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1. 发明申请

US20110034472A1 Novel Compounds for Treatment of Cancer and Disorders Associated With Angiogenesis Function 审中-公开
标题翻译：用于治疗与血管生成功能相关的癌症和疾病的新型化合物
公开(公告)号：US20110034472A1
公开(公告)日：2011-02-10
申请号：US12831973
申请日：2010-07-07
申请人： Nouri NEAMATI , Antonio GAROFALO
发明人： Nouri NEAMATI , Antonio GAROFALO
IPC分类号： A61K31/4985 , C07D487/04 , C12N5/071 , A61P35/00 , A61P35/02 , A61P27/02 , A61P3/10
CPC分类号： C07D271/113 , A61K31/4985 , C07D209/86 , C07D211/96 , C07D215/20 , C07D215/36 , C07D231/14 , C07D239/84 , C07D239/93 , C07D239/95 , C07D249/12 , C07D275/06 , C07D307/68 , C07D311/12 , C07D333/38 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/04 , C07D417/12 , C07D473/06 , C07D487/04 , C07D495/04 , C07D495/14
摘要： Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.
摘要翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病。还公开了制备化合物，药物组合物和含有化合物的包装产品的方法，使用这些分子治疗癌症的方法（例如白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管发生功能相关的病症（例如年龄相关性黄斑变性，黄斑营养不良和糖尿病），监测治疗的方法，基因表达谱的方法和方法调节细胞生长，细胞周期，凋亡或基因表达。

2. 发明申请

US20110275646A1 Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function 审中-公开
标题翻译：用于治疗与血管生成功能相关的癌症和疾病的新型化合物
公开(公告)号：US20110275646A1
公开(公告)日：2011-11-10
申请号：US13111766
申请日：2011-05-19
申请人： Nouri NEAMATI , Antonio GAROFALO
发明人： Nouri NEAMATI , Antonio GAROFALO
IPC分类号： A61K31/4985 , A61P35/00 , A61P35/02 , A61K31/4439
CPC分类号： C07D487/04 , C07D471/14
摘要： Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating gene expression.
摘要翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病。还公开了制备化合物，药物组合物和含有化合物的包装产品的方法，使用这些分子治疗癌症的方法（例如，白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管发生功能相关的病症（例如年龄相关性黄斑变性，黄斑营养不良和糖尿病），监测治疗的方法，基因表达谱的方法和方法调节基因表达。

3. 发明授权

US07947682B2 Substituted N′-pyrrolo[1,2-a]quinoxalin-4-yl-hydrazides as anti-cancer agents 失效
标题翻译：取代的N'-吡咯并[1,2-a]喹喔啉-4-基 - 酰肼作为抗癌剂
公开(公告)号：US07947682B2
公开(公告)日：2011-05-24
申请号：US11027465
申请日：2004-12-29
申请人： Nouri Neamati , Antonio Garofalo
发明人： Nouri Neamati , Antonio Garofalo
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04 , C07D471/14
摘要： Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Such compounds include a compound of Formula II, wherein R is H, alkyl, or halogen; R′ is H, alkyl, or halogen; X is CH or N; and Y comprises a homocyclic or heterocyclic ring. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating gene expression.
摘要翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病。这些化合物包括式II化合物，其中R是H，烷基或卤素; R'是H，烷基或卤素; X是CH或N; 并且Y包含一个或多个杂环。还公开了制备化合物，药物组合物和含有化合物的包装产品的方法，使用这些分子治疗癌症的方法（例如，白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管发生功能相关的病症（例如年龄相关性黄斑变性，黄斑营养不良和糖尿病），监测治疗的方法，基因表达谱的方法和方法调节基因表达。

