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1. 发明申请

WO1998003536A1 CHEMICALLY-INDUCIBLE ARABIDOPSIS PR-1 PROMOTER 审中-公开
标题翻译：化学诱导性ARABIDOPSIS PR-1 PROMOTER
公开(公告)号：WO1998003536A1
公开(公告)日：1998-01-29
申请号：PCT/US1997012626
申请日：1997-07-18
申请人： NOVARTIS CORPORATION , LEBEL, Edouard, Guillaume , RYALS, John, Andrew , THORNE, Leigh , UKNES, Scott, Joseph , WARD, Eric, Russell
发明人： NOVARTIS CORPORATION
IPC分类号： C07H21/04
CPC分类号： C12N15/8238 , C07K14/415
摘要： The nucleic acid sequence of the full-length, chemically inducible Arabidopsis PR-1 promoter has been discovered and is disclosed herein. Furthermore, cis-acting regulatory elements in the Arabidopsis PR-1 promoter involved in chemical induction have been characterized using deletion and linker-scanning mutagenesis and in vivo footprinting. It has been discovered that at least a portion of the region of promoter between positions -698 and -621 (relative to the transcription start site of the PR-1 gene) is required for induction of gene expression by chemicals. Two 10-bp linker-scanning mutations centered at 640-bp and 610-bp upstream from the transcription start site abolish the inducibility of the promoter while another 10-bp mutation centered at -670 bp results in average induced expression levels 4-fold higher than the unmutated promoter. Additionally, inducible in vivo footprints are located at positions -629 and -628 and at position -604 on the coding strand and at position -641 on the non-coding strand. The use of chemically inducible Arabidopsis PR-1 promoter fragments to regulate gene expression in plants in the presence of inducing chemicals such as SA, INA, and BTH is disclosed, as well as the use of these elements for the isolation of transcriptional regulatory proteins involved in the promoter regulation and for the construction of inducible hybrid promoters.
摘要翻译：已经发现了全长化学诱导型拟南芥PR-1启动子的核酸序列，并在此公开。此外，参与化学诱导的拟南芥PR-1启动子中的顺式作用调节元件已经使用缺失和连接物扫描诱变和体内足迹进行表征。已经发现，通过化学物质诱导基因表达需要至少部分-698和-621位点之间的启动子区域（相对于PR-1基因的转录起始位点）。以转录起始位点上游640-bp和610-bp为中心的两个10-bp接头扫描突变消除了启动子的诱导性，而另一个以-670bp为中心的10-bp突变导致平均诱导的表达水平高4倍比未突变的启动子。此外，可诱导的体内足迹位于编码链上的位置-629和-628，位置-604位于非编码链上-641位。公开了使用化学诱导型拟南芥PR-1启动子片段在诱导化学物质如SA，INA和BTH存在下调节植物中的基因表达，以及这些元件用于分离涉及转录调节蛋白的用途在启动子调节和诱导型杂合启动子的构建中。

2. 发明授权

US07057016B2 Process for the production of biologically active protein 失效
标题翻译：生物活性蛋白生产工艺
公开(公告)号：US07057016B2
公开(公告)日：2006-06-06
申请号：US09813271
申请日：2001-03-20
申请人： Nico Cerletti
发明人： Nico Cerletti
IPC分类号： C07K14/495 , C07K5/08 , C08K5/41 , C08K5/16
CPC分类号： C07K14/495
摘要： The present invention relates to a folding process for the preparation of biologically active, dimeric, TGF-β (Transforming Growth Factor type β)-like protein in a detergent-free folding buffer.
摘要翻译：本发明涉及用于在无洗涤剂折叠缓冲液中制备生物活性的二聚体，TGF-β（转化生长因子型β）样蛋白的折叠方法。

