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1. 发明专利

AU2013264966A1 Dinuceloside polyphosphates for the treatment of pain 未知
公开(公告)号：AU2013264966A1
公开(公告)日：2015-01-22
申请号：AU2013264966
申请日：2013-05-24
申请人： BURNASHEV NAIL , GINIATULLIN RASHID , LOZOVAYA NATALYA , MILLER ANDREW DAVID
发明人： MILLER ANDREW DAVID , LOZOVAYA NATALYA , BURNASHEV NAIL , GINIATULLIN RASHID
IPC分类号： A61K31/7084 , A61P29/02
摘要： The invention provides a dinucleoside polyphosphate analogue, or a pharmaceutically acceptable salt thereof, for use in the inhibition (or down-regulation) of a pain, via a transducing ATP -gated P2X3 receptor, often by means of high-affinity desensitisation (HAD) mechanism.

2. 发明申请

WO2011041495A1 TISSUE PROCESSING CASSETTE 审中-公开
标题翻译：组织加工CASSETTE
公开(公告)号：WO2011041495A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/050843
申请日：2010-09-30
申请人： RICHARD-ALLAN SCIENTIFIC COMPANY , MILLER, Andrew, David , DAVIES, Robert, Paul , POUNCEY, Mathew
发明人： MILLER, Andrew, David , DAVIES, Robert, Paul , POUNCEY, Mathew
IPC分类号： C12M3/00
CPC分类号： G01N1/31 , G01N2035/00306
摘要： A device (10, 100) for use in handling and processing of a sample. The device (10, 100) includes a sample processing cassette (12, 1 12) having a sample container portion (14, 1 14) configured to contain a sample therein and an extension member (26, 126) operatively coupled to the sample container portion (14, 1 14). The device (10, 1 10) is size-adjustable to present a first footprint of a standard sized cassette for use during certain automated steps designed to function with standard sized cassettes, such as labeling, embedding and sectioning (microtomy), and a second reduced footprint for use during chemical processing, such as fixation and dehydration.
摘要翻译：一种用于处理和处理样品的装置（10,100）。装置（10,100）包括具有构造成容纳样品的样品容器部分（14,144）的样品处理盒（12,122）和可操作地连接到样品容器的延伸构件（26,126）部分（14,144）。所述装置（10,110）可调节尺寸，以呈现标准尺寸盒的第一印迹，以便在设计成与标准尺寸的盒（例如标签，嵌入和切片（切片））一起工作的某些自动化步骤期间使用，以及第二减少化学处理过程中使用的占地面积，如固定和脱水。

3. 发明申请

WO2010011147A1 INDOLE COMPOUNDS 审中-公开
标题翻译： INDOLE化合物
公开(公告)号：WO2010011147A1
公开(公告)日：2010-01-28
申请号：PCT/NO2009/000270
申请日：2009-07-23
申请人： THIA MEDICA AS , BERGE, Rolf , SKORVE, Jon , MILLER, Andrew David , JØRGENSEN, Michael R. , BHURRUTH-ALCOR, Yushma , RØST, Therese
发明人： BERGE, Rolf , SKORVE, Jon , MILLER, Andrew David , JØRGENSEN, Michael R. , BHURRUTH-ALCOR, Yushma , RØST, Therese
IPC分类号： C07D209/08 , A61K31/405 , A61P3/04 , A61P3/10 , A61P25/28 , A61P29/00
CPC分类号： C07D209/08
摘要： Novel indole compounds which interact with peroxisome proliferator-activated receptors (PPARs) are disclosed. The compounds have an influence on metabolic diseases, obesity and diabetes.
摘要翻译：公开了与过氧化物酶体增殖物激活受体（PPAR）相互作用的新型吲哚化合物。这些化合物对代谢疾病，肥胖症和糖尿病有影响。

4. 发明申请

WO2006016097A3 VECTOR COMPRISING POLYMER MODIFIED SIRNA LIPOSOMES 审中-公开
标题翻译：包含聚合物改性SIRNA脂质体的载体
公开(公告)号：WO2006016097A3
公开(公告)日：2006-11-23
申请号：PCT/GB2005002634
申请日：2005-07-06
申请人： IC VEC LTD , KELLER MICHAEL , JORGENSEN MICHAEL , MILLER ANDREW DAVID , PEROUZEL ERIC
发明人： KELLER MICHAEL , JORGENSEN MICHAEL , MILLER ANDREW DAVID , PEROUZEL ERIC
IPC分类号： A61K48/00 , A61K9/127 , C12N15/88
CPC分类号： A61K9/1272 , A61K48/00 , A61K48/0091 , A61K2121/00 , C12N15/88 , Y10T428/2984
摘要： The present invention relates to a non-viral delivery vector comprising a liposome, wherein one or more lipids of the liposome are coupled, reversibly or irreversibly, to one or more polymers, and wherein the liposome comprises siRNA.
摘要翻译：本发明涉及包含脂质体的非病毒递送载体，其中所述脂质体的一种或多种脂质可逆地或不可逆地与一种或多种聚合物偶联，并且其中所述脂质体包含siRNA。

