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1. 发明申请

WO2006089206A9 METHODS TO ENHANCE CARBON MONOXIDE DEHYDROGENASE ACTIVITY AND USES THEREOF 审中-公开
标题翻译：提高一氧化碳脱氢酶活性的方法及其用途
公开(公告)号：WO2006089206A9
公开(公告)日：2006-12-14
申请号：PCT/US2006005797
申请日：2006-02-16
申请人： MASSACHUSETTS INST TECHNOLOGY , BERRY DAVID A , LANGER ROBERT S , RESNICK RICHARD J
发明人： BERRY DAVID A , LANGER ROBERT S , RESNICK RICHARD J
IPC分类号： C12P1/04 , C01B3/02 , C12N9/02
CPC分类号： C12P3/00 , C12N9/0008 , C12Y102/99002
摘要： This invention relates, in part, to methods and compositions for modulating the water- gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water- gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention.
摘要翻译：本发明部分涉及用于调节水煤气变换反应（例如，促进水煤气变换正向反应）或其中水煤气变换反应已被调节的方法和组合物。因此，所述方法和组合物也部分涉及提高一氧化碳（CO）的氧化速率，用于增加CO（例如，一氧化碳脱氢酶（CODH）酶复合物）的可用性，用于去除和/ 或促进氢和/或二氧化碳（CO 2）的释放，用于调节细胞的氧化还原电位，用于防止自由基损伤和/或促进细胞存活率等。本发明还部分涉及用于以下方法和组合物调节CODH活性，例如增加CODH活性。还提供了用于调节PSII反应（例如促进PSII正向反应）或其中PSII反应已被调节的方法和组合物。 PSII反应的调节可以与水煤气变换反应的调节相结合。本发明还部分涉及调节PSII活性的方法和组合物，例如增加PSII活性。本发明还涉及前述方法和组合物的用途。例如，提供了用于生产氢和/或用于消除CO的方法和组合物。所提供的方法和组合物可以用于多种工业和医学应用，并且这样的应用也作为本发明的一部分提供。

2. 发明申请

WO2006089206A3 METHODS TO ENHANCE CARBON MONOXIDE DEHYDROGENASE ACTIVITY AND USES THEREOF 审中-公开
标题翻译：加强一氧化碳脱氢酶活性的方法及其用途
公开(公告)号：WO2006089206A3
公开(公告)日：2007-02-22
申请号：PCT/US2006005797
申请日：2006-02-16
申请人： MASSACHUSETTS INST TECHNOLOGY , BERRY DAVID A , LANGER ROBERT S , RESNICK RICHARD J
发明人： BERRY DAVID A , LANGER ROBERT S , RESNICK RICHARD J
IPC分类号： C12P1/04 , C01B3/02 , C12N9/02
CPC分类号： C12P3/00 , C12N9/0008 , C12Y102/99002
摘要： This invention relates, in part, to methods and compositions for modulating the water- gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water- gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention.
摘要翻译：本发明部分地涉及用于调节水煤气变换反应（例如，促进水煤气前进反应）或其中水煤气变换反应被调制的方法和组合物。因此，方法和组成也部分地涉及提高一氧化碳（CO）的氧化速率，以增加CO（例如，一氧化碳脱氢酶（CODH）酶复合物）的可用性，用于除去和/ 或促进氢和/或二氧化碳（CO 2）的释放，用于调节细胞的氧化还原电位，用于防止自由基损伤和/或促进细胞存活力等。本发明还部分涉及用于调节CODH活性，如增加CODH活性。还提供了用于调节PSII反应（例如，促进PSII正向反应）或其中已经调节PSII反应的方法和组合物。 PSII反应的调节可以与水煤气变换反应的调节相结合。本发明还部分涉及用于调节PSII活性的方法和组合物，例如增加PSII活性。本发明还涉及上述方法和组合物的用途。例如，提供了用于生产氢和/或消除CO的方法和组合物。所提供的方法和组合物可用于各种工业和医疗应用，并且这些应用也作为本发明的一部分提供。

