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1. 发明申请

WO2010080337A1 INFLATABLE MOLD FOR MAINTAINING POSTERIOR SPINAL ELEMENTS IN A DESIRED ALIGNMENT 审中-公开
标题翻译：用于维持正确对齐的前列腺素元素的可充氧模具
公开(公告)号：WO2010080337A1
公开(公告)日：2010-07-15
申请号：PCT/US2009/067610
申请日：2009-12-11
申请人： DISC DYNAMICS, INC. , AHRENS, Michael , MARTZ, Erik, O. , BURKE, Ronald , CARTER, Benjamin, F.
发明人： AHRENS, Michael , MARTZ, Erik, O. , BURKE, Ronald , CARTER, Benjamin, F.
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2/4405 , A61F2002/30062 , A61F2002/30079 , A61F2002/3008 , A61F2002/30092 , A61F2002/30177 , A61F2002/302 , A61F2002/30224 , A61F2002/30242 , A61F2002/3025 , A61F2002/30252 , A61F2002/30273 , A61F2002/30289 , A61F2002/30565 , A61F2002/30579 , A61F2002/30583 , A61F2002/30586 , A61F2002/30588 , A61F2002/30677 , A61F2002/30841 , A61F2002/30878 , A61F2002/4435 , A61F2002/444 , A61F2002/4495 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0085 , A61F2210/009 , A61F2230/0056 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0073 , A61F2230/0086 , A61F2230/0091 , A61F2250/0098 , A61F2310/00011 , A61F2310/00179
摘要： A system for the in situ formation of prostheses between adjacent vertebrae of a patient. The system includes a first mold (54) adapted to be located in an intervertebral disc space between the adjacent vertebrae and at least a second mold adapted to be positioned between adjacent posterior elements. Lumens (52) are fluidly coupled to each of the molds. One or more in situ curable biomaterials (70) are delivered through the lumens to the molds. The at least partially cured biomaterial and the molds cooperate to maintain a desired alignment and spacing of the intervertebral disc space and the posterior elements.
摘要翻译：用于在患者的相邻椎骨之间原位形成假体的系统。该系统包括适于位于相邻椎骨之间的椎间盘空间中的第一模具（54）和适于定位在相邻后部元件之间的至少第二模具。流明（52）流体耦合到每个模具。一个或多个原位可固化的生物材料（70）通过管腔被递送到模具中。至少部分固化的生物材料和模具协作以保持椎间盘空间和后部元件的期望的对准和间隔。

2. 发明申请

WO2007140078A2 MOLD ASSEMBLY FOR INTERVERTEBRAL PROSTHESIS 审中-公开
标题翻译：模拟组装用于椎间盘突出症
公开(公告)号：WO2007140078A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/068225
申请日：2007-05-04
申请人： DISC DYNAMICS, INC. , AHRENS, Michael , MARTZ, Erik O. , BURKE, Ronald , CARTER, Benjamin F.
发明人： AHRENS, Michael , MARTZ, Erik O. , BURKE, Ronald , CARTER, Benjamin F.
IPC分类号： A61F2/44 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/46
CPC分类号： A61F2/441 , A61F2002/30062 , A61F2002/30079 , A61F2002/3008 , A61F2002/30092 , A61F2002/30177 , A61F2002/302 , A61F2002/30224 , A61F2002/30242 , A61F2002/3025 , A61F2002/30252 , A61F2002/30273 , A61F2002/30289 , A61F2002/30565 , A61F2002/30579 , A61F2002/30583 , A61F2002/30586 , A61F2002/30588 , A61F2002/30677 , A61F2002/30841 , A61F2002/30878 , A61F2002/4435 , A61F2002/444 , A61F2002/4495 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0085 , A61F2210/009 , A61F2230/0056 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0073 , A61F2230/0086 , A61F2230/0091 , A61F2250/0098 , A61F2310/00011 , A61F2310/00179
摘要： A mold assembly for the in situ formation of a prosthesis in an annulus located in an intervertebral disc space between adjacent vertebrae of a patient. The mold assembly includes at least a first mold having at least one interior cavity adapted to be located in the intervertebral disc space. At least a first lumen has a distal end fluidly coupled to the mold at a first location. One or more discrete reinforcing structures are located in the intervertebral disc space with the mold. One or more biomaterials are provided to be delivered to the interior cavity through the first lumen. The at least partially cured biomaterial, the reinforcing structures and the mold cooperating to form the prosthesis.
摘要翻译：一种用于在位于患者的相邻椎骨之间的椎间盘空间中的环中原位形成假体的模具组件。模具组件至少包括具有适于位于椎间盘空间中的至少一个内腔的第一模具。至少第一内腔具有在第一位置处流体地联接到模具的远端。一个或多个离散的加强结构位于与模具的椎间盘空间中。提供一种或多种生物材料以通过第一内腔输送到内腔。所述至少部分固化的生物材料，所述加强结构和所述模具协作以形成所述假体。

