专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110275646A1 Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function 审中-公开
标题翻译：用于治疗与血管生成功能相关的癌症和疾病的新型化合物
公开(公告)号：US20110275646A1
公开(公告)日：2011-11-10
申请号：US13111766
申请日：2011-05-19
申请人： Nouri NEAMATI , Antonio GAROFALO
发明人： Nouri NEAMATI , Antonio GAROFALO
IPC分类号： A61K31/4985 , A61P35/00 , A61P35/02 , A61K31/4439
CPC分类号： C07D487/04 , C07D471/14
摘要： Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating gene expression.
摘要翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病。还公开了制备化合物，药物组合物和含有化合物的包装产品的方法，使用这些分子治疗癌症的方法（例如，白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管发生功能相关的病症（例如年龄相关性黄斑变性，黄斑营养不良和糖尿病），监测治疗的方法，基因表达谱的方法和方法调节基因表达。

2. 发明申请

US20110212467A1 INHIBITORS OF dUTPase 审中-公开
标题翻译： dUTPase的抑制剂
公开(公告)号：US20110212467A1
公开(公告)日：2011-09-01
申请号：US13061068
申请日：2009-08-27
申请人： Robert D. Ladner , Nouri Neamati
发明人： Robert D. Ladner , Nouri Neamati
IPC分类号： G01N33/573 , C12N5/09 , C07D261/16 , C07D417/12 , C07D285/125 , C07D473/04
CPC分类号： A61K31/513
摘要： Evidence demonstrating that elevated expression of dUTPase protects breast cancer cells from the expansion of the intracellular uracil pool, translating to reduced growth inhibition following treatment with 5-FU is provided. The implementation of in silica drug development techniques to identify and develop small molecule inhibitors of dUTPase are reported. As 5-FU and the oral 5-FU pro-drug capecitabine remain central agents in the treatment of a variety of malignancies, the clinical utility of a small molecule inhibitor to dUTPase represents a viable strategy to improve the clinical efficacy of these mainstay chemotherapeutic agents.
摘要翻译：证明dUTPase表达升高保护乳腺癌细胞免于细胞内尿嘧啶库扩增，转化为用5-FU处理后减少的生长抑制。报道了二氧化硅药物开发技术的实施，以鉴定和开发dUTPase的小分子抑制剂。由于5-FU和口服5-FU前药卡培他滨仍然是治疗各种恶性肿瘤的中枢药物，小分子抑制剂对dUTPase的临床应用代表了改善这些主要化学治疗剂临床疗效的可行策略。

3. 发明授权

US07947682B2 Substituted N′-pyrrolo[1,2-a]quinoxalin-4-yl-hydrazides as anti-cancer agents 失效
标题翻译：取代的N'-吡咯并[1,2-a]喹喔啉-4-基 - 酰肼作为抗癌剂
公开(公告)号：US07947682B2
公开(公告)日：2011-05-24
申请号：US11027465
申请日：2004-12-29
申请人： Nouri Neamati , Antonio Garofalo
发明人： Nouri Neamati , Antonio Garofalo
IPC分类号： C07D487/04 , A61K31/519 , A61P35/04
CPC分类号： C07D487/04 , C07D471/14
摘要： Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Such compounds include a compound of Formula II, wherein R is H, alkyl, or halogen; R′ is H, alkyl, or halogen; X is CH or N; and Y comprises a homocyclic or heterocyclic ring. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating gene expression.
摘要翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病。这些化合物包括式II化合物，其中R是H，烷基或卤素; R'是H，烷基或卤素; X是CH或N; 并且Y包含一个或多个杂环。还公开了制备化合物，药物组合物和含有化合物的包装产品的方法，使用这些分子治疗癌症的方法（例如，白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管发生功能相关的病症（例如年龄相关性黄斑变性，黄斑营养不良和糖尿病），监测治疗的方法，基因表达谱的方法和方法调节基因表达。

4. 发明授权

US08445677B2 Substituted pyrimidyl guanidine derivatives having anticancer activity 有权
标题翻译：具有抗癌活性的取代的嘧啶胍衍生物
公开(公告)号：US08445677B2
公开(公告)日：2013-05-21
申请号：US12604365
申请日：2009-10-22
申请人： Nouri Neamati , Jinxia Deng
发明人： Nouri Neamati , Jinxia Deng
IPC分类号： C07D239/02
CPC分类号： C07D239/02 , A61K31/423 , A61K31/47 , A61K31/496 , A61K31/4985 , A61K31/505 , A61K31/517 , A61K31/5377 , C07D263/58 , C07D401/06 , C07D401/12 , C07D413/14 , C07D498/04 , G06F19/701 , G06F19/706 , G06F19/707
摘要： Disclosed are pyrimidyl guanidine derivatives having anticancer activity. The pyimidyl guanidine derivatives have the structure: R1 is a cyclic (1-7 member) or acyclic (1-7 member) aliphatic, aromatic, heterocyclic groups optionally substituted, R2 is a cyclic (3-7 member) aliphatic, aromatic, heterocyclic groups optionally substituted by functional groups and R3 is a cyclic (3-7 member) aliphatic, aromatic, heterocyclic groups.
摘要翻译：公开了具有抗癌活性的嘧啶基胍衍生物。吡啶基胍衍生物具有以下结构：R 1是任选取代的环状（1-7成员）或无环（1-7成员）脂族，芳族，杂环基团，R 2是环状（3-7成员）脂族，芳族，杂环任选被官能团取代的基团，并且R 3是环状（3-7成员）脂族，芳族，杂环基团。

