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1. 发明申请

WO2013067349A1 NOVEL CHEMISTRY USED IN BIOSENSORS 审中-公开
标题翻译：生物传感器中使用的新化学物质
公开(公告)号：WO2013067349A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/063319
申请日：2012-11-02
申请人： OHMX CORPORATION , BERTIN, Paul, A.
发明人： BERTIN, Paul, A.
IPC分类号： C07F17/02 , C12Q1/00 , G01N33/543
CPC分类号： C07F17/02 , C08F4/61925 , C12Q1/001 , C12Q1/004 , G01N27/3271 , G01N33/5438
摘要： The invention relates to novel compositions of 1,3-disubstituted ferrocenes useful for the modification of electrodes. Formula (I).
摘要翻译：本发明涉及可用于电极修饰的1,3-二取代二茂铁的新组合物。式（I）。

2. 发明申请

WO2011146143A3 ENZYMATIC ACTIVITY OF PSA AS DIAGNOSTIC MARKER FOR PROSTATE CANCER 审中-公开
标题翻译： PSA作为诊断标记的前列腺癌的酶活性
公开(公告)号：WO2011146143A3
公开(公告)日：2012-05-31
申请号：PCT/US2011000919
申请日：2011-05-23
申请人： OHMX CORP , AHRENS MICHAEL , ANDERSON BYRON , BERTIN PAUL A , CATALONA WILLIAM J , GEORGANOPOULOU DIMITRA , UNIV NORTHWESTERN
发明人： AHRENS MICHAEL , ANDERSON BYRON , BERTIN PAUL A , CATALONA WILLIAM J , GEORGANOPOULOU DIMITRA
IPC分类号： C12Q1/37 , G01N33/574
CPC分类号： C12Q1/37 , G01N33/57434
摘要： The present invention is directed to the diagnosis of cancer associated with enzymaticaliy active PSA in samples.
摘要翻译：本发明涉及与样品中酶活性PSA相关的癌症的诊断。

3. 发明申请

WO2011034668A1 ENZYME TRIGGERED REDOX ALTERING CHEMICAL ELIMINATION (E-TRACE) IMMUNOASSAY 审中-公开
标题翻译： ENZYME TRIGGERED REDOX ALTERING化学消除（电子跟踪）免疫
公开(公告)号：WO2011034668A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/044918
申请日：2010-08-09
申请人： OHMX CORPORATION , BERTIN, Paul, A.
发明人： BERTIN, Paul, A.
IPC分类号： C12Q1/00 , G01N27/48 , G01N33/543
CPC分类号： G01N27/26 , G01N33/5438 , G01N2610/00
摘要： The invention provides compositions and methods for the detection of target analytes in a test sample. Thus, the invention provides a solid support comprising an, electrode comprising: a self -assembled monolayer (SAM). A covalently attached electroactive active moiety (EAM) comprising a transition metal complex comprising a self -immolativa moiety (SIM) and a peroxides sensitive moiety (PSM), wherein said EAM has a first E0 and a capture binding ligand that binds the analyte, and a self -assembled monolayer (SAM).
摘要翻译：本发明提供了用于在测试样品中检测目标分析物的组合物和方法。因此，本发明提供了包含电极的固体支持物，其包括：自组装单层（SAM）。一种共价连接的电活性活性部分（EAM），其包含过渡金属络合物，该过渡金属络合物包含自偏摩霉素部分（SIM）和过氧化物敏感部分（PSM），其中所述EAM具有结合分析物的第一E0和捕获结合配体，自组装单层（SAM）。

4. 发明申请

WO2012100078A1 ENZYME TRIGGERED REDOX ALTERING CHEMICAL ELIMINATION (E-TRACE) IMMMUNOASSAY 审中-公开
标题翻译： ENZYME TRIGGERED REDOX ALTERING CHEMICAL ELIMINATION（E-TRACE）IMMMUNOASSAY
公开(公告)号：WO2012100078A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/021904
申请日：2012-01-19
申请人： OHMX CORPORATION , BERTIN, Paul, A. , AHRENS, Michael
发明人： BERTIN, Paul, A. , AHRENS, Michael
IPC分类号： G01N33/543
CPC分类号： G01N33/54306 , C12Q1/005 , G01N31/22
摘要： Described are methods for detecting a target analyte in a test sample by providing a solid support comprising an electrode comprising: (i) a self-assembled monolayer (SAM), (ii) a covalently attached electroactive active moiety (EAM) comprising a transition metal complex comprising a self-immolative moiety and a peroxide sensitive moiety (PSM), wherein said EAM has a first E 0 ; then contacting the target analyte and said solid support under conditions wherein said target analyte reacts with a peroxide generating enzyme to generate peroxide and said self- immolative moiety is removed such that said EAM has a second E 0 test sample; and then detecting said second E 0 as an indication of the presence of said target analyte. Also provided are compositions for use in the preceding methods.
摘要翻译：描述了通过提供包括电极的固体支持物来检测测试样品中的目标分析物的方法，所述固体支持物包括：（i）自组装单层（SAM），（ii）共价连接的电活性活性部分（EAM），其包含过渡金属复合物，其包含自身残留部分和过氧化物敏感部分（PSM），其中所述EAM具有第一E0; 然后在其中所述目标分析物与产生过氧化物的酶反应产生过氧化物的条件下接触目标分析物和所述固体支持物，并且去除所述自消除部分，使得所述EAM具有第二种E0测试样品; 然后检测所述第二E0作为所述目标分析物的存在的指示。还提供了用于前述方法的组合物。

