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1. 发明公开

EP3236865A1 A DEVICE FOR PROVIDING A STERILE LIMITED SPACE FOR SURGERY 有权转让
标题翻译：一种为手术提供无菌有限空间的设备
公开(公告)号：EP3236865A1
公开(公告)日：2017-11-01
申请号：EP14825354.5
申请日：2014-12-23
申请人： Ahrens, Michael
发明人： Ahrens, Michael
IPC分类号： A61B17/34 , A61L2/00
CPC分类号： A61B90/40 , A61B17/3423 , A61B17/3431 , A61B42/50 , A61B50/10 , A61B50/13 , A61B50/15 , A61B50/20 , A61B2050/105 , A61B2050/21 , A61B2217/005 , A61B2217/007 , A61F13/00085 , A61L2/18
摘要： A device for establishing and maintaining a sterile environment for conducting surgical procedures is disclosed. In particular, the tent-like device provides an interior space attachable to a patient's skin to allow surgical treatment of the patient. Several aspects of the invention are directed to devices to be used in connection with such a surgical procedure using the tent-like device. According to the invention, an isolation device for providing a sterile operation chamber above a skin region of a patient is provided, in particular for performing a surgical procedure, said isolation device comprising an inflatable bag coupled to a support frame, the support frame having a transport configuration and an operation configuration. In the transport configuration, the first inflatable bag is confined, such as to have compact dimensions. In the operation configuration, the first inflatable bag is extended, such as to form said sterile operation chamber.
摘要翻译：本发明涉及一种用于建立和保持用于进行外科手术的无菌环境的装置。具体地，本发明涉及一种提供内部空间并且可附接到患者皮肤以允许手术治疗患者的帐篷状装置。本发明的几个方面涉及与使用帐篷状装置的外科手术相关的装置。根据本发明，提供了一种用于在患者的皮肤区域上方提供无菌操作室的隔离装置，特别用于执行外科手术，所述隔离装置包括耦合到支撑框架的可膨胀袋，所述支撑框架具有运输配置和运行配置，其中在运输配置中，第一充气袋被封闭，例如具有紧凑的尺寸; 在操作配置中，第一充气袋被延伸，以形成所述无菌操作室。

2. 发明申请

WO2009042403A1 INSTRUMENT SET AND SYSTEM FOR PERFORMING SPINAL NUCLECTOMY 审中-公开
标题翻译：用于执行脊柱核素的仪器和系统
公开(公告)号：WO2009042403A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/075840
申请日：2008-09-10
申请人： DISC DYNAMICS, INC. , MARTZ, Erik O. , LEHUEC, Jean-charles , AHRENS, Michael
发明人： MARTZ, Erik O. , LEHUEC, Jean-charles , AHRENS, Michael
IPC分类号： A61B17/16 , A61B17/17 , A61B17/34 , A61B19/00 , A61F2/44 , A61F2/46
CPC分类号： A61B17/1604 , A61B17/1671 , A61B17/3421 , A61B34/20 , A61B2017/00261 , A61B2017/3405 , A61B2017/3407 , A61B2017/3445 , A61B2090/034 , A61B2090/062 , A61F2/441 , A61F2/4611
摘要： A nuclectomy system for creating a nuclear cavity in an annulus located in an intervertebral disc space to receive an intervertebral prosthesis. The system involves identifying a plurality of regions in at least a portion of the nucleus. A sequence for removing the regions is also determined. At least one annulotomy is formed in the annulus along an annular axis to provide access to the nucleus. A guide system is positioned relative to the annulotomy. The guide system is configured to limit motion of at least one surgical tool relative to the guide system. A portion of the nucleus is removed from a first region using the surgical tool. At least one of the guide system and the surgical tool are configured to remove a portion of the nucleus from a second region. A portion of the nucleus is removed from a second region using the surgical tool.
摘要翻译：用于在位于椎间盘空间中的环中产生核腔以接收椎间假体的核结肠切除术系统。该系统涉及在核的至少一部分中识别多个区域。还确定了用于去除区域的序列。沿着环形轴线在环形区域中形成至少一个瓣膜切开术以提供对细胞核的接近。引导系统相对于瓣膜切开术定位。引导系统被配置为限制至少一个手术工具相对于引导系统的运动。使用外科手术工具从第一区域去除一部分细胞核。引导系统和手术工具中的至少一个被配置为从第二区域移除核的一部分。使用外科手术工具从第二区域去除一部分细胞核。

