专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2023067090A1 IPSC INDUCTION AND PROGENY DERIVATION 审中-公开
公开(公告)号：WO2023067090A1
公开(公告)日：2023-04-27
申请号：PCT/EP2022/079266
申请日：2022-10-20
申请人： ROSLIN TECHNOLOGIES LIMITED
发明人： MEE, Joe , SINGH, Pritika , JACKSON, Melany
IPC分类号： C12N5/074 , C12N5/077 , A23L13/00
摘要： A method of inducing pluripotency in somatic cells derived from a non-human domestic companion animal or farm animal comprises culturing neural stem cells (NSCs) in the presence of vectors that express Klf4, Oct4 and Sox2, and suitably in the absence of cMyc.

2. 发明申请

WO2016198862A1 NANOPARTICLES 审中-公开
标题翻译：纳米粒子
公开(公告)号：WO2016198862A1
公开(公告)日：2016-12-15
申请号：PCT/GB2016/051693
申请日：2016-06-08
申请人： KING'S COLLEGE LONDON
发明人： THANOU, Maria , WRIGHT, Michael James Lee , CENTELLES, Miguel , MILLER, Andrew David , GEDROYC, Wladyslaw
IPC分类号： A61K9/127 , A61K49/08 , A61K49/10 , A61K49/18 , A61K31/4745 , A61K31/704
CPC分类号： A61K9/1272 , A61K31/4745 , A61K31/704 , A61K41/0052 , A61K49/085 , A61K49/106 , A61K49/1812 , A61K49/1839
摘要： The invention provides a (drug-containing) lipid nanoparticle with: (i) at least one phospholipid; (ii) at least one lysolipid; and (iii) at least one phospholipid comprising a hydrophilic polymer;and (iv) at least one structural lipid of formula (I) which has the following general structure: (I) wherein R and R' are long hydrocarbyl hydrophobic chains, Y is a linker element, and PHG is a polar head group described as large according to its van der Waals radius, and which is different from the phospholipid (i). The lipid nanoparticle can release a drug (or API) from within the lipid nanoparticleas a result of focussed ultrasound (FUS) applied continuously, at least twice, to a desired part of the body to induce hyperthermia (an increase in temperature). FUS is applied after the lipid nanoparticle containing the drug has been administered to the live subject, and causes controlled release of the drug at the desired site of the body. Ultrasound is then halted, and the site of interest allowed to cool. Ultrasound is then applied again. Lipidnanoparticles can be labelled (for MRI, NIRF imaging),enablin greal time monitoring of the drug in the human body. Imaging information can be used to direct and guide the nature of the FUS applied to the site of interest.
摘要翻译：本发明提供了一种（含药物）脂质纳米颗粒，其具有：（i）至少一种磷脂; （ii）至少一种溶脂剂; 至少一种包含亲水性聚合物的磷脂;和（iv）至少一种具有以下一般结构的式（I）结构脂质：（I）其中R和R'是长烃基疏水链，Y是连接体元件，PHG是根据其范德华半径描述为大的极性头基，并且与磷脂（i）不同。脂质纳米颗粒可以从脂质纳米颗粒内释放药物（或API），这是聚焦超声（FUS）连续施用至少两次到身体所需部位以诱发高热（温度升高）的结果。在含有药物的脂质纳米颗粒已经施用于活体受试者之后施用FUS，并且导致药物在体内所需位点的受控释放。然后停止超声波，感兴趣的部位允许冷却。然后再次应用超声波。脂质体纳米颗粒可以被标记（用于MRI，NIRF成像），对人体中药物的安定时间进行时间监测。成像信息可用于指导和指导应用于感兴趣的站点的FUS的性质。

