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1. 发明申请

WO2003018755A2 WILD-TYPE RAS AS A CANCER THERAPEUTIC AGENT 审中-公开
标题翻译：野生型作为癌症治疗剂
公开(公告)号：WO2003018755A2
公开(公告)日：2003-03-06
申请号：PCT/US2002/026830
申请日：2002-08-23
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , YOU, Ming , WANG, Yian , ZHANG, Zhongqui
发明人： YOU, Ming , WANG, Yian , ZHANG, Zhongqui
IPC分类号： C12N
CPC分类号： A61K38/1709 , A61K48/00 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： Methods for inhibiting proliferation of a cell, particularly a cancer cell are provided. The method comprises increasing intracellular levels of one or more wild-type ras proteins in the cell. In one aspect, the method comprises introducing and expressing a nucleic molecule that encodes a wild-type ras protein in the cell. In another aspect, intracellular levels of one more ras proteins are increased by introducing one or more wild-type ras proteins into the cell. The present invention also relates to the therapeutic use of wild-type ras proteins or nucleic acids that encode one or more wild-type ras proteins in the treatment of tumors or cancer, or prophylactically to prevent formation of tumors or cancer. Methods of characterizing or evaluating cancer in a humans or other mammals are provided. In one embodiment, the method comprises assaying for a loss of function mutation in one or more endogenous ras alleles in the genome of tumor cells obtained from the subject. In another embodiment, the method comprises assaying for a loss of function mutation in one or more endogenous ras alleles and an activating mutation in one or more ras alleles in tumor cells obtained from the subject.
摘要翻译：提供了抑制细胞增殖的方法，特别是癌细胞。该方法包括增加细胞中一种或多种野生型ras蛋白的细胞内水平。一方面，该方法包括在细胞中引入和表达编码野生型ras蛋白的核酸分子。另一方面，通过将一种或多种野生型ras蛋白引入细胞中来增加一种或多种ras蛋白的细胞内水平。本发明还涉及编码一种或多种野生型ras蛋白质的野生型ras蛋白质或核酸在治疗肿瘤或癌症或预防性形成肿瘤或癌症中的治疗用途。提供了表征或评估人类或其他哺乳动物中的癌症的方法。在一个实施方案中，该方法包括测定从受试者获得的肿瘤细胞基因组中的一种或多种内源ras等位基因中的功能缺失突变。在另一个实施方案中，所述方法包括测定从受试者获得的肿瘤细胞中一种或多种内源ras等位基因中的功能缺失突变和一种或多种ras等位基因中的激活突变。

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