3. 发明申请

WO2006083328A3 BIOLOGICALLY ACTIVE SURFACES AND METHODS OF THEIR USE 审中-公开
标题翻译：生物活性表面及其使用方法
公开(公告)号：WO2006083328A3
公开(公告)日：2006-12-14
申请号：PCT/US2005032811
申请日：2005-09-15
申请人： MASSACHUSETTS INST TECHNOLOGY , BERRY DAVID A , KHADEMHOSSEINI ALIREZA , SUH KAHP Y , SASISEKHARAN RAM , LANGER ROBERT S
发明人： BERRY DAVID A , KHADEMHOSSEINI ALIREZA , SUH KAHP Y , SASISEKHARAN RAM , LANGER ROBERT S
IPC分类号： C08B37/00 , A61K31/726 , C08L5/00
CPC分类号： C08L5/08 , A61K31/726 , A61K31/727 , A61K31/737 , A61L17/10 , A61L27/20 , A61L27/38 , A61L29/043 , A61L31/042 , C08J7/047 , C08J2405/00 , C09D105/08 , C08L5/10
摘要： The invention relates to the immobilization of polysaccharides on a substrate. In particular, the invention relates to biologically active surfaces formed by the immobilization of glycosaminoglycans on a substrate. The invention also provides biologically active surfaces that contain one or more different glycosaminoglycans and, optionally, one or more other agents. These agents can be biological or therapeutic agents. The invention also relates to methods of using the surfaces of the invention, such as, methods of affecting biological processes, eliciting patterns of cellular response, screening, treatment, diagnosis and preventing food contamination and/or spoilage.
摘要翻译：本发明涉及在底物上固定多糖。特别地，本发明涉及通过在基质上固定糖胺聚糖形成的生物活性表面。本发明还提供含有一种或多种不同的糖胺聚糖和任选的一种或多种其它试剂的生物活性表面。这些试剂可以是生物或治疗剂。本发明还涉及使用本发明的表面的方法，例如影响生物过程的方法，引发细胞反应的模式，筛选，治疗，诊断和预防食物污染和/或腐败。

4. 发明申请

WO2008005509A3 METHODS AND COMPOSITIONS FOR ALTERING BIOLOGICAL SURFACES 审中-公开
标题翻译：改变生物表面的方法和组合物
公开(公告)号：WO2008005509A3
公开(公告)日：2009-02-19
申请号：PCT/US2007015525
申请日：2007-07-06
申请人： MASSACHUSETTS INST TECHNOLOGY , KARP JEFFREY M , KHADEMHOSSEINI ALIREZA , BERRY DAVID A , LANGER ROBERT S , GU FRANK
发明人： KARP JEFFREY M , KHADEMHOSSEINI ALIREZA , BERRY DAVID A , LANGER ROBERT S , GU FRANK
IPC分类号： A61K6/06 , A61L24/02
CPC分类号： A61K8/11 , A61K6/0008 , A61K6/0017 , A61K6/0067 , A61K6/0085 , A61K6/0235 , A61K6/024 , A61K6/0612 , A61K6/0643 , A61K6/0668 , A61K8/19 , A61K8/88 , A61K2800/412 , A61K2800/94 , A61L24/02 , A61Q11/00 , Y10T428/2982 , C08L1/286 , C08L5/00 , C08L5/08 , C08L33/02 , C08L1/00
摘要： Compositions, methods and kits are provided for altering the properties of a biological surface using particles such as, for instance, calcium based particles in combination with an agent that binds to the biological surface. Properties such as color, sheen, texture, strength, and odor of biological surfaces such as teeth and bone are alterable.
摘要翻译：提供了组合物，方法和试剂盒，用于使用颗粒例如钙基颗粒与结合生物表面的试剂组合来改变生物表面的性质。诸如牙齿和骨骼等生物表面的颜色，光泽，质地，强度和气味等特性是可以改变的。

5. 发明申请

WO2005110438A3 METHODS AND PRODUCTS RELATED TO THE INTRACELLULAR DELIVERY OF POLYSACCHARIDES 审中-公开
标题翻译：与多糖的细胞内递送相关的方法和产品
公开(公告)号：WO2005110438A3
公开(公告)日：2006-05-26
申请号：PCT/US2005013110
申请日：2005-04-13
申请人： MASSACHUSETTS INST TECHNOLOGY , BERRY DAVID A , ANDERSON DANIEL G , LYNN DAVID M , SASISEKHARAN RAM , LANGER ROBERT S
发明人： BERRY DAVID A , ANDERSON DANIEL G , LYNN DAVID M , SASISEKHARAN RAM , LANGER ROBERT S
IPC分类号： A01N1/02 , A61K31/726 , A61K31/727 , A61K31/737 , A61K45/06 , A61K47/34 , A61K47/48 , A61P19/08 , A61P27/02 , A61P35/00
CPC分类号： A61K45/06 , A61K31/726 , A61K31/727 , A61K31/737 , A61K31/785 , A61K47/593 , A61K2300/00
摘要： The invention relates, in part, to methods and compositions for the intracellular delivery of polysaccharides. In particular, the methods and compositions relate to the intracellular delivery of glycosaminoglycans, such as heparin. The invention in other aspects relates to the use of glycosaminoglycans for the treatment of proliferative disorders, such as cancer. The invention is still other aspects relates to improving cell viability. The invention also relates to the delivery of polysaccharides while avoiding unwanted effects of the polysaccharides. For example, heparin can be delivered while avoiding its anticoagulant effects.
摘要翻译：本发明部分地涉及多糖的细胞内递送的方法和组合物。特别地，所述方法和组合物涉及糖胺聚糖如肝素的细胞内递送。本发明在其它方面涉及糖胺聚糖用于治疗增殖性疾病如癌症的用途。本发明还涉及提高细胞活力的其它方面。本发明还涉及多糖的递送，同时避免多糖的不期望的影响。例如，可以输送肝素同时避免其抗凝血作用。

