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1. 发明授权

US4931256A Apparatus for dilution and measurement in automated immunoassay techniques 失效
标题翻译：用于自动免疫测定技术稀释和测量的装置
公开(公告)号：US4931256A
公开(公告)日：1990-06-05
申请号：US217829
申请日：1988-10-11
申请人： Daniel R. Mack , Alfred H. Sturtevant , Henry L. Schwartz
发明人： Daniel R. Mack , Alfred H. Sturtevant , Henry L. Schwartz
IPC分类号： G01N35/10
CPC分类号： G01N35/1009 , G01N2035/1025 , G01N2035/103 , G01N2035/1032 , G01N2035/1086 , Y10S436/809
摘要： Apparatus are provided which automatically add diluent/quench reagent in such a manner as to enable adequate mixing as well as a short period for further mixing in automated immunoassay techniques. The probes for adding the diluent/quench reagents are offset from the optics module probe so that reagents are being added to a second row while the optics probe aspirates solutions from a first row.
摘要翻译：提供了以自动添加稀释剂/猝灭试剂的方式，使得能够在自动化免疫测定技术中进行充分混合以及短时间进一步混合。用于添加稀释剂/猝灭试剂的探针从光学模块探针偏移，使得试剂被添加到第二行，同时光学探针从第一行吸出溶液。

2. 发明授权

US4751052A Tube alignment apparatus 失效
标题翻译：管对准装置
公开(公告)号：US4751052A
公开(公告)日：1988-06-14
申请号：US850941
申请日：1986-04-11
申请人： Henry L. Schwartz , Alfred H. Sturtevant
发明人： Henry L. Schwartz , Alfred H. Sturtevant
IPC分类号： B01L99/00 , G01N35/10 , G01N35/00
CPC分类号： G01N35/109 , B01L99/00
摘要： An apparatus for centering the open end of tubes prior to the insertion of a probe is described. The tube aligning means has a frustoconical inner surface to gather the tube mouth held loosely in a tube rack. The tube is centered relative to the probe. The aligning means is caused to move along the probe shaft axis by cooperation of an outer probe surface and an inner female surface for receiving the probe. In the preferred embodiment, a spool-like cylindrical member is positioned within the arms of a U-shaped bracket which limits the vertical and restricts the rotational movement of the aligning member.
摘要翻译：描述了在插入探针之前使管的开口端居中的装置。管对准装置具有截头圆锥形内表面，以收集宽松地保持在管架中的管嘴。管相对于探头居中。使对准装置通过外探头表面和用于接收探针的内凹表面的配合沿着探针轴线移动。在优选实施例中，线轴状圆柱形构件位于U形支架的臂内，其限制了垂直并限制对准构件的旋转运动。

3. 发明授权

US5851488A Apparatus for automatic electro-optical chemical assay determination 失效
标题翻译：自动电光化学测定装置
公开(公告)号：US5851488A
公开(公告)日：1998-12-22
申请号：US608693
申请日：1996-02-29
申请人： Tom Saul , Henry L. Schwartz , Todd Guion , Hans O. Ribi
发明人： Tom Saul , Henry L. Schwartz , Todd Guion , Hans O. Ribi
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01N21/6428
摘要： An electro-optical instrument for measuring a quantitative physical parameter of a sample in a diagnostic cartridge is provided.
摘要翻译：提供一种用于测量诊断盒中样品的定量物理参数的电光仪器。