3. 发明申请

WO2008110828A1 METHOD FOR PREVENTION OF AGE-RELATED MACULAR DEGENERATION (AMD) 审中-公开
标题翻译：预防与年龄相关的黄斑变性（AMD）的方法
公开(公告)号：WO2008110828A1
公开(公告)日：2008-09-18
申请号：PCT/GB2008/000925
申请日：2008-03-14
申请人： DSM IP ASSETS B.V. , WRIGHT, Simon, Mark , BENDIK, Igor , SANCAK, Özgür , SCHALCH, Wolfgang , WITTWER, Jonas
发明人： BENDIK, Igor , SANCAK, Özgür , SCHALCH, Wolfgang , WITTWER, Jonas
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/172
摘要： A method of prevention of age-related macular degeneration (AMD) involves, in a first step, taking a sample from an individual and detecting the presence of a polymorphism (rsl 1200638 or rs 10490924, or an SNP related to or associated with a (high temperature requirement) serine protease). In a second step the individual is provided with a substance that can prevent AMD, or can mitigate or alleviate symptoms of AMD. The substance is a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual. The invention also provides a method of determining the substance to be administered to an individual, which individual may be susceptible of having age-related macular degeneration (or an age-related macular degeneration-related disorder) by detecting the presence of the polymorphism and identifying a substance capable of preventing or treating age-related macular degeneration in that individual. The method may additionally comprise providing (such as administering or communicating) the substance (or its identity) to the individual.
摘要翻译：预防年龄相关性黄斑变性（AMD）的方法包括，在第一步中，从个体取样品并检测多态性（rs1112638或rs10490924或与（高温需求）丝氨酸蛋白酶相关或相关的SNP）。在第二步中，向个体提供能够预防AMD的物质，或者可以缓解或缓解AMD的症状。该物质是含有叶黄素和/或玉米黄质和/或某种抗氧化剂（或其混合物）的个体的药物。本发明还提供了测定待施用于个体的物质的方法，所述个体可能通过检测多态性的存在并鉴定出与年龄相关的黄斑变性（或与年龄相关的黄斑变性有关的病症）能够预防或治疗该个体的年龄相关性黄斑变性的物质。该方法可以另外包括向个体提供（例如给予或传递）物质（或其身份）。

4. 发明申请

WO2007029008A3 METHOD OF TREATMENT OR PREVENTION OF AGE-RELATED MACULAR DEGENERATION 审中-公开
公开(公告)号：WO2007029008A3
公开(公告)日：2007-03-15
申请号：PCT/GB2006/003331
申请日：2006-09-08
申请人： DSM IP ASSETS B.V. , WRIGHT, Simon, Mark , GORALCZYC, Regina , DE SAIZIEU, Antoine , SCHALCH, Wolgfang , BENDIK, Igor
发明人： GORALCZYC, Regina , DE SAIZIEU, Antoine , SCHALCH, Wolgfang , BENDIK, Igor
IPC分类号： A61K31/047 , A61K31/375 , A61K31/355 , A61K33/30 , A61K33/34 , A61P27/02
摘要： A method of treatment and/or prevention of age-related macular degeneration (AMD) wherein, in a first step, the need for treatment or susceptibility to AMD is determined for an individual and, in a second step, a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual. The invention also provides a method of determining a substance to be administered to an individual, which individual may be susceptible of having age-related macular degeneration (or an age-related macular degeneration-related disorder) comprising: a) determining the susceptibility of the individual to age-related macular degeneration (usually genetically, by detection of an SNP); and b) on the basis of the determination in a), identifying a substance capable of preventing or treating age-related macular degeneration in that individual. The method may additionally comprise providing (such as administering or communicating) the substance (or its identity) to the individual.

