专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008021542A3 LYSINE ACTEYLATION SITES 审中-公开
公开(公告)号：WO2008021542A3
公开(公告)日：2008-02-21
申请号：PCT/US2007/018367
申请日：2007-08-17
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GU, Ting-lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
发明人： HORNBECK, Peter , GU, Ting-lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
IPC分类号： A61K38/00
摘要： The invention discloses 322 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.

2. 发明申请

WO2008008998A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测信号通路中的蛋白质磷酸化的试剂
公开(公告)号：WO2008008998A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073534
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
发明人： HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , C07K16/18 , C07K16/32 , C07K16/40 , G01N33/60 , G01N33/6842 , G01N33/6845 , G01N33/6848
摘要： The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.
摘要翻译：本发明公开了在信号转导蛋白质和途径中鉴定的新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽）用于选择性检测和定量这些磷酸化位点/ 蛋白质以及为此目的使用试剂的方法。在所鉴定的磷酸化位点中存在发生在以下蛋白质类型中的位点：衔接子/支架蛋白质，粘附/细胞外基质蛋白质，凋亡蛋白质，钙结合蛋白质，细胞周期调节蛋白质，分子伴侣蛋白质，染色质，DNA结合/修复/ 细胞骨架蛋白，内质网或高尔基蛋白，酶蛋白，G /调节蛋白，抑制蛋白，运动/收缩蛋白，磷酸酶，蛋白酶，Ser / Thr蛋白激酶，蛋白激酶（Tyr） RNA结合蛋白，转录调节因子，肿瘤抑制蛋白，泛素缀合系统蛋白和功能未知的蛋白。

3. 发明申请

WO2007133689A2 REAGENTS FOR THE DETECTION OF PROTEIN ACETYLATION SIGNALING PATHWAYS 审中-公开
标题翻译：检测蛋白质乙酰化信号途径的试剂
公开(公告)号：WO2007133689A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011420
申请日：2007-05-11
申请人： CELL SIGNALING TECHNOLOGY, INC. , GUO, Ailan , LI, Yu , GU, Ting-lei , MITCHELL, Jeffrey , HORNBECK, Peter
发明人： GUO, Ailan , LI, Yu , GU, Ting-lei , MITCHELL, Jeffrey , HORNBECK, Peter
IPC分类号： B21D11/10
CPC分类号： G01N33/6842 , C07K16/44
摘要： The invention discloses 426 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Methyltransferases, Transcription factors, Transcription coactivators, Translation initiation complex proteins, Oxireductases, Protein kinases, RNA binding proteins, Secreted proteins, Transferases, Transporter proteins, Ubiquitin conjugating system proteins, Motor proteins, Phosphotases, Proteases, Phospholipases, Receptor proteins and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的426个新的乙酰化位点和人蛋白质乙酰化信号通路的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化位点/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：甲基转移酶，转录因子，转录共激活因子，翻译起始复合蛋白，氧化还原酶，蛋白激酶，RNA结合蛋白，分泌蛋白，转移酶，转运蛋白，泛素缀合系统蛋白，马达蛋白质，磷酸酶，蛋白酶，磷脂酶，受体蛋白和囊泡蛋白。

4. 发明申请

WO2009126306A2 COMPOSITIONS AND METHODS FOR DETECTING EGFR MUTATIONS IN CANCER 审中-公开
标题翻译：用于检测癌症中EGFR突变的组合物和方法
公开(公告)号：WO2009126306A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/002247
申请日：2009-04-10
申请人： CELL SIGNALING TECHNOLOGY, INC. , GU, Ting-Lei , WU, Jiong , KANE, Susan , HAACK, Herbert , WIELER, James , CAI, Jun-ming , RIMKUNAS, Victoria , YU, Jian
发明人： GU, Ting-Lei , WU, Jiong , KANE, Susan , HAACK, Herbert , WIELER, James , CAI, Jun-ming , RIMKUNAS, Victoria , YU, Jian
IPC分类号： A61K48/00
CPC分类号： C07K16/2863 , C07K14/4703 , C07K14/485 , C07K2317/20 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/57423 , G01N33/57484 , G01N2800/52
摘要： The invention discloses binding agents to the E746 - A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.
摘要翻译：本发明公开了表皮生长因子受体（EGFR）分子中E746-A750缺失和L858R点突变的结合剂及其使用方法，包括诊断和治疗癌症的方法。