3. 发明授权

US6066447A Modified oligonucleotides 失效
标题翻译：修饰的寡核苷酸
公开(公告)号：US6066447A
公开(公告)日：2000-05-23
申请号：US687456
申请日：1996-11-12
申请人： Alain De Mesmaeker , Adrian Waldner , Jacques Lebreton , Marc-Olivier Bevierre , Catherine Lesueur
发明人： Alain De Mesmaeker , Adrian Waldner , Jacques Lebreton , Marc-Olivier Bevierre , Catherine Lesueur
IPC分类号： G01N33/566 , A61K31/70 , A61K31/7088 , A61K49/00 , A61P31/12 , A61P43/00 , C07H21/00 , C12Q1/68
CPC分类号： C07H21/00
摘要： Oligonucleotides of the formula: 5'(U).sub.n -3' in which U is an identical or different radical of a natural or a synthetic nucleoside and n is a number from 2 to 200 comprising at least one structural unit of two consecutive nucleosides wherein one of the nucleotides is substituted in the 2'-position or wherein the nucleotides are substituted differently in their 2'-position and wherein the backbone is modified.
摘要翻译： PCT No.PCT / EP95 / 00156 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT 1995年1月17日PCT PCT。公开号WO95 / 20597 日期1995年8月3日，式：5'（U）n-3'的寡核苷酸，其中U是天然或合成核苷的相同或不同基团，n是2至200的数，包括至少一个结构单元的两个连续的核苷，其中一个核苷酸在2'-位上被取代，或其中核苷酸在其2'-位置被不同地取代，并且其中主链被修饰。

4. 发明授权

US6048824A 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides 失效
标题翻译： 2-硝基亚甲基/ 2-氰基亚氨基/ 2-硝基 - 亚氨基 - 吡咯烷酮和哌啶，中间体及其作为农药的用途
公开(公告)号：US6048824A
公开(公告)日：2000-04-11
申请号：US532553
申请日：1995-11-22
申请人： Peter Maienfisch , Jozef Gonda , Olivier Jacob , Laurenz Gsell
发明人： Peter Maienfisch , Jozef Gonda , Olivier Jacob , Laurenz Gsell
IPC分类号： A01N43/36 , A01N43/40 , A01N43/54 , A01N43/58 , A01N43/84 , A01N43/86 , A01N43/88 , A01N47/38 , A01N51/00 , C07D401/06 , C07D417/06
CPC分类号： C07D401/06 , A01N43/40 , A01N47/38 , A01N51/00 , C07D417/06
摘要： Compounds of formula (I), wherein A is an unsubstituted or substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical wherein a ring nitrogen atom may have been replaced by a group ##STR2## R.sub.1 is hydrogen or C.sub.1 -C.sub.3 alkyl; R.sub.2 is hydrogen or C.sub.1 -C.sub.3 alkyl; R.sub.3 is hydrogen, an unsubstituted or substituted C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl group, or C(.dbd.O)--R.sub.5, R.sub.5 is C.sub.1 -C.sub.4 alkyl C.sub.1 -C.sub.4 alkoxy, an unsubstituted or substituted phenyl, phenoxy or benzyloxy group, or N(R.sub.6).sub.2, each R.sub.6, independently of the other, is hydrogen, C.sub.1 -C.sub.4 alkyl or unsubstituted or substituted phenyl, X is CH--NO.sub.2, N--CN or N--NO.sub.2 and n is from 1 to 3, in free form or in salt form, and, where appropriate, tautomers of those compounds and the salts thereof, can be used as agrochemical active ingredients and can be prepared in a manner known per se.
摘要翻译： PCT No.PCT / EP94 / 00963 Sec。 371日期：1995年11月22日 102（e）日期1995年11月22日PCT 1994年3月26日PCT公布。出版物WO94 / 24124 日期：1994年10月27日，式（I）化合物其中A是未取代或取代的芳环或非芳香单环或双环杂环基，其中环氮原子可以被基团R 1取代为氢或C 1 -C 3烷基; R2是氢或C1-C3烷基; R3是氢，未取代或取代的C1-C6烷基，C3-C6环烷基C2-C6链烯基或C2-C6炔基，或C（= O）-R5，R5是C1-C4烷基C1-C4烷氧基，未取代或取代的苯基，苯氧基或苄基氧基或N（R6）2，每个R6独立地为氢，C1-C4烷基或未取代或取代的苯基，X为CH-NO2，N-CN或N-NO2，n为1至3 ，以游离形式或盐形式，并且在适当时，这些化合物及其盐的互变异构体可以用作农业化学活性成分，并且可以以本身已知的方式制备。

