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1. 发明授权

US09193959B2 T7 RNA polymerase variants with enhanced thermostability 有权
标题翻译：具有增强热稳定性的T7 RNA聚合酶变体
公开(公告)号：US09193959B2
公开(公告)日：2015-11-24
申请号：US13069514
申请日：2011-03-23
申请人： Harald Sobek , Johann-Peter Thalhofer , Rainer Mueller , Manfred Schmidt , Michael Greif , Armin Ruf , Christian Rudolph
发明人： Harald Sobek , Johann-Peter Thalhofer , Rainer Mueller , Manfred Schmidt , Michael Greif , Armin Ruf , Christian Rudolph
IPC分类号： C12N9/12 , C12P19/34
CPC分类号： C12N9/1247 , C12P19/34 , C12Y207/07006
摘要： The present invention provides improved variants of T7 RNA polymerase by introducing novel mutations which lead to improved thermostability of the enzyme. According to the invention, amino acid substitutions at the positions Val426, Ser633, Val650, Thr654, Ala702, Val795, and combinations thereof are advantageous.
摘要翻译：本发明通过引入导致酶的热稳定性的新突变来提供T7RNA聚合酶的改进变体。根据本发明，位置Val426，Ser633，Val650，Thr654，Ala702，Val795及其组合的氨基酸取代是有利的。

2. 发明授权

US07772264B2 Salt and polymorphs of a DPPIV inhibitor 失效
标题翻译： DPPIV抑制剂的盐和多晶型物
公开(公告)号：US07772264B2
公开(公告)日：2010-08-10
申请号：US11376862
申请日：2006-03-16
申请人： Stefan Abrecht , Andre Gerard Bubendorf , Stephan Goetzoe , Olaf Grassmann , Francois Montavon , Regina Moog , Franziska Rohrer , Armin Ruf , Michelangelo Scalone , Urs Schwitter , Shaoning Wang
发明人： Stefan Abrecht , Andre Gerard Bubendorf , Stephan Goetzoe , Olaf Grassmann , Francois Montavon , Regina Moog , Franziska Rohrer , Armin Ruf , Michelangelo Scalone , Urs Schwitter , Shaoning Wang
IPC分类号： A61K31/42 , A61K31/40 , C07D263/34 , C07D207/09
CPC分类号： C07D413/12
摘要： The invention is concerned with (S)-1-{[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.
摘要翻译：本发明涉及该化合物的（S）-1 - {[2-（5-甲基-2-苯基 - 恶唑-4-基） - 乙氨基] - 乙酰基} - 吡咯烷-2-甲磺酸酯和结晶多晶型物。该化合物及其多晶型与先前已知的化合物相比表现出优异的性质，可用作治疗与DPP-IV相关的疾病的药物。

3. 发明申请

US20080001586A1 Control Circuit for Controlling an Electronic Circuit and Method for This 失效
标题翻译：用于控制电子电路的控制电路及其方法
公开(公告)号：US20080001586A1
公开(公告)日：2008-01-03
申请号：US10593516
申请日：2005-02-07
申请人： Jochen Kuehner , Robert Plikat , Stefan Mueller , Stephan Rees , Armin Ruf
发明人： Jochen Kuehner , Robert Plikat , Stefan Mueller , Stephan Rees , Armin Ruf
IPC分类号： G05F1/10
CPC分类号： H03K4/02 , H03K17/04123 , H03K17/0822 , H03K17/166
摘要： A control circuit for controlling an electronic circuit, which has a current path through a semiconductor switch and a line; when the semiconductor switch is switched, the inductance of the line and/or of a component in the current path producing an excess voltage between a first and a second current-carrying terminal of the semiconductor switch; the control circuit having a controllable current source for charging or discharging a charge-controlled gate of the semiconductor switch with the aid of a control current, as well as a control unit; the control unit controlling the current source in such a manner, that in the case of a switching operation, the terminal voltage across the current-carrying terminals of the semiconductor switch does not exceed a predefined setpoint terminal voltage.
摘要翻译：一种用于控制具有通过半导体开关和线路的电流通路的电子电路的控制电路; 当切换半导体开关时，电流路径中的线路和/或部件的电感在半导体开关的第一和第二载流端子之间产生过电压; 控制电路具有可控电流源，用于借助控制电流对半导体开关的电荷控制栅极进行充电或放电，以及控制单元; 控制单元以这种方式控制电流源，即在切换操作的情况下，半导体开关的通电端子两端的端子电压不超过预定的设定点终端电压。