3. 发明申请

WO2009042403A1 INSTRUMENT SET AND SYSTEM FOR PERFORMING SPINAL NUCLECTOMY 审中-公开
标题翻译：用于执行脊柱核素的仪器和系统
公开(公告)号：WO2009042403A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/075840
申请日：2008-09-10
申请人： DISC DYNAMICS, INC. , MARTZ, Erik O. , LEHUEC, Jean-charles , AHRENS, Michael
发明人： MARTZ, Erik O. , LEHUEC, Jean-charles , AHRENS, Michael
IPC分类号： A61B17/16 , A61B17/17 , A61B17/34 , A61B19/00 , A61F2/44 , A61F2/46
CPC分类号： A61B17/1604 , A61B17/1671 , A61B17/3421 , A61B34/20 , A61B2017/00261 , A61B2017/3405 , A61B2017/3407 , A61B2017/3445 , A61B2090/034 , A61B2090/062 , A61F2/441 , A61F2/4611
摘要： A nuclectomy system for creating a nuclear cavity in an annulus located in an intervertebral disc space to receive an intervertebral prosthesis. The system involves identifying a plurality of regions in at least a portion of the nucleus. A sequence for removing the regions is also determined. At least one annulotomy is formed in the annulus along an annular axis to provide access to the nucleus. A guide system is positioned relative to the annulotomy. The guide system is configured to limit motion of at least one surgical tool relative to the guide system. A portion of the nucleus is removed from a first region using the surgical tool. At least one of the guide system and the surgical tool are configured to remove a portion of the nucleus from a second region. A portion of the nucleus is removed from a second region using the surgical tool.
摘要翻译：用于在位于椎间盘空间中的环中产生核腔以接收椎间假体的核结肠切除术系统。该系统涉及在核的至少一部分中识别多个区域。还确定了用于去除区域的序列。沿着环形轴线在环形区域中形成至少一个瓣膜切开术以提供对细胞核的接近。引导系统相对于瓣膜切开术定位。引导系统被配置为限制至少一个手术工具相对于引导系统的运动。使用外科手术工具从第一区域去除一部分细胞核。引导系统和手术工具中的至少一个被配置为从第二区域移除核的一部分。使用外科手术工具从第二区域去除一部分细胞核。