5. 发明授权

US5977332A Oligonucleotides having 2'-ether groups 失效
标题翻译：具有2'-醚基团的寡核苷酸
公开(公告)号：US5977332A
公开(公告)日：1999-11-02
申请号：US26713
申请日：1998-02-20
申请人： Pierre Martin
发明人： Pierre Martin
IPC分类号： G01N33/50 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7076 , A61P31/12 , A61P35/00 , C07H19/06 , C07H19/067 , C07H19/10 , C07H19/16 , C07H19/167 , C07H19/20 , C07H21/00 , C07H21/02 , C07H21/04
CPC分类号： C07H19/06 , C07H19/16 , C07H21/00 , Y02P20/55
摘要： Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen or a protecting group, orR.sub.1 has those meanings andR.sub.2 is a radical forming a phosphorus-containing nucleotide bridge group;B is a purine or pyrimidine radical or an analogue thereof; andR.sub.3 is OH, or F, and oligonucleotides that comprise those nucleosides are described.
摘要翻译：下式的化合物其中R 1和R 2各自独立于另一个氢或保护基，或者R 1具有这些含义，并且R 2是形成含磷核苷酸桥基的基团; B是嘌呤或嘧啶基或其类似物; 和R 3是OH或F，并且描述了包含这些核苷的寡核苷酸。

6. 发明授权

US5969116A Nucleosides and oligonucleotides having 2'-ether groups 失效
标题翻译：具有2'-醚基团的核苷和寡核苷酸
公开(公告)号：US5969116A
公开(公告)日：1999-10-19
申请号：US459434
申请日：1995-06-02
申请人： Pierre Martin
发明人： Pierre Martin
IPC分类号： A61K49/00 , A61K31/70 , C07H20060101 , C07H19/04 , C07H19/06 , C07H19/067 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/167 , C07H19/20 , C07H19/23 , C07H21/00 , C07H21/02 , C12Q1/68 , G01N33/50 , C07H19/00 , A01N43/04
CPC分类号： C07H19/06 , C07H19/04 , C07H19/16 , C07H21/00 , Y02P20/55
摘要： Compounds of the formula ##STR1## are described wherein R.sub.1 and R.sub.2 are each independently of the other hydrogen or a protecting group, orR.sub.1 has those definitions andR.sub.2 is a radical forming a phosphorus-containing nucleotide bridge group;B is a purine or pyrimidine radical or an analogue thereof; andR.sub.3 is a radical of formula Ia, Ib or Ic ##STR2## wherein R.sub.4 is hydrogen, C.sub.1 -C.sub.21 alkyl, C.sub.2 -C.sub.21 alkenyl, C.sub.2 -C.sub.21 alkynyl or --C(.dbd.O)-alkyl;R.sub.5 is hydrogen, C.sub.1 -C.sub.10 alkyl, --CH.sub.2 --O--R.sub.6 or a radical of formula Ib;R.sub.6 is hydrogen, C.sub.1 -C.sub.22 alkyl, C.sub.3 -C.sub.21 alkenyl, or partially or completely fluorine-substituted C.sub.1 -C.sub.10 alkyl or --[(CH.sub.2).sub.2 --O].sub.m --R.sub.7 ;R.sub.7 is hydrogen or C.sub.1 -C.sub.21 alkyl;Z is --(CH.sub.2).sub.p -- or --(CH.sub.2 --CH.sub.2 --O).sub.q --CH.sub.2 CH.sub.2 --, it being possible for Z in the case of --CH.sub.2 -- to be unsubstituted or substituted by one or more identical or different substituents selected from C.sub.1 -C.sub.10 alkyl, C.sub.5 -C.sub.6 cycloalkyl and unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted phenyl;n is a number from 1 to 12;m is a number from 1 to 4;p is a number from 1 to 10; andq is a number from 1 to 4.
摘要翻译：其中R 1和R 2各自独立地为氢或保护基，R 1具有这些定义，R 2为形成含磷核苷酸桥基的基团; B是嘌呤或嘧啶基或其类似物; 并且R 3是式Ia，Ib或Ic的基团，其中R 4是氢，C 1 -C 21烷基，C 2 -C 21烯基，C 2 -C 21炔基或-C（= O） - 烷基; R5是氢，C1-C10烷基，-CH2-O-R6或式Ib的基团; R 6是氢，C 1 -C 22烷基，C 3 -C 21烯基或部分或完全氟取代的C 1 -C 10烷基或 - [（CH 2）2 -O] m -R 7; R7是氢或C1-C21烷基; Z是 - （CH 2）p - 或 - （CH 2 -CH 2 -O）q -CH 2 CH 2 - ，在-CH 2 - 的情况下Z可能是未取代的或被一个或多个相同或不同的选自C 1 C 10烷基，C 5 -C 6环烷基和未取代的或C 1 -C 4烷基取代的苯基; n是从1到12的数字; m是从1到4的数字; p是从1到10的数字; q是从1到4的数字。