4. 发明申请

US20070182459A1 Transistor arrangement for rectifier and inverter 失效
标题翻译：整流器和逆变器的晶体管布置
公开(公告)号：US20070182459A1
公开(公告)日：2007-08-09
申请号：US11569580
申请日：2006-01-27
申请人： Stephan Rees , Armin Ruf , Ulrich Ammann
发明人： Stephan Rees , Armin Ruf , Ulrich Ammann
IPC分类号： H03K5/153
CPC分类号： H02M7/53875 , H02M1/08 , H03K17/063 , H03K17/302
摘要： The invention relates to a transistor arrangement (1) comprising a transistor (10), which is provided with first and second connections (12, 14) and a control connection (16) for controlling a current flow (iD) between said first and second connections (12, 14), a signal processing device (22) exposed to the transistor control voltage (uDS) for admitting said control connection (16) according to a differential voltage (uDS) supplied between the first and second connections (12, 14) and a control device (23) which is associated with the signal processing device (22) and switches it between at least two operating modes. An inverter signal (uWR) causes, for an uWR value=0, an effect in such a way that the transistor (10) is used in the form of a conductor for uDS 0. For uWR=uWR, said transistor (10) is permanently conductive.
摘要翻译：本发明涉及一种包括晶体管（10）的晶体管装置（1），其配备有第一和第二连接（12,14）和用于控制电流流动的控制连接（16）在所述第一和第二连接（12,14）之间的信号处理装置（22），暴露于所述晶体管控制电压（uDS）的信号处理装置（22），用于根据在所述第一和第二连接之间提供的差分电压（uDS）来允许所述控制连接第一和第二连接（12,14）和与信号处理装置（22）相关联并在至少两个操作模式之间切换的控制装置（23）。对于uWR值= 0，反相器信号（uWR）使得以这样一种方式使晶体管（10）以uDS <0的导体形式使用并且被锁定用于uDS> 0的效果。对于uWR = uWR，所述晶体管（10）是永久导电的。

5. 发明授权

US07616047B2 Transistor arrangement for rectifier and inverter 失效
标题翻译：整流器和逆变器的晶体管布置
公开(公告)号：US07616047B2
公开(公告)日：2009-11-10
申请号：US11569580
申请日：2006-01-27
申请人： Stephan Rees , Armin Ruf , Ulrich Ammann
发明人： Stephan Rees , Armin Ruf , Ulrich Ammann
IPC分类号： H01J19/82
CPC分类号： H02M7/53875 , H02M1/08 , H03K17/063 , H03K17/302
摘要： A transistor arrangement has first and second terminals and a control terminal which sets a current flow between the first and second terminals, and a signal conditioning device which applies a transistor control voltage to the control terminal in a manner dependent on a differential voltage present between the first and second terminals, and a driving apparatus is assigned to the signal conditioning device and switches the latter between at least two operating modes.
摘要翻译：晶体管装置具有第一和第二端子以及设置第一和第二端子之间的电流的控制端子，以及信号调节装置，其以取决于存在于第一和第二端子之间的差分电压的方式向控制端子施加晶体管控制电压第一和第二端子，并且驱动装置被分配给信号调节装置，并且在至少两个操作模式之间切换。