5. 发明申请

US20110034472A1 Novel Compounds for Treatment of Cancer and Disorders Associated With Angiogenesis Function 审中-公开
标题翻译：用于治疗与血管生成功能相关的癌症和疾病的新型化合物
公开(公告)号：US20110034472A1
公开(公告)日：2011-02-10
申请号：US12831973
申请日：2010-07-07
申请人： Nouri NEAMATI , Antonio GAROFALO
发明人： Nouri NEAMATI , Antonio GAROFALO
IPC分类号： A61K31/4985 , C07D487/04 , C12N5/071 , A61P35/00 , A61P35/02 , A61P27/02 , A61P3/10
CPC分类号： C07D271/113 , A61K31/4985 , C07D209/86 , C07D211/96 , C07D215/20 , C07D215/36 , C07D231/14 , C07D239/84 , C07D239/93 , C07D239/95 , C07D249/12 , C07D275/06 , C07D307/68 , C07D311/12 , C07D333/38 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/04 , C07D417/12 , C07D473/06 , C07D487/04 , C07D495/04 , C07D495/14
摘要： Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.
摘要翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病。还公开了制备化合物，药物组合物和含有化合物的包装产品的方法，使用这些分子治疗癌症的方法（例如白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管发生功能相关的病症（例如年龄相关性黄斑变性，黄斑营养不良和糖尿病），监测治疗的方法，基因表达谱的方法和方法调节细胞生长，细胞周期，凋亡或基因表达。

6. 发明申请

US20070155750A1 INTEGRIN-BINDING SMALL MOLECULES 有权
标题翻译：整合结合小分子
公开(公告)号：US20070155750A1
公开(公告)日：2007-07-05
申请号：US11559857
申请日：2006-11-14
申请人： Nouri NEAMATI , Raveendra DAYAM
发明人： Nouri NEAMATI , Raveendra DAYAM
IPC分类号： A61K31/519 , A61K31/525
CPC分类号： A61K31/517 , A61K31/00 , A61K31/195 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4375 , A61K31/4985 , A61K31/519 , A61K31/52 , A61K31/525 , A61K31/53 , A61K31/635 , A61K45/06 , C07D233/96 , C07D239/88 , C07D251/54 , C07D253/075 , C07D277/54 , C07D277/82 , C07D403/06 , C07D405/04 , C07D405/06 , C07D487/04 , C07D487/14 , C07D498/04
摘要： The present invention relates to compositions containing integrin-binding small molecules. Also disclosed are methods of binding integrins to these small molecules and methods of identifying small molecules binding to integrins.
摘要翻译：本发明涉及含有整联蛋白结合小分子的组合物。还公开了将整联蛋白与这些小分子结合的方法以及鉴定结合整联蛋白的小分子的方法。

7. 发明申请

US20060235034A1 Novel compounds for treatment of cancer and disorders associated with angiogenesis function 审中-公开
标题翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病
公开(公告)号：US20060235034A1
公开(公告)日：2006-10-19
申请号：US11265593
申请日：2005-11-01
申请人： Nouri Neamati
发明人： Nouri Neamati
IPC分类号： A61K31/517 , A61K31/4709 , A61K31/4704 , A61K31/366 , A61K31/165 , C07D498/14
CPC分类号： C07D239/84 , C07C243/32 , C07C243/38 , C07D209/86 , C07D211/96 , C07D215/22 , C07D215/36 , C07D231/14 , C07D239/93 , C07D239/95 , C07D249/12 , C07D271/113 , C07D275/06 , C07D307/68 , C07D311/12 , C07D333/38 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/04 , C07D417/12 , C07D473/06 , C07D487/04 , C07D495/04 , C07D495/14
摘要： Novel compounds for treatment of cancer and disorders associated with angiogenesis function. Also disclosed are a method of preparing the compounds, pharmaceutical compositions and packaged products containing the compounds, a method of using these molecules to treat cancer (e.g., leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, renal cancer, and prostate cancer) and disorders associated with angiogenesis function (e.g., age-related macular degeneration, macular dystrophy, and diabetes), a method of monitoring the treatment, a method of profiling gene expression, and a method of modulating cell growth, cell cycle, apoptosis, or gene expression.
摘要翻译：用于治疗癌症的新型化合物和与血管生成功能相关的疾病。还公开了制备化合物，药物组合物和含有化合物的包装产品的方法，使用这些分子治疗癌症的方法（例如，白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，乳腺癌，肾癌和前列腺癌）和与血管发生功能相关的病症（例如年龄相关性黄斑变性，黄斑营养不良和糖尿病），监测治疗的方法，基因表达谱的方法和方法调节细胞生长，细胞周期，凋亡或基因表达。