6. 发明申请

WO2012027675A3 POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 审中-公开
标题翻译：聚（氨基 - 氨基醇），其制备及其用途
公开(公告)号：WO2012027675A3
公开(公告)日：2012-05-10
申请号：PCT/US2011049360
申请日：2011-08-26
申请人： MASSACHUSETTS INST TECHNOLOGY , MA MINGLIN , LIU WENDY F , LANGER ROBERT S , ANDERSON DANIEL GRIFFITH
发明人： MA MINGLIN , LIU WENDY F , LANGER ROBERT S , ANDERSON DANIEL GRIFFITH
IPC分类号： C08G73/00 , A61K31/16 , A61L31/10 , C08G65/22 , C09D5/14
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

7. 发明申请

WO2011084620A3 PARTICLES FOR MULTIPLE AGENT DELIVERY 审中-公开
标题翻译：多种代理商交付的颗粒
公开(公告)号：WO2011084620A3
公开(公告)日：2011-11-17
申请号：PCT/US2010060814
申请日：2010-12-16
申请人： BRIGHAM & WOMENS HOSPITAL , MASSACHUSETTS INST TECHNOLOGY , FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S
发明人： FAROKHZAD OMID C , KOLISHETTI NAGESH , DHAR SHANTA , LIPPARD STEPHEN J , LANGER ROBERT S
IPC分类号： A61K47/48 , A61K9/20 , A61K9/22 , A61K47/30 , A61P25/28 , A61P35/00
CPC分类号： A61K45/06 , A61K47/593 , A61K47/60 , A61K47/6937
摘要： Delivery compositions are provided that include two or more active agents, wherein at least one active agent is conjugated to a polymer. The delivery compositions allow for controlled release of multiple active agents, including active agents with varying solubility, charge, and/or molecular weight.
摘要翻译：提供包含两种或更多种活性剂的递送组合物，其中至少一种活性剂与聚合物缀合。递送组合物允许控制释放多种活性剂，包括具有不同溶解度，电荷和/或分子量的活性剂。

8. 发明申请

WO2010053572A2 AMINOALCOHOL LIPIDOIDS AND USES THEREOF 审中-公开
标题翻译：氨基酚脂质体及其用途
公开(公告)号：WO2010053572A2
公开(公告)日：2010-05-14
申请号：PCT/US2009006018
申请日：2009-11-06
申请人： MASSACHUSETTS INST TECHNOLOGY , MAHON KERRY PETER , LOVE KEVIN THOMAS , LEVINS CHRISTOPHER G , WHITEHEAD KATHRYN ANN , LANGER ROBERT S , ANDERSON DANIEL GRIFFITH
发明人： MAHON KERRY PETER , LOVE KEVIN THOMAS , LEVINS CHRISTOPHER G , WHITEHEAD KATHRYN ANN , LANGER ROBERT S , ANDERSON DANIEL GRIFFITH
IPC分类号： C07C217/42 , A61K47/18 , B01J31/12 , C07D241/04
CPC分类号： C07D295/13 , A61K9/107 , A61K9/1271 , A61K9/5123 , A61K31/7088 , A61K38/02 , A61K47/16 , A61K47/48023 , A61K47/48061 , A61K47/54 , A61K47/545 , A61K48/0025 , B01J2531/0252 , B01J2531/845 , C07C215/14 , C07C217/08 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
摘要翻译：氨基醇类固醇通过使胺与环氧化物封端的化合物反应来制备。还提供了从市售的原料制备氨基醇类固醇的方法。氨基醇类固醇可以由外消旋或立体化学纯环氧化物制备。氨基醇类固醇或其盐形式优选是可生物降解的和生物相容的并且可以用于各种药物递送系统中。鉴于这些氨基醇类脂质化合物的氨基部分，它们特别适用于递送多核苷酸。已经制备了含有本发明的类脂和多核苷酸的复合物，胶束，脂质体或颗粒。本发明的类脂质也可用于制备用于药物递送的微粒。考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