7. 发明授权

US5935976A Antiviral ethers of aspartate protease substrate isosteres 失效
标题翻译：天冬氨酸蛋白酶底物等位基因的抗病毒醚
公开(公告)号：US5935976A
公开(公告)日：1999-08-10
申请号：US138076
申请日：1998-08-21
申请人： Guido Bold , Hans-Georg Capraro , Alexander Fassler , Marc Lang , Shripad Subray Bhagwat , Satish Chandra Khanna , Janis Karlis Lazdins , Jurgen Mestan
发明人： Guido Bold , Hans-Georg Capraro , Alexander Fassler , Marc Lang , Shripad Subray Bhagwat , Satish Chandra Khanna , Janis Karlis Lazdins , Jurgen Mestan
IPC分类号： C07D295/12 , A61K31/075 , A61K31/16 , A61K31/165 , A61K31/275 , A61K31/325 , A61K31/35 , A61K31/351 , A61K31/352 , A61K31/395 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/4418 , A61K31/4427 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/695 , A61K38/05 , A61P31/12 , A61P31/18 , C07C237/22 , C07C255/60 , C07C271/22 , C07C311/19 , C07C311/42 , C07C317/50 , C07D207/12 , C07D207/16 , C07D207/26 , C07D207/28 , C07D209/18 , C07D209/42 , C07D211/40 , C07D211/46 , C07D211/48 , C07D211/60 , C07D211/62 , C07D213/30 , C07D213/65 , C07D213/81 , C07D213/82 , C07D277/06 , C07D277/20 , C07D277/40 , C07D277/56 , C07D295/155 , C07D295/215 , C07D307/20 , C07D307/33 , C07D309/04 , C07D309/12 , C07D311/24 , C07D317/60 , C07D401/04 , C07K5/00
CPC分类号： C07D207/26 , A61K31/47 , A61K31/495 , C07C255/60 , C07C271/22 , C07C311/19 , C07C311/42 , C07C317/50 , C07D207/28 , C07D209/42 , C07D211/46 , C07D211/62 , C07D213/30 , C07D213/82 , C07D277/06 , C07D277/40 , C07D295/155 , C07D307/20 , C07D309/04 , C07D309/12 , C07D311/24 , C07D317/60 , C07C2101/14 , C07C2102/10
摘要： Antiretroviral compounds (which are effective, for example, against HIV) of the formula I ##STR1## in which R.sub.1 is an acyl radical lower-alkoxy-lower-alkanoyl whose lower alkoxy radical is unsubstituted or is substituted by halogen, phenyl, lower alkoxy or a heterocyclic radical selected from piperidinyl, pyrrolidinyl, tetrahydropyranyl, tetrahydrofuranyl, thiazolidinyl, thiazolyl, indolyl or 4H-1-benzopyranyl which is unsubstituted or substituted by oxo, hydroxyl, amino, lower alkyl, lower-alkoxycarbonyl and/or phenyl-lower-alkoxycarbonyl; lower alkanoyl which is unsubstituted or is substituted by one of the said unsubstituted or substituted heterocyclic radicals; arylcarbonyl or heterocyclylcarbonyl which are substituted by heterocyclyl or heterocyclyl-lower-alkyl; phenyl-lower-alkanoyl which is substituted by hydroxyl and lower alkyl; or arylsulfonyl;or the residue of an amino acid which is defined in accordance with the description (and which may be acylated on the amino nitrogen by one of the abovementioned acyl radicals);R.sub.2 and R.sub.3 are in each case cyclohexyl, cyclohexenyl, phenyl, naphthyl or tetrahydronaphthyl which are unsubstituted or substituted by lower alkyl, phenyl, cyanophenyl, phenyl-lower-alkyl, halogen, halo-lower-alkyl, cyano, hydroxyl, lower alkoxy, phenyl-lower-alkoxyl, pyridyl-lower-alkoxy, lower-alkoxy-lower-alkoxy, lower-alkoxycarbonyl-lower-alkoxy, carboxyl-lower-alkoxy, hydroxyl-lower-alkoxy, carbamoyl-lower-alkoxy, cyano-lower-alkoxy, and phenyl-lower-alkanesulfonyl which is unsubstituted or substituted by halogen;R.sub.4 is lower alkyl, cyclohexyl or phenyl; and R.sub.5 is lower alkyl; and n is 1 or 2,or salts thereof, are novel.
摘要翻译：其中R1是其低级烷氧基未被取代或被卤素，苯基，低级烷氧基或杂环取代的酰基低级烷氧基 - 低级 - 烷酰基的抗逆转录酶病毒化合物（其例如抗HIV）选自哌啶基，吡咯烷基，四氢吡喃基，四氢呋喃基，噻唑烷基，噻唑基，吲哚基或4H-1-苯并吡喃基，其未被取代或被氧代，羟基，氨基，低级烷基，低级烷氧基羰基和/或苯基 - 低级 - 烷氧基羰基取代。低级烷酰基，其未被取代或被所述未取代或取代的杂环基之一取代; 被杂环基或杂环基 - 低级烷基取代的芳基羰基或杂环基羰基; 被羟基和低级烷基取代的苯基 - 低级 - 烷酰基; 或芳基磺酰基; 或根据描述定义的氨基酸的残基（并且可以通过上述酰基之一在氨基氮上酰化）; 苯基，氰基苯基，苯基 - 低级 - 烷基，卤素，卤代低级烷基，氰基，羟基，低级烷氧基，低级烷氧基，低级烷氧基，低级烷氧基，低级烷氧基，低级烷氧基 - 低级烷氧基，低级烷氧基 - 低级 - 烷氧基，低级烷氧基 - 低级 - 烷氧基，羧基 - 低级 - 烷氧基，羟基 - 低级 - 烷氧基，氨基甲酰基 - 低级烷氧基，烷氧基和未被卤素取代的苯基 - 低级烷基磺酰基; R4是低级烷基，环己基或苯基; R5为低级烷基; n为1或2，或其盐为新颖的。