4. 发明申请

WO2010027622A1 RETENTION STRUCTURE FOR IN SITU FORMATION OF AN INTERVERTEBRAL PROSTHESIS 审中-公开
标题翻译：用于形成椎间盘突出症的保留结构
公开(公告)号：WO2010027622A1
公开(公告)日：2010-03-11
申请号：PCT/US2009/053768
申请日：2009-08-13
申请人： DISC DYNAMICS, INC. , AHRENS, Michael , MARTZ, Erik, O.
发明人： AHRENS, Michael , MARTZ, Erik, O.
IPC分类号： A61F2/44 , A61B17/70
CPC分类号： A61F2/441 , A61B17/7094 , A61B17/7095 , A61B17/7097 , A61B17/8811 , A61F2002/30004 , A61F2002/30032 , A61F2002/30062 , A61F2002/30079 , A61F2002/3008 , A61F2002/30092 , A61F2002/30144 , A61F2002/30177 , A61F2002/302 , A61F2002/30224 , A61F2002/30242 , A61F2002/3025 , A61F2002/30252 , A61F2002/30261 , A61F2002/30273 , A61F2002/30289 , A61F2002/30471 , A61F2002/30565 , A61F2002/30579 , A61F2002/30583 , A61F2002/30586 , A61F2002/30588 , A61F2002/30677 , A61F2002/30841 , A61F2002/30878 , A61F2002/4435 , A61F2002/444 , A61F2002/448 , A61F2002/4495 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0085 , A61F2210/009 , A61F2220/0091 , A61F2230/0017 , A61F2230/0056 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0073 , A61F2230/0082 , A61F2230/0086 , A61F2230/0091 , A61F2250/0014 , A61F2250/003 , A61F2250/0098 , A61F2310/00011 , A61F2310/00023 , A61F2310/00179
摘要： An assembly for the in situ formation of a prosthesis (136) in an intervertebral disc space between adjacent vertebrae of a patient. At least one retention structure (124, 126) is located in the intervertebral disc space. A distal end of at least one lumen (120) is located proximate the at least one retention structure. One or more in situ curable biomaterials (70) are delivered to the intervertebral disc space through the first lumen and into engagement with the retention structure. The retention structure serves to retain at least a portion of the biomaterial in the intervertebral disc space by surface tension, adhesion, mechanical capture, friction, viscosity, and/or a variety, of other mechanisms. The at least partially cured biomaterial and the at least one retention structure cooperate to comprise the prosthesis.
摘要翻译：一种用于在患者的相邻椎骨之间的椎间盘空间中原位形成假体（136）的组件。至少一个保持结构（124,126）位于椎间盘空间中。至少一个腔（120）的远端位于至少一个保持结构附近。一个或多个原位可固化生物材料（70）通过第一内腔被输送到椎间盘空间并与保留结构接合。保留结构用于通过其他机制的表面张力，粘附力，机械捕获，摩擦，粘度和/或各种方式将至少一部分生物材料保留在椎间盘空间中。所述至少部分固化的生物材料和所述至少一个保留结构配合以构成所述假体。

5. 发明公开

EP1981423A2 NUCLECTOMY METHOD AND APPARATUS 审中-公开
标题翻译： NUCLECTOMY方法和设备
公开(公告)号：EP1981423A2
公开(公告)日：2008-10-22
申请号：EP06848870.9
申请日：2006-11-30
申请人： Disc Dynamics, Inc.
发明人： YUAN, Hansen A. , HOOK, Scott G. , MARTZ, Erik O. , AHRENS, Michael
IPC分类号： A61B17/88 , A61F2/44 , A61B17/00 , A61B17/32 , A61F2/46
CPC分类号： A61B17/1606 , A61B34/10 , A61B2017/00261
摘要： A nuclectomy system for creating a nuclear cavity (24) located in an intervertebral disc space (19) and for preparing the nuclear cavity to receive an intervertebral prosthesis. An opening through the annulus (25) is formed along an annulotomy axis (404) to provide access to a nucleus (29). A portion of the nucleus is removed in a first region surrounding the annulotomy axis using at least a first surgical tool (300). Another portion of the nucleus is removed from a second region using at least a second surgical tool (320/ 360). An evaluation mold (13, 13' ) is positioned in the nuclear cavity and a fluid is delivered to the evaluation mold so that the mold substantially fills the nuclear cavity. The amount of nucleus removed is estimated. One or more of the removing steps are optionally repeated as necessary until an adequate amount of the nucleus is removed.
摘要翻译：一种用于形成位于椎间盘空间（19）中的核腔（24）并用于制备核腔以接纳椎间假体的核结节系统。沿瓣环切开轴线（404）形成通过瓣环（25）的开口以提供通向核（29）的通路。使用至少第一手术工具（300）在围绕纤维环切除术轴线的第一区域中去除一部分髓核。使用至少第二手术工具（320/360）将核的另一部分从第二区域移除。评估模具（13,13'）定位在核腔中，并且流体被输送到评估模具，使得模具基本上填充核腔。估计去除的核的量。根据需要可选地重复一个或多个去除步骤，直到去除足够量的核。

