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1. 发明申请

WO2008008998A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测信号通路中的蛋白质磷酸化的试剂
公开(公告)号：WO2008008998A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073534
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
发明人： HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , C07K16/18 , C07K16/32 , C07K16/40 , G01N33/60 , G01N33/6842 , G01N33/6845 , G01N33/6848
摘要： The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.
摘要翻译：本发明公开了在信号转导蛋白质和途径中鉴定的新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽）用于选择性检测和定量这些磷酸化位点/ 蛋白质以及为此目的使用试剂的方法。在所鉴定的磷酸化位点中存在发生在以下蛋白质类型中的位点：衔接子/支架蛋白质，粘附/细胞外基质蛋白质，凋亡蛋白质，钙结合蛋白质，细胞周期调节蛋白质，分子伴侣蛋白质，染色质，DNA结合/修复/ 细胞骨架蛋白，内质网或高尔基蛋白，酶蛋白，G /调节蛋白，抑制蛋白，运动/收缩蛋白，磷酸酶，蛋白酶，Ser / Thr蛋白激酶，蛋白激酶（Tyr） RNA结合蛋白，转录调节因子，肿瘤抑制蛋白，泛素缀合系统蛋白和功能未知的蛋白。

2. 发明申请

WO2008009000A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
标题翻译：在信号通路中检测蛋白质磷酸化的试剂
公开(公告)号：WO2008009000A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/073537
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
发明人： HORNBECK, Peter , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , C12Q1/485 , G01N33/6842 , G01N33/6845 , G01N33/6848 , G01N33/6872
摘要： The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, Protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.
摘要翻译：本发明公开了在信号转导蛋白和途径中鉴定的新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，以及使用用于此目的的试剂。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：衔接子/支架蛋白，粘附/细胞外基质蛋白，凋亡蛋白，钙结合蛋白，细胞周期调节蛋白，伴侣蛋白，染色质，DNA结合/修复/复制蛋白，细胞骨架蛋白，内质网或高尔基体蛋白，酶蛋白，G /调节蛋白，抑制蛋白，运动/收缩蛋白，磷酸酶，蛋白酶，Ser / Thr蛋白激酶，蛋白激酶（Tyr），受体/通道/细胞表面蛋白， RNA结合蛋白，转录调节物，肿瘤抑制蛋白，泛素偶联系统蛋白和功能未知的蛋白。

3. 发明申请

WO2007027906A3 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS 审中-公开
公开(公告)号：WO2007027906A3
公开(公告)日：2007-03-08
申请号：PCT/US2006/034050
申请日：2006-08-31
申请人： CELL SIGNALING TECHNOLOGY, INC. , POLAKIEWICZ, Roberto , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
发明人： POLAKIEWICZ, Roberto , GOSS, Valerie , LEE, Kimberly , GU, Ting-Lei , MORITZ, Albrecht
IPC分类号： G01N33/53
摘要： The invention discloses nearly 288 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeletal proteins, Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor proteins, Immunoglobulin Superfamily proteins, Inhibitor proteins, Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription proteins, Serine/Threonine Protein Kinases, Tyrosine Kinases, Protein Phosphatases, and Translation/Transporter proteins.

4. 发明申请

WO2006086111A2 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS 审中-公开
标题翻译：用于检测白血病信号途径中蛋白质磷酸化的试剂
公开(公告)号：WO2006086111A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/000979
申请日：2006-01-12
申请人： CELL SIGNALING TECHNOLOGY, INC. , GOSS, Valerie , MORITZ, Albrecht , GU, Ting-Lei , LEE, Kimberly , POLAKIEWICZ, Roberto
发明人： GOSS, Valerie , MORITZ, Albrecht , GU, Ting-Lei , LEE, Kimberly , POLAKIEWICZ, Roberto
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C07K14/47 , C07K16/18 , C07K16/40 , C07K16/44
摘要： The invention discloses 424 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeletal proteins, Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor proteins, Immunoglobulin Superfamily proteins, Inhibitor proteins, Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription proteins, Serine/Threonine Protein Kinases, Tyrosine Kinases, Protein Phosphatases, and Translation/Transporter proteins.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的424个新的磷酸化位点和人类白血病的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质作为使用试剂用于此目的的方法。所鉴定的磷酸化位点是以下蛋白质类型的位点：适配器/支架蛋白，细胞骨架蛋白，细胞代谢酶，G蛋白/ GTP酶激活/鸟嘌呤核苷酸交换因子蛋白，免疫球蛋白超家族蛋白，抑制蛋白，脂质激酶，核DNA 修复/ RNA结合/转录蛋白，丝氨酸/苏氨酸蛋白激酶，酪氨酸激酶，蛋白磷酸酶和翻译/转运蛋白。

