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1. 发明申请

WO2008021542A3 LYSINE ACTEYLATION SITES 审中-公开
公开(公告)号：WO2008021542A3
公开(公告)日：2008-02-21
申请号：PCT/US2007/018367
申请日：2007-08-17
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GU, Ting-lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
发明人： HORNBECK, Peter , GU, Ting-lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
IPC分类号： A61K38/00
摘要： The invention discloses 322 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.

2. 发明申请

WO2007133689A2 REAGENTS FOR THE DETECTION OF PROTEIN ACETYLATION SIGNALING PATHWAYS 审中-公开
标题翻译：检测蛋白质乙酰化信号途径的试剂
公开(公告)号：WO2007133689A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011420
申请日：2007-05-11
申请人： CELL SIGNALING TECHNOLOGY, INC. , GUO, Ailan , LI, Yu , GU, Ting-lei , MITCHELL, Jeffrey , HORNBECK, Peter
发明人： GUO, Ailan , LI, Yu , GU, Ting-lei , MITCHELL, Jeffrey , HORNBECK, Peter
IPC分类号： B21D11/10
CPC分类号： G01N33/6842 , C07K16/44
摘要： The invention discloses 426 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Methyltransferases, Transcription factors, Transcription coactivators, Translation initiation complex proteins, Oxireductases, Protein kinases, RNA binding proteins, Secreted proteins, Transferases, Transporter proteins, Ubiquitin conjugating system proteins, Motor proteins, Phosphotases, Proteases, Phospholipases, Receptor proteins and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的426个新的乙酰化位点和人蛋白质乙酰化信号通路的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化位点/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：甲基转移酶，转录因子，转录共激活因子，翻译起始复合蛋白，氧化还原酶，蛋白激酶，RNA结合蛋白，分泌蛋白，转移酶，转运蛋白，泛素缀合系统蛋白，马达蛋白质，磷酸酶，蛋白酶，磷脂酶，受体蛋白和囊泡蛋白。

3. 发明申请

WO2008073162A3 LYSINE ACETYLATION SITES 审中-公开
公开(公告)号：WO2008073162A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/018275
申请日：2007-08-17
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GU, Ting-Lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
发明人： HORNBECK, Peter , GU, Ting-Lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
IPC分类号： A61K38/00
摘要： The invention discloses 332 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.

4. 发明申请

WO2008054597A2 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：WO2008054597A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/021086
申请日：2007-09-28
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GUO, Ailan , RIKOVA, Klarisa , MORITZ, Albrecht , SPEK, Erik , POSSEMATO, Anthony , FARNSWORTH, Charles , BOCCALATTE, Francesco , YU, Jian , MITCHELL, Jeffrey , RUSH, John , GOSS, Valerie , GU, Ting-lei , LI, Yu , STOKES, Matthew
发明人： HORNBECK, Peter , GUO, Ailan , RIKOVA, Klarisa , MORITZ, Albrecht , SPEK, Erik , POSSEMATO, Anthony , FARNSWORTH, Charles , BOCCALATTE, Francesco , YU, Jian , MITCHELL, Jeffrey , RUSH, John , GOSS, Valerie , GU, Ting-lei , LI, Yu , STOKES, Matthew
IPC分类号： G01N33/574
CPC分类号： C12Q1/485 , A61K38/00 , A61K39/0011 , C07K14/4748 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K16/44 , C07K2317/34 , C12Q1/42 , G01N33/574 , G01N33/6812 , G01N33/6842
摘要： The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的318个新磷酸化位点，包含本发明磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新型磷酸化位点的抗体，以及诊断和治疗用途以上。

5. 发明申请

WO2007133702A2 REAGENTS FOR THE DETECTION OF PROTEIN ACETYLATION SIGNALING PATHWAYS 审中-公开
标题翻译：检测蛋白质乙酰化信号途径的试剂
公开(公告)号：WO2007133702A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011444
申请日：2007-05-11
申请人： CELL SIGNALING TECHNOLOGY, INC. , GUO, Ailan , GU, Ting-Lei , MITCHELL, Jeffrey , HORNBECK, Peter
发明人： GUO, Ailan , GU, Ting-Lei , MITCHELL, Jeffrey , HORNBECK, Peter
IPC分类号： B05D5/06
CPC分类号： G01N33/68 , C07K16/18 , C07K16/44 , G01N33/6842
摘要： The invention discloses 432 novel acetylatioπ sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Acetyltransferases, Adaptor/Scaffold proteins, Actin binding proteins, Adhesion proteins, Apoptosis proteins, Calcium-binding proteins, Cell Cycle Regulation proteins, Cell Surface proteins, DNA binding proteins, DNA replication proteins, Channel proteins, Chaperone proteins, Cellular Metabolism enzymes, Cytoskeletal proteins, DNA repair proteins, Endoplasmic reticulum proteins, Enzyme proteins, G protein and GTPase Activating proteins, Guanine Nucleotide Exchange Factors, Helicase proteins, lsomerase proteins, Extracelluar matrix proteins, Hydrolases, Ligase proteins, Lipid kinases, lnhibtor proteins, Lipid Binding proteins and Lyases.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的432种新的乙酰基部位，以及人类蛋白质乙酰化信号传导途径的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化部位/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：乙酰转移酶，适配器/支架蛋白，肌动蛋白结合蛋白，粘附蛋白，细胞凋亡蛋白，钙结合蛋白，细胞周期调节蛋白，细胞表面蛋白，DNA结合蛋白，DNA 复制蛋白，通道蛋白，伴侣蛋白，细胞代谢酶，细胞骨架蛋白，DNA修复蛋白，内质网蛋白，酶蛋白，G蛋白和GTP酶活化蛋白，鸟嘌呤核苷酸交换因子，Helicase蛋白，lsomerase蛋白，Extracelluar基质蛋白，水解酶，连接酶蛋白，脂质激酶，抑制蛋白，脂质结合蛋白和裂解酶。

