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1. 发明专利

GB351412A Improvements in heating devices for motor vehicles 未知
公开(公告)号：GB351412A
公开(公告)日：1931-06-15
申请号：GB825830
申请日：1930-03-14
申请人： CHRISTIAN RUDOLPH MUELLER
IPC分类号： B60H1/06
摘要： 351,412. Radiators for motor vehicles. MUELLER, C. R., 222, Louise Avenue, Highland Park, Michigan, U.S.A. March 14, 1930, No. 8258. Convention date, March 14, 1929. [Class 29.] In conjunction with means for conveying air, warmed by passage through the engine radiator, to the interior of the body of a motor vehicle, shutters 14a may be provided in front of the radiator to enable the supply of air to be regulated. For this purpose, the shutters, which are of the usual pivoted type, may be adjusted from the driver's seat by a rod 60, Fig. 1, or automatically by means of a thermostat 90, Fig. 10, placed in the air current at the back of the radiator.

2. 发明专利

FR430388A 未知
公开(公告)号：FR430388A
公开(公告)日：1911-10-14
申请号：FR430388D
申请日：1911-06-01
申请人： JOHN RUDOLPH CHRISTIAN RUDOLPH , ANDERS GUSTAF THISELL
发明人： RUDOLPHS JOHN RUDOLPH CHRISTIAN , THISELL ANDERS GUSTAF
IPC分类号： B01J6/00

3. 发明授权

US09319317B1 Systems and methods for disseminating addresses in distributed switching environments 有权
标题翻译：在分布式交换环境中传播地址的系统和方法
公开(公告)号：US09319317B1
公开(公告)日：2016-04-19
申请号：US14170055
申请日：2014-01-31
申请人： Derek Martin Spadaro , Mark Christian Rudolph , Timothy James Schlichter
发明人： Derek Martin Spadaro , Mark Christian Rudolph , Timothy James Schlichter
IPC分类号： H04L12/28 , H04L12/741
CPC分类号： H04L45/745
摘要： In a distributed switching environment, a plurality of switches are clustered together to form a stack, and it is generally desirable for forwarding tables, such as MAC tables, to be synchronized so that their mappings are consistent. When a switch receives a packet having a source address (e.g., MAC address) that is unknown, the switch is configured to disseminate the source address to the other switches of the stack. Rather than using software protocols to disseminate the source address, the switch instead transmits a multicast packet that (1) includes the unknown source address and (2) spoofs the other switches into believing that the packet was received on the same port from which the unknown source address was received on ingress to the stack. Thus, the other switches learn the unknown source address in hardware without having to rely on software for updating their forwarding tables.
摘要翻译：在分布式交换环境中，多个交换机被聚集在一起以形成堆栈，并且通常期望将诸如MAC表之类的转发表同步以便它们的映射是一致的。当交换机接收到具有未知的源地址（例如，MAC地址）的分组时，交换机被配置为将源地址传播到堆叠的其他交换机。而不是使用软件协议来传播源地址，而是切换发送（1）包括未知源地址的组播分组，以及（2）欺骗其他交换机，以相信该分组在未知的相同端口上被接收源地址在入口处收到。因此，其他交换机在硬件中学习未知源地址，而不必依赖软件来更新其转发表。

4. 发明申请

US20110256589A1 T7 RNA POLYMERASE VARIANTS WITH ENHANCED THERMOSTABILITY 有权
标题翻译：具有增强热稳定性的T7 RNA聚合酶变体
公开(公告)号：US20110256589A1
公开(公告)日：2011-10-20
申请号：US13069514
申请日：2011-03-23
申请人： Harald Sobek , Johann-Peter Thalhofer , Rainer Mueller , Manfred Schmidt , Michael Greif , Armin Ruf , Christian Rudolph
发明人： Harald Sobek , Johann-Peter Thalhofer , Rainer Mueller , Manfred Schmidt , Michael Greif , Armin Ruf , Christian Rudolph
IPC分类号： C12P19/34 , C12N5/10 , C12N15/63 , C12N9/10 , C07H21/00
CPC分类号： C12N9/1247 , C12P19/34 , C12Y207/07006
摘要： The present invention provides improved variants of T7 RNA polymerase by introducing novel mutations which lead to improved thermostability of the enzyme. According to the invention, amino acid substitutions at the positions Val426, Ser633, Val650, Thr654, Ala702, Val795, and combinations thereof are advantageous.
摘要翻译：本发明通过引入导致酶的热稳定性的新突变来提供T7RNA聚合酶的改进变体。根据本发明，位置Val426，Ser633，Val650，Thr654，Ala702，Val795及其组合的氨基酸取代是有利的。

