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1. 发明公开

EP2841590A4 NUCLEIC ACIDS, CELLS, AND METHODS FOR PRODUCING SECRETED PROTEINS 审中-公开
标题翻译： NUCLEIC，细胞及其制造方法的分泌蛋白
公开(公告)号：EP2841590A4
公开(公告)日：2016-03-23
申请号：EP13781040
申请日：2013-04-29
申请人： PRONUTRIA INC , GORA KATHERINE G , ROBICHON-IYER CARINE , SILVER NATHANIEL W , BERRY DAVID A
发明人： GORA KATHERINE G , ROBICHON-IYER CARINE , SILVER NATHANIEL W , BERRY DAVID A , GAOZHONG SHEN , YOUNG DAVID M , BASU SUBHAYU
IPC分类号： C12P21/06 , A23J1/00 , C07K14/195 , C07K14/405 , C12N1/20 , C12N15/74 , C12P21/00 , C12P21/02
CPC分类号： A23J1/009 , C07K14/195 , C07K14/405 , C07K2319/01 , C07K2319/036 , C12N9/2448 , C12N15/625 , C12P21/00 , C12P21/02

2. 发明公开

EP2841590A2 NUCLEIC ACIDS, CELLS, AND METHODS FOR PRODUCING SECRETED PROTEINS 审中-公开
标题翻译： NUCLEIC，细胞及其制造方法的分泌蛋白
公开(公告)号：EP2841590A2
公开(公告)日：2015-03-04
申请号：EP13781040.4
申请日：2013-04-29
申请人： Pronutria, Inc. , Gora, Katherine, G. , Robichon-iyer, Carine , Silver, Nathaniel, W. , Berry, David, A.
发明人： GORA, Katherine, G. , ROBICHON-IYER, Carine , SILVER, Nathaniel, W. , BERRY, David, A. , GAOZHONG, Shen , YOUNG, David, M. , BASU, Subhayu
IPC分类号： C12P21/06 , C12N1/20 , C12N15/74
CPC分类号： A23J1/009 , C07K14/195 , C07K14/405 , C07K2319/01 , C07K2319/036 , C12N9/2448 , C12N15/625 , C12P21/00 , C12P21/02
摘要： A method for producing a secreted recombinant polypeptide sequence is provided. In some embodiments it comprises providing a recombinant microorganism comprising a recombinant nucleic acid comprising a first nucleic acid sequence encoding the recombinant polypeptide sequence operatively linked to a second nucleic acid sequence encoding a signal peptide; and culturing the recombinant microorganism in a culture medium under conditions sufficient for production and secretion of the recombinant protein by the recombinant microorganism. In some embodiments the coding sequence for the signal peptide is not native to the recombinant microorganism. In some embodiments the recombinant microorganism is photo synthetic. Also provided are recombinant photosynthetic microorganisms, isolated polypeptides comprising a signal peptide comprising an amino acid sequence disclosed herein, and isolated nucleic acids comprising a coding sequence for one of the signal peptides, among other things.

3. 发明专利

IL244697D0 Compositions and formulations for maintaining and increasing muscle mass, strength, and performance and methods of production and use thereof 未知
公开(公告)号：IL244697D0
公开(公告)日：2016-04-21
申请号：IL24469716
申请日：2016-03-21
申请人： PRONUTRIA INC , SILVER NATHANIEL W , HAMM LUKE , WILLIAMS ALISON , HAMILL MICHAEL J , BERRY DAVID A , CHEN YING JA , BASU SUBHAYU , ERBE DAVID , VON MALTZAHN GEOFFREY
IPC分类号： A23L33/00
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

4. 发明专利

IL244668D0 Compositions and formulations for prevention and treatment of diabetes and obesity, and methods of production and use thereof in glucose and caloric control 未知
公开(公告)号：IL244668D0
公开(公告)日：2016-04-21
申请号：IL24466816
申请日：2016-03-20
申请人： PRONUTRIA INC , SILVER NATHANIEL W , HAMM LUKE , ROBICHON IYER CARINE , WILLIAMS ALISON , HAMILL MICHAEL J , BERRY DAVID A , RAHMAN SHAILA , HEARD KATHRYN
IPC分类号： A23J20060101 , A23L33/00
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

