式下，SRAM宏中的位单元的电源电压（例如，VDDI）降低SRAM电源电压（例如VDD）的约20-40％，足以将数据保留在位单元中。当不需要访问SRAM时，SRAM在睡眠模式下运行，消耗很少或没有电源。

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