4. 发明申请

US20090305688A1 Method of Enabling a Combinational Service and Communication Network Implementing the Service 有权
标题翻译：启用组合服务和通信网络实施服务的方法
公开(公告)号：US20090305688A1
公开(公告)日：2009-12-10
申请号：US12086276
申请日：2005-12-09
申请人： Mario Bonnet , Pino Castrogiovanni , Antonio Garofalo , Gianni Luca Guglielmi
发明人： Mario Bonnet , Pino Castrogiovanni , Antonio Garofalo , Gianni Luca Guglielmi
IPC分类号： H04W76/02
CPC分类号： H04W4/08 , H04L12/1822 , H04L12/189 , H04L29/06027 , H04L65/4038 , H04W8/186 , H04W92/02
摘要： A method for enabling a combinational service in a communication network in which a plurality of terminals can operate, includes: establishing a first plurality of connections toward the plurality of terminals based on first terminal identifiers, providing a management entity with the first identifiers; providing the management entity with second identifiers of selected terminals included in at least part of said plurality; associating the first identifiers and the second identifiers with the combinational service; and establishing, by means of the management entity, a second plurality of connections toward said selected terminals by employing the second identifiers.
摘要翻译：一种在多个终端能够操作的通信网络中实现组合服务的方法，包括：基于第一终端标识符向多个终端建立第一多个连接，向管理实体提供第一标识符; 向所述管理实体提供包括在所述多个的至少一部分中的所选终端的第二标识符; 将第一标识符和第二标识符与组合服务相关联; 以及借助于所述管理实体，通过采用所述第二标识符来建立朝向所述选定终端的第二多个连接。

5. 发明申请

US20060142294A1 Novel compounds for treatment of cancer and disorders associated with angiogenesis function 失效
标题翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病
公开(公告)号：US20060142294A1
公开(公告)日：2006-06-29
申请号：US11027465
申请日：2004-12-29
申请人： Nouri Neamati , Antonio Garofalo
发明人： Nouri Neamati , Antonio Garofalo
IPC分类号： A61K31/498 , C07D487/14
CPC分类号： C07D487/04 , C07D471/14
摘要： Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating gene expression.
摘要翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病。还公开了制备化合物，药物组合物和含有化合物的包装产品的方法，使用这些分子治疗癌症的方法（例如，白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管发生功能相关的病症（例如年龄相关性黄斑变性，黄斑营养不良和糖尿病），监测治疗的方法，基因表达谱的方法和方法调节基因表达。

6. 发明授权

US07015212B1 Thiazepine inhibitors of HIV-1 integrase 失效
标题翻译： HIV-1整合酶的噻吗嗪抑制剂
公开(公告)号：US07015212B1
公开(公告)日：2006-03-21
申请号：US10009210
申请日：2000-05-10
申请人： Nouri Neamati , Yves Pommier , Antonio Garofalo , Vito Nacci
发明人： Nouri Neamati , Yves Pommier , Antonio Garofalo , Vito Nacci
IPC分类号： C07D513/04 , A61K31/55 , A61P31/18
CPC分类号： C07D513/04
摘要： The present invention discloses non-catechol compounds, such as thiazolothiazepines, and analogs and derivatives thereof, which are anti-integrase inhibitors. The compounds, which are useful as treatments for HIV disease, include compounds (I), (II), (III), or pharmaceutically acceptable salts thereof wherein A is thiazole, benzene, naphthalene, pyridine, pyrimidine, pyrazine, or quinoline; R is one or more of H, halogen, lower alkyl, lower alkoxy, NO2, lower ester or carboxylic acid; X—Y is CH2—S, S—CH2, CH2—O, CH2—S(O). S(O)—CH2, CH2—CH2, CH2—CH2—CH2, or CH2—CH2—CH2—CH2; R4 is H or hydroxy; R5 is H, phenyl, or alkylamine; W is S or O; and R6 is H, substituted or unsubstituted alkyl or amine; and Z is S, O, CH2, CH2CH2, or C═O.
摘要翻译：本发明公开了非邻苯二酚化合物，如噻唑并噻嗪类及其类似物及其衍生物，它们是抗整联酶抑制剂。可用作HIV疾病治疗的化合物包括化合物（I），（II），（III）或其药学上可接受的盐，其中A是噻唑，苯，萘，吡啶，嘧啶，吡嗪或喹啉; R是H，卤素，低级烷基，低级烷氧基，NO 2，低级酯或羧酸中的一种或多种。 XY是CH 2 -S，S-CH 2，CH 2 -O，CH 2 -S（ O）。 S（O）-CH 2 CH 2，CH 2 -CH 2，CH 2 -CH 2 CH 2 CH 2或CH 2 -CH 2 -CH 2 CH 2 CH 2， 2 R 4是H或羟基; R 5是H，苯基或烷基胺; W是S或O; R 6是H，取代或未取代的烷基或胺; Z是S，O，CH 2，CH 2 CH 2，或C-O。