5. 发明申请

WO2013067349A9 NOVEL CHEMISTRY USED IN BIOSENSORS 审中-公开
标题翻译：生物传感器中使用的新化学物质
公开(公告)号：WO2013067349A9
公开(公告)日：2014-05-30
申请号：PCT/US2012063319
申请日：2012-11-02
申请人： OHMX CORP , BERTIN PAUL A , AHRENS MICHAEL J
发明人： BERTIN PAUL A , AHRENS MICHAEL J
IPC分类号： C07F17/02 , C12Q1/00 , G01N33/543
CPC分类号： C07F17/02 , C08F4/61925 , C12Q1/001 , C12Q1/004 , G01N27/3271 , G01N33/5438
摘要： The invention relates to novel compositions of 1,3-disubstituted ferrocenes useful for the modification of electrodes. Formula (I).
摘要翻译：本发明涉及可用于电极修饰的1,3-二取代二茂铁的新组合物。式（I）。

6. 发明申请

WO2011146143A2 DETECTION OF CANCER BY ASSAYING PSA ENZYMATIC ACTIVITY 审中-公开
标题翻译：通过测定PSA酶活性检测癌症
公开(公告)号：WO2011146143A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/000919
申请日：2011-05-23
申请人： OHMX CORPORATION , AHRENS, Michael , ANDERSON, Byron , BERTIN, Paul, A. , CATALONA, William, J. , GEORGANOPOULOU, Dimitra , NORTHWESTERN UNIVERSITY
发明人： AHRENS, Michael , ANDERSON, Byron , BERTIN, Paul, A. , CATALONA, William, J. , GEORGANOPOULOU, Dimitra
IPC分类号： G01N33/50
CPC分类号： C12Q1/37 , G01N33/57434
摘要： The present invention is directed to the diagnosis of cancer associated with enzymaticaliy active PSA in samples.
摘要翻译：本发明涉及与样品中酶活性PSA相关的癌症的诊断。

7. 发明申请

WO2009052422A1 ELECTROCHEMICAL ASSAY FOR THE DETECTION OF ENZYMES 审中-公开
标题翻译：用于检测酶的电化学测定
公开(公告)号：WO2009052422A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080363
申请日：2008-10-17
申请人： OHMX CORPORATION , BERTIN, Paul, A.
发明人： BERTIN, Paul, A.
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要： Compositions and methods for the detection of enzymes using the nuclear reorganization energy, lambda, of an electron transfer process. The method comprises adding a test sample comprising a target enzyme to a solid support comprising an electrode, the electrode comprising a self-assembled monolayer (SAM), a covalently attached eletroactive active moiety (EAM) comprising a transi metal complex with an EO, and a plurality of substrates attached to said electrode, wherein said substrates are substrates of said enzyme. The method further comprises contacting said target enzyme and said substrates to form a plurality of reactants and determining the presence of said enzyme by measuring a change of said EO.
摘要翻译：使用电子转移过程的核重组能量λ检测酶的组合物和方法。该方法包括将包含靶酶的测试样品添加到包含电极的固体支持物上，所述电极包含自组装单层（SAM），包含与EO的跨金属络合物的共价连接的电活性活性部分（EAM），以及附着到所述电极的多个基底，其中所述底物是所述酶的底物。该方法还包括使所述目标酶和所述底物接触以形成多种反应物，并通过测量所述EO的变化来确定所述酶的存在。

8. 发明专利

IL257932D0 Modified cytotoxins and their therapeutic use 未知
公开(公告)号：IL257932D0
公开(公告)日：2018-06-03
申请号：IL25793218
申请日：2018-03-06
申请人： UNIV CALIFORNIA , VYBYL HOLDINGS INC , CALLMANN CASSANDRA E , THOMPSON MATTHEW P , LEGUYADER CLARE L M , GIANNESCHI NATHAN C , BERTIN PAUL A
发明人： CALLMANN CASSANDRA E , THOMPSON MATTHEW P , LEGUYADER CLARE L M , GIANNESCHI NATHAN C , BERTIN PAUL A
IPC分类号： C07D20060101
摘要： The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.

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