9. 发明申请

WO2010011327A3 RADIATIVE HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS 审中-公开
标题翻译：用于药物递送和其他应用的放射性加热
公开(公告)号：WO2010011327A3
公开(公告)日：2010-05-06
申请号：PCT/US2009004285
申请日：2009-07-23
申请人： CHILDRENS MEDICAL CENTER , MASSACHUSETTS INST TECHNOLOGY , GEN HOSPITAL CORP , HOARE TODD R , KOHANE DANIEL S , FENN ALAN J , NEELEY WILLIAM L , LANGER ROBERT S
发明人： HOARE TODD R , KOHANE DANIEL S , FENN ALAN J , NEELEY WILLIAM L , LANGER ROBERT S
IPC分类号： C08J3/28 , A61K41/00 , A61K47/02 , A61K47/32 , A61K47/34 , C08L33/26 , C08L39/04 , C08L49/00 , C08L79/02 , C08L81/02
CPC分类号： A61K41/0028 , A61K9/0002 , A61K9/0024 , A61K9/0097 , A61K47/32 , C08G73/0266 , C08L79/02
摘要： The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using microwave radiation or other forms of radiation, e.g., radiofrequency radiation. Such systems and methods may be useful, for example, in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation- sensitive polymer or other radiation-sensitive material. Exposure of the radiation- sensitive material to radiation such as microwave and/or radiofrequency radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article. For instance, a drug may be contained in a heat-sensitive material positioned in thermal communication with the radiation-sensitive material, or a drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material positioned in thermal communication with the radiation-sensitive material. In another aspect of the invention, a receive antenna, such as a microwave receive antenna may be used to focus microwave and/or radiofrequency radiation on an article. For instance, the receive antenna may focus microwave and/or radiofrequency radiation on a radiation-sensitive material in the article. Such focusing may be useful, in some embodiments, to control release of a drug or other releasable species from the article. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, and the like.
摘要翻译：本发明一般涉及使用外部触发器（例如使用微波辐射或其他形式的辐射，例如射频辐射）从制品中释放可释放物质的系统和方法。这样的系统和方法可用于例如生物应用（例如，作为受试者内的植入物），工业应用，商业应用等。本发明的一个方面通常涉及含有辐射敏感聚合物或其它辐射敏感材料的制品。将辐射敏感材料暴露于辐射如微波和/或射频辐射可能导致材料温度升高。在某些情况下，可以使用这种温度升高来引起药物或其它可释放物质从制品中的释放。例如，药物可以包含在与辐射敏感材料热定位的热敏材料中，或者药物可以包含在外壳内，所述外壳至少部分地被定位的热敏材料隔离与辐射敏感材料进行热交换。在本发明的另一方面，诸如微波接收天线的接收天线可用于将微波和/或射频辐射聚焦在物品上。例如，接收天线可以将微波和/或射频辐射聚焦在制品中的辐射敏感材料上。在一些实施方案中，这种聚焦可能是有用的，以控制药物或其它可释放物质从制品的释放。本发明的其它方面涉及制造或使用这些制品的系统和方法，例如通过将物品植入受试者内，涉及这种制品的治疗方法，包括这种制品的试剂盒等。

10. 发明申请

WO2009142719A3 TYMPANIC MEMBRANE PERMEATING EAR DROPS AND USES THEREOF 审中-公开
标题翻译：透明膜渗透油墨及其用途
公开(公告)号：WO2009142719A3
公开(公告)日：2010-01-07
申请号：PCT/US2009003084
申请日：2009-05-19
申请人： MASSACHUSETTS INST TECHNOLOGY , CHILDRENS MEDICAL CENTER , SIMONS EMMANUEL JOHN , HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S
发明人： SIMONS EMMANUEL JOHN , HOARE TODD R , KOHANE DANIEL S , LANGER ROBERT S
IPC分类号： A61K8/00 , A61K8/18
CPC分类号： A61K9/0046 , A61K47/48023 , A61K47/48046 , A61K47/4823 , A61K47/48784 , A61K47/54 , A61K47/543 , A61K47/61 , A61K47/6903 , Y10S514/817
摘要： The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) across the tympanic membrane. Such compositions are particularly useful in the treatment of otitis media. Additionally, the composition may include a sustained release agents that, in some embodiments form sustained release reservoirs, in situ, once administered to a patient.
摘要翻译：本发明提供了用于在完整鼓膜上非侵入性递送治疗剂的组合物和方法。例如，组合物包括渗透促进剂，其增加穿过鼓膜的治疗剂（例如抗生素）的通量。这样的组合物特别可用于治疗中耳炎。另外，组合物可以包括在一些实施方案中形成持续释放储存器的持续释放剂，其一旦施用于患者就位。

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