5. 发明申请

WO2013163654A2 NUCLEIC ACIDS, CELLS, AND METHODS FOR PRODUCING SECRETED PROTEINS 审中-公开
标题翻译：核酸，细胞和生产分泌蛋白的方法
公开(公告)号：WO2013163654A2
公开(公告)日：2013-10-31
申请号：PCT/US2013/038682
申请日：2013-04-29
申请人： PRONUTRIA, INC. , GORA, Katherine, G. , ROBICHON-IYER, Carine , SILVER, Nathaniel, W. , BERRY, David, A.
发明人： GORA, Katherine, G. , ROBICHON-IYER, Carine , SILVER, Nathaniel, W. , BERRY, David, A. , GAOZHONG, Shen , YOUNG, David, M. , BASU, Subhayu
IPC分类号： C12P21/02
CPC分类号： A23J1/009 , C07K14/195 , C07K14/405 , C07K2319/01 , C07K2319/036 , C12N9/2448 , C12N15/625 , C12P21/00 , C12P21/02
摘要： A method for producing a secreted recombinant polypeptide sequence is provided. In some embodiments it comprises providing a recombinant microorganism comprising a recombinant nucleic acid comprising a first nucleic acid sequence encoding the recombinant polypeptide sequence operatively linked to a second nucleic acid sequence encoding a signal peptide; and culturing the recombinant microorganism in a culture medium under conditions sufficient for production and secretion of the recombinant protein by the recombinant microorganism. In some embodiments the coding sequence for the signal peptide is not native to the recombinant microorganism. In some embodiments the recombinant microorganism is photo synthetic. Also provided are recombinant photosynthetic microorganisms, isolated polypeptides comprising a signal peptide comprising an amino acid sequence disclosed herein, and isolated nucleic acids comprising a coding sequence for one of the signal peptides, among other things.
摘要翻译：提供了分泌重组多肽序列的制备方法。在一些实施方案中，其包括提供重组微生物，其包含重组核酸，其包含编码与编码信号肽的第二核酸序列有效连接的重组多肽序列的第一核酸序列; 并在足以由重组微生物生产和分泌重组蛋白的条件下在培养基中培养重组微生物。在一些实施方案中，信号肽的编码序列不是重组微生物天然的。在一些实施方案中，重组微生物是合成的。还提供了重组光合微生物，包含包含本文公开的氨基酸序列的信号肽的分离的多肽和包含用于信号肽之一的编码序列的分离的核酸等。

6. 发明申请

WO2010036951A2 METHODS AND COMPOSITIONS FOR PRODUCING CARBON-BASED PRODUCTS OF INTEREST IN MICRO-ORGANISMS 审中-公开
标题翻译：在微生物中生产碳基产品的方法和组合物
公开(公告)号：WO2010036951A2
公开(公告)日：2010-04-01
申请号：PCT/US2009058467
申请日：2009-09-25
申请人： JOULE BIOTECHNOLOGIES INC , RIDLEY CHRISTIAN P , ROBERTSON DAN E , BERRY DAVID A , SKRALY FRANK A
发明人： RIDLEY CHRISTIAN P , ROBERTSON DAN E , BERRY DAVID A , SKRALY FRANK A
IPC分类号： C12P7/64
CPC分类号： C12P7/065 , C12N1/20 , C12N9/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/0083 , C12N9/1007 , C12N9/1029 , C12N9/88 , C12N15/74 , C12P1/04 , C12P5/00 , C12P5/02 , C12P5/026 , C12P7/00 , C12P7/6409 , C12P7/6427 , C12P7/6436 , C12P7/6463 , C12P7/6472 , C12P7/649 , C12P13/04 , C12R1/01 , C12Y103/03006 , Y02E50/13 , Y02E50/17 , Y02E50/18 , Y02E50/343
摘要： Genes encoding polypeptides useful for producing carbon-based products of interest and methods for expressing such genes in host cells are disclosed.
摘要翻译：公开了编码可用于产生感兴趣的基于碳的产物的多肽的基因和在宿主细胞中表达此类基因的方法。