8. 发明申请

US20140051709A1 Compositions and Methods for Treating Myotonic Dystrophy Type 1 审中-公开
标题翻译：治疗强直性营养不良1型的组合物和方法
公开(公告)号：US20140051709A1
公开(公告)日：2014-02-20
申请号：US13587858
申请日：2012-08-16
申请人： Sita REDDY , Lucio Comai , Nouri Neamati
发明人： Sita REDDY , Lucio Comai , Nouri Neamati
IPC分类号： A61K31/366 , A61K31/4196 , C07D413/04 , A61K31/4245 , C07D401/04 , A61P21/00 , C07D311/16 , C07D405/06 , A61K31/496 , C07D417/04 , A61K31/427 , C07D405/04 , A61K31/437
CPC分类号： C07D405/04 , C07D311/16 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Disclosed is a compound for treatment of Myotonic Dystrophy type 1 having the formula: Wherein X is selected from the group consisting of O, N, C, or S, Y is a homo- or heteroatomic 5-membered ring comprising one or more atoms selected from the group consisting of N, O, S, and C, Z is an optionally substituted aryl group or optionally substituted heteroaryl, including but not limited to halogenated benzenes, pyridines, substituted benzene, substituted pyridine, R2=hydroxy, acyl, alkoxyl, esters, ethers, cyclic ethers, and lactones, R3=H, alkyl, an optionally substituted alkyl, aliphatic ether, ester, cyclic unsaturated and aromatic ring groups, and R1, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, alkyl, and alkoxyl or a pharmaceutically or cosmetically acceptable salt, solvate, or hydrate thereof.
摘要翻译：公开了用于治疗具有下式的1型肌强直营养不良的化合物：其中X选自O，N，C或S，Y是包含一个或多个选自原子的均聚或杂原子的5元环包括但不限于卤代苯，吡啶，取代的苯，取代的吡啶，R2 =羟基，酰基，烷氧基，烷氧基，酯，醚，环醚和内酯，R3 = H，烷基，任选取代的烷基，脂肪族醚，酯，环状不饱和和芳族环基，R 1，R 4和R 5独立地选自氢，卤素，烷基和烷氧基或其药学或化妆品可接受的盐，溶剂合物或水合物。

9. 发明授权

US07928113B2 Integrin-binding small molecules 有权
标题翻译：整合素结合小分子
公开(公告)号：US07928113B2
公开(公告)日：2011-04-19
申请号：US11559857
申请日：2006-11-14
申请人： Nouri Neamati , Raveendra Dayam
发明人： Nouri Neamati , Raveendra Dayam
IPC分类号： A61K31/517 , A61K31/44
CPC分类号： A61K31/517 , A61K31/00 , A61K31/195 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4375 , A61K31/4985 , A61K31/519 , A61K31/52 , A61K31/525 , A61K31/53 , A61K31/635 , A61K45/06 , C07D233/96 , C07D239/88 , C07D251/54 , C07D253/075 , C07D277/54 , C07D277/82 , C07D403/06 , C07D405/04 , C07D405/06 , C07D487/04 , C07D487/14 , C07D498/04
摘要： The present invention relates to compositions containing integrin-binding small molecules. Also disclosed are methods of binding integrins to these small molecules and methods of identifying small molecules binding to integrins.
摘要翻译：本发明涉及含有整联蛋白结合小分子的组合物。还公开了将整联蛋白与这些小分子结合的方法以及鉴定结合整联蛋白的小分子的方法。

10. 发明申请

US20100210836A1 SMALL MOLECULE INHIBITORS OF LYMPHOID TYROSINE PHOSPHATASE 审中-公开
标题翻译：小分子抑制剂LYMPHOID TYROSINE PHOSPHATASE的小分子抑制剂
公开(公告)号：US20100210836A1
公开(公告)日：2010-08-19
申请号：US12705198
申请日：2010-02-12
申请人： Nunzio BOTTINI , Nouri Neamati
发明人： Nunzio BOTTINI , Nouri Neamati
IPC分类号： C07D401/14 , C07D413/14
CPC分类号： C07D401/14
摘要： The present invention relates to lymphoid tyrosine phosphatase inhibitors and autoimmunity. More specifically, the invention relates to the identification of lymphoid tyrosine phosphatase inhibitors and the analysis of the structure-activity relationship.
摘要翻译：本发明涉及淋巴样酪氨酸磷酸酶抑制剂和自身免疫。更具体地，本发明涉及淋巴样酪氨酸磷酸酶抑制剂的鉴定和结构 - 活性关系的分析。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式