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1. 发明申请

WO2012051433A3 SYSTEM AND METHOD FOR ELECTRICALLY ABLATING TISSUE OF A PATIENT 审中-公开
公开(公告)号：WO2012051433A3
公开(公告)日：2012-04-19
申请号：PCT/US2011/056177
申请日：2011-10-13
申请人： ANGIODYNAMICS, INC. , CALLAS, Peter , WARDEN, David , PEARSON, Robert, M.
发明人： CALLAS, Peter , WARDEN, David , PEARSON, Robert, M.
IPC分类号： A61B18/00 , A61B18/12 , A61N1/18 , A61N1/04
摘要： System for electrically ablating tissue of a patient through a plurality of electrodes includes a memory, a processor and a treatment control module stored in the memory and executable by the processor. The treatment control module generates an estimated treatment region based on the number of electrical pulses to be applied.

2. 发明申请

WO2006127236A2 SURGICAL INSTRUMENTS AND METHODS FOR USE IN REDUCED-ACCESS SURGICAL SITES 审中-公开
标题翻译：手术仪器和使用减少手术手术的方法
公开(公告)号：WO2006127236A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/017443
申请日：2006-05-04
申请人： CARDIOTHORACIC SYSTEMS, INC. , DAVIS, John, W. , WILLIS, Geoffrey, H. , WILLIS, Eric , GRESL, Charles , CALLAS, Peter , VASSILIADES, Thomas
发明人： DAVIS, John, W. , WILLIS, Geoffrey, H. , WILLIS, Eric , GRESL, Charles , CALLAS, Peter , VASSILIADES, Thomas
IPC分类号： A61B1/32
CPC分类号： A61B17/0218 , A61B90/50 , A61B90/57 , A61B2017/0243 , A61B2017/306
摘要： Devices and methods for stabilizing a portion of an organ or tissue in a closed or restricted space surgical site. Devices and methods for manipulating an organ or tissue in a closed or restricted space surgical site. Devices and methods for positioning and orienting stabilizers and manipulators I a closed or restricted space surgical site.
摘要翻译：用于稳定封闭或受限空间手术部位的器官或组织的一部分的装置和方法。在封闭或受限制的空间手术部位操作器官或组织的装置和方法。用于定位和定向稳定器和操纵器的装置和方法I是封闭或受限的空间手术部位。

3. 发明申请

WO2010138919A3 SYSTEM AND METHOD FOR SYNCHRONIZING ENERGY DELIVERY TO THE CARDIAC RHYTHM 审中-公开
标题翻译：用于同步向CARDIAC RHYTHM提供能量的系统和方法
公开(公告)号：WO2010138919A3
公开(公告)日：2011-02-24
申请号：PCT/US2010036734
申请日：2010-05-28
申请人： ANGIODYNAMICS INC , CALLAS PETER , LOVEWELL JAMES , STRIBLING BRADLEY C , WARDEN DAVE
发明人： CALLAS PETER , LOVEWELL JAMES , STRIBLING BRADLEY C , WARDEN DAVE
IPC分类号： A61N1/365 , A61B5/04 , A61N1/368
CPC分类号： A61N1/3706 , A61N1/327 , A61N1/365 , A61N1/3702
摘要： A system for synchronizing application of treatment signals with a cardiac rhythm is provided. The system includes a memory that receives and stores a synchronization signal indicating that a predetermined phase such as R-wave of a cardiac rhythm of a patient has started. A synchronization module analyzes whether the stored synchronization signal is erroneous and if so, prevents a medical treatment device from applying a treatment energy signal such as an IRE pulse to a patient to take into account an irregular heart beat and noise in the synchronization signal in order to maximize safety of the patient.
摘要翻译：提供了一种用于同步处理信号与心律的应用的系统。该系统包括存储器，其接收并存储指示诸如患者的心律的R波之类的预定相位已经开始的同步信号。同步模块分析所存储的同步信号是否是错误的，如果是，则防止医疗设备向患者施加诸如IRE脉冲的治疗能量信号，以按顺序考虑同步信号中的不规则心跳和噪声以最大限度地提高患者的安全性。