7. 发明授权

US08195147B2 Method of enabling a combinational service and communication network implementing the service 有权
标题翻译：实现服务的组合服务和通信网络的方法
公开(公告)号：US08195147B2
公开(公告)日：2012-06-05
申请号：US12086276
申请日：2005-12-09
申请人： Mario Bonnet , Pino Castrogiovanni , Antonio Garofalo , Gianni Luca Guglielmi
发明人： Mario Bonnet , Pino Castrogiovanni , Antonio Garofalo , Gianni Luca Guglielmi
IPC分类号： H04W76/02
CPC分类号： H04W4/08 , H04L12/1822 , H04L12/189 , H04L29/06027 , H04L65/4038 , H04W8/186 , H04W92/02
摘要： A method for enabling a combinational service in a communication network in which a plurality of terminals can operate, includes: establishing a first plurality of connections toward the plurality of terminals based on first terminal identifiers, providing a management entity with the first identifiers; providing the management entity with second identifiers of selected terminals included in at least part of said plurality; associating the first identifiers and the second identifiers with the combinational service; and establishing, by means of the management entity, a second plurality of connections toward said selected terminals by employing the second identifiers.
摘要翻译：一种在多个终端能够操作的通信网络中实现组合服务的方法，包括：基于第一终端标识符向多个终端建立第一多个连接，向管理实体提供第一标识符; 向所述管理实体提供包括在所述多个的至少一部分中的所选终端的第二标识符; 将第一标识符和第二标识符与组合服务相关联; 以及借助于所述管理实体，通过采用所述第二标识符来建立朝向所述选定终端的第二多个连接。

8. 发明申请

US20090093489A1 NOVEL COMPOUNDS FOR TREATMENT OF CANCER AND DISORDERS ASSOCIATED WITH ANGIOGENESIS FUNCTION 审中-公开
标题翻译：用于治疗与血液发生功能相关的癌症和疾病的新型化合物
公开(公告)号：US20090093489A1
公开(公告)日：2009-04-09
申请号：US11868423
申请日：2007-10-05
申请人： Nouri Neamati , Antonio Garofalo
发明人： Nouri Neamati , Antonio Garofalo
IPC分类号： A61K31/4985 , C07D487/04 , A61P35/00 , A61P3/10 , A61P27/00
CPC分类号： C07D271/113 , A61K31/4985 , C07D209/86 , C07D211/96 , C07D215/20 , C07D215/36 , C07D231/14 , C07D239/84 , C07D239/93 , C07D239/95 , C07D249/12 , C07D275/06 , C07D307/68 , C07D311/12 , C07D333/38 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/04 , C07D417/12 , C07D473/06 , C07D487/04 , C07D495/04 , C07D495/14
摘要： Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.
摘要翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病。还公开了制备化合物，药物组合物和含有化合物的包装产品的方法，使用这些分子治疗癌症的方法（例如，白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管发生功能相关的病症（例如年龄相关性黄斑变性，黄斑营养不良和糖尿病），监测治疗的方法，基因表达谱的方法和方法调节细胞生长，细胞周期，凋亡或基因表达。

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