6. 发明申请

US20060217428A1 Salt and polymorphs of a DPPIV inhibitor 失效
标题翻译： DPPIV抑制剂的盐和多晶型物
公开(公告)号：US20060217428A1
公开(公告)日：2006-09-28
申请号：US11376862
申请日：2006-03-16
申请人： Stefan Abrecht , Andre Bubendorf , Stephan Goetzoe , Olaf Grassmann , Francois Montavon , Regina Moog , Franziska Rohrer , Armin Ruf , Michelangelo Scalone , Urs Schwitter , Shaoning Wang
发明人： Stefan Abrecht , Andre Bubendorf , Stephan Goetzoe , Olaf Grassmann , Francois Montavon , Regina Moog , Franziska Rohrer , Armin Ruf , Michelangelo Scalone , Urs Schwitter , Shaoning Wang
IPC分类号： A61K31/422 , C07D413/02
CPC分类号： C07D413/12
摘要： The invention is concerned with (S)-1-{[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethylamino]-acetyl}-pyrrolidine-2-carbonitrile mesylate and crystalline polymorphs of this compound. This compound and its polymorphic forms exhibits superior properties compared to the previously known compounds and can be used as medicament for the treatment of disorders which are associated with DPP-IV.
摘要翻译：本发明涉及该化合物的（S）-1 - {[2-（5-甲基-2-苯基 - 恶唑-4-基） - 乙氨基] - 乙酰基} - 吡咯烷-2-甲磺酸酯和结晶多晶型物。该化合物及其多晶型与先前已知的化合物相比表现出优异的性质，可用作治疗与DPP-IV相关的疾病的药物。

7. 发明申请

US20050202548A1 Crystalline structure of oxidosqualene synthase 审中-公开
标题翻译：氧化茜素合酶的结晶结构
公开(公告)号：US20050202548A1
公开(公告)日：2005-09-15
申请号：US10885190
申请日：2004-07-06
申请人： Armin Ruf , Tanja Schulz-Gasch , Ralf Thoma
发明人： Armin Ruf , Tanja Schulz-Gasch , Ralf Thoma
IPC分类号： G01N23/20 , A61K45/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P31/10 , A61P33/00 , A61P35/00 , C07K16/40 , C12N9/90 , C12N15/09 , C12Q1/533 , G06F19/00 , C12N9/02 , G01N33/48 , G01N33/50
CPC分类号： C12N9/90 , C07K16/40 , C07K2299/00 , C12Y504/99007
摘要： The present invention relates to crystal forms of mammmalian OSC and the crystal structure information obtained from them, to methods of preparing such crystal forms, and to their use for the identification and/or design of inhibitors of OSC activity. A further subject matter of the invention are methods for the identification and/or design of inhibitor compounds of OSC activity, the inhibitor compounds of OSC activity identified by these methods and their use in pharmaceutical compositions for the treatment and/or prevention of diseases which are associated with OSC comprising hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections and gallstones, and/or treatment and/or prophylaxis of impaired glucose tolerance, diabetes, tumors and/or hyperproliferative disorders, preferably for the treatment and/or prophylaxis of hypercholesterolemia and/or hyperlipemia.
摘要翻译：本发明涉及乳制品OSC的结晶形式及其获得的晶体结构信息，制备此类晶型的方法及其用于鉴定和/或设计OSC活性抑制剂的用途。本发明的另一主题是用于鉴定和/或设计OSC活性的抑制剂化合物的方法，通过这些方法鉴定的OSC活性的抑制剂化合物及其在药物组合物中的用途，用于治疗和/或预防与OSC相关，包括高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染和胆结石，和/或治疗和/或预防糖耐量异常，糖尿病，肿瘤和/或过度增殖性疾病，优选用于治疗和/或预防的高胆固醇血症和/或高脂血症。