6. 发明申请

WO2008008998A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测信号通路中的蛋白质磷酸化的试剂
公开(公告)号：WO2008008998A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073534
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
发明人： HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , C07K16/18 , C07K16/32 , C07K16/40 , G01N33/60 , G01N33/6842 , G01N33/6845 , G01N33/6848
摘要： The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.
摘要翻译：本发明公开了在信号转导蛋白质和途径中鉴定的新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽）用于选择性检测和定量这些磷酸化位点/ 蛋白质以及为此目的使用试剂的方法。在所鉴定的磷酸化位点中存在发生在以下蛋白质类型中的位点：衔接子/支架蛋白质，粘附/细胞外基质蛋白质，凋亡蛋白质，钙结合蛋白质，细胞周期调节蛋白质，分子伴侣蛋白质，染色质，DNA结合/修复/ 细胞骨架蛋白，内质网或高尔基蛋白，酶蛋白，G /调节蛋白，抑制蛋白，运动/收缩蛋白，磷酸酶，蛋白酶，Ser / Thr蛋白激酶，蛋白激酶（Tyr） RNA结合蛋白，转录调节因子，肿瘤抑制蛋白，泛素缀合系统蛋白和功能未知的蛋白。

7. 发明申请

WO2008036337A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测白血病信号途径中蛋白质磷酸化的试剂
公开(公告)号：WO2008036337A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/020343
申请日：2007-09-18
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-lei , MORITZ, Albrecht
发明人： HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-lei , MORITZ, Albrecht
IPC分类号： A61K39/395
CPC分类号： C07K16/44
摘要： The invention discloses 443 novel phosphorylation sites identified in leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在白血病中鉴定的443个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

8. 发明申请

WO2008009004A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
公开(公告)号：WO2008009004A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073542
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-lei , MORITZ, Albrecht
发明人： HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-lei , MORITZ, Albrecht
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C07B59/008 , C07K14/47 , C07K16/44 , G01N33/6842 , G01N2458/15
摘要： The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.

9. 发明申请

WO2008009000A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
标题翻译：在信号通路中检测蛋白质磷酸化的试剂
公开(公告)号：WO2008009000A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073537
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
发明人： HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , C12Q1/485 , G01N33/6842 , G01N33/6845 , G01N33/6848 , G01N33/6872
摘要： The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, Protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.
摘要翻译：本发明公开了在信号转导蛋白和途径中鉴定的新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，以及使用用于此目的的试剂。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：衔接子/支架蛋白，粘附/细胞外基质蛋白，凋亡蛋白，钙结合蛋白，细胞周期调节蛋白，伴侣蛋白，染色质，DNA结合/修复/复制蛋白，细胞骨架蛋白，内质网或高尔基体蛋白，酶蛋白，G /调节蛋白，抑制蛋白，运动/收缩蛋白，磷酸酶，蛋白酶，Ser / Thr蛋白激酶，蛋白激酶（Tyr），受体/通道/细胞表面蛋白， RNA结合蛋白，转录调节物，肿瘤抑制蛋白，泛素偶联系统蛋白和功能未知的蛋白。

10. 发明申请

WO2008030543A2 TYROSINE, SERINE AND THREONINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸，丝氨酸和磷酸化磷酸化位点
公开(公告)号：WO2008030543A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/019488
申请日：2007-09-07
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , MORITZ, Albrecht , RUSH, John , BEAUSOLEIL, Sean , VILLEN, Judit , GERBER, Scott , GYGI, Steven
发明人： HORNBECK, Peter , MORITZ, Albrecht , RUSH, John , BEAUSOLEIL, Sean , VILLEN, Judit , GERBER, Scott , GYGI, Steven
IPC分类号： C07K16/46
CPC分类号： C07K16/18 , C07K16/28 , C07K16/2833 , C07K16/2863 , C07K16/30 , C07K2317/30 , C07K2317/34
摘要： The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和白血病中鉴定的155个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

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