8. 发明授权

US5891429A Recombinant human granulocyte-macrophage-colony stimulating factor (GM-CSF) 失效
标题翻译：重组人粒细胞巨噬细胞集落刺激因子（GM-CSF）
公开(公告)号：US5891429A
公开(公告)日：1999-04-06
申请号：US466308
申请日：1995-06-06
申请人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong , Elizabeth A. Wang
发明人： Steven C. Clark , Randal J. Kaufman , Gordon G. Wong , Elizabeth A. Wang
IPC分类号： A61K38/00 , C07K14/535 , C12N15/27 , C12N15/70 , C12N15/81 , C12N15/85 , A61K38/19 , C07K1/20
CPC分类号： C12N15/85 , C07K14/535 , C12N15/70 , C12N15/81 , A61K38/00 , C12N2800/206 , C12N2830/00 , C12N2830/702 , C12N2840/105 , C12N2840/44
摘要： A method for preparing and isolating a transformation vector containing CSF/cDNA is described. The method comprises:preparing RNA from a cell that produces CSF;preparing polyadenylated messenger RNA from said RNA;preparing single stranded cDNA from said messenger RNA;converting the single stranded cDNA to double stranded cDNA;inserting the double stranded cDNA into transformation vectors and transforming bacteria with said vector to form colonies;picking pools of 200 to 500 colonies each and isolating plasmid DNA from each pool;transfecting the plasmid DNA into suitable host cells for expressing CSF protein;culturing the transfected cells and assaying the supernatant for CSF activity; andselecting CSF positive pools and screening the colonies used to make the pool to identify a colony having CSF activity. Also described are a cDNA coding for a protein having CSF activity (i.e. CSF/cDNA), a microorganism or cell line transformed with a recombinant vector containing such CSF/cDNA, and a method for producing CSF protein by expressing said CSF/cDNA by culturing a microorganism or cell line. The invention also provides a method of purifying the CSF proteins and the purified proteins so produced.
摘要翻译：描述了制备和分离含有CSF / cDNA的转化载体的方法。该方法包括：从产生CSF的细胞制备RNA; 从所述RNA制备聚腺苷酸化的信使RNA; 从所述信使RNA制备单链cDNA; 将单链cDNA转化为双链cDNA; 将双链cDNA插入转化载体并用所述载体转化细菌以形成菌落; 分别取200至500个菌落的池，每个池中分离出质粒DNA; 将质粒DNA转染到合适的宿主细胞中以表达CSF蛋白; 培养转染的细胞并测定上清液的CSF活性; 并选择CSF阳性池并筛选用于制备池的菌落以鉴定具有CSF活性的菌落。还描述了编码具有CSF活性的蛋白质（即CSF / cDNA）的cDNA，用含有这种CSF / cDNA的重组载体转化的微生物或细胞系，以及通过培养表达所述CSF / cDNA来产生CSF蛋白的方法微生物或细胞系。本发明还提供了纯化CSF蛋白质和如此制备的纯化蛋白质的方法。

