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1. 发明申请

WO2009032722A1 CARBAMYLATED PROTEINS AND RISK OF CARDIOVASCULAR DISEASE 审中-公开
标题翻译：碳水化合物蛋白质和心血管疾病风险
公开(公告)号：WO2009032722A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/074557
申请日：2008-08-28
申请人： THE CLEVELAND CLINIC FOUNDATION , HAZEN, Stanely, L. , WANG, Zeneng , NICHOLLS, Stephen, James , DIDONATO, Joe
发明人： HAZEN, Stanely, L. , WANG, Zeneng , NICHOLLS, Stephen, James , DIDONATO, Joe
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/92 , G01N33/6812 , G01N33/6854 , G01N2333/75 , G01N2333/765 , G01N2800/32
摘要： Methods for characterizing a test subject's, particularly a human test subject's, risk of having cardiovascular disease or developing cardiovascular disease are provided. Also provided are methods for characterizing a test subject's risk of experiencing a complication of cardiovascular disease near term. The methods comprise determining levels of one or more carbamylated biomarkers in a bodily fluid of the test subject and/or comparing these levels with a reference value. In certain embodiments, the carbamylated biomarkers are carbamylated albumin, carbamylated fibrinogen, carbamylated immunoglobulin and carbamylated apolipoprotein A. In other embodiments, particularly where the test subject does not have clinical evidence of renal disease, the carbamylated biomarker is free and/or total peptide-bound homocitrulline.
摘要翻译：提供了表征测试对象，特别是人体测试对象的心血管疾病或发展为心血管疾病的风险的方法。还提供了表征测试受试者在短期内经历心血管疾病并发症的风险的方法。所述方法包括确定测试对象的体液中的一种或多种氨基甲酰化生物标志物的水平和/或将这些水平与参考值进行比较。在某些实施方案中，氨基甲酰化的生物标志物是氨基甲酰化的白蛋白，氨基甲酰化纤维蛋白原，氨基甲酰化的免疫球蛋白和氨基甲酰化的载脂蛋白A.在其它实施方案中，特别是在测试受试者没有肾脏疾病的临床证据的情况下，氨基甲酰化的生物标志物是游离的和/ 结合高丝氨酸。

2. 发明申请

WO2005123962A3 GENE TARGETING IN EUKARYOTIC CELLS BY GROUP II INTRON RIBONUCLEOPROTEIN PARTICLES 审中-公开
公开(公告)号：WO2005123962A3
公开(公告)日：2005-12-29
申请号：PCT/US2005/020894
申请日：2005-06-14
申请人： THE UNIVERSITY OF TEXAS AT AUSTIN , CUI, Xiaoxia , LAMBOWITZ, Alan , VERNON, Jamie, L. , WATANBE, Kazuo
发明人： CUI, Xiaoxia , LAMBOWITZ, Alan , VERNON, Jamie, L. , WATANBE, Kazuo
IPC分类号： C12N15/85
摘要： Provided herein are methods of disrupting DNA substrates in eukaryotic cells and methods of introducing exogenous polynucleotides into target sites in the DNA substrates In certain embodiments the methods comprise introducing a purified group II intron ribonucleoprotein (RNP) particle into the host cell. In certain embodiments the method comprises introducing a group II intron RNP particle and a DNA construct comprising an exogenous polynucleotide flanked by sequences that are homologous to sequences that flank the target site in the endogenous DNA substrate. In certain embodiments, the methods also involve introducing magnesium ions into the eukaryotic cells.