4. 发明申请

WO2008013743A2 METHODS FOR INHIBITING REPERFUSION INJURY 审中-公开
标题翻译：抑制再灌注损伤的方法
公开(公告)号：WO2008013743A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016432
申请日：2007-07-19
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , MICHAL, Eugene, T. , CALLAS, Peter, L. , LUDWIG, Florian, N.
发明人： MICHAL, Eugene, T. , CALLAS, Peter, L. , LUDWIG, Florian, N.
IPC分类号： A61K31/4433 , A61K31/56 , A61M25/00 , A61P9/10
CPC分类号： A61M25/104 , A61M2025/1095
摘要： A method that includes introducing a catheter assembly to an obstructed region of a blood vessel lumen and recanalizing the obstructed region with the catheter assembly is disclosed. Prior to or during recanalization, a treatment agent may be delivered through the catheter assembly to a vessel region downstream to the obstructed region. The treatment agent may have a property that will inhibit reperfusion injury. Alternatively, a medical device may be introduced to an obstructed region of a blood vessel lumen and the obstructed region recanalized with the medical device. The treatment agent may be delivered to a vessel region downstream to the obstructed region. The treatment agent may include at least one of an immunosuppresant and an antioxidant. In other methods, a delivery cannula may be introduced to an unperfused region of an occluded vessel without disrupting the occlusion and the treatment agent having a property that will inhibit reperfusion injury may be delivered to the unperfused region through the delivery cannula. After delivering the treatment agent, the occluded vessel may be recanalized by advancing an angioplasty device into the occluded vessel.
摘要翻译：公开了一种方法，其包括将导管组件引入血管内腔的阻塞区域并且用导管组件再通过阻塞区域。在再通之前或期间，处理剂可以通过导管组件递送到阻塞区域下游的血管区域。处理剂可具有抑制再灌注损伤的性质。或者，可以将医疗装置引入血管腔的阻塞区域，并且与医疗装置再通的阻塞区域。处理剂可以被输送到阻塞区域下游的容器区域。处理剂可以包括免疫抑制剂和抗氧化剂中的至少一种。在其它方法中，输送插管可以被引入封闭血管的未灌注区域而不破坏闭塞，并且具有抑制再灌注损伤的性质的治疗剂可通过输送导管输送到未灌注区域。在递送治疗剂之后，通过将血管成形术装置推入闭塞的血管中，封闭的血管可以再通。

5. 发明申请

WO2006127241A3 ABLATION INSTRUMENTS AND METHODS FOR PERFORMING ABALATION 审中-公开
标题翻译：排除仪器和执行排放的方法
公开(公告)号：WO2006127241A3
公开(公告)日：2007-07-26
申请号：PCT/US2006017527
申请日：2006-05-05
申请人： CARDIOTHORACIC SYS INC , CHIN ALBERT K , CALLAS PETER , UEMURA SHUJI , WILLIS GEOFFREY H
发明人： CHIN ALBERT K , CALLAS PETER , UEMURA SHUJI , WILLIS GEOFFREY H
IPC分类号： A61B18/14
CPC分类号： A61B18/1482 , A61B2018/0022 , A61B2018/00351 , A61B2018/00375
摘要： Methods, devices and instruments provided for performing ablation transmurally across the wall of an organ. Devices may directly access tissue to be ablated through direct access openings formed in the patient and, optionally, an organ where the ablation is to be performed. Instruments facilitating making openings, dissecting, and delivery of ablation instruments are also described.
摘要翻译：提供用于跨器官壁穿透的方法，装置和仪器。设备可以直接通过形成在患者中的直接进入开口和任选地进行消融的器官访问要消融的组织。还描述了促进消融器械的开口，解剖和输送的仪器。

6. 发明申请

WO2006104835A1 TISSUE WELDING AND CUTTING APPARATUS 审中-公开
标题翻译：组织焊接和切割设备
公开(公告)号：WO2006104835A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/010568
申请日：2006-03-24
申请人： ORIGIN MEDSYSTEMS, INC. , LAU, Liming , ESCANO, Arnold, M. , JARRARD, Jerry , HO, Sam , ABBOTT, Ryan, C. , LIN, Arthur, M. , MCQUISTON, Jesse , CALLAS, Peter, L. , WILLIS, Geoffrey, H. , STEWART, Michael, C. , BARKMAN, Kimberly, D. , LAMBERTI, Joseph, N. , DANG, Kenny, L.
发明人： LAU, Liming , ESCANO, Arnold, M. , JARRARD, Jerry , HO, Sam , ABBOTT, Ryan, C. , LIN, Arthur, M. , MCQUISTON, Jesse , CALLAS, Peter, L. , WILLIS, Geoffrey, H. , STEWART, Michael, C. , BARKMAN, Kimberly, D. , LAMBERTI, Joseph, N. , DANG, Kenny, L.
IPC分类号： A61B18/08 , A61B18/14
CPC分类号： A61B18/085 , A61B17/29 , A61B18/1445 , A61B90/03 , A61B2017/00084 , A61B2017/00353 , A61B2017/00504 , A61B2017/2912 , A61B2017/2936 , A61B2017/2945 , A61B2017/3445 , A61B2018/1432
摘要： A surgical apparatus and methods for severing and welding tissue, in particular blood vessels, including an elongated shaft (36) having a pair of relatively movable jaws (40, 42) at a distal end thereof. A first heating element (46) on one of the jaws heats up to a first temperature and forms a welded region within the tissue, while a second heating element (48) on one of the jaws heats up to a second temperature and severs the tissue within the welded region. A control handle (38) includes controls for opening and closing the jaws, and may include an actuator for sending current through the first and second heating elements. The first and second heating elements may be electrically connected in series, and the first heating element may be bifurcated such that it conducts about one half of the current as the second heating element.
摘要翻译：一种用于切断和焊接组织，特别是血管的手术装置和方法，包括在其远端具有一对相对可动的钳口（40,42）的细长轴（36）。其中一个颚板上的第一加热元件（46）加热至第一温度并在组织内形成焊接区域，而其中一个颚板上的第二加热元件（48）加热至第二温度并切断组织在焊接区域内。控制手柄（38）包括用于打开和关闭钳口的控制装置，并且可包括用于通过第一和第二加热元件发送电流的致动器。第一和第二加热元件可以串联电连接，并且第一加热元件可以分叉，使得其作为第二加热元件传导大约电流的一半。