9. 发明授权

US5866124A Antiidiotypic antibodies for high molecular weight-melanoma associated antigen 失效
标题翻译：用于高分子量黑素瘤相关抗原的抗独特型抗体
公开(公告)号：US5866124A
公开(公告)日：1999-02-02
申请号：US650262
申请日：1996-05-22
申请人： Norman Hardman , Gerd Pluschke , Brendan Murray
发明人： Norman Hardman , Gerd Pluschke , Brendan Murray
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P35/00 , C07K16/00 , C07K16/32 , C07K16/42 , C07K16/46 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , C12R1/91 , F02B75/02 , G01N33/574 , G01N33/577 , G01N33/68
CPC分类号： C07K16/4266 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2319/02 , C07K2319/50 , F02B2075/027 , Y10S435/81
摘要： The invention concerns antiidiotypic antibodies comprising human constant regions, and murine variable regions bearing the internal image of human high molecular weight-melanoma associated antigen which have the specificity of said antibody. These antiidiotypic monoclonal antibodies have immune-regulatory functions and can therefore be used for diagnostic and therapeutic purposes, such as the treatment of melanoma.
摘要翻译： PCT No.PCT / EP93 / 00505 Sec。 371日期：1994年9月14日 102（e）1994年9月14日PCT 1993年3月5日PCT公布。公开号WO93 / 19180 PCT 日期1993年9月30日本发明涉及包含人恒定区的抗独特型抗体以及具有所述抗体特异性的人类高分子量 - 黑素瘤相关抗原的内部图像的鼠可变区。这些抗独特型单克隆抗体具有免疫调节功能，因此可用于诊断和治疗目的，例如治疗黑素瘤。

10. 发明授权

US5859336A Synthetic DNA sequence having enhanced activity in maize 失效
标题翻译：在玉米中具有增强活性的合成DNA序列
公开(公告)号：US5859336A
公开(公告)日：1999-01-12
申请号：US459448
申请日：1995-06-02
申请人： Michael G. Koziel , Nalini M. Desai , Kelly S. Lewis , Gregory W. Warren , Stephen V. Evola , Lyle D. Crossland , Martha S. Wright , Ellis J. Merlin , Karen L. Launis , Cindy G. Bowman , John L. Dawson , Erik M. Dunder , Gary M. Pace , Janet L. Suttie
发明人： Michael G. Koziel , Nalini M. Desai , Kelly S. Lewis , Gregory W. Warren , Stephen V. Evola , Lyle D. Crossland , Martha S. Wright , Ellis J. Merlin , Karen L. Launis , Cindy G. Bowman , John L. Dawson , Erik M. Dunder , Gary M. Pace , Janet L. Suttie
IPC分类号： A01H5/00 , A01H5/10 , C07H21/04 , C07K14/325 , C12N5/04 , C12N9/12 , C12N9/88 , C12N15/09 , C12N15/11 , C12N15/32 , C12N15/54 , C12N15/60 , C12N15/82 , C12N15/87 , C12N15/63
CPC分类号： C07K14/325 , C12N15/8286 , C12N9/12 , C12N9/88
摘要： DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.
摘要翻译：公开了优化用于在植物中表达的DNA序列。 DNA序列优选编码杀虫多肽，特别是来自苏云金芽孢杆菌的杀虫蛋白。还提供植物启动子，特定组织特异性和组织优选启动子。另外公开了包含所述DNA序列的转化载体。转化载体在转化为玉米时表现出高水平的杀虫活性。

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