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1. 发明公开

EP2841590A4 NUCLEIC ACIDS, CELLS, AND METHODS FOR PRODUCING SECRETED PROTEINS 审中-公开
标题翻译： NUCLEIC，细胞及其制造方法的分泌蛋白
公开(公告)号：EP2841590A4
公开(公告)日：2016-03-23
申请号：EP13781040
申请日：2013-04-29
申请人： PRONUTRIA INC , GORA KATHERINE G , ROBICHON-IYER CARINE , SILVER NATHANIEL W , BERRY DAVID A
发明人： GORA KATHERINE G , ROBICHON-IYER CARINE , SILVER NATHANIEL W , BERRY DAVID A , GAOZHONG SHEN , YOUNG DAVID M , BASU SUBHAYU
IPC分类号： C12P21/06 , A23J1/00 , C07K14/195 , C07K14/405 , C12N1/20 , C12N15/74 , C12P21/00 , C12P21/02
CPC分类号： A23J1/009 , C07K14/195 , C07K14/405 , C07K2319/01 , C07K2319/036 , C12N9/2448 , C12N15/625 , C12P21/00 , C12P21/02

2. 发明申请

WO2013163654A3 NUCLEIC ACIDS, CELLS, AND METHODS FOR PRODUCING SECRETED PROTEINS 审中-公开
标题翻译：核酸，细胞和生产分泌蛋白的方法
公开(公告)号：WO2013163654A3
公开(公告)日：2014-01-30
申请号：PCT/US2013038682
申请日：2013-04-29
申请人： PRONUTRIA INC , GORA KATHERINE G , ROBICHON-IYER CARINE , SILVER NATHANIEL W , BERRY DAVID A
发明人： GORA KATHERINE G , ROBICHON-IYER CARINE , SILVER NATHANIEL W , BERRY DAVID A , GAOZHONG SHEN , YOUNG DAVID M , BASU SUBHAYU
IPC分类号： C12P21/06 , C12N1/20 , C12N15/74
CPC分类号： A23J1/009 , C07K14/195 , C07K14/405 , C07K2319/01 , C07K2319/036 , C12N9/2448 , C12N15/625 , C12P21/00 , C12P21/02
摘要： A method for producing a secreted recombinant polypeptide sequence is provided. In some embodiments it comprises providing a recombinant microorganism comprising a recombinant nucleic acid comprising a first nucleic acid sequence encoding the recombinant polypeptide sequence operatively linked to a second nucleic acid sequence encoding a signal peptide; and culturing the recombinant microorganism in a culture medium under conditions sufficient for production and secretion of the recombinant protein by the recombinant microorganism. In some embodiments the coding sequence for the signal peptide is not native to the recombinant microorganism. In some embodiments the recombinant microorganism is photo synthetic. Also provided are recombinant photosynthetic microorganisms, isolated polypeptides comprising a signal peptide comprising an amino acid sequence disclosed herein, and isolated nucleic acids comprising a coding sequence for one of the signal peptides, among other things.
摘要翻译：提供了分泌重组多肽序列的制备方法。在一些实施方案中，其包括提供重组微生物，其包含重组核酸，其包含编码与编码信号肽的第二核酸序列有效连接的重组多肽序列的第一核酸序列; 并在足以由重组微生物生产和分泌重组蛋白的条件下在培养基中培养重组微生物。在一些实施方案中，信号肽的编码序列不是重组微生物天然的。在一些实施方案中，重组微生物是合成的。还提供了重组光合微生物，包含包含本文公开的氨基酸序列的信号肽的分离的多肽和包含用于信号肽之一的编码序列的分离的核酸等。

3. 发明专利

CA2892021A1 ENGINEERED SECRETED PROTEINS AND METHODS 未知
公开(公告)号：CA2892021A1
公开(公告)日：2014-05-30
申请号：CA2892021
申请日：2013-11-20
申请人： PRONUTRIA INC
发明人： BASU SUBHAYU , GORA KATHERINE G , CHEN YING-JA , YOUNG DAVID M , SILVER NATHANIEL W , HAMILL MICHAEL , BERRY DAVID A
IPC分类号： C07K4/00 , A23J1/00 , A23J3/00 , A23J3/20 , A23L1/305 , A23L33/00 , C07K7/08 , C07K14/195 , C07K14/37 , C12N1/00 , C12N1/21 , C12N9/00 , C12N15/31 , C12P21/00 , C40B40/02 , C40B40/08 , C40B60/00 , G01N33/68
摘要： Nutritive proteins are provided herein. Also provided are various other embodiments including nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, vectors for expressing the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins. Nutritive proteins include engineered proteins, wherein the engineered proteins comprise a sequence of at least 20 amino acids that comprise an altered amino acid sequence compared to the amino acid sequence of a reference secreted protein and a ratio of essential amino acids to total amino acids present in the engineered protein higher than the ratio of essential amino acids to total amino acids present in the reference secreted protein. In some embodiments, the engineered protein comprises at least one essential amino acid residue substitution of a non-essential amino acid residue in the reference secreted protein.

