专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4931256A Apparatus for dilution and measurement in automated immunoassay techniques 失效
标题翻译：用于自动免疫测定技术稀释和测量的装置
公开(公告)号：US4931256A
公开(公告)日：1990-06-05
申请号：US217829
申请日：1988-10-11
申请人： Daniel R. Mack , Alfred H. Sturtevant , Henry L. Schwartz
发明人： Daniel R. Mack , Alfred H. Sturtevant , Henry L. Schwartz
IPC分类号： G01N35/10
CPC分类号： G01N35/1009 , G01N2035/1025 , G01N2035/103 , G01N2035/1032 , G01N2035/1086 , Y10S436/809
摘要： Apparatus are provided which automatically add diluent/quench reagent in such a manner as to enable adequate mixing as well as a short period for further mixing in automated immunoassay techniques. The probes for adding the diluent/quench reagents are offset from the optics module probe so that reagents are being added to a second row while the optics probe aspirates solutions from a first row.
摘要翻译：提供了以自动添加稀释剂/猝灭试剂的方式，使得能够在自动化免疫测定技术中进行充分混合以及短时间进一步混合。用于添加稀释剂/猝灭试剂的探针从光学模块探针偏移，使得试剂被添加到第二行，同时光学探针从第一行吸出溶液。

2. 发明授权

US4816418A Method and apparatus for performing automated, multi-sequential immunoassays 失效
标题翻译：用于进行自动化，多次免疫测定的方法和装置
公开(公告)号：US4816418A
公开(公告)日：1989-03-28
申请号：US757676
申请日：1985-07-22
申请人： Daniel R. Mack , Michael G. Konicek
发明人： Daniel R. Mack , Michael G. Konicek
IPC分类号： G01N35/00 , G01N35/02 , G01N35/06
CPC分类号： G01N35/00732 , G01N35/026 , G01N2035/00772 , Y10S436/80 , Y10S436/808
摘要： Methods and apparatus useful in automated performance of immunoassays, in some preferred embodiments, relying upon the sandwich immunoassay technique, are described. Each rack of reaction tubes is uniquely identified by an optical identifier disc which is read by the automatic controller. The assays are performed at two stations which configuration thereby permits arrays to be run on a second rack of reaction tubes while the first rack is in process. The cooperation of the identifier disc and the automatic controller minimizes operator error and helps improve the reliability of the data obtained.
摘要翻译：描述了在一些优选实施方案中依赖于夹心免疫测定技术在免疫测定的自动表现中有用的方法和装置。每个反应管的机架由光学识别盘唯一地标识，该光学识别盘由自动控制器读取。测定在两个站进行，其结构由此允许阵列在第一个机架正在进行时在第二个反应管上运行。标识符盘和自动控制器的协作最大限度地减少了操作员的错误，并有助于提高所获得数据的可靠性。

3. 发明授权

US4751052A Tube alignment apparatus 失效
标题翻译：管对准装置
公开(公告)号：US4751052A
公开(公告)日：1988-06-14
申请号：US850941
申请日：1986-04-11
申请人： Henry L. Schwartz , Alfred H. Sturtevant
发明人： Henry L. Schwartz , Alfred H. Sturtevant
IPC分类号： B01L99/00 , G01N35/10 , G01N35/00
CPC分类号： G01N35/109 , B01L99/00
摘要： An apparatus for centering the open end of tubes prior to the insertion of a probe is described. The tube aligning means has a frustoconical inner surface to gather the tube mouth held loosely in a tube rack. The tube is centered relative to the probe. The aligning means is caused to move along the probe shaft axis by cooperation of an outer probe surface and an inner female surface for receiving the probe. In the preferred embodiment, a spool-like cylindrical member is positioned within the arms of a U-shaped bracket which limits the vertical and restricts the rotational movement of the aligning member.
摘要翻译：描述了在插入探针之前使管的开口端居中的装置。管对准装置具有截头圆锥形内表面，以收集宽松地保持在管架中的管嘴。管相对于探头居中。使对准装置通过外探头表面和用于接收探针的内凹表面的配合沿着探针轴线移动。在优选实施例中，线轴状圆柱形构件位于U形支架的臂内，其限制了垂直并限制对准构件的旋转运动。