7. 发明申请

WO2008057578A1 NMR SYSTEMS FOR IN VIVO DETECTION OF ANALYTES 审中-公开
标题翻译：用于检测分析物的NMR系统
公开(公告)号：WO2008057578A1
公开(公告)日：2008-05-15
申请号：PCT/US2007/023516
申请日：2007-11-08
申请人： T2 BIOSYSTEMS, INC. , LEE, W., David , BERRY, David, A.
发明人： LEE, W., David , BERRY, David, A.
IPC分类号： G01R33/28 , G01R33/465
CPC分类号： G01R33/465 , A61B5/0075 , A61B5/055 , A61B5/062 , A61B5/076 , A61B5/14503 , A61B5/14507 , A61B5/14528 , A61B5/14532 , A61B5/14546 , A61B5/686 , A61B5/7257 , A61B5/7264 , A61B5/7278 , A61B6/12 , A61B8/0841 , A61B90/90 , A61B90/98 , A61B2576/00 , G01N24/08 , G01N24/088 , G01R33/285 , G01R33/287 , G01R33/30 , G01R33/34092 , G01R33/383 , G01R33/50 , G01R33/5601
摘要： This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.
摘要翻译：本发明一般涉及用于体内检测分析物的NMR系统。更具体地说，在某些实施方案中，本发明涉及其中超顺磁性纳米颗粒暴露于Larmor频率处或接近拉莫尔频率处的磁场和射频（RF）激发的系统，使得纳米粒子的聚集和/或解聚在生物流体中的给定分析物的存在和/或浓度是从所监测的RF回波响应体内检测的。

8. 发明申请

WO2008005509A2 METHODS AND COMPOSITIONS FOR ALTERING BIOLOGICAL SURFACES 审中-公开
标题翻译：改变生物表面的方法和组合物
公开(公告)号：WO2008005509A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/015525
申请日：2007-07-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KARP, Jeffrey, M. , KHADEMHOSSEINI, Alireza , BERRY, David, A. , LANGER, Robert, S. , GU, Frank
发明人： KARP, Jeffrey, M. , KHADEMHOSSEINI, Alireza , BERRY, David, A. , LANGER, Robert, S. , GU, Frank
IPC分类号： A61K6/06 , A61L24/02 , A61K8/24 , A61Q11/00
CPC分类号： A61K8/11 , A61K6/0008 , A61K6/0017 , A61K6/0067 , A61K6/0085 , A61K6/0235 , A61K6/024 , A61K6/0612 , A61K6/0643 , A61K6/0668 , A61K8/19 , A61K8/88 , A61K2800/412 , A61K2800/94 , A61L24/02 , A61Q11/00 , Y10T428/2982 , C08L1/286 , C08L5/00 , C08L5/08 , C08L33/02 , C08L1/00
摘要： Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.
摘要翻译：提供了组合物，方法和试剂盒，用于使用颗粒例如钙基颗粒与结合生物表面的试剂组合来改变生物表面的性质。诸如牙齿和骨骼等生物表面的颜色，光泽，质地，强度和气味等特性是可以改变的。