5. 发明申请

WO2008153636A1 PHOSPHO-SPECIFIC ANTIBODIES TO P13K REGULATORY SUBUNIT AND USES THEREOF 审中-公开
标题翻译：磷酸特异性抗体对P13K法规亚基及其用途
公开(公告)号：WO2008153636A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/005791
申请日：2008-05-05
申请人： CELLSIGNALING TECHNOLOGY, INC. , WIEDERHOLD, Thorsten , GOSS, Valerie , MORITZ, Albrecht , RIKOVA, Klarisa , GU, Ting-Lei , HORNBECK, Peter
发明人： WIEDERHOLD, Thorsten , GOSS, Valerie , MORITZ, Albrecht , RIKOVA, Klarisa , GU, Ting-Lei , HORNBECK, Peter
IPC分类号： G01N33/574 , A61K39/395
CPC分类号： G01N33/573 , C07K16/40
摘要： The invention discloses ten newly discovered PI3K regulatory subunit phosphorylation sites, tyrosines 467, 452, 463, and 470 in PI3KR1 (PI3Kp85 alpha), tyrosines 464, 460, and 467 in PI3KR2 (PI3Kp85 beta), and tyrosines 199, 184, and 202 in PI3KR3 (PI3Kp55 gamma), and provides reagents, including polyclonal and monoclonal antibodies, that selectively bind to PI3K when phosphorylated at one of the disclosed sites. Also provided are assays utilizing this reagent, including methods for determining the phosphorylation of PI3K in a biological sample, selecting a patient suitable for PI3K inhibitor therapy, profiling PI3K activation in a test tissue, and identifying a compound that modulates phosphorylation of PI3K in a test tissue, by using a detectable reagent, such as the disclosed antibody, that binds to PI3K only when phosphorylated at a disclosed site. The sample or test tissue may be taken from a subject suspected of having cancer, such as lymphoma, glioma, and colon cancer, involving altered PI3K signaling.
摘要翻译：本发明公开了PI3KR1（PI3Kp85α），PI3KR2（PI3Kp85β）中酪氨酸464,460和467和酪氨酸199,184和202中的10个新发现的PI3K调节亚基磷酸化位点，酪氨酸467,452,463和470 在PI3KR3（PI3Kp55γ）中，并且提供试剂，包括多克隆和单克隆抗体，当在所公开的位点之一磷酸化时选择性地结合PI3K。还提供了使用该试剂的测定法，包括用于测定生物样品中PI3K的磷酸化的方法，选择适合于PI3K抑制剂治疗的患者，在测试组织中分析PI3K活化，以及鉴定在测试中调节PI3K磷酸化的化合物组织，通过使用仅在所公开的位点磷酸化时与PI3K结合的可检测试剂，例如所公开的抗体。样品或测试组织可以取自怀疑患有癌症的受试者，例如淋巴瘤，神经胶质瘤和结肠癌，涉及改变的PI3K信号传导。

6. 发明申请

WO2007133702A2 REAGENTS FOR THE DETECTION OF PROTEIN ACETYLATION SIGNALING PATHWAYS 审中-公开
标题翻译：检测蛋白质乙酰化信号途径的试剂
公开(公告)号：WO2007133702A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011444
申请日：2007-05-11
申请人： CELL SIGNALING TECHNOLOGY, INC. , GUO, Ailan , GU, Ting-Lei , MITCHELL, Jeffrey , HORNBECK, Peter
发明人： GUO, Ailan , GU, Ting-Lei , MITCHELL, Jeffrey , HORNBECK, Peter
IPC分类号： B05D5/06
CPC分类号： G01N33/68 , C07K16/18 , C07K16/44 , G01N33/6842
摘要： The invention discloses 432 novel acetylatioπ sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Acetyltransferases, Adaptor/Scaffold proteins, Actin binding proteins, Adhesion proteins, Apoptosis proteins, Calcium-binding proteins, Cell Cycle Regulation proteins, Cell Surface proteins, DNA binding proteins, DNA replication proteins, Channel proteins, Chaperone proteins, Cellular Metabolism enzymes, Cytoskeletal proteins, DNA repair proteins, Endoplasmic reticulum proteins, Enzyme proteins, G protein and GTPase Activating proteins, Guanine Nucleotide Exchange Factors, Helicase proteins, lsomerase proteins, Extracelluar matrix proteins, Hydrolases, Ligase proteins, Lipid kinases, lnhibtor proteins, Lipid Binding proteins and Lyases.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的432种新的乙酰基部位，以及人类蛋白质乙酰化信号传导途径的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化部位/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：乙酰转移酶，适配器/支架蛋白，肌动蛋白结合蛋白，粘附蛋白，细胞凋亡蛋白，钙结合蛋白，细胞周期调节蛋白，细胞表面蛋白，DNA结合蛋白，DNA 复制蛋白，通道蛋白，伴侣蛋白，细胞代谢酶，细胞骨架蛋白，DNA修复蛋白，内质网蛋白，酶蛋白，G蛋白和GTP酶活化蛋白，鸟嘌呤核苷酸交换因子，Helicase蛋白，lsomerase蛋白，Extracelluar基质蛋白，水解酶，连接酶蛋白，脂质激酶，抑制蛋白，脂质结合蛋白和裂解酶。

7. 发明申请

WO2008073162A3 LYSINE ACETYLATION SITES 审中-公开
公开(公告)号：WO2008073162A3
公开(公告)日：2008-06-19
申请号：PCT/US2007/018275
申请日：2007-08-17
申请人： CELL SIGNALING TECHNOLOGY, INC. , HORNBECK, Peter , GU, Ting-Lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
发明人： HORNBECK, Peter , GU, Ting-Lei , GUO, Ailan , FARNSWORTH, Charles , LI, Yu , MITCHELL, Jeffrey
IPC分类号： A61K38/00
摘要： The invention discloses 332 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.