5. 发明申请

WO2003055906A1 MODIFIED BACTERIAL SURFACE LAYER PROTEINS 审中-公开
标题翻译：改性细菌表面层蛋白
公开(公告)号：WO2003055906A1
公开(公告)日：2003-07-10
申请号：PCT/EP2002/014749
申请日：2002-12-23
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , POUWELS, Pieter, Hendrik , SMIT, Egbert , TIELEN, Frans
发明人： POUWELS, Pieter, Hendrik , SMIT, Egbert , TIELEN, Frans
IPC分类号： C07K14/335
CPC分类号： C07K14/335 , C07K2319/00 , C12N2810/55
摘要： Modified bacterial surface layer (S-layer) proteins are disclosed where the modification is the insertion, at an internal location, of a heterologous polypeptide, or polypeptide of interest. The polypeptide is a binding or target protein, such as an antigen or antibody, or part thereof, in particular a bacterial antigen (e.g. from Clostridium tetani such as TTFC). The modified surface layer protein can then be expressed on the surface of the bacterial cell and used in a vaccine. Also disclosed are bacteria which have been modified to express a heterologous surface layer protein, but which do not as a wild-type possess an S-layer (such as L. casei), and modified bacteria which express only a modified surface layer protein (and not the wild-type S-layer protein). The wild type S-layer is completely replaced with the modified version where the polynucleotide encoding the modified version is integrated into the bacterial genome. The modified S-proteins can form crystalline arrays, sheets or layers that can be used to bind functional molecules (e.g. receptors) to solid surfaces (Au, silicon wafers) in biosensors.
摘要翻译：公开了修饰的细菌表面层（S层）蛋白，其中修饰是在异源多肽或感兴趣的多肽的内部位置插入。多肽是结合或靶蛋白，例如抗原或抗体，或其部分，特别是细菌抗原（例如来自破伤风梭菌如TTFC）。然后可以将修饰的表面蛋白质在细菌细胞的表面上表达并用于疫苗中。还公开了已经被修饰以表达异源表面蛋白但是不具有野生型的具有S层（例如干酪乳杆菌）的细菌和仅表达改性表面蛋白的修饰细菌（而不是野生型S层蛋白）。野生型S层完全被编码修饰版本的多核苷酸整合到细菌基因组中的修饰版本替代。修饰的S-蛋白质可以形成可用于将功能性分子（例如受体）结合到生物传感器中的固体表面（Au，硅晶片）的晶体阵列，片或层。

6. 发明申请

WO2002010423A3 ISOLATION OF MICROBIAL OILS 审中-公开
公开(公告)号：WO2002010423A3
公开(公告)日：2002-02-07
申请号：PCT/EP2001/008903
申请日：2001-08-01
申请人： DSM N.V. , HENDRIK, Louis , SCHAAP, Albert
发明人： HENDRIK, Louis , SCHAAP, Albert
IPC分类号： C12P7/64
摘要： The extraction of a microbial or single cell oil, for example comprising one or more polyunsaturated fatty acids (PUFAs), directly from microbial cells is disclosed which avoids the need for solvents. After fermentation, the microbial cells are pasteurised, washed and the cell walls lysed or disrupted by a mechanical (e.g. homogenisation), physical (boiling or drying), chemical (solvents) or enzymatic (cell wall degrading enzymes) technique. The oil (containing the PUFA) is then separated from the resulting cell wall debris. This is achieved by centrifugation, which results is an oily phase (top layer) that contains the oil which that can be separated from an aqueous phase (containing the cell wall debris). The oil can then be extracted and if necessary the PUFA can be purified or isolated from the oil.

7. 发明申请

WO2015079240A1 COMPOSITIONS 审中-公开
标题翻译：组合物
公开(公告)号：WO2015079240A1
公开(公告)日：2015-06-04
申请号：PCT/GB2014/053521
申请日：2014-11-27
申请人： GLOBALACORN LTD.
发明人： MILLER, Andrew David
IPC分类号： A61K45/06 , A61K31/7084 , A61P23/00 , A61P29/00
CPC分类号： A61K31/7084 , A61K9/0014 , A61K9/0021 , A61K9/127 , A61K9/7061 , A61K31/09 , A61K31/167 , A61K31/245 , A61K45/06 , C12N15/1138 , C12N2310/14 , C12N2320/31 , C12N2320/32 , C12N2320/51 , A61K2300/00
摘要： The present invention relates to administration of a dinucleoside polyphosphate analogue or a pharmaceutically acceptable salt thereof, topically in a formulation comprising a suitable excipient or using a device for transdermal delivery, and/or combined with a nanoparticle carrier. The present invention also relates to the therapeutic use of such compositions or devices, in particular in the treatment of painor epilepsy. The analogue may be combined with an anaesthetic (such as a salt form) or delivered in a nanoparticle.
摘要翻译：本发明涉及在包含合适的赋形剂或使用透皮递送装置和/或与纳米颗粒载体组合的制剂中局部施用二核苷多磷酸酯类似物或其药学上可接受的盐。本发明还涉及这种组合物或装置的治疗用途，特别是治疗油漆癫痫。类似物可以与麻醉剂（例如盐形式）组合或在纳米颗粒中递送。