5. 发明授权

US09193959B2 T7 RNA polymerase variants with enhanced thermostability 有权
标题翻译：具有增强热稳定性的T7 RNA聚合酶变体
公开(公告)号：US09193959B2
公开(公告)日：2015-11-24
申请号：US13069514
申请日：2011-03-23
申请人： Harald Sobek , Johann-Peter Thalhofer , Rainer Mueller , Manfred Schmidt , Michael Greif , Armin Ruf , Christian Rudolph
发明人： Harald Sobek , Johann-Peter Thalhofer , Rainer Mueller , Manfred Schmidt , Michael Greif , Armin Ruf , Christian Rudolph
IPC分类号： C12N9/12 , C12P19/34
CPC分类号： C12N9/1247 , C12P19/34 , C12Y207/07006
摘要： The present invention provides improved variants of T7 RNA polymerase by introducing novel mutations which lead to improved thermostability of the enzyme. According to the invention, amino acid substitutions at the positions Val426, Ser633, Val650, Thr654, Ala702, Val795, and combinations thereof are advantageous.
摘要翻译：本发明通过引入导致酶的热稳定性的新突变来提供T7RNA聚合酶的改进变体。根据本发明，位置Val426，Ser633，Val650，Thr654，Ala702，Val795及其组合的氨基酸取代是有利的。

6. 发明申请

US20120252071A1 T7 RNA POLYMERASE VARIANTS WITH CYSTEINE-SERINE SUBSTITUTIONS 审中-公开
标题翻译： T7 RNA聚合酶与CYSTEINE-丝氨酸取代的变体
公开(公告)号：US20120252071A1
公开(公告)日：2012-10-04
申请号：US13436110
申请日：2012-03-30
申请人： Michael Greif , Christian Rudolph , Manfred Schmidt , Harald Sobek , Johann-Peter Thalhofer
发明人： Michael Greif , Christian Rudolph , Manfred Schmidt , Harald Sobek , Johann-Peter Thalhofer
IPC分类号： C12P19/34 , C12N9/12
CPC分类号： C12N9/1247 , C12Y207/07006
摘要： The present disclosure provide novel variants of T7 RNA polymerase. Embodiments of T7 variants, according to the instant invention, include a Cysteine-Serine substitution on position 723 of the amino acid sequence of the T7 polypeptide. Embodiments of T7 variants according to the instant invention have a DNA-dependent RNA polymerase enzymatic activity and a reduced tendency to form intramolecular homodimers by way of oxidizing thiol groups. The amino acid substitutions within the T7 variants disclosed herein impact minimally, if at all, the RNA polymerase activity of the T7 polypeptide. Further, the mutations of the disclosed embodiments may optionally be combined with mutations which provide enhanced thermostability compared to the wild-type reference.
摘要翻译：本公开提供了T7RNA聚合酶的新变体。根据本发明的T7变体的实施方案包括T7多肽的氨基酸序列的位置723上的半胱氨酸 - 丝氨酸取代。根据本发明的T7变体的实施方案具有DNA依赖性RNA聚合酶酶活性，并且通过氧化硫醇基形成分子内同型二聚体的趋势降低。本文公开的T7变体内的氨基酸取代最小程度地影响T7多肽的RNA聚合酶活性。此外，所公开的实施方案的突变可以任选地与与野生型参考物相比提供增强的热稳定性的突变组合。

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