3. 发明申请

WO2012100078A1 ENZYME TRIGGERED REDOX ALTERING CHEMICAL ELIMINATION (E-TRACE) IMMMUNOASSAY 审中-公开
标题翻译： ENZYME TRIGGERED REDOX ALTERING CHEMICAL ELIMINATION（E-TRACE）IMMMUNOASSAY
公开(公告)号：WO2012100078A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/021904
申请日：2012-01-19
申请人： OHMX CORPORATION , BERTIN, Paul, A. , AHRENS, Michael
发明人： BERTIN, Paul, A. , AHRENS, Michael
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , C12Q1/005 , G01N31/22
摘要： Described are methods for detecting a target analyte in a test sample by providing a solid support comprising an electrode comprising: (i) a self-assembled monolayer (SAM), (ii) a covalently attached electroactive active moiety (EAM) comprising a transition metal complex comprising a self-immolative moiety and a peroxide sensitive moiety (PSM), wherein said EAM has a first E 0 ; then contacting the target analyte and said solid support under conditions wherein said target analyte reacts with a peroxide generating enzyme to generate peroxide and said self- immolative moiety is removed such that said EAM has a second E 0 test sample; and then detecting said second E 0 as an indication of the presence of said target analyte. Also provided are compositions for use in the preceding methods.
摘要翻译：描述了通过提供包括电极的固体支持物来检测测试样品中的目标分析物的方法，所述固体支持物包括：（i）自组装单层（SAM），（ii）共价连接的电活性活性部分（EAM），其包含过渡金属复合物，其包含自身残留部分和过氧化物敏感部分（PSM），其中所述EAM具有第一E0; 然后在其中所述目标分析物与产生过氧化物的酶反应产生过氧化物的条件下接触目标分析物和所述固体支持物，并且去除所述自消除部分，使得所述EAM具有第二种E0测试样品; 然后检测所述第二E0作为所述目标分析物的存在的指示。还提供了用于前述方法的组合物。

4. 发明申请

WO2007140078A2 MOLD ASSEMBLY FOR INTERVERTEBRAL PROSTHESIS 审中-公开
标题翻译：模拟组装用于椎间盘突出症
公开(公告)号：WO2007140078A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/068225
申请日：2007-05-04
申请人： DISC DYNAMICS, INC. , AHRENS, Michael , MARTZ, Erik O. , BURKE, Ronald , CARTER, Benjamin F.
发明人： AHRENS, Michael , MARTZ, Erik O. , BURKE, Ronald , CARTER, Benjamin F.
IPC分类号： A61F2/44 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/46
CPC分类号： A61F2/441 , A61F2002/30062 , A61F2002/30079 , A61F2002/3008 , A61F2002/30092 , A61F2002/30177 , A61F2002/302 , A61F2002/30224 , A61F2002/30242 , A61F2002/3025 , A61F2002/30252 , A61F2002/30273 , A61F2002/30289 , A61F2002/30565 , A61F2002/30579 , A61F2002/30583 , A61F2002/30586 , A61F2002/30588 , A61F2002/30677 , A61F2002/30841 , A61F2002/30878 , A61F2002/4435 , A61F2002/444 , A61F2002/4495 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0085 , A61F2210/009 , A61F2230/0056 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0073 , A61F2230/0086 , A61F2230/0091 , A61F2250/0098 , A61F2310/00011 , A61F2310/00179
摘要： A mold assembly for the in situ formation of a prosthesis in an annulus located in an intervertebral disc space between adjacent vertebrae of a patient. The mold assembly includes at least a first mold having at least one interior cavity adapted to be located in the intervertebral disc space. At least a first lumen has a distal end fluidly coupled to the mold at a first location. One or more discrete reinforcing structures are located in the intervertebral disc space with the mold. One or more biomaterials are provided to be delivered to the interior cavity through the first lumen. The at least partially cured biomaterial, the reinforcing structures and the mold cooperating to form the prosthesis.
摘要翻译：一种用于在位于患者的相邻椎骨之间的椎间盘空间中的环中原位形成假体的模具组件。模具组件至少包括具有适于位于椎间盘空间中的至少一个内腔的第一模具。至少第一内腔具有在第一位置处流体地联接到模具的远端。一个或多个离散的加强结构位于与模具的椎间盘空间中。提供一种或多种生物材料以通过第一内腔输送到内腔。所述至少部分固化的生物材料，所述加强结构和所述模具协作以形成所述假体。

