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1. 发明授权

US10307470B2 Antibody-mediated anti-tumor activity induced by Reishi mushroom polysaccharides 有权
公开(公告)号：US10307470B2
公开(公告)日：2019-06-04
申请号：US14906663
申请日：2014-07-26
申请人： ACADEMIA SINICA , Chi-Huey Wong , Chung-Yi Wu , Hsien-Yeh Hsu , Shih-Fen Liao , Chi-Hui Liang
发明人： Chi-Huey Wong , Chung-Yi Wu , Hsien-Yeh Hsu , Shih-Fen Liao , Chi-Hui Liang
IPC分类号： A61K39/00 , A61K36/074
摘要： Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW=˜35 kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-α-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.

2. 发明申请

US20110028428A1 HIRSUTELLA SINENSIS MYCELIA COMPOSITIONS AND METHODS FOR TREATING SEPSIS AND RELATED INFLAMMATORY RESPONSES 失效
标题翻译： HIRSUTELLA SINENSIS MYCELIA组合物和治疗食欲和相关的炎症反应的方法
公开(公告)号：US20110028428A1
公开(公告)日：2011-02-03
申请号：US12750655
申请日：2010-03-30
申请人： Chi-Huey Wong , Alice L. Yu , Wen-Bin Yang , Eugene Fan , Hsien-Yeh Hsu , Peishan Lee , Tseng-Rong Tu , Chin-Chung Hung
发明人： Chi-Huey Wong , Alice L. Yu , Wen-Bin Yang , Eugene Fan , Hsien-Yeh Hsu , Peishan Lee , Tseng-Rong Tu , Chin-Chung Hung
IPC分类号： A61K31/715 , A61P29/00 , A61P27/02 , A61P1/04 , A61P19/02
CPC分类号： A61K31/715
摘要： Compositions comprising Hirsutella sinensis mycelia extracts and chromatographically separated polysaccharide-enriched fractions thereof are provided. Methods for extracting Hirsutella sinensis mycelia are provided. Compositions for methods for their use in amelioration, prevention and treatment of sepsis, acute endotoxemia and inflammatory responses are disclosed.
摘要翻译：提供了包含中华绒螯蟹菌丝体提取物和色谱分离的多糖富集部分的组合物。提供了中华绒螯蟹提取物的方法。公开了其用于改善，预防和治疗败血症，急性内毒素血症和炎性反应的方法的组合物。

3. 发明授权

US08486914B2 Hirsutella sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses 失效
标题翻译： Hirsutella sinensis菌丝体组合物和治疗败血症和相关炎症反应的方法
公开(公告)号：US08486914B2
公开(公告)日：2013-07-16
申请号：US12750655
申请日：2010-03-30
申请人： Chi-Huey Wong , Alice L. Yu , Wen-Bin Yang , Eugene Fan , Hsien-Yeh Hsu , Peishan Lee , Tseng-Rong Tu , Chin-Chung Hung
发明人： Chi-Huey Wong , Alice L. Yu , Wen-Bin Yang , Eugene Fan , Hsien-Yeh Hsu , Peishan Lee , Tseng-Rong Tu , Chin-Chung Hung
IPC分类号： A61K31/715
CPC分类号： A61K31/715
摘要： Compositions comprising Hirsutella sinensis mycelia extracts and chromatographically separated polysaccharide-enriched fractions thereof are provided. Methods for extracting Hirsutella sinensis mycelia are provided. Compositions for methods for their use in amelioration, prevention and treatment of sepsis, acute endotoxemia and inflammatory responses are disclosed.
摘要翻译：提供了包含中华绒螯蟹菌丝体提取物和色谱分离的多糖富集部分的组合物。提供了中华绒螯蟹提取物的方法。公开了其用于改善，预防和治疗败血症，急性内毒素血症和炎性反应的方法的组合物。