7. 发明申请

WO2012051433A2 SYSTEM AND METHOD FOR ELECTRICALLY ABLATING TISSUE OF A PATIENT 审中-公开
标题翻译：用于电击患者组织的系统和方法
公开(公告)号：WO2012051433A2
公开(公告)日：2012-04-19
申请号：PCT/US2011056177
申请日：2011-10-13
申请人： ANGIODYNAMICS INC , CALLAS PETER , WARDEN DAVID , PEARSON ROBERT M
发明人： CALLAS PETER , WARDEN DAVID , PEARSON ROBERT M
IPC分类号： A61B18/00 , A61B18/12 , A61N1/04 , A61N1/18
CPC分类号： A61B18/14 , A61B34/25 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/143
摘要： System for electrically ablating tissue of a patient through a plurality of electrodes includes a memory, a processor and a treatment control module stored in the memory and executable by the processor. The treatment control module generates an estimated treatment region based on the number of electrical pulses to be applied.
摘要翻译：用于通过多个电极电消融患者组织的系统包括存储器，处理器和存储在存储器中并且可由处理器执行的治疗控制模块。治疗控制模块基于待施加的电脉冲的数量生成估计的治疗区域。

8. 发明申请

WO2010002706A1 EPICARDIAL CLIP 审中-公开
公开(公告)号：WO2010002706A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/048700
申请日：2009-06-25
申请人： MAQUET CARDIOVASCULAR LLC , CALLAS, Peter, Tachi , LOMBARDI, Pierluca , STEWART, Michael, C. , LAU, Liming , JURAVIC, Mark, S. , ANDERSON, Evan , LAMBERTI, Joe , CHIN, Albert, K. , WANG, Tammy
发明人： CALLAS, Peter, Tachi , LOMBARDI, Pierluca , STEWART, Michael, C. , LAU, Liming , JURAVIC, Mark, S. , ANDERSON, Evan , LAMBERTI, Joe , CHIN, Albert, K. , WANG, Tammy
IPC分类号： A61F2/00
CPC分类号： A61F2/2451 , A61F2/2442 , A61F2/2478 , A61F2/2481 , A61F2/2496
摘要： An epicardial clip for reshaping the annulus of the mitral valve of a heart. The epicardial clip includes a curved member having an anterior segment configured to be positioned in the transverse sinus of the heart, a posterior segment configured to be positioned on the posterior side of the heart, such as on or inferior to the atrioventricular groove, and a lateral segment extending between the anterior segment and the posterior segment. The lateral segment includes a curve such that the first end of the member is positioned at or above the plane of the mitral valve and the second end of the member is positioned at or below the plane of the mitral valve.
摘要翻译：用于重塑心脏二尖瓣环的心外膜。心外膜包括弯曲构件，其具有被构造成定位在心脏的横向窦内的前部区段，构造成位于心脏后侧（例如在房室下方或下方）的后部区段，以及侧段在前段和后段之间延伸。横向段包括曲线，使得构件的第一端定位在二尖瓣的平面上或上方，并且构件的第二端位于二尖瓣的平面处或下方。