3. 发明申请

WO2004034888A2 METHOD FOR RATING SEVERITY OF PSORIASIS 审中-公开
标题翻译：评估PSORIASIS的严重性的方法
公开(公告)号：WO2004034888A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/033218
申请日：2003-10-20
申请人： ELLIS, Charles, N.
发明人： ELLIS, Charles, N.
IPC分类号： A61B
CPC分类号： A61B5/7264 , A61B5/441
摘要： Methods for rating the severity of psoriasis in a patient are provided. Such methods comprise assessing the percent of the patient’s body surface exhibiting signs of psoriasis, assessing the overall elevation, erythema, and scale of the patient’s psoriasis plaques, and classifying the severity of the patient’s psoriasis into at least four classes based upon the percent of the patient’s body surface exhibiting signs of psoriasis adjusted by the overall elevation, erythema and scale of the patient’s psoriasis plaques. In the present methods the weight given to one or more of the overall qualities of elevation, erythema or scale of the patient’s psoriasis plaques in classifying the severity of the patient’s psoriasis into a higher class is greater than the weight given to other of the overall qualities. A computer readable medium and system for practicing the present methods are also provided.
摘要翻译：提供了评估患者牛皮癣严重程度的方法。这些方法包括评估患有牛皮癣症状的患者身体表面的百分比，评估患者牛皮癣斑块的总体高度，红斑和鳞屑以及将患者牛皮癣的严重程度分为至少四个等级，基于患者的身体表面呈现由银屑病斑块的整体高程，红斑和鳞屑调节的银屑病征象。在本方法中，给予患者牛皮癣斑块的高度，红斑或鳞屑的一个或多个整体质量的重量将患者牛皮癣的严重程度分类为更高级别的重量大于给予其他整体品质的重量。还提供了一种用于实施本方法的计算机可读介质和系统。

4. 发明申请

WO2004000236A3 MODIFIED SODIUM IODIDE SYMPORTER PROTEINS AND GENES FOR IMAGING AND CANCER THERAPY 审中-公开
公开(公告)号：WO2004000236A3
公开(公告)日：2003-12-31
申请号：PCT/US2003/020111
申请日：2003-06-25
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , JHIANG, Sissy, M. , SHEN, Daniel, Hy , LIN, Xiaoqin
发明人： JHIANG, Sissy, M. , SHEN, Daniel, Hy , LIN, Xiaoqin
IPC分类号： C12N15/00
摘要： The invention provides modified sodium iodide symporter (NIS) proteins, and polynucleotides encoding modified NIS proteins. The modified NIS proteins have a net electrostatic charge more positive than that of corresponding wild-type NIS proteins. Expression of a modified NIS protein in a cell results in higher intracellular concentrations of NIS substrates as compared to equivalent expression of the corresponding wild-type NIS protein in a cell. The invention also provides methods for imaging cells or for therapy of cancer cells, using the modified NIS proteins to facilitate transport of NIS substrates into cells in the body of an individual. Uptake of NIS substrates suitable for either imaging or that have cytotoxic activity, into the cells of the individual that express modified NIS protein facilitate detection of the substrate (for imaging) or killing of the cancer cells (for therapy).

5. 发明申请

WO2003064020A3 ALCOHOL AND GLYCOL MODIFIED ALUMINUM TRI-ALKOXIDE COMPLEXES 审中-公开
公开(公告)号：WO2003064020A3
公开(公告)日：2003-08-07
申请号：PCT/US2003/002503
申请日：2003-01-28
申请人： FEDERAL PROCESS CORPORATION , PRATT, Charles, E. , KOWALCZYK, Gregory, E.
发明人： PRATT, Charles, E. , KOWALCZYK, Gregory, E.
IPC分类号： C07F5/06
摘要： Disclosed is an aluminum tri-alkoxide compound represented by Formula (I): (I) A1(X) a (Y) b wherein "X" is an alkoxide moiety of one or more normal or iso-monohydroxy alcohols having from about 6 to 14 carbon atoms, and "Y" is an alkoxide moiety of one or more glycols having from about 6 to 8 carbon atoms. For those aluminum trialkoxides that comprise alkoxide moieties of alcohols having 6 or 7 carbon atoms,"a" is 0.1 to 0.75 moles and "b" is 1.45 to 1.125 moles. For those aluminum tri-alkoxides comprising alkoxide moieties of alcohols having 8 to 14 carbon atoms, "a" is 0.25 to 0.85 and "b" is 1.45 to 1.075. Further disclosed is a solution having the aluminum trialkoxide and a solvent. Still further disclosed is a process for making a printing ink vehicle.