4. 发明申请

US20070105814A1 METHODS AND COMPOSITIONS ASSOCIATED WITH ADMINISTRATION OF AN EXTRACT OF GANODERMA LUCIDUM 有权
标题翻译：与甘草提取物相关的方法和组合物
公开(公告)号：US20070105814A1
公开(公告)日：2007-05-10
申请号：US11534204
申请日：2006-09-21
申请人： Kuo-Feng Hua , Hsien-Yeh Hsu , Chi-Huey Wong
发明人： Kuo-Feng Hua , Hsien-Yeh Hsu , Chi-Huey Wong
IPC分类号： A61K31/715 , A01N43/04
CPC分类号： A61K36/074
摘要： The present disclosure provides methods for increasing the lipopolysaccharide-induced secretion of IL-1 by macrophages, for increasing serum levels of IL-1 in a mammal, for increasing the serum level of IL-1 receptor antagonist (IL-1Ra) in a mammal, for increasing the secretion of IL-1 by a monocyte, for increasing the secretion of IL-1Ra by a monocyte, for increasing the secretion of IL-1Ra by a macrophage, for increasing expression of TLR4 on the surface of a macrophage, for increasing expression of CD14 on the surface of macrophage, for increasing the uptake and clearance of lipopolysaccharide (LPS) by a LPS-stimulated macrophage, and for increasing lipopolysaccharide (LPS)-stimulated activation of at least one of ERK, JNK, and p38 in a macrophage. The methods of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from Ganoderma lucidum.
摘要翻译：本公开提供了增加脂多糖诱导的巨噬细胞分泌IL-1的方法，用于增加哺乳动物中IL-1的血清水平，以增加哺乳动物中IL-1受体拮抗剂（IL-1Ra）的血清水平用于增加单核细胞分泌IL-1，增加单核细胞分泌IL-1Ra，增加巨噬细胞分泌IL-1Ra，增加巨噬细胞表面TLR4的表达，为增加巨噬细胞表面CD14的表达，增加LPS刺激的巨噬细胞对脂多糖（LPS）的吸收和清除，并增加脂多糖（LPS）刺激ERK，JNK和p38中的至少一种的活化巨噬细胞本公开的方法涉及从灵芝向哺乳动物和免疫细胞施用含岩藻糖的糖蛋白部分。

5. 发明授权

US07687064B2 Methods and compositions associated with administration of an extract of Ganoderma lucidum 有权
标题翻译：与灵芝提取物的给药相关的方法和组合物
公开(公告)号：US07687064B2
公开(公告)日：2010-03-30
申请号：US11534204
申请日：2006-09-21
申请人： Kuo-Feng Hua , Hsien-Yeh Hsu , Chi-Huey Wong
发明人： Kuo-Feng Hua , Hsien-Yeh Hsu , Chi-Huey Wong
IPC分类号： A61K36/06 , A61K9/00 , A61K47/00 , A23K1/17
CPC分类号： A61K36/074
摘要： The present disclosure provides methods for increasing the lipopolysaccharide-induced secretion of IL-1 by macrophages, for increasing serum levels of IL-1 in a mammal, for increasing the serum level of IL-1 receptor antagonist (IL-1Ra) in a mammal, for increasing the secretion of IL-1 by a monocyte, for increasing the secretion of IL-1Ra by a monocyte, for increasing the secretion of IL-1Ra by a macrophage, for increasing expression of TLR4 on the surface of a macrophage, for increasing expression of CD14 on the surface of macrophage, for increasing the uptake and clearance of lipopolysaccharide (LPS) by a LPS-stimulated macrophage, and for increasing lipopolysaccharide (LPS)-stimulated activation of at least one of ERK, JNK, and p38 in a macrophage. The methods of the disclosure involve the administration to mammals and immune cells of a fucose-containing glycoprotein fraction from Ganoderma lucidum.
摘要翻译：本公开提供了增加脂多糖诱导的巨噬细胞分泌IL-1的方法，用于增加哺乳动物中IL-1的血清水平，以增加哺乳动物中IL-1受体拮抗剂（IL-1Ra）的血清水平用于增加单核细胞分泌IL-1，增加单核细胞分泌IL-1Ra，增加巨噬细胞分泌IL-1Ra，增加巨噬细胞表面TLR4的表达，为增加巨噬细胞表面CD14的表达，增加LPS刺激的巨噬细胞对脂多糖（LPS）的吸收和清除，并增加脂多糖（LPS）刺激ERK，JNK和p38中的至少一种的活化巨噬细胞本公开的方法涉及从灵芝向哺乳动物和免疫细胞施用含岩藻糖的糖蛋白部分。

6. 发明授权

US5084565A Probes for the specific detection of Escherichia coli and Shigella 失效
标题翻译：特异性检测ESCHERICHIA COLI和SHIGELLA的探索
公开(公告)号：US5084565A
公开(公告)日：1992-01-28
申请号：US233683
申请日：1988-08-18
申请人： Kyriaki Parodos , Hsien-Yeh Hsu , David Sobell , Janice M. McCarty , David J. Lane
发明人： Kyriaki Parodos , Hsien-Yeh Hsu , David Sobell , Janice M. McCarty , David J. Lane
IPC分类号： C12Q1/68 , C12R1/01 , C12R1/19
CPC分类号： C12Q1/689 , Y10S435/839 , Y10S435/843 , Y10S435/844 , Y10S435/849 , Y10S435/852 , Y10S435/856 , Y10S435/875 , Y10S435/879 , Y10S435/88 , Y10S435/882 , Y10S435/883 , Y10S435/884 , Y10S435/885 , Y10S435/886 , Y10S436/808
摘要： Nucleic acid probes capable of specifically hybridizing to rRNA of E. coli and Shigella species and not to rRNA of non-E. coli/Shigella are described along with methods utilizing such probes for the specific detection of E. coli and/or Shigella in food and other samples.

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