5. 发明申请

WO2003011252A1 PHARMACEUTICAL COMPOSITION COMPRISING LIPIDS COMPRISING A POLAR AND A NONPOLAR MOIETY 审中-公开
标题翻译：包含极性和非极性环境的脂肪的药物组合物
公开(公告)号：WO2003011252A1
公开(公告)日：2003-02-13
申请号：PCT/GB2002/003488
申请日：2002-07-29
申请人： MITSUBISHI CHEMICAL CORPORATION , FLETCHER, Steven , JORGENSEN, Michael, R. , MILLER, Andrew, David
发明人： FLETCHER, Steven , JORGENSEN, Michael, R. , MILLER, Andrew, David
IPC分类号： A61K9/127
CPC分类号： A61K9/1273
摘要： The present invention provides a composition comprising (i) a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein the non-polar moiety is of the formula X-Y-Z- wherein X is an acetylenic hydrocarbyl group containing a single C≡C bond, Y is O or CH 2 , and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula -[T] m PHG, wherein [T] m is an optional group selected from C(O), NH, NR 1 , NHC(O), C(O)NH, NR 1 C(O) and C(O)NR 1 and CH 2 , where R 1 is a hydrocarbyl group, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties (ii) a therapeutic agent.
摘要翻译：本发明提供一种组合物，其包含（i）包含至少一个非极性部分和极性部分的脂质化合物，其中所述非极性部分具有式XYZ-，其中X是含有单个CC键的炔属烃基，Y是O或CH 2，Z是任选的烃基，其中极性部分具有式 - [T] m PHG，其中[T] m是选自C（O），NH，NR 1，NHC （O），C（O）NH，NR1C（O）和C（O）NR1和CH2，其中R1是烃基，其中PHG是极性头基，其中m是非极性部分的数目 ii）治疗剂。

6. 发明申请

WO1996034887A2 ANTISENSE PEPTIDES 审中-公开
标题翻译：抗原肽
公开(公告)号：WO1996034887A2
公开(公告)日：1996-11-07
申请号：PCT/GB1996001082
申请日：1996-05-07
申请人： IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE , LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE , MILLER, Andrew, David , RAYNES, John, Graham
发明人： IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE , LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
IPC分类号： C07K14/52
CPC分类号： C07K14/545 , A61K38/00 , C07K14/52 , C07K14/525 , C07K14/5421
摘要： Antisense peptides are provided which are useful in antagonising the biological effects of target molecules. In particular, the target molecule is a cytokine, e.g. IL-1 alpha or IL-1 beta , TNF alpha or IL-8 and the antisense peptides thus find use in treating or preventing conditions mediated by these cytokines, for instance inflammatory conditions or cancer.
摘要翻译：提供了可用于拮抗靶分子的生物学作用的反义肽。特别地，靶分子是细胞因子，例如。因此IL-1α或IL-1β，TNFα或IL-8和反义肽可用于治疗或预防由这些细胞因子介导的病症，例如炎性病症或癌症。

7. 发明申请

WO2007072042A3 IDENTIFICATION OF APOPTOSIS INDUCING PROTEINS 审中-公开
标题翻译：鉴定疫苗诱导蛋白
公开(公告)号：WO2007072042A3
公开(公告)日：2008-02-07
申请号：PCT/GB2006004898
申请日：2006-12-22
申请人： IMP INNOVATIONS LTD , FREEMAN THOMAS CHARLES , MILLER ANDREW DAVID , PALMER ELLA LOUISE
发明人： FREEMAN THOMAS CHARLES , MILLER ANDREW DAVID , PALMER ELLA LOUISE
IPC分类号： A61K38/17 , A61P35/00
CPC分类号： C07K14/4747
摘要： The present invention relates to the treatment and/or prophylaxis of a disease through the regulation of one or more genes involved in apoptosis. The invention also relates to a vector for use in regulating expression of the one or more genes in the treatment and/or prophylaxis of a disease involving apoptosis.
摘要翻译：本发明涉及通过调节参与凋亡的一种或多种基因治疗和/或预防疾病。本发明还涉及用于调节一种或多种基因在治疗和/或预防涉及凋亡的疾病中的表达的载体。