6. 发明申请

WO2003031592A3 GENE MARKERS FOR BEEF MARBLING AND TENDERNESS 审中-公开
公开(公告)号：WO2003031592A3
公开(公告)日：2003-04-17
申请号：PCT/US2002/032631
申请日：2002-10-11
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , JACKWOOD, Daral, J. , FLUHARTY, Francis
发明人： JACKWOOD, Daral, J. , FLUHARTY, Francis
IPC分类号： C12Q1/68
摘要： Methods and compositions are provided for objectively identifying: i) bovine animals having the genetic potential to produce beef that is marbled or tender, and ii) bovine carcasses whose beef is marbled or tender. The methods comprise extracting DNA from a sample obtained from a bovine animal or carcass, assaying for the presence of a DNA comprising a sequence, referred to hereinafter as a "genetic marker", in the DNA sample. In one aspecet, the genetic marker is a marker of marbling, and comprises the sequence set forth in SEQ ID NO. 1. In another aspect, the genetic marker is a marker of tenderness, and comprises the sequence set forth in SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4 or combinations thereof. The compositions include primers that ammplify markers of marbled or tender beef present in bovine animal or carcass genomes and hybridization probes to detect marbling or tenderness markers.

7. 发明申请

WO2003018755A2 WILD-TYPE RAS AS A CANCER THERAPEUTIC AGENT 审中-公开
标题翻译：野生型作为癌症治疗剂
公开(公告)号：WO2003018755A2
公开(公告)日：2003-03-06
申请号：PCT/US2002/026830
申请日：2002-08-23
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , YOU, Ming , WANG, Yian , ZHANG, Zhongqui
发明人： YOU, Ming , WANG, Yian , ZHANG, Zhongqui
IPC分类号： C12N
CPC分类号： A61K38/1709 , A61K48/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： Methods for inhibiting proliferation of a cell, particularly a cancer cell are provided. The method comprises increasing intracellular levels of one or more wild-type ras proteins in the cell. In one aspect, the method comprises introducing and expressing a nucleic molecule that encodes a wild-type ras protein in the cell. In another aspect, intracellular levels of one more ras proteins are increased by introducing one or more wild-type ras proteins into the cell. The present invention also relates to the therapeutic use of wild-type ras proteins or nucleic acids that encode one or more wild-type ras proteins in the treatment of tumors or cancer, or prophylactically to prevent formation of tumors or cancer. Methods of characterizing or evaluating cancer in a humans or other mammals are provided. In one embodiment, the method comprises assaying for a loss of function mutation in one or more endogenous ras alleles in the genome of tumor cells obtained from the subject. In another embodiment, the method comprises assaying for a loss of function mutation in one or more endogenous ras alleles and an activating mutation in one or more ras alleles in tumor cells obtained from the subject.
摘要翻译：提供了抑制细胞增殖的方法，特别是癌细胞。该方法包括增加细胞中一种或多种野生型ras蛋白的细胞内水平。一方面，该方法包括在细胞中引入和表达编码野生型ras蛋白的核酸分子。另一方面，通过将一种或多种野生型ras蛋白引入细胞中来增加一种或多种ras蛋白的细胞内水平。本发明还涉及编码一种或多种野生型ras蛋白质的野生型ras蛋白质或核酸在治疗肿瘤或癌症或预防性形成肿瘤或癌症中的治疗用途。提供了表征或评估人类或其他哺乳动物中的癌症的方法。在一个实施方案中，该方法包括测定从受试者获得的肿瘤细胞基因组中的一种或多种内源ras等位基因中的功能缺失突变。在另一个实施方案中，所述方法包括测定从受试者获得的肿瘤细胞中一种或多种内源ras等位基因中的功能缺失突变和一种或多种ras等位基因中的激活突变。

8. 发明申请

WO2002076394A3 ENZYME-BASED ANTI-CANCER COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2002076394A3
公开(公告)日：2002-10-03
申请号：PCT/US2002/008922
申请日：2002-03-22
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , LEE, Robert , PAN, Xing
发明人： LEE, Robert , PAN, Xing
IPC分类号： A61K38/47
摘要： A composition for treating cancer is provided. The composition is a hexosaminidase covalently attached to a cancer cell targeting ligand and improves selectively of the hexosaminidase for tumor cells. In certain embodiments, the hexosaminidase is alternately chitinase (N-acetyl-glucosaminohydrolase), chitosanase, or N-acetyl-hexosaminidase and the targeting ligand is either a monoclonal antibody, an antibody fragment immunospecific to a tumor cell or cancer cell antigen, epidermal growth factor (EGF), fibroblast growth factor (FGF), transferrin, or folic acid. Also provided is a method for treating cancerous tumours comprising administering the composition to a patient that has a cancerous tumor.