4. 发明授权

US5227304A Method for counting whole blood diluent and detergent reagent system 失效
标题翻译：全血稀释剂和洗涤剂试剂系统计数方法
公开(公告)号：US5227304A
公开(公告)日：1993-07-13
申请号：US918162
申请日：1992-07-21
申请人： Show-Chu Wong
发明人： Show-Chu Wong
IPC分类号： G01N33/50
CPC分类号： G01N33/5094 , Y10T436/107497 , Y10T436/108331 , Y10T436/25625
摘要： An improved multi-purpose blood diluent for use with a gentle lysing agent and improved detergent reagent system are disclosed which are especially suitable for use in routine electronic enumeration and volumetric differentation of blood cells. The preferred imidazole stabilizer used in the diluent reagent is found to be an excellent cell stabilizing agent and buffer for maintaining cell morphology during operation. A synergistic combination of a superior antimicrobial agent, the preferred Triadine-10, used in the diluent and the detergent reagents, not only prevents bacterial or fungal growth, but also helps to stabilize cells and to obtain distinct volumetric differentiation of certain leukocyte subpopulations. The preferred Brij 35 in a balanced salt solution has proved to be an efficient and cost effective detergent to ensure accurate results and trouble-free operation of the analyzers.
摘要翻译：公开了一种用于温和裂解剂和改进的洗涤剂试剂系统的改进的多用途血液稀释剂，其特别适用于常规电子计数和血细胞的体积分化。发现稀释剂中使用的优选的咪唑稳定剂是在操作期间维持细胞形态的优异的细胞稳定剂和缓冲液。在稀释剂和洗涤剂中使用的优良抗菌剂，优选的三联组合物10的协同组合不仅可以防止细菌或真菌生长，而且有助于稳定细胞并获得某些白细胞亚群的不同体积分化。平衡盐溶液中优选的Brij 35被证明是一种高效和经济的洗涤剂，以确保分析仪的准确结果和无故障运行。

5. 发明授权

US5008202A Blood diluent for red blood cell analysis 失效
标题翻译：血液稀释液用于红细胞分析
公开(公告)号：US5008202A
公开(公告)日：1991-04-16
申请号：US277334
申请日：1988-11-29
申请人： Sherburne M. Edmondson , Carlos E. Luna
发明人： Sherburne M. Edmondson , Carlos E. Luna
IPC分类号： A01N37/44 , G01N33/50
CPC分类号： A01N37/44 , G01N33/5094 , Y10T436/10 , Y10T436/108331
摘要： Method for diluting blood, blood diluent, and antimicrobial agents and reagents, especially suitable for use in enumeration and sizing of blood cells. The antimicrobial agent in the blood diluent is potent, but relatively non-toxic to humans, and inexpensive. Furthermore, it does not interfere with blood analysis performed on an automated, blood-analysis instrument.

6. 发明授权

US5017497A Particle discriminator and method 失效
标题翻译：粒子鉴别器和方法
公开(公告)号：US5017497A
公开(公告)日：1991-05-21
申请号：US327416
申请日：1989-03-20
申请人： Bernard Gerard de Grooth , Jan Greve , Leonardus W. M. M. Terstappen
发明人： Bernard Gerard de Grooth , Jan Greve , Leonardus W. M. M. Terstappen
IPC分类号： G01N21/64 , G01N15/00 , G01N15/14 , G01N21/21 , G01N21/27 , G01N21/53
CPC分类号： G01N15/1434 , G01N2015/0065 , G01N2015/149 , G01N2021/4704 , G01N21/21 , G01N21/6445
摘要： Method and apparatus for analyzing particles based on different depolarizing structure associated with the different particle types. Cells in a flow cytometer are illuminated with a linearly polarized light, producing scattered depolarized light whose intensity range, at a selected measuring angle, and in a suitable discriminating space, is used to analyze different particle types.
摘要翻译：基于与不同粒子类型相关的不同去极化结构分析颗粒的方法和装置。用线性偏振光照射流式细胞仪中的细胞，产生散射的去偏振光，其强度范围以选定的测量角度和合适的辨别空间用于分析不同的粒子类型。

7. 发明授权

US4745071A Method for the volumetric differentiation of blood cells types 失效
标题翻译：血细胞类型的体积分化方法
公开(公告)号：US4745071A
公开(公告)日：1988-05-17
申请号：US914637
申请日：1986-10-02
申请人： James D. Lapicola , Sherburne M. Edmondson, Jr.
发明人： James D. Lapicola , Sherburne M. Edmondson, Jr.
IPC分类号： G01N33/50
CPC分类号： G01N33/5094 , Y10T436/107497 , Y10T436/108331
摘要： Improved reagents and methods for obtaining distinct volumetric differentiation of platelets, erythocytes and certain leukocyute subpopulations are disclosed. 1,3-dimethylurea is disclosed as a cell stabilizing agent for use in the blood diluent reagent. A hematology analyzer detergent is described wherein the addition of a wetting agent to the diluent of the instant invention provides the necessary attributes of an automatic analyzer detergent. The lysing reagent exploits the selective and intrinsically gentle lytic qualities of the dodecyl quaternary ammonium salt. The improved method modifies the leukocytes so that the frequent lymphocyte and neutrophil subpopulations are well separated on a volume scale, permitting quantitative evaluation of infrequent and rare leukocyte subpopulations as well as improved enumeration of the lymphocytes and neutrophils.
摘要翻译：公开了用于获得血小板，红细胞和某些白细胞亚群的不同体积分化的改进的试剂和方法。公开了1,3-二甲基脲作为用于血液稀释剂的细胞稳定剂。描述了血液学分析仪洗涤剂，其中向本发明的稀释剂中加入润湿剂提供了自动分析仪洗涤剂的必要属性。裂解试剂利用十二烷基季铵盐的选择性和本质上温和的溶解性质。改进的方法改变白细胞，使得频繁的淋巴细胞和嗜中性粒细胞亚群在体积尺度上被良好地分离，允许定量评估罕见的和罕见的白细胞亚群，以及改善淋巴细胞和嗜中性粒细胞的计数。