8. 发明申请

US20090270506A1 CRYSTALLINE STRUCTURE OF OXIDOSQUALENE SYNTHASE 审中-公开
标题翻译：氧化亚烷基合成酶的结晶结构
公开(公告)号：US20090270506A1
公开(公告)日：2009-10-29
申请号：US12041258
申请日：2008-03-03
申请人： ARMIN RUF , TANJA SCHULZ-GASCH , RALF THOMA
发明人： ARMIN RUF , TANJA SCHULZ-GASCH , RALF THOMA
IPC分类号： A61K31/192 , C12N9/90 , C12Q1/00 , A61P35/00 , G06F19/00 , A61P3/10 , A61P9/00 , C07C229/00
CPC分类号： C12N9/90 , C07K16/40 , C07K2299/00 , C12Y504/99007
摘要： The present invention relates to crystal forms of mammalian OSC and the crystal structure information obtained from them, to methods of preparing such crystal forms, and to their use for the identification and/or design of inhibitors of OSC activity. A further subject matter of the invention are methods for the identification and/or design of inhibitor compounds of OSC activity, the inhibitor compounds of OSC activity identified by these methods and their use in pharmaceutical compositions for the treatment and/or prevention of diseases which are associated with OSC comprising hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections and gallstones, and/or treatment and/or prophylaxis of impaired glucose tolerance, diabetes, tumors and/or hyperproliferative disorders, preferably for the treatment and/or prophylaxis of hypercholesterolemia and/or hyperlipemia.
摘要翻译：本发明涉及哺乳动物OSC的结晶形式和从它们获得的晶体结构信息，制备这种晶型的方法及其用于鉴定和/或设计OSC活性抑制剂的用途。本发明的另一主题是用于鉴定和/或设计OSC活性的抑制剂化合物的方法，通过这些方法鉴定的OSC活性的抑制剂化合物及其在药物组合物中的用途，用于治疗和/或预防与OSC相关，包括高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，寄生虫感染和胆结石，和/或治疗和/或预防糖耐量异常，糖尿病，肿瘤和/或过度增殖性疾病，优选用于治疗和/或预防的高胆固醇血症和/或高脂血症。

9. 发明授权

US07459954B2 Control circuit for controlling an electronic circuit and method for this 失效
标题翻译：用于控制电子电路的控制电路及其方法
公开(公告)号：US07459954B2
公开(公告)日：2008-12-02
申请号：US10593516
申请日：2005-02-07
申请人： Jochen Kuehner , Robert Plikat , Stefan Mueller , Stephan Rees , Armin Ruf
发明人： Jochen Kuehner , Robert Plikat , Stefan Mueller , Stephan Rees , Armin Ruf
IPC分类号： H03K17/04
CPC分类号： H03K4/02 , H03K17/04123 , H03K17/0822 , H03K17/166
摘要： A control circuit for controlling an electronic circuit, which has a current path through a semiconductor switch and a line; when the semiconductor switch is switched, the inductance of the line and/or of a component in the current path producing an excess voltage between a first and a second current-carrying terminal of the semiconductor switch; the control circuit having a controllable current source for charging or discharging a charge-controlled gate of the semiconductor switch with the aid of a control current, as well as a control unit; the control unit controlling the current source in such a manner, that in the case of a switching operation, the terminal voltage across the current-carrying terminals of the semiconductor switch does not exceed a predefined setpoint terminal voltage.
摘要翻译：一种用于控制具有通过半导体开关和线路的电流通路的电子电路的控制电路; 当切换半导体开关时，电流路径中的线路和/或部件的电感在半导体开关的第一和第二载流端子之间产生过电压; 控制电路具有可控电流源，用于借助控制电流对半导体开关的电荷控制栅极进行充电或放电，以及控制单元; 控制单元以这种方式控制电流源，即在切换操作的情况下，半导体开关的通电端子两端的端子电压不超过预定的设定点终端电压。

10. 发明申请

US20080085928A1 Sulfonamide derivatives 失效
标题翻译：磺酰胺衍生物
公开(公告)号：US20080085928A1
公开(公告)日：2008-04-10
申请号：US11903580
申请日：2007-09-24
申请人： Wolfgang Haap , Paul Hebeisen , Eric Kitas , Philipp Kohler , Holger Kuehne , Armin Ruf
发明人： Wolfgang Haap , Paul Hebeisen , Eric Kitas , Philipp Kohler , Holger Kuehne , Armin Ruf
IPC分类号： A61K31/381 , A61K31/18 , A61K31/34 , C07C311/15 , C07D317/46 , C07D333/02 , C07D307/02 , A61P3/10 , A61K31/357
CPC分类号： C07C311/58 , C07D307/64 , C07D317/62 , C07D333/34 , C07D333/38
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R1, R2, m and n have the meaning given in claim 1 and which can be used in the form of pharmaceutical compositions.
摘要翻译：式（I）化合物及其药学上可接受的盐和酯，其中L，R 1，R 2，m和n具有权利要求1中给出的含义，其可以以药物组合物的形式使用。

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