6. 发明公开

EP2023865A2 MOLD ASSEMBLY FOR INTERVERTEBRAL PROSTHESIS 审中-公开
标题翻译： FORM安排一盘假体
公开(公告)号：EP2023865A2
公开(公告)日：2009-02-18
申请号：EP07783268.1
申请日：2007-05-04
申请人： Disc Dynamics, Inc.
发明人： AHRENS, Michael , MARTZ, Erik O. , BURKE, Ronald , CARTER, Benjamin F.
IPC分类号： A61F2/44 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/46
CPC分类号： A61F2/441 , A61F2002/30062 , A61F2002/30079 , A61F2002/3008 , A61F2002/30092 , A61F2002/30177 , A61F2002/302 , A61F2002/30224 , A61F2002/30242 , A61F2002/3025 , A61F2002/30252 , A61F2002/30273 , A61F2002/30289 , A61F2002/30565 , A61F2002/30579 , A61F2002/30583 , A61F2002/30586 , A61F2002/30588 , A61F2002/30677 , A61F2002/30841 , A61F2002/30878 , A61F2002/4435 , A61F2002/444 , A61F2002/4495 , A61F2002/4629 , A61F2210/0004 , A61F2210/0014 , A61F2210/0085 , A61F2210/009 , A61F2230/0056 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0073 , A61F2230/0086 , A61F2230/0091 , A61F2250/0098 , A61F2310/00011 , A61F2310/00179
摘要： A mold assembly for the in situ formation of a prosthesis inside an annulus located in an intervertebral disc space between adjacent vertebrae of a patient. The mold assembly includes at least a first mold (54) having at least one interior cavity adapted to be located in the intervertebral disc space. At least a first lumen (52) has a distal end fluidly coupled to the mold at a first location. One or more discrete reinforcing structures are located in the intervertebral disc space with the mold. One or more biomaterials (70) are provided to be delivered to the interior cavity through the first lumen. The at least partially cured biomaterial, the reinforcing structures and the mold cooperating to form the prosthesis.

7. 发明申请

WO2007002766A2 OPTICAL TRANSPONDER WITH ACTIVE HEAT TRANSFER 审中-公开
标题翻译：具有有源热传输的光学传输器
公开(公告)号：WO2007002766A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/025203
申请日：2006-06-27
申请人： INTEL CORPORATION , AHRENS, Michael
发明人： AHRENS, Michael
CPC分类号： H01L23/427 , G02B6/4292 , G02B6/4296 , H01L2924/0002 , H01L2924/00
摘要： According to embodiments of the present invention, an optical transponder module generates heat when operating and a heat pipe disposed in the module body performs active heat transfer from a hot end of the optical transponder module to a cooler end of the optical transponder module. A heat pipe disposed in an external clip-in heat sink may remove heat from the optical transponder body.
摘要翻译：根据本发明的实施例，光学应答器模块在操作时产生热量，并且设置在模块主体中的热管执行从光学应答器模块的热端到光学应答器模块的较冷端的主动热传递。设置在外部夹入散热器中的热管可以从光学应答器主体移除热量。

8. 发明申请

WO2011146143A2 DETECTION OF CANCER BY ASSAYING PSA ENZYMATIC ACTIVITY 审中-公开
标题翻译：通过测定PSA酶活性检测癌症
公开(公告)号：WO2011146143A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/000919
申请日：2011-05-23
申请人： OHMX CORPORATION , AHRENS, Michael , ANDERSON, Byron , BERTIN, Paul, A. , CATALONA, William, J. , GEORGANOPOULOU, Dimitra , NORTHWESTERN UNIVERSITY
发明人： AHRENS, Michael , ANDERSON, Byron , BERTIN, Paul, A. , CATALONA, William, J. , GEORGANOPOULOU, Dimitra
IPC分类号： G01N33/50
CPC分类号： C12Q1/37 , G01N33/57434
摘要： The present invention is directed to the diagnosis of cancer associated with enzymaticaliy active PSA in samples.
摘要翻译：本发明涉及与样品中酶活性PSA相关的癌症的诊断。