4. 发明授权

US4730631A Probe wash station 失效
标题翻译：探头清洗站
公开(公告)号：US4730631A
公开(公告)日：1988-03-15
申请号：US757742
申请日：1985-07-22
申请人： Henry L. Schwartz
发明人： Henry L. Schwartz
IPC分类号： G01N35/10 , B08B3/04
CPC分类号： G01N35/1004 , Y10S220/06
摘要： For use with an apparatus for performing biological fluid assays, the apparatus having a probe assembly that includes a tubular probe, a probe wash station for washing the tubular probe with a washing fluid. The probe wash station comprises a probe washing receptacle that is adapted to receive the tubular probe, the receptable having an anti-splash mechanism therein for preventing the splashing of the washing fluid.
摘要翻译：为了与用于执行生物流体测定的装置一起使用，该装置具有包括管状探针的探针组件，用于用洗涤液洗涤管状探针的探针洗涤台。探针洗涤台包括适于容纳管状探针的探针洗涤容器，该容器可在其中具有用于防止洗涤液飞溅的防溅机构。

5. 发明授权

US4424813A Multi-mode ultrasound scanner 失效
标题翻译：多模超声波扫描仪
公开(公告)号：US4424813A
公开(公告)日：1984-01-10
申请号：US292948
申请日：1981-08-14
申请人： James F. Havlice , Albert S. Waxman , Henry L. Schwartz , David E. Stepner
发明人： James F. Havlice , Albert S. Waxman , Henry L. Schwartz , David E. Stepner
IPC分类号： G01N29/265 , G10K11/35 , G01N29/04
CPC分类号： G10K11/355 , G01N29/0645 , G01N29/265
摘要： A multi-mode scanner head employing split (semicircular transducers) is described. In some modes such as simultaneous B-scan and M-scan each transducer moves independent of the other. For continuous Doppler mode the transducers move together. The relatively small, hand-held scanner head is particularly useful for cardiac examinations.
摘要翻译：描述了采用分割（半圆形换能器）的多模扫描头。在某些模式下，例如同步B扫描和M扫描，每个传感器独立于另一个移动。对于连续多普勒模式，传感器一起移动。相对较小的手持扫描头对于心脏检查特别有用。

6. 发明授权

US5770070A Radioactive waste disposal cartridge 失效
标题翻译：放射性废物处理盒
公开(公告)号：US5770070A
公开(公告)日：1998-06-23
申请号：US316733
申请日：1994-10-03
申请人： Thomas E. Davis , Henry L. Schwartz
发明人： Thomas E. Davis , Henry L. Schwartz
IPC分类号： G01N27/447 , B01J47/12 , G01N30/00 , G21F9/12 , B01D27/02
CPC分类号： B01J47/126 , G21F9/12
摘要： This invention relates to the use of a unique apparatus and method for extracting radioactive components from liquids, such as electrophoresis buffers. In the present invention, the radioactive liquid is pumped or transported by other suitable means and is passed through a cartridge having an elongated chamber that contains an exchange medium. The exchange medium, i.e. exchange resin, is contained within the elongated chamber between an upper frit and a lower frit. Further, the cartridge has a means within the elongated chamber for retaining pressure between the upper frit and the lower frit. The nucleotides, being charged molecules, bind to the exchange medium and are removed from the liquid. The liquid then exits the cartridge and has such a low amount of radioactivity that it can be disposed of to a conventional drain.
摘要翻译：本发明涉及使用从液体如电泳缓冲液中提取放射性成分的独特装置和方法。在本发明中，放射性液体被其他合适的装置泵送或输送，并且通过具有包含交换介质的细长室的盒。交换介质，即交换树脂，被包含在上玻璃料和下玻璃料之间的细长室内。此外，盒具有在细长室内的装置，用于保持上玻璃料和下玻璃料之间的压力。作为带电分子的核苷酸与交换介质结合并从液体中除去。液体然后离开墨盒，并且具有如此低的放射性量，使其能够被排放到常规的排水口。

