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1. 发明授权

US4816418A Method and apparatus for performing automated, multi-sequential immunoassays 失效
标题翻译：用于进行自动化，多次免疫测定的方法和装置
公开(公告)号：US4816418A
公开(公告)日：1989-03-28
申请号：US757676
申请日：1985-07-22
申请人： Daniel R. Mack , Michael G. Konicek
发明人： Daniel R. Mack , Michael G. Konicek
IPC分类号： G01N35/00 , G01N35/02 , G01N35/06
CPC分类号： G01N35/00732 , G01N35/026 , G01N2035/00772 , Y10S436/80 , Y10S436/808
摘要： Methods and apparatus useful in automated performance of immunoassays, in some preferred embodiments, relying upon the sandwich immunoassay technique, are described. Each rack of reaction tubes is uniquely identified by an optical identifier disc which is read by the automatic controller. The assays are performed at two stations which configuration thereby permits arrays to be run on a second rack of reaction tubes while the first rack is in process. The cooperation of the identifier disc and the automatic controller minimizes operator error and helps improve the reliability of the data obtained.
摘要翻译：描述了在一些优选实施方案中依赖于夹心免疫测定技术在免疫测定的自动表现中有用的方法和装置。每个反应管的机架由光学识别盘唯一地标识，该光学识别盘由自动控制器读取。测定在两个站进行，其结构由此允许阵列在第一个机架正在进行时在第二个反应管上运行。标识符盘和自动控制器的协作最大限度地减少了操作员的错误，并有助于提高所获得数据的可靠性。

2. 发明授权

US4931256A Apparatus for dilution and measurement in automated immunoassay techniques 失效
标题翻译：用于自动免疫测定技术稀释和测量的装置
公开(公告)号：US4931256A
公开(公告)日：1990-06-05
申请号：US217829
申请日：1988-10-11
申请人： Daniel R. Mack , Alfred H. Sturtevant , Henry L. Schwartz
发明人： Daniel R. Mack , Alfred H. Sturtevant , Henry L. Schwartz
IPC分类号： G01N35/10
CPC分类号： G01N35/1009 , G01N2035/1025 , G01N2035/103 , G01N2035/1032 , G01N2035/1086 , Y10S436/809
摘要： Apparatus are provided which automatically add diluent/quench reagent in such a manner as to enable adequate mixing as well as a short period for further mixing in automated immunoassay techniques. The probes for adding the diluent/quench reagents are offset from the optics module probe so that reagents are being added to a second row while the optics probe aspirates solutions from a first row.
摘要翻译：提供了以自动添加稀释剂/猝灭试剂的方式，使得能够在自动化免疫测定技术中进行充分混合以及短时间进一步混合。用于添加稀释剂/猝灭试剂的探针从光学模块探针偏移，使得试剂被添加到第二行，同时光学探针从第一行吸出溶液。

3. 发明授权

US4803050A Method and apparatus for liquid addition and aspiration in automated immunoassay techniques 失效
标题翻译：用于自动免疫测定技术中液体添加和抽吸的方法和装置
公开(公告)号：US4803050A
公开(公告)日：1989-02-07
申请号：US888848
申请日：1986-07-22
申请人： Daniel R. Mack
发明人： Daniel R. Mack
IPC分类号： G01N33/543 , G01N35/02 , G01N35/10 , G01N35/06
CPC分类号： G01N35/1083 , G01N33/54366 , G01N35/026 , G01N2035/1025 , Y10T436/113332
摘要： Apparatus and method for adding liquid to, aspirating liquid from, a rack of reaction tubes wherein a rack and carriage-dependent probes are made to move relative each other in the horizontal and vertical planes. The method calls for performing the first half of a wash sequence on tube located at x row, y column, then completing the sequence on tube at (x-1) row, y column, and returning to the tube at x row, (y+1) column to initiate the first half of the sequence. This "backtracking" of probes permits an incubation-soak period without cumulatively extending the total rack processing time.
摘要翻译：用于将液体添加到吸液器的装置和方法，其中反应管的架架使得齿条和滑架相关的探针在水平和垂直平面中彼此相对移动。该方法要求在位于x行y列的管上执行洗涤序列的前半部分，然后在（x-1）行y列处完成管上的序列，并返回到x行的管（y +1）列以启动序列的前半部分。探针的“回溯”允许孵育 - 浸泡时间，而不会累积延长总架处理时间。

4. 发明授权

US4140488A Sample liquid transfer means in an automatic chemical testing apparatus 失效
标题翻译：自动化学测试仪器中的样品液体转移装置
公开(公告)号：US4140488A
公开(公告)日：1979-02-20
申请号：US830705
申请日：1977-09-06
申请人： Daniel R. Mack , James R. Eseke
发明人： Daniel R. Mack , James R. Eseke
IPC分类号： B01L3/02 , G01N35/10 , G01N1/14 , G01N31/00
CPC分类号： G01N35/1083 , B01L3/022
摘要： Means for reducing intersample contamination in an automatic chemical testing apparatus, in which liquid from a sample is aspirated from a sample source into a reservoir, and aliquots of the sample are each dispensed into individual reaction containers for analysis by well-known means. A cylindrical reservoir is utilized with a piston therein shaped for pushing out virtually all of the remaining sample from the cylinder after dispensing the sample liquid through a hollow needle, communicating with the cylinder. A solid pin coaxially mounted within the piston is projected through the needle and has minimum clearance therewith, for pushing remaining sample out of the needle. The portion of the pin projecting through the needle is retracted into the piston prior to aspiration of liquid from a next sample.
摘要翻译：用于减少自动化学测试装置中的样品间污染的手段，其中将来自样品的液体从样品源吸入储存器，并将样品的等分试样分配到各个反应容器中，以通过公知的方法分析。使用圆柱形储存器，其中活塞形成用于在将样品液体通过与气缸连通的中空针头之后，从气缸中推出几乎所有剩余的样品。同轴地安装在活塞内的固体销通过针头突出并且具有最小的间隙，用于将剩余的样品推出针头。在从下一个样品抽取液体之前，突出穿过针头的销的部分缩回到活塞中。

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