8. 发明申请

WO2008078102A2 LIPID 审中-公开
公开(公告)号：WO2008078102A2
公开(公告)日：2008-07-03
申请号：PCT/GB2007004967
申请日：2007-12-21
申请人： IMUTHES LTD , UNIV WITWATERSRAND , MILLER ANDREW DAVID , ARBUTHNOT PATRICK , JORGENSEN MICHAEL , KELLER MICHAEL , KAMALY NAZILA , AISSAOUI ABDERRAHIM , THANOU MAYA
发明人： MILLER ANDREW DAVID , ARBUTHNOT PATRICK , JORGENSEN MICHAEL , KELLER MICHAEL , KAMALY NAZILA , AISSAOUI ABDERRAHIM , THANOU MAYA
IPC分类号： A61K9/127 , A61K47/34 , A61K47/48 , C07C237/22 , C07F9/10 , C07J41/00 , C08G73/02 , C12N15/11 , C12N15/88
CPC分类号： C07C237/22 , A01K2267/0337 , A61K9/1272 , A61K47/34 , A61K47/543 , A61K47/6907 , A61K47/6911 , A61K48/0025 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2730/10111 , Y10T428/2984
摘要： The present invention provides a lipid of the formula (I) R 3 R 4 N-[Y] q -(C p H 2p )-X-Linker-NR 1 R 2 (I) wherein R 3 and R 4 are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (C n H 2n )NR 5 , wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R 5 is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from -NR 7 -, -C(=O)-N R 8 -, -NR 9 -C(=O)-, -C(=O)-, -O-, and -NR 10 -C(=0)0-, wherein each R 7 , R 8 , R 9 and R 10 is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula -(OCH 2 CH 2 ) 1-10 , -NR 6 -(CvH 2v )-C(=O)-, wherein R 6 is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and -C(=0)-(CH 2 ) 0-10 -CH 2 -C(=0)-; R 1 is selected from acyclic groups having from 4 to 30 carbon atoms; and R 2 is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.
摘要翻译：本发明提供式（I）的脂类R 3 R 4 N - [Y] q - （C p 其中R 3是氢原子，其中R 3，R 2，R 2，R 2，R 2，R 2，和R 4独立地选自H和烃基; q是从1至10的整数; Y表示一个基团（C n H n H 2n）NR 5，其中（i）当q为1时，n为2或（ii ）当q大于1时，每个Y可以相同或不同，并且每个n是独立地选自1至10的整数，条件是对于至少一个单元Y，n是2，和（iii）每个R 5个独立地选自H和烃基; p是从1到10的整数; X是选自-NR 7 - ， - C（= O）-NR 8 - ， - NR 9 -C（ = O） - ， - C（= O） - ， - O-和-NR 10 -C（= O）O-，其中每个R 7，R R 9，R 9和R 10独立地选自H和烃基，连接子是选自氨基酸残基，肽残基的任选基团和式 - （OCH 2 CH 2 CH 2）1 - ， - NR 6 - （C v H C（= O） - ，其中R 6为H或烃基，v为选自1至11的整数，且-C（= O ） - （CH _{2 ）_{0-10 -CH _{2 -C（= O） - ; R 1选自具有4至30个碳原子的无环基团; R 2选自H和具有4-30个碳原子的无环基。所述脂质可用于递送载体（例如胶束或脂质体）中以递送一种或多种（治疗或诊断）试剂。}}}

9. 发明申请

WO2003047549A3 POST-COATED LIPOSOME/LIPOPLEX FOR TARGETED DRUG/GENE DELIVERY AND LIPID LINKED TO A DELIVERY, TARGETING OR STABILISING MOIETY 审中-公开
公开(公告)号：WO2003047549A3
公开(公告)日：2003-06-12
申请号：PCT/GB2002/005471
申请日：2002-12-04
申请人： MITSUBISHI CHEMICAL CORPORATION , JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
发明人： JORGENSEN, Michael , KELLER, Michael , MILLER, Andrew, David , PEROUZEL, Eric
IPC分类号： A61K47/48
摘要： The present invention provides a delivery vehicle for a therapeutic agent comprising a modified lipid and a therapeutic agent; wherein the modified lipid comprises a lipid and a delivery, targeting or stabilising moiety (DTS moiety); wherein the lipid is linked to the DTS moiety via a linker which is stable in biological fluid and which is unstable in defined conditions; and wherein the DTS moiety is linked to the lipid alter formation of a complex of lipid and therapeutic agent.

10. 发明申请

WO0248380A3 GLYCOSILATED CATIONIC LIPIDS FOR LIPOSOMES USED IN DRUG DELIVERY 审中-公开
标题翻译：用于药物输送中用于脂质体的糖溶性阳离子脂肪
公开(公告)号：WO0248380A3
公开(公告)日：2002-10-24
申请号：PCT/GB0105383
申请日：2001-12-05
申请人： IC VEC LTD , JORGENSEN MICHAEL , KELLER MICHAEL , MILLER ANDREW DAVID , PEROUZEL ERIC
发明人： JORGENSEN MICHAEL , KELLER MICHAEL , MILLER ANDREW DAVID , PEROUZEL ERIC
IPC分类号： A61K9/127 , A61K31/15 , A61K31/575 , A61K31/7088 , A61K47/28 , A61K48/00 , C07J41/00 , C12N15/64 , C12N15/88 , C07J9/00
CPC分类号： C12N15/88 , A61K9/1272 , A61K31/15 , A61K31/575 , A61K48/00 , C07J41/00 , C07J41/0055 , C12N15/64 , A61K2300/00
摘要： The present invention provides a compound capable of acting as a cationic lipid, the compound comprises a cholesterol group and a carbohydrate moiety.
摘要翻译：本发明提供能够作为阳离子脂质的化合物，该化合物包含胆固醇基团和碳水化合物部分。

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