5. 发明申请

WO2007002124A1 OPTICAL TRANSPONDER WITH PASSIVE HEAT TRANSFER 审中-公开
标题翻译：具有被动传热的光学传送器
公开(公告)号：WO2007002124A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024037
申请日：2006-06-20
申请人： INTEL CORPORATION , AHRENS, Michael
发明人： AHRENS, Michael
IPC分类号： H04B10/152 , G02B6/43
CPC分类号： G02B6/4246 , G02B6/3897 , G02B6/4284
摘要： According to embodiments of the present invention, an optical transponder module generates heat when operating and at least a copper heat wick and/or a copper block are disposed in the module body to perform passive transfer of heat from inside the optical transponder module to outside the optical transponder module. The heat wick may be soldered to thermal vias in the printed circuit board that is internal to the optical transponder module and positioned over the laser transmitter circuitry. The copper block may be positioned in a cutout in the optical transponder module body to acts as a heat spreader. Thermal grease, compounds, paste, interface material, etc., may be used to help the conduction of heat.
摘要翻译：根据本发明的实施例，光学应答器模块在操作时产生热量，并且至少铜模块和/或铜模块布置在模块主体中以执行从光学应答器模块内部向外部的热量的传递光转发器模块。热芯可以焊接到印刷电路板中的热转换器，该通孔位于光发送应答器模块的内部并且位于激光发射器电路之上。铜块可以定位在光学应答器模块体中的切口中，用作散热器。导热油脂，化合物，糊剂，界面材料等可用于帮助热传导。

6. 发明申请

WO2011146143A3 ENZYMATIC ACTIVITY OF PSA AS DIAGNOSTIC MARKER FOR PROSTATE CANCER 审中-公开
标题翻译： PSA作为诊断标记的前列腺癌的酶活性
公开(公告)号：WO2011146143A3
公开(公告)日：2012-05-31
申请号：PCT/US2011000919
申请日：2011-05-23
申请人： OHMX CORP , AHRENS MICHAEL , ANDERSON BYRON , BERTIN PAUL A , CATALONA WILLIAM J , GEORGANOPOULOU DIMITRA , UNIV NORTHWESTERN
发明人： AHRENS MICHAEL , ANDERSON BYRON , BERTIN PAUL A , CATALONA WILLIAM J , GEORGANOPOULOU DIMITRA
IPC分类号： C12Q1/37 , G01N33/574
CPC分类号： C12Q1/37 , G01N33/57434
摘要： The present invention is directed to the diagnosis of cancer associated with enzymaticaliy active PSA in samples.
摘要翻译：本发明涉及与样品中酶活性PSA相关的癌症的诊断。

7. 发明申请

WO2007002766A2 OPTICAL TRANSPONDER WITH ACTIVE HEAT TRANSFER 审中-公开
标题翻译：具有有源热传输的光学传输器
公开(公告)号：WO2007002766A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/025203
申请日：2006-06-27
申请人： INTEL CORPORATION , AHRENS, Michael
发明人： AHRENS, Michael
CPC分类号： H01L23/427 , G02B6/4292 , G02B6/4296 , H01L2924/0002 , H01L2924/00
摘要： According to embodiments of the present invention, an optical transponder module generates heat when operating and a heat pipe disposed in the module body performs active heat transfer from a hot end of the optical transponder module to a cooler end of the optical transponder module. A heat pipe disposed in an external clip-in heat sink may remove heat from the optical transponder body.
摘要翻译：根据本发明的实施例，光学应答器模块在操作时产生热量，并且设置在模块主体中的热管执行从光学应答器模块的热端到光学应答器模块的较冷端的主动热传递。设置在外部夹入散热器中的热管可以从光学应答器主体移除热量。