9. 发明申请

WO2008024718A1 EPICARDIAL LEAD 审中-公开
公开(公告)号：WO2008024718A1
公开(公告)日：2008-02-28
申请号：PCT/US2007/076323
申请日：2007-08-20
申请人： CARDIAC PACEMAKERS, INC. , CALLAS, Peter L. , GREENLAND, John S. , HEIL JR., Ronald W. , WESTLUND, Randy W. , KELLEY, Peter T.
发明人： CALLAS, Peter L. , GREENLAND, John S. , HEIL JR., Ronald W. , WESTLUND, Randy W. , KELLEY, Peter T.
IPC分类号： A61N1/05
CPC分类号： A61N1/059
摘要： A lead for implanting into the epicardium includes a pair of tissue anchors coupled to a tissue engaging member, forming an anchor mechanism. The tissue anchors include electrodes coupled to conductors extending from the tissue engaging member. The tissue anchors are movable from a low profile configuration to an implanting configuration in which the tissue anchors are angled away from the tissue engaging member. A device for implanting the lead includes one or more lumens, including a lead lumen and a vacuum lumen terminating at a distal opening in the device. Suction is applied at the distal opening through the vacuum lumen to draw an epicardial bleb. The anchor mechanism of the lead is withdrawn proximally past the bleb, causing the tissue anchors to pierce the epicardium. The device is then withdrawn proximally over the conductors.
摘要翻译：用于植入到心外膜的引线包括耦合到组织接合构件的一对组织锚，形成锚固机构。组织锚定器包括耦合到从组织接合构件延伸的导体的电极。组织锚固件可从低轮廓构型移动到植入构造，其中组织锚定件远离组织接合构件成角度。用于植入引线的装置包括一个或多个腔，包括引导腔和终止于装置中的远端开口处的真空腔。通过真空腔在远端开口处施加抽吸以绘制心外膜。铅的锚定机构在近端被撤回通过气泡，导致组织锚固件刺穿心外膜。然后将器件向近端退出导体。

10. 发明申请

WO2006104836A2 APPARATUS FOR REGULATING TISSUE WELDER JAWS 审中-公开
标题翻译：用于调节组织焊接机的装置
公开(公告)号：WO2006104836A2
公开(公告)日：2006-10-05
申请号：PCT/US2006010569
申请日：2006-03-24
申请人： ORIGIN MEDSYSTEMS INC , LAU LIMING , LIN ARTHUR , HO SAM , ABBOTT RYAN , DANG KENNY , MCQUISTON JESSE , CALLAS PETER , ESCANO ARNOLD , STEWART MICHAEL , JARRARD JERRY , LAMBERTI JOSEPH , WILLIAMS JUSTIN , YEE CHRISTOPHER
发明人： LAU LIMING , LIN ARTHUR , HO SAM , ABBOTT RYAN , DANG KENNY , MCQUISTON JESSE , CALLAS PETER , ESCANO ARNOLD , STEWART MICHAEL , JARRARD JERRY , LAMBERTI JOSEPH , WILLIAMS JUSTIN , YEE CHRISTOPHER
IPC分类号： A61B18/08 , A61B17/14 , A61B17/28
CPC分类号： A61B18/085 , A61B17/29 , A61B18/082 , A61B18/1445 , A61B90/03 , A61B2017/00084 , A61B2017/00353 , A61B2017/00504 , A61B2017/2912 , A61B2017/2936 , A61B2017/2945 , A61B2017/3445 , A61B2018/00089 , A61B2018/00601 , A61B2018/00607 , A61B2018/00619 , A61B2018/1432
摘要： A surgical apparatus and methods for severing and welding tissue, in particular blood vessels, including an elongated shaft having a pair of relatively movable jaws at a distal end thereof. A first heating element on one of the jaws heats up to a first temperature and form a welded region within the tissue, while a second heating element on one of the jaws heats up to a second temperature and sever the tissue within the welded region. A control handle includes controls for opening and closing the jaws, and may include an actuator for sending current through the first and second heating elements. A force-limiting mechanism provided either within the control handle, in the elongated shaft, or at the jaws limits the pressure applied to the tissue by the jaws to ensure that the tissue is severed and the ends effectively welded within a short amount of time.
摘要翻译：用于切断和焊接组织，特别是血管的手术设备和方法，包括在其远端具有一对相对可动的钳口的细长轴。其中一个颚板上的第一加热元件加热至第一温度并在组织内形成焊接区域，而其中一个颚板上的第二加热元件加热至第二温度并切断焊接区域内的组织。控制手柄包括用于打开和关闭夹爪的控制装置，并且可包括用于通过第一和第二加热元件发送电流的致动器。设置在控制手柄，细长轴或钳口内的力限制机构限制由钳口施加到组织上的压力，以确保组织被切断并且端部在短时间内有效地焊接。

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