4. 发明公开

EP2922416A4 ENGINEERED SECRETED PROTEINS AND METHODS 审中-公开
标题翻译： VERFAHREN上的MANIPULIERTE SEKRETIERTE蛋白
公开(公告)号：EP2922416A4
公开(公告)日：2016-07-20
申请号：EP13856957
申请日：2013-11-20
申请人： PRONUTRIA INC
发明人： BASU SUBHAYU , GORA KATHERINE G , CHEN YING-JA , YOUNG DAVID M , SILVER NATHANIEL W , HAMILL MICHAEL , BERRY DAVID A
IPC分类号： C07K14/32 , A23L33/00 , A23L33/17 , A61K38/16 , C07K14/38
CPC分类号： C07K14/32 , A23L33/18 , A23L33/30 , A23V2002/00 , A61K38/16 , A61K38/1709 , C07K14/195 , C07K14/37 , C12N9/00 , C12N9/2428 , C12N9/2437 , C12N9/2445 , C12N9/2482 , C12P21/02
摘要： Nutritive proteins are provided herein. Also provided are various other embodiments including nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, vectors for expressing the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins. Nutritive proteins include engineered proteins, wherein the engineered proteins comprise a sequence of at least 20 amino acids that comprise an altered amino acid sequence compared to the amino acid sequence of a reference secreted protein and a ratio of essential amino acids to total amino acids present in the engineered protein higher than the ratio of essential amino acids to total amino acids present in the reference secreted protein. In some embodiments, the engineered protein comprises at least one essential amino acid residue substitution of a non-essential amino acid residue in the reference secreted protein.
摘要翻译：营养蛋白质在本文中提供。还提供了各种其它实施方案，包括编码蛋白质的核酸，制备蛋白质的重组微生物，用于表达蛋白质的载体，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物，以及使用蛋白质的方法。营养蛋白包括工程蛋白质，其中工程改造的蛋白质包含至少20个氨基酸的序列，其包含改变的氨基酸序列，与参考分泌蛋白质的氨基酸序列相比，必需氨基酸与总氨基酸的比例存在于工程蛋白高于参考分泌蛋白中存在的必需氨基酸与总氨基酸的比例。在一些实施方案中，工程改造的蛋白质包含参考分泌蛋白质中非必需氨基酸残基的至少一个必需氨基酸残基取代。

5. 发明申请

WO2014081884A1 ENGINEERED SECRETED PROTEINS AND METHODS 审中-公开
标题翻译：工程分泌蛋白质和方法
公开(公告)号：WO2014081884A1
公开(公告)日：2014-05-30
申请号：PCT/US2013071091
申请日：2013-11-20
申请人： PRONUTRIA INC
发明人： BASU SUBHAYU , GORA KATHERINE G , CHEN YING-JA , YOUNG DAVID M , SILVER NATHANIEL W , HAMILL MICHAEL , BERRY DAVID A
IPC分类号： A23L1/305 , A23L1/29
CPC分类号： C07K14/32 , A23L33/18 , A23L33/30 , A23V2002/00 , A61K38/16 , A61K38/1709 , C07K14/195 , C07K14/37 , C12N9/00 , C12N9/2428 , C12N9/2437 , C12N9/2445 , C12N9/2482 , C12P21/02
摘要： Nutritive proteins are provided herein. Also provided are various other embodiments including nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, vectors for expressing the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins. Nutritive proteins include engineered proteins, wherein the engineered proteins comprise a sequence of at least 20 amino acids that comprise an altered amino acid sequence compared to the amino acid sequence of a reference secreted protein and a ratio of essential amino acids to total amino acids present in the engineered protein higher than the ratio of essential amino acids to total amino acids present in the reference secreted protein. In some embodiments, the engineered protein comprises at least one essential amino acid residue substitution of a non-essential amino acid residue in the reference secreted protein.
摘要翻译：营养蛋白质在本文中提供。还提供了各种其它实施方案，包括编码蛋白质的核酸，制备蛋白质的重组微生物，用于表达蛋白质的载体，使用重组微生物制备蛋白质的方法，包含蛋白质的组合物以及使用蛋白质的方法。营养蛋白包括工程蛋白质，其中工程改造的蛋白质包含至少20个氨基酸的序列，其包含改变的氨基酸序列，与参考分泌蛋白质的氨基酸序列相比，必需氨基酸与总氨基酸的比例存在于工程蛋白质高于参考分泌蛋白质中存在的必需氨基酸与总氨基酸的比例。在一些实施方案中，工程改造的蛋白质包含参考分泌蛋白质中非必需氨基酸残基的至少一个必需氨基酸残基取代。

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