8. 发明申请

WO2013067349A9 NOVEL CHEMISTRY USED IN BIOSENSORS 审中-公开
标题翻译：生物传感器中使用的新化学物质
公开(公告)号：WO2013067349A9
公开(公告)日：2014-05-30
申请号：PCT/US2012063319
申请日：2012-11-02
申请人： OHMX CORP , BERTIN PAUL A , AHRENS MICHAEL J
发明人： BERTIN PAUL A , AHRENS MICHAEL J
IPC分类号： C07F17/02 , C12Q1/00 , G01N33/543
CPC分类号： C07F17/02 , C08F4/61925 , C12Q1/001 , C12Q1/004 , G01N27/3271 , G01N33/5438
摘要： The invention relates to novel compositions of 1,3-disubstituted ferrocenes useful for the modification of electrodes. Formula (I).
摘要翻译：本发明涉及可用于电极修饰的1,3-二取代二茂铁的新组合物。式（I）。

9. 发明申请

WO2011146143A2 DETECTION OF CANCER BY ASSAYING PSA ENZYMATIC ACTIVITY 审中-公开
标题翻译：通过测定PSA酶活性检测癌症
公开(公告)号：WO2011146143A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/000919
申请日：2011-05-23
申请人： OHMX CORPORATION , AHRENS, Michael , ANDERSON, Byron , BERTIN, Paul, A. , CATALONA, William, J. , GEORGANOPOULOU, Dimitra , NORTHWESTERN UNIVERSITY
发明人： AHRENS, Michael , ANDERSON, Byron , BERTIN, Paul, A. , CATALONA, William, J. , GEORGANOPOULOU, Dimitra
IPC分类号： G01N33/50
CPC分类号： C12Q1/37 , G01N33/57434
摘要： The present invention is directed to the diagnosis of cancer associated with enzymaticaliy active PSA in samples.
摘要翻译：本发明涉及与样品中酶活性PSA相关的癌症的诊断。

10. 发明申请

WO2010080337A1 INFLATABLE MOLD FOR MAINTAINING POSTERIOR SPINAL ELEMENTS IN A DESIRED ALIGNMENT 审中-公开
标题翻译：用于维持正确对齐的前列腺素元素的可充氧模具
公开(公告)号：WO2010080337A1
公开(公告)日：2010-07-15
申请号：PCT/US2009/067610
申请日：2009-12-11
申请人： DISC DYNAMICS, INC. , AHRENS, Michael , MARTZ, Erik, O. , BURKE, Ronald , CARTER, Benjamin, F.
发明人： AHRENS, Michael , MARTZ, Erik, O. , BURKE, Ronald , CARTER, Benjamin, F.
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2/4405 , A61F2002/30062 , A61F2002/30079 , A61F2002/3008 , A61F2002/30092 , A61F2002/30177 , A61F2002/302 , A61F2002/30224 , A61F2002/30242 , A61F2002/3025 , A61F2002/30252 , A61F2002/30273 , A61F2002/30289 , A61F2002/30565 , A61F2002/30579 , A61F2002/30583 , A61F2002/30586 , A61F2002/30588 , A61F2002/30677 , A61F2002/30841 , A61F2002/30878 , A61F2002/4435 , A61F2002/444 , A61F2002/4495 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0085 , A61F2210/009 , A61F2230/0056 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0073 , A61F2230/0086 , A61F2230/0091 , A61F2250/0098 , A61F2310/00011 , A61F2310/00179
摘要： A system for the in situ formation of prostheses between adjacent vertebrae of a patient. The system includes a first mold (54) adapted to be located in an intervertebral disc space between the adjacent vertebrae and at least a second mold adapted to be positioned between adjacent posterior elements. Lumens (52) are fluidly coupled to each of the molds. One or more in situ curable biomaterials (70) are delivered through the lumens to the molds. The at least partially cured biomaterial and the molds cooperate to maintain a desired alignment and spacing of the intervertebral disc space and the posterior elements.
摘要翻译：用于在患者的相邻椎骨之间原位形成假体的系统。该系统包括适于位于相邻椎骨之间的椎间盘空间中的第一模具（54）和适于定位在相邻后部元件之间的至少第二模具。流明（52）流体耦合到每个模具。一个或多个原位可固化的生物材料（70）通过管腔被递送到模具中。至少部分固化的生物材料和模具协作以保持椎间盘空间和后部元件的期望的对准和间隔。

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