5. 发明申请

WO2009075825A2 TRANSLOCATION AND MUTANT TNK1 KINASE IN HUMAN LYMPHOMA 审中-公开
标题翻译：跨淋巴细胞和突变型TNK1在人淋巴瘤中的激酶
公开(公告)号：WO2009075825A2
公开(公告)日：2009-06-18
申请号：PCT/US2008/013516
申请日：2008-12-08
申请人： CELL SIGNALING TECHNOLOGY, INC. , GU, Ting-Lei
发明人： GU, Ting-Lei
IPC分类号： C12N9/12
CPC分类号： C12N9/12
摘要： In accordance with the invention, a novel gene translocation in human Hodgkin's lymphoma (HL) that results in a fusion protein combining part of C17ORF61 with Thirty-eight-negative kinase 1 (Tnkl) kinase has now been identified. The TNK1-C17ORF61 fusion protein, which retains TNKl tyrosine kinase activity, was confirmed to drive the proliferation and survival of Hodgkin's lymphoma (HL) cell line, L-540. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant TNKl kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of this new fusion protein and truncated kinase enables new methods for determining the presence of these mutant TNK1 kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.
摘要翻译：根据本发明，人霍奇金淋巴瘤（HL）中的新基因易位导致融合蛋白结合部分C17ORF61与三十八阴性激酶1（Tnk1）激酶鉴定。保留TNK1酪氨酸激酶活性的TNK1-C17ORF61融合蛋白被证实能够驱动霍奇金淋巴瘤（HL）细胞系L-540的增殖和存活。因此，本发明部分地提供了编码所公开的突变型TNK1激酶多肽的分离的多核苷酸和载体，用于检测它的探针，分离的突变多肽，重组多肽和用于检测融合和截短的多肽的试剂。所公开的这种新的融合蛋白和截短的激酶的鉴定使得能够确定生物样品中这些突变型TNK1激酶多肽的存在的新方法，筛选抑制蛋白质的化合物的方法，以及抑制癌症进展的方法，其特征在于突变的多核苷酸或多肽，其也由本发明提供。

6. 发明申请

WO2009054939A2 CANCER CLASSIFICATION AND METHODS OF USE 审中-公开
标题翻译：癌症分类及使用方法
公开(公告)号：WO2009054939A2
公开(公告)日：2009-04-30
申请号：PCT/US2008/011969
申请日：2008-10-21
申请人： CELL SIGNALING TECHNOLOGY, INC. , RIKOVA, Klarisa
发明人： RIKOVA, Klarisa
IPC分类号： C07K16/30 , G01N33/566 , G01N33/574
CPC分类号： G01N33/57423 , A61K31/506 , C12Q1/485 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57415 , G01N33/5743 , G01N33/57434 , G01N33/57446 , G01N33/57492 , G01N2333/91205 , G01N2800/52 , G01N2800/7028
摘要： The present invention relates to methods of classifying cancer cells based on the presence, absence or level of a tyrosine kinase or a phosphorylated tyrosine kinase. The present invention also relates to methods of treating cancer using cancer classification. The present invention further relates to methods of determining the effectiveness of a treatment for cancer using cancer classification.
摘要翻译：本发明涉及基于酪氨酸激酶或磷酸化酪氨酸激酶的存在，不存在或水平对癌细胞进行分类的方法。本发明还涉及使用癌症分类治疗癌症的方法。本发明还涉及使用癌症分类来确定癌症治疗的有效性的方法。

7. 发明申请

WO2008073162A3 LYSINE ACETYLATION SITES 审中-公开
公开(公告)号：WO2008073162A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/018275
申请日：2007-08-17
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GU, Ting-Lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
发明人： HORNBECK, Peter , GU, Ting-Lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
IPC分类号： A61K38/00
摘要： The invention discloses 332 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.

8. 发明申请

WO2008030543A2 TYROSINE, SERINE AND THREONINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸，丝氨酸和磷酸化磷酸化位点
公开(公告)号：WO2008030543A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/019488
申请日：2007-09-07
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , MORITZ, Albrecht , RUSH, John , BEAUSOLEIL, Sean , VILLEN, Judit , GERBER, Scott , GYGI, Steven
发明人： HORNBECK, Peter , MORITZ, Albrecht , RUSH, John , BEAUSOLEIL, Sean , VILLEN, Judit , GERBER, Scott , GYGI, Steven
IPC分类号： C07K16/46
CPC分类号： C07K16/18 , C07K16/28 , C07K16/2833 , C07K16/2863 , C07K16/30 , C07K2317/30 , C07K2317/34
摘要： The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和白血病中鉴定的155个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

9. 发明申请

WO2009051846A3 TRANSLOCATION AND MUTANT ROS KINASE IN HUMAN NON-SMALL CELL LUNG CARCINOMA 审中-公开
公开(公告)号：WO2009051846A3
公开(公告)日：2009-04-23
申请号：PCT/US2008/011968
申请日：2008-10-20
申请人： CELL SIGNALING TECHNOLOGY, INC. , GU, Ting-lei , GUO, Ailan
发明人： GU, Ting-lei , GUO, Ailan
IPC分类号： C12N15/00 , C12P21/02 , C07K14/00 , A61K38/16
摘要： In accordance with the invention, a novel gene translocation, (5q32, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of CD74 with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The CD74-ROS fusion protein is anticipated to drive the proliferation and survival of a subgroup of NSCLC tumors. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of the new fusion protein enables new methods for determining the presence of these mutant ROS kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.

10. 发明申请

WO2008036337A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测白血病信号途径中蛋白质磷酸化的试剂
公开(公告)号：WO2008036337A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/020343
申请日：2007-09-18
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-lei , MORITZ, Albrecht
发明人： HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-lei , MORITZ, Albrecht
IPC分类号： A61K39/395
CPC分类号： C07K16/44
摘要： The invention discloses 443 novel phosphorylation sites identified in leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在白血病中鉴定的443个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式