7. 发明授权

US5536662A Cell assay device 失效
标题翻译：细胞测定装置
公开(公告)号：US5536662A
公开(公告)日：1996-07-16
申请号：US161198
申请日：1993-12-02
申请人： Gillian M. K. Humphries , Donald L. Miller , Jeffrey M. Libby , Henry L. Schwartz
发明人： Gillian M. K. Humphries , Donald L. Miller , Jeffrey M. Libby , Henry L. Schwartz
IPC分类号： B01D63/08 , C12M1/00 , C12M1/12 , C12M1/34
CPC分类号： C12M25/04 , Y10S435/817
摘要： This invention encompasses porous microchambers which contain cells and permit liquid to flow in and out of the chamber while retaining cells within the chamber. These porous microchambers serve as disposable devices for placing cells in a microflowchamber so that properties of the cells within the porous microchamber can be measured.
摘要翻译：本发明包括含有细胞并允许液体进入和流出室的多孔微室，同时保持室内的孔。这些多孔微孔板用作将细胞置于微流室中的一次性装置，以便可以测量多孔微室内的细胞的性质。

8. 发明授权

US5503985A Disposable device for diagnostic assays 失效
标题翻译：一次性诊断测定装置
公开(公告)号：US5503985A
公开(公告)日：1996-04-02
申请号：US179749
申请日：1994-01-07
申请人： Cheryl A. Cathey , Henry L. Schwartz , Tom Saul , Jeffrey D. Langford
发明人： Cheryl A. Cathey , Henry L. Schwartz , Tom Saul , Jeffrey D. Langford
IPC分类号： G01N33/48 , B01F13/00 , B01F13/08 , B01L3/00 , C12M1/34 , C12Q1/00 , G01N33/52 , G01N33/543 , G01N35/00 , G01N33/542 , G01N33/558
CPC分类号： B01L3/50273 , B01F13/0059 , B01F13/0818 , B01L3/5027 , B01L3/502746 , G01N33/54366 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/087 , B01L2400/0406 , B01L2400/0688 , B01L2400/086 , B01L3/502738 , G01N2035/00267 , Y10S435/81 , Y10S435/973 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81
摘要： A disposable diagnostic device and method of its use are provided. The device comprises a housing containing first and second flow paths orthogonal to each other. The first flow path commences at a sample addition port and continues through a transport channel which feeds sample to an incubation area by means of capillary flow. The incubation area comprises a signal producing system and is underneath an optically-clear window. The first flow path terminates in a top waste reservoir which receives sample and wash fluid. The second flow path begins on one side of the incubation area at an inlet port over a side reagent reservoir. Liquid flows along the second flow path from the side reagent reservoir across the incubation area into the side waste reservoir. The incubation area may comprise agitation means for homogenous dispersion of reagent into liquid. Various reagents of a signal producing system may be contained within the device and the necessary liquids added automatically by appropriate instrumentation, so as to have the assay carried out automatically, without technician involvement, providing an accurate and sensitive determination.
摘要翻译：提供了一次性诊断装置及其使用方法。该装置包括容纳彼此正交的第一和第二流动路径的壳体。第一流路在样品加入口处开始并继续通过运送通道，其通过毛细管流将样品送入孵育区。孵化区包括信号产生系统，并在光学透明的窗口下方。第一流路终止于接收样品和洗涤流体的顶部废物储存器中。第二流路在侧试剂储存器的入口处从孵化区的一侧开始。液体沿着第二流动路径从侧面试剂储存器流过孵化区域流入侧面废物储存器。孵育区域可以包括用于将试剂均匀分散到液体中的搅拌装置。信号产生系统的各种试剂可以包含在装置内，并且通过适当的仪器自动加入必需的液体，以便在没有技术人员参与的情况下自动进行测定，提供精确和灵敏的测定。