8. 发明申请

WO2009148628A2 TYROSINE PHOSPHORYLATION SITES IN TNK1 KINASE 审中-公开
标题翻译： TNK1激酶中的酪氨酸磷酸化位点
公开(公告)号：WO2009148628A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/003454
申请日：2009-06-08
申请人： CELL SIGNALING TECHNOLOGY, INC. , GU, Ting-Lei
发明人： GU, Ting-Lei
IPC分类号： C07K16/18 , G01N33/53
CPC分类号： G01N33/573 , C07K16/40 , C12Q1/485 , G01N33/574 , G01N33/57426
摘要： The invention discloses novel phosphorylation sites in the TNKl protein that were identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising such phosphorylation sites, antibodies that specifically bind to such phosphorylation sites, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的TNK1蛋白中的新型磷酸化位点，包含这种磷酸化位点的肽（包括AQUA肽），特异性结合于这种磷酸化位点的抗体以及上述的诊断和治疗用途。

9. 发明申请

WO2012162373A1 ROS KINASE IN LUNG CANCER 审中-公开
标题翻译： ROS在肺癌中发生
公开(公告)号：WO2012162373A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/039108
申请日：2012-05-23
申请人： CELL SIGNALING TECHNOLOGY, INC. , RIMKUNAS, Victoria McGuinness , HAACK, Herbert , GU, Ting-Lei , GUO, Ailan , POSSEMATO, Anthony Paul , CROSBY, Katherine Eleanor , TUCKER, Meghan Ann , REEVES, Cynthia
发明人： RIMKUNAS, Victoria McGuinness , HAACK, Herbert , GU, Ting-Lei , GUO, Ailan , POSSEMATO, Anthony Paul , CROSBY, Katherine Eleanor , TUCKER, Meghan Ann , REEVES, Cynthia
IPC分类号： G01N33/574
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N2333/912
摘要： The invention provides the identification of the presence of polypeptides with ROS kinase activity in mammalian lung cancer. In some embodiments, the polypeptide with ROS kinase activity is the result of a fusion between a ROS-encoding polynucleotide and a polynucleotide encoding a second (non-ROS) polypeptide. Three different fusion partners of ROS are described, namely proteins encoded by the FIG gene, the SLC34A2 gene, and the CD74 gene. The invention enables new methods for determining the presence of a polypeptide with ROS kinase activity in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer (e.g., a lung cancer).
摘要翻译：本发明提供了哺乳动物肺癌中存在具有ROS激酶活性的多肽的鉴定。在一些实施方案中，具有ROS激酶活性的多肽是编码ROS编码多核苷酸和编码第二（非ROS）多肽的多核苷酸之间融合的结果。描述了ROS的三种不同的融合配偶体，即由FIG基因编码的蛋白质，SLC34A2基因和CD74基因。本发明使得用于确定生物样品中具有ROS激酶活性的多肽的存在的新方法，用于筛选抑制蛋白质的化合物的方法，以及抑制癌症进展的方法（例如肺癌）。

10. 发明申请

WO2009126306A2 COMPOSITIONS AND METHODS FOR DETECTING EGFR MUTATIONS IN CANCER 审中-公开
标题翻译：用于检测癌症中EGFR突变的组合物和方法
公开(公告)号：WO2009126306A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/002247
申请日：2009-04-10
申请人： CELL SIGNALING TECHNOLOGY, INC. , GU, Ting-Lei , WU, Jiong , KANE, Susan , HAACK, Herbert , WIELER, James , CAI, Jun-ming , RIMKUNAS, Victoria , YU, Jian
发明人： GU, Ting-Lei , WU, Jiong , KANE, Susan , HAACK, Herbert , WIELER, James , CAI, Jun-ming , RIMKUNAS, Victoria , YU, Jian
IPC分类号： A61K48/00
CPC分类号： C07K16/2863 , C07K14/4703 , C07K14/485 , C07K2317/20 , C07K2317/34 , C07K2317/56 , C07K2317/565 , G01N33/57423 , G01N33/57484 , G01N2800/52
摘要： The invention discloses binding agents to the E746 - A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.
摘要翻译：本发明公开了表皮生长因子受体（EGFR）分子中E746-A750缺失和L858R点突变的结合剂及其使用方法，包括诊断和治疗癌症的方法。

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