9. 发明申请

WO2012100078A1 ENZYME TRIGGERED REDOX ALTERING CHEMICAL ELIMINATION (E-TRACE) IMMMUNOASSAY 审中-公开
标题翻译： ENZYME TRIGGERED REDOX ALTERING CHEMICAL ELIMINATION（E-TRACE）IMMMUNOASSAY
公开(公告)号：WO2012100078A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/021904
申请日：2012-01-19
申请人： OHMX CORPORATION , BERTIN, Paul, A. , AHRENS, Michael
发明人： BERTIN, Paul, A. , AHRENS, Michael
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , C12Q1/005 , G01N31/22
摘要： Described are methods for detecting a target analyte in a test sample by providing a solid support comprising an electrode comprising: (i) a self-assembled monolayer (SAM), (ii) a covalently attached electroactive active moiety (EAM) comprising a transition metal complex comprising a self-immolative moiety and a peroxide sensitive moiety (PSM), wherein said EAM has a first E 0 ; then contacting the target analyte and said solid support under conditions wherein said target analyte reacts with a peroxide generating enzyme to generate peroxide and said self- immolative moiety is removed such that said EAM has a second E 0 test sample; and then detecting said second E 0 as an indication of the presence of said target analyte. Also provided are compositions for use in the preceding methods.
摘要翻译：描述了通过提供包括电极的固体支持物来检测测试样品中的目标分析物的方法，所述固体支持物包括：（i）自组装单层（SAM），（ii）共价连接的电活性活性部分（EAM），其包含过渡金属复合物，其包含自身残留部分和过氧化物敏感部分（PSM），其中所述EAM具有第一E0; 然后在其中所述目标分析物与产生过氧化物的酶反应产生过氧化物的条件下接触目标分析物和所述固体支持物，并且去除所述自消除部分，使得所述EAM具有第二种E0测试样品; 然后检测所述第二E0作为所述目标分析物的存在的指示。还提供了用于前述方法的组合物。

10. 发明申请

WO2007002124A1 OPTICAL TRANSPONDER WITH PASSIVE HEAT TRANSFER 审中-公开
标题翻译：具有被动传热的光学传送器
公开(公告)号：WO2007002124A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024037
申请日：2006-06-20
申请人： INTEL CORPORATION , AHRENS, Michael
发明人： AHRENS, Michael
IPC分类号： H04B10/152 , G02B6/43
CPC分类号： G02B6/4246 , G02B6/3897 , G02B6/4284
摘要： According to embodiments of the present invention, an optical transponder module generates heat when operating and at least a copper heat wick and/or a copper block are disposed in the module body to perform passive transfer of heat from inside the optical transponder module to outside the optical transponder module. The heat wick may be soldered to thermal vias in the printed circuit board that is internal to the optical transponder module and positioned over the laser transmitter circuitry. The copper block may be positioned in a cutout in the optical transponder module body to acts as a heat spreader. Thermal grease, compounds, paste, interface material, etc., may be used to help the conduction of heat.
摘要翻译：根据本发明的实施例，光学应答器模块在操作时产生热量，并且至少铜模块和/或铜模块布置在模块主体中以执行从光学应答器模块内部向外部的热量的传递光转发器模块。热芯可以焊接到印刷电路板中的热转换器，该通孔位于光发送应答器模块的内部并且位于激光发射器电路之上。铜块可以定位在光学应答器模块体中的切口中，用作散热器。导热油脂，化合物，糊剂，界面材料等可用于帮助热传导。

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