9. 发明授权

US4407293A Ultrasound imaging apparatus for providing simultaneous B-scan and Doppler data 失效
标题翻译：用于提供同时B扫描和多普勒数据的超声成像装置
公开(公告)号：US4407293A
公开(公告)日：1983-10-04
申请号：US257506
申请日：1981-04-24
申请人： Joe R. Suarez, Jr. , Henry L. Schwartz , Anthony J. Rossetti , Paul D. Corl
发明人： Joe R. Suarez, Jr. , Henry L. Schwartz , Anthony J. Rossetti , Paul D. Corl
IPC分类号： G01N29/06 , A61B8/00 , G01S7/52 , G01S15/89 , G10K11/35 , A61B5/02
CPC分类号： G10K11/355 , G01S15/8979 , G01S7/52073
摘要： An ultrasound imaging apparatus is described. The hand-held device includes a first oscillating transducer for providing a B-scan display and an offset second transducer which is manually positioned for providing Doppler data. The transducer pulses are interlaced and Doppler transmissions are inhibited to permit B-scan transmissions. However, circuits provide a continuous signal representing a Doppler signal when the Doppler transmissions are inhibited.
摘要翻译：描述超声成像装置。手持装置包括用于提供B扫描显示的第一振荡换能器和手动定位以提供多普勒数据的偏移的第二换能器。换能器脉冲是隔行扫描，多普勒传输被禁止允许B扫描传输。然而，当抑制多普勒传输时，电路提供表示多普勒信号的连续信号。

10. 发明授权

US5798215A Device for use in analyte detection assays 失效
标题翻译：用于分析物检测测定的装置
公开(公告)号：US5798215A
公开(公告)日：1998-08-25
申请号：US420987
申请日：1995-04-06
申请人： Cheryl A. Cathey , Tom Saul , Nicole D. Bloom , Hans O. Ribi , Henry L. Schwartz , Jeffrey B. Langford , David J. Paul
发明人： Cheryl A. Cathey , Tom Saul , Nicole D. Bloom , Hans O. Ribi , Henry L. Schwartz , Jeffrey B. Langford , David J. Paul
IPC分类号： G01N31/00 , B01F13/00 , B01F13/08 , B01L3/00 , B01L7/00 , G01N21/78 , G01N33/48 , G01N33/53 , G01N33/543 , G01N35/00 , G01N33/558
CPC分类号： G01N33/54366 , B01F13/0059 , B01F13/0818 , B01L3/5027 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0487 , B01L2400/0677 , B01L2400/0688 , B01L2400/086 , B01L3/50273 , B01L3/502738 , B01L7/52 , G01N2035/00267 , Y10S435/81 , Y10S436/805 , Y10S436/807 , Y10S436/808 , Y10S436/81
摘要： A device and method for its use in diagnostic assays are provided. The device comprises at least one assay path, where an assay path includes a main flow path and at least one side reagent channel. The main flow path begins at a sample addition port, continues through a main reagent area into an incubation area and ends in a waste area. In fluid communication with the main flow path is at least one side reagent channel that begins at a liquid addition port, continues through a side reagent area and ends in said main channel at a region between the main reagent and waste areas, usually upstream from the incubation area. Agitation means may be included in at least one of the main and side reagent areas and/or the incubation area. At least one fluid interruption means located at various positions along the main and side reagent channels upstream from the incubation area provide for control over reagent interaction and fluid flow through the device. Applications in which the device finds use include diagnostic assays employing signal producing systems based on the interactions of specific binding pair members, where an optical signal is related to the presence of analyte.
摘要翻译：提供了一种用于诊断测定的装置和方法。该装置包括至少一个测定路径，其中测定路径包括主流路径和至少一个侧试剂通道。主流路开始于样品添加口，继续通过主试剂区进入孵育区，并结束于废物区。与主流路流体连通是至少一个从液体添加口开始的侧试剂通道，通过侧试剂区域继续并在主试剂和废物区域之间的区域中终止于所述主通道，通常在孵化区。搅拌装置可以包括在主试剂区域和侧试剂区域和/或孵化区域中的至少一个中。位于沿孵化区域上游的主要和侧面试剂通道的不同位置处的至少一个流体中断装置提供对通过装置的试剂相互作用和流体流动的控制。设备使用的应用包括基于特定结合对成员的相互作用的信号产生系统的诊断测定，其中光学信号与分析物的存在相关。

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