专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO9907872A9 PROCESS FOR THE PREPARATION OF HMG-CoA REDUCTASE INHIBITORS 审中-公开
标题翻译：制备HMG-CoA还原酶抑制剂的方法
公开(公告)号：WO9907872A9
公开(公告)日：2003-06-26
申请号：PCT/JP9803396
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK , TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
发明人： TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
IPC分类号： C12P7/62 , C12P17/06 , C12N1/20
CPC分类号： C12R1/07 , C12P7/62 , C12P17/06
摘要： A process for the preparation of compounds represented by general formula (II-a) (wherein R is hydrogen, optionally substituted alkyl or alkali metal; and R is optionally substituted alkyl or aryl) or lactones (II-b) derived therefrom through ring closure, which comprises treating a compound resulting from a bacillus and represented by general formula (I-a) (wherein R and R are each as described above) or a lactone (I-b) derived therefrom through ring closure with an enzyme source having the activity of forming the compounds (II-a) or (II-b) from the compounds (I-a) or (I-b) in a reaction fluid to form the compound (II-a) or (II-b) in the reaction fluid, and recovering the compound (II-a) or (II-b) from the reaction fluid.
摘要翻译：制备由通式（II-a）表示的化合物（其中R 1为氢，任选取代的烷基或碱金属; R 2为任选取代的烷基或芳基）或内酯（II-b）的方法），其包括处理由芽孢杆菌产生并由通式（Ia）表示的化合物（其中R 1和R 2各自如上所述）或由其衍生的内酯（Ib）通过具有在反应流体中从化合物（Ia）或（Ib）形成化合物（II-a）或（II-b）的活性的酶源的闭环以形成化合物（II-a）或（II -b），并从反应液中回收化合物（II-a）或（II-b）。

2. 发明专利

AT389026T 未知
公开(公告)号：AT389026T
公开(公告)日：2008-03-15
申请号：AT98935282
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
IPC分类号： C12P7/62 , C12N1/20 , C12P17/06
摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (II-a)Ü or the lactone form of Compound (II-a) Ähereinafter referred to as Compound (II-b)Ü which comprises subjecting a compound represented by general formula (I-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (I-a)Ü or the lactone form of Compound (I-a) Ähereinafter referred to as Compound (I-b)Ü to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.

3. 发明专利

AU7318700A Novel transaldolase gene 未知
公开(公告)号：AU7318700A
公开(公告)日：2001-04-24
申请号：AU7318700
申请日：2000-09-21
申请人： KYOWA HAKKO KOGYO KK
发明人： IKEDA MASATO , TAKANO YUTAKA , NAKANO TETSUO , KAMADA NOZOMU
IPC分类号： C12N1/21 , C12N9/10 , C12N15/54 , C12P19/18
摘要： Attempts are made to provide a novel transaldolase gene; a polypeptide encoded by this gene; a recombinant DNA obtained by integrating this gene; a microorganism carrying this recombinant DNA; and a process for producing an aromatic amino acid, an aromatic vitamin, L-histidine, riboflavin, a nucleic acid, a nucleic acid-associated substance, a novel saccharide, etc. by using the above microorganism. As the results of extensive studies, a novel transaldolase gene is isolated from chromosomal DNA of a microorganism belonging to the genus Corynebacterium as a DNA fragment complementary to the requirement for shikimic acid of a transketolase defective variant obtained as a variant with the requirement for shikimic acid belonging to the genus Corynebacterium. Further, a recombinant DNA containing this gene is constructed and transferred into a host microorganism, thereby achieving the objects as described above.

4. 发明专利

CA2299634A1 PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS 未知
公开(公告)号：CA2299634A1
公开(公告)日：1999-02-18
申请号：CA2299634
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： MOTOYAMA HIROAKI , OCHIAI KEIKO , OZAKI AKIO , TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO
IPC分类号： C12P7/62 , C12P17/06 , C12N1/20
摘要： A process for the preparation of compounds represented by general formula (II a) (wherein R1 is hydrogen, optionally substituted alkyl or alkali metal; and R2 is optionally substituted alkyl or aryl) or lactones (II-b) derived therefrom through ring closure, which comprises treating a compound resulting from a bacillus and represented by general formula (I-a) (wherein R1 and R2 are each as described above) or a lactone (I-b) derived therefrom through ring closure with an enzyme source having the activity of forming the compounds (II a) or (II-b) from the compounds (I-a) or (I-b) in a reaction fluid to form the compound (II-a) or (II-b) in the reaction fluid, and recovering the compound (II-a) or (II-b) from the reaction fluid.