9. 发明申请

WO2006076627A3 METHODS AND COMPOSITIONS RELATED TO MODULATING THE EXTRACELLULAR STEM CELL ENVIRONMENT 审中-公开
标题翻译：与调节细胞外细胞环境相关的方法和组合物
公开(公告)号：WO2006076627A3
公开(公告)日：2007-03-08
申请号：PCT/US2006001321
申请日：2006-01-12
申请人： MASSACHUSETTS INST TECHNOLOGY , SASISEKHARAN RAM , SENGUPTA SHILADITYA , KEISER NISHLA , EAVARONE DAVID , KIZILTEPE BILGICER TANYEL , CHANDRASEKARAN AARTHI , BERRY DAVID A , HOLLEY KRISTINE
发明人： SASISEKHARAN RAM , SENGUPTA SHILADITYA , KEISER NISHLA , EAVARONE DAVID , KIZILTEPE BILGICER TANYEL , CHANDRASEKARAN AARTHI , BERRY DAVID A , HOLLEY KRISTINE
IPC分类号： A61K38/47 , A61K31/726 , A61K31/727 , C12N5/071 , C12N5/0735
CPC分类号： A61K31/726 , A61K31/727 , A61K38/47 , C12N5/0606 , C12N5/0691 , C12N2501/70 , C12N2506/02
摘要： This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Such modulation, in some aspects of the invention, is accomplished by agents that modulate glycosaminoglycans in the stem cell microenvironment (i.e., at or on the cell surface and/or in the extracellular matrix). Therefore, methods and compositions are provide for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided. Furthermore, the invention relates, in part, to tissues, and uses thereof, formed by the methods and compositions provided. Moreover, the invention also relates, in part, to methods of treatment using the methods and compositions provided.
摘要翻译：本发明部分涉及调节干细胞环境的方法和组合物。更具体地，本发明部分涉及用于调节干细胞分化的方法和组合物。在本发明的某些方面，这种调节是通过调节干细胞微环境中的糖胺聚糖（即在细胞表面上和/或细胞外基质中）上的调节剂来完成的。因此，提供了在干细胞的微环境中调节糖胺聚糖部分，例如硫酸乙酰肝素糖胺聚糖（HSGAG）部分的方法和组合物。还提供了用于促进或抑制胚胎干细胞分化（例如分化成内皮细胞）的方法和组合物。因此，本发明还部分地涉及可以用所提供的方法和组合物产生的细胞群体（例如内皮细胞群体或贫瘠的内皮细胞群体）。此外，本发明部分地涉及通过所提供的方法和组合物形成的组织及其用途。此外，本发明还部分涉及使用提供的方法和组合物的治疗方法。

10. 发明申请

WO2006089206A9 METHODS TO ENHANCE CARBON MONOXIDE DEHYDROGENASE ACTIVITY AND USES THEREOF 审中-公开
标题翻译：提高一氧化碳脱氢酶活性的方法及其用途
公开(公告)号：WO2006089206A9
公开(公告)日：2006-12-14
申请号：PCT/US2006005797
申请日：2006-02-16
申请人： MASSACHUSETTS INST TECHNOLOGY , BERRY DAVID A , LANGER ROBERT S , RESNICK RICHARD J
发明人： BERRY DAVID A , LANGER ROBERT S , RESNICK RICHARD J
IPC分类号： C12P1/04 , C01B3/02 , C12N9/02
CPC分类号： C12P3/00 , C12N9/0008 , C12Y102/99002
摘要： This invention relates, in part, to methods and compositions for modulating the water- gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water- gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention.
摘要翻译：本发明部分涉及用于调节水煤气变换反应（例如，促进水煤气变换正向反应）或其中水煤气变换反应已被调节的方法和组合物。因此，所述方法和组合物也部分涉及提高一氧化碳（CO）的氧化速率，用于增加CO（例如，一氧化碳脱氢酶（CODH）酶复合物）的可用性，用于去除和/ 或促进氢和/或二氧化碳（CO 2）的释放，用于调节细胞的氧化还原电位，用于防止自由基损伤和/或促进细胞存活率等。本发明还部分涉及用于以下方法和组合物调节CODH活性，例如增加CODH活性。还提供了用于调节PSII反应（例如促进PSII正向反应）或其中PSII反应已被调节的方法和组合物。 PSII反应的调节可以与水煤气变换反应的调节相结合。本发明还部分涉及调节PSII活性的方法和组合物，例如增加PSII活性。本发明还涉及前述方法和组合物的用途。例如，提供了用于生产氢和/或用于消除CO的方法和组合物。所提供的方法和组合物可以用于多种工业和医学应用，并且这样的应用也作为本发明的一部分提供。

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