8. 发明授权

US4726237A Fluid metering apparatus and method 失效
标题翻译：流体计量装置及方法
公开(公告)号：US4726237A
公开(公告)日：1988-02-23
申请号：US746988
申请日：1985-06-19
申请人： Ching Yung
发明人： Ching Yung
IPC分类号： G01F3/14 , G01F3/30 , G01F3/32 , G01F7/00 , G01F11/22 , G01N1/00 , G01N1/38 , G01N35/02 , G01N1/10
CPC分类号： G01N35/1097 , G01N1/38
摘要： A transfer valve system, method and apparatus are disclosed having a three element valve with a central element sandwiched between front and rear outer elements. Between an aspiration and a discharge position the front and rear outer elements are moved in opposite directions of unequal distances in the same direction with respect to the central member or one outer member and the central member are moved in the same or opposite direction with respect to the other outer member so long as the outer members end up shifted with respect to each other. In the aspiration position, two sample segments are contained in series within the valve. In one embodiment of the invention, one segment is contained within a conduit in the central member and the other segment is contained within a passageway in the rear member. In another embodiment of the invention, the two segments are contained within different conduits of the central member.
摘要翻译：公开了一种转换阀系统，方法和装置，其具有夹在前后外部元件之间的中心元件的三元件阀。在抽吸和排出位置之间，前后外部元件相对于中心构件或一个外部构件在相同方向上以不相等的方向相反的方向移动，并且中心构件相对于中心构件或一个外部构件以相同或相反的方向移动另一个外部构件，只要外部构件相对于彼此最终移动。在抽吸位置，两个样品段在阀内串联包含。在本发明的一个实施例中，一个部分包含在中心部件中的导管内，另一个部分被容纳在后部部件中的通道内。在本发明的另一个实施例中，两个段被包含在中心构件的不同导管内。

9. 发明授权

US4713218A Tube trap apparatus 失效
标题翻译：管陷阱装置
公开(公告)号：US4713218A
公开(公告)日：1987-12-15
申请号：US757646
申请日：1985-07-22
申请人： Henry L. Schwartz
发明人： Henry L. Schwartz
IPC分类号： B01L99/00 , G01N35/10 , G01N37/00
CPC分类号： G01N35/109 , B01L99/00
摘要： A tube restraining apparatus is described for centering the mouth of a loosely held test tube prior to the insertion of a probe. The apparatus is automatically activated by a motor driven carriage and the cooperation of the probe and the bail. The mouth of the tube is centered by contacting the tube rim with the conical inner surface of the restrainer.
摘要翻译：描述了一种管限制装置，用于在插入探针之前使松散保持的试管的口对中。该装置由马达驱动的托架自动启动，并且探头和吊环的配合。管的嘴部通过将管边缘与限制器的锥形内表面接触而居中。

10. 发明授权

US4622468A Fluorescence intensity compensation method and device 失效
标题翻译：荧光强度补偿方法及装置
公开(公告)号：US4622468A
公开(公告)日：1986-11-11
申请号：US754659
申请日：1985-07-15
申请人： Andrew Stefanski , Alfred H. Sturtevant , Michael G. Konicek , Peter E. Lobban
发明人： Andrew Stefanski , Alfred H. Sturtevant , Michael G. Konicek , Peter E. Lobban
IPC分类号： G01J1/36 , G01N21/64
CPC分类号： G01N21/64 , G01J1/36 , G01N2201/127 , G01N2201/12753
摘要： Variations in the intensity of a light source and the sensitivity of a fluorescence detector photo-multiplier tube are simultaneously compensated by measuring the intensity (I.sub.LS1) of the light source at the sample excitation frequency with a silicon detector, measuring the intensity (I.sub.LS2) of the light source at the emission frequency with another silicon detector, measuring with the photo-multiplier detector the intensity (I.sub.S) of the sample's fluorescence and the intensity (I.sub.LS3) of the light source at the emission frequency of the sample and then calculating a value F as representative of the sample's fluorescence according to the formula: ##EQU1##
摘要翻译：通过用硅检测器测量样品激发频率下的光源的强度（ILS1），同时补偿光源强度的变化和荧光检测器光电倍增管的灵敏度，测量光源的强度（ILS2）用另一硅检测器的发射频率的光源，用光电倍增管检测器测量样品的荧光强度（IS）和光源在样品发射频率下的强度（ILS3），然后计算值 F作为样品荧光的代表，根据以下公式：

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式