8. 发明申请

WO2008078102A3 LIPIDS AND THEIR USE AS NON-VIRAL DELIVERY VEHICLE 审中-公开
公开(公告)号：WO2008078102A3
公开(公告)日：2008-07-03
申请号：PCT/GB2007/004967
申请日：2007-12-21
申请人： IMUTHES LIMITED , UNIVERSITY OF THE WITWATERSRAND , MILLER, Andrew, David , ARBUTHNOT, Patrick , JORGENSEN, Michael , KELLER, Michael , KAMALY, Nazila , AISSAOUI, Abderrahim , THANOU, Maya
发明人： MILLER, Andrew, David , ARBUTHNOT, Patrick , JORGENSEN, Michael , KELLER, Michael , KAMALY, Nazila , AISSAOUI, Abderrahim , THANOU, Maya
IPC分类号： A61K9/127 , A61K47/34 , A61K47/48 , C07C237/22 , C07F9/10 , C07J41/00 , C08G73/02 , C12N15/88
摘要： The present invention provides a lipid of the formula (I) R 3 R 4 N-[Y] q -(C p H 2p )-X-Linker-NR 1 R 2 (I) wherein R 3 and R 4 are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (C n H 2n )NR 5 , wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R 5 is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from -NR 7 -, -C(=O)-N R 8 -, -NR 9 -C(=O)-, -C(=O)-, -O-, and -NR 10 -C(=0)0-, wherein each R 7 , R 8 , R 9 and R 10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula -(OCH 2 CH 2 ) 1-10 , -NR 6 -(CvH 2v )-C(=O)-, wherein R 6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and -C(=0)-(CH 2 ) 0-10 -CH 2 -C(=0)-; R 1 is selected from acyclic groups having from 4 to 30 carbon atoms; and R 2 is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.

9. 发明申请

WO2003009700A1 COCCIDIOSTATS 审中-公开
标题翻译：抗球虫药
公开(公告)号：WO2003009700A1
公开(公告)日：2003-02-06
申请号：PCT/EP2002/008158
申请日：2002-07-22
申请人： DSM N.V. , VAN DOESUM, Johannes, Henricus , KIES, Arie, Karst
发明人： VAN DOESUM, Johannes, Henricus , KIES, Arie, Karst
IPC分类号： A23K1/16
CPC分类号： C12Y101/03004 , A23K20/10 , A23K20/158 , A23K20/189 , A23K50/70 , A23V2002/00 , A61K31/20 , C12Y113/11012 , A23V2200/10 , A23V2250/1862 , A23V2250/1882
摘要： The use of a polyunsaturated fatty acid (PUFA) as, or in the preparation of, a coccidiostat is disclosed. PUFAs have been discovered to have coccidiostatic activity, and can therefore be used in the treatment or prophylaxis of coccidiosis. They can be employed in both veterinary and pharmaceutical compositions to treat both humans and animals. The PUFA may also be included in animal feed. The PUFA is active against single cell coccidia organisms, especially of the subgroup Eimeriorina, in particular in E. acervulina, E. maxima or E. tenella .
摘要翻译：公开了使用多不饱和脂肪酸（PUFA）或制备球虫抑制剂。已经发现PUFA具有抗球虫活性，因此可用于治疗或预防球虫病。它们可以用于兽医和药物组合物中以治疗人和动物。 PUFA也可以包括在动物饲料中。 PUFA对单细胞球虫生物体尤其是亚麻组，尤其是大肠埃希氏菌（E.acervulina），大肠埃希氏菌（E.gala）或大肠杆菌（E. tenella）有活性。

10. 发明申请

WO2015101678A2 METHOD FOR TREATING SKIN CANCER USING RADIATION THERAPY 审中-公开
标题翻译：使用放射疗法治疗皮肤癌的方法
公开(公告)号：WO2015101678A2
公开(公告)日：2015-07-09
申请号：PCT/EP2015/050184
申请日：2015-01-07
申请人： HACKENSACK UNIVERSITY MEDICAL CENTER
发明人： SUH, K. Stephen , SAROJINI, Sreeja , TUNA, Mehmet , BARBIERE, Joseph , NDLOVU, Alois , PECORA, Andrew , INGENITO, Anthony
IPC分类号： A61N5/10
CPC分类号： A61N5/1077 , A61K31/337 , A61K31/353 , A61K31/365 , A61N5/1031 , A61N2005/1098

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式