9. 发明申请

WO2006128015A2 POLYMER COMPOSITIONS AND ADHESIVES, COATINGS AND SEALANTS MADE THEREFROM 审中-公开
标题翻译：聚合物组合物和粘合剂，涂料和密封剂
公开(公告)号：WO2006128015A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/020492
申请日：2006-05-24
申请人： TREMCO INCORPORATED , FENG, Ta-Min , MISHRA, Steve, S.
发明人： FENG, Ta-Min , MISHRA, Steve, S.
IPC分类号： C08K5/54
CPC分类号： C09D175/04 , C08K5/01 , C08K5/54 , C08L19/006 , C08L75/04 , C08L83/00 , C08L83/04 , C08L101/10 , C08L2666/14 , C09D109/00 , C09D127/06 , C09J109/00 , C09J127/06 , C09J171/02 , C09J175/04 , C09K3/1018
摘要： Polymer compositions for preparing sealants, adhesives and coatings are provide The polymer compositions comprise from 1 to 99% by weight of an organic polym comprising functional silane groups, from 1 to 45% by weight (based on total polymer) of least one reactive or non-reactive organopolysiloxane polymer; from 0 to 98 % by weig (based on total polymer) of an organic polymer that lacks functional silane groups.
摘要翻译：提供用于制备密封剂，粘合剂和涂料的聚合物组合物聚合物组合物包含1至99重量％的包含官能硅烷基团的有机聚合物，1至45重量％（基于总聚合物）至少一种反应性或非反应性反应性有机聚硅氧烷聚合物; 0〜98％（以总聚合物计），缺乏官能性硅烷基团的有机聚合物。

10. 发明申请

WO2005123937A2 METHODS FOR EXPRESSING RNP PARTICLES IN EUKARYOTIC CELLS 审中-公开
标题翻译：用于在核细胞中表达RNP颗粒的方法
公开(公告)号：WO2005123937A2
公开(公告)日：2005-12-29
申请号：PCT/US2005/020893
申请日：2005-06-14
申请人： THE UNIVERSITY OF TEXAS AT AUSTIN , CUI, Xiaoxia , LAMBOWITZ, Alan , SALDANHA, Roland
发明人： CUI, Xiaoxia , LAMBOWITZ, Alan , SALDANHA, Roland
IPC分类号： C12P21/06
CPC分类号： C12N15/63 , C12N15/85
摘要： Provided herein are nucleic acid constructs and methods for producing or enhancing the production of group II intron RNP particles in eukaryotic cells. The present methods comprise introducing at least one nucleic acid construct comprising a nucleic acid encoding a modified or wild type group II intron RNA and a wild-type or modified group II intron-encoded protein into the eukaryotic cell, and maintaining the cell under conditions that allow for expression of the group II intron RNA and the group II intron-encoded protein in the cell. The nucleic acid encoding the group II intron RNA is operably linked to an RNA polymerase I, an RNA polymerase II, or an RNA polymerase III promoter, and the nucleic acid encoding the group II intron-encoded protein is operably linked to an RNA polymerase II promoter. In certain embodiments, a subcellular localization signal is attached to the group II intron-encoded protein.
摘要翻译：本文提供了核酸构建体和用于在真核细胞中产生或增强II组内含子RNP颗粒的生产的方法。本发明的方法包括将包含编码经修饰或野生型II组内含子RNA的核酸和野生型或修饰II型内含子编码蛋白质的至少一种核酸构建体引入真核细胞中，并将细胞维持在允许在细胞中表达II组内含子RNA和II组内含子编码的蛋白质。编码II组内含子RNA的核酸可操作地连接到RNA聚合酶I，RNA聚合酶II或RNA聚合酶III启动子，编码II组内含子编码蛋白的核酸可操作地连接到RNA聚合酶II 子。在某些实施方案中，将亚细胞定位信号连接到II组内含子编码的蛋白质。

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