5. 发明专利

CA2299634C PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS 未知
公开(公告)号：CA2299634C
公开(公告)日：2007-10-16
申请号：CA2299634
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： MOTOYAMA HIROAKI , OCHIAI KEIKO , OZAKI AKIO , ANDO KATSUHIKO , MORI HIDEO , TAKANO YUTAKA , HASEGAWA MASARU
IPC分类号： C12N1/20 , C12P7/62 , C12P17/06
摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (see formula I) wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (II-a)] or the lactone form of Compound (II-a) [hereinafter referred to as Compound (II-b)] which comprises subjecting a compound represented by general formula (I-a): (see formula II) (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R2 represents a substituted or unsubstituted alkyl or aryl group) [hereinafter referred to as Compound (I-a)] or the lactone form of Compound (I-a) [hereinafter referred to as Compound (I-b)] to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.

6. 发明专利

CA2297613A1 PROCESS FOR PRODUCING PURINE NUCLEOTIDES 未知
公开(公告)号：CA2297613A1
公开(公告)日：2000-08-08
申请号：CA2297613
申请日：2000-02-02
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKANO YUTAKA , IKEDA MASATO , FUJIO TATSURO
IPC分类号： C12N9/00 , C12N9/12 , C12N9/16 , C12P19/32 , C12P19/40 , C07H21/04 , C12P19/30
摘要： The present invention provides a process for producing a purine nucleotide which comprises: culturing in a medium a microorganism having the ability to produce a precursor of the purine nucleotide and carrying an introduced DNA which can induce and express an enzyme capable of synthesizing the purine nucleotide from said precursor; allowing said precursor of the purine nucleotide to accumulate in the culture; inducing and expressing the enzyme capable of synthesizing the purine nucleotide from said precursor; allowing the purine nucleotide formed from said precursor to accumulate in said culture; and then recovering said purine nucleotide therefrom. Microorganisms useful in said process are also provided.

7. 发明专利

AU8460698A Process for the preparation of hmg-coa reductase inhibitors 未知
公开(公告)号：AU8460698A
公开(公告)日：1999-03-01
申请号：AU8460698
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
IPC分类号： C12P7/62 , C12P17/06 , C12N1/20
摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (II-a)Ü or the lactone form of Compound (II-a) Ähereinafter referred to as Compound (II-b)Ü which comprises subjecting a compound represented by general formula (I-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (I-a)Ü or the lactone form of Compound (I-a) Ähereinafter referred to as Compound (I-b)Ü to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.

8. 发明专利

CA2077308A1 GENE EXPRESSION REGULATORY DNA 未知
公开(公告)号：CA2077308A1
公开(公告)日：1993-03-03
申请号：CA2077308
申请日：1992-09-01
申请人： KYOWA HAKKO KOGYO KK
发明人： KATSUMATA RYOICHI , TAKANO YUTAKA
IPC分类号： C12N1/21 , C12N9/10 , C12N9/38 , C12N9/88 , C12N15/09 , C12N15/60 , C12N15/77 , C12P21/02 , C12R1/01 , C12R1/13 , C12R1/15 , C12N15/11
摘要： The present invention provides a gene expression regulatory DNA and a process for preparing a protein using the same. A DNA derived from the isocitrate lyase (ICL) gene of a coryneform bacterium regulates expression of a structural gene encoding a protein when incorporated into a vector DNA together with said structural gene and introduced into a host coryneform bacterium, and a useful protein can be efficiently produced using the DNA.

9. 发明专利

DE69839248D1 未知
公开(公告)号：DE69839248D1
公开(公告)日：2008-04-24
申请号：DE69839248
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
IPC分类号： C12P7/62 , C12N1/20 , C12P17/06
摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (II-a)Ü or the lactone form of Compound (II-a) Ähereinafter referred to as Compound (II-b)Ü which comprises subjecting a compound represented by general formula (I-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (I-a)Ü or the lactone form of Compound (I-a) Ähereinafter referred to as Compound (I-b)Ü to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.

10. 发明专利

DE69839248T2 未知
公开(公告)号：DE69839248T2
公开(公告)日：2009-04-02
申请号：DE69839248
申请日：1998-07-30
申请人： KYOWA HAKKO KOGYO KK
发明人： TAKANO YUTAKA , HASEGAWA MASARU , MORI HIDEO , ANDO KATSUHIKO , OCHIAI KEIKO , MOTOYAMA HIROAKI , OZAKI AKIO
IPC分类号： C12P7/62 , C12N1/20 , C12P17/06
摘要： Disclosed is a process for producing a compound represented by general formula (II-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (II-a)Ü or the lactone form of Compound (II-a) Ähereinafter referred to as Compound (II-b)Ü which comprises subjecting a compound represented by general formula (I-a): (wherein R represents a hydrogen atom, a substituted or unsubstituted alkyl group, or an alkali metal; and R represents a substituted or unsubstituted alkyl or aryl group) Ähereinafter referred to as Compound (I-a)Ü or the lactone form of Compound (I-a) Ähereinafter referred to as Compound (I-b)Ü to the action of an enzyme source derived from a microorganism belonging to the genus Bacillus and capable of converting Compound (I-a) or Compound (I-b) into Compound (II-a) or Compound (II-b) in a reaction mixture to form Compound (II-a) or Compound (II-b) in the reaction mixture, and recovering Compound (II-a) or Compound (II-b) from the reaction mixture.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式