专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007122447A1 CYCLODIPEPTIDE SYNTHETASE AND ITS USE FOR SYNTHESIS OF CYCLO(TYR-Xaa) CYCLODIPEPTIDES 审中-公开
标题翻译：环磷酰胺合成酶及其用于合成CYCLO（TYR-Xaa）环磷酰胺的用途
公开(公告)号：WO2007122447A1
公开(公告)日：2007-11-01
申请号：PCT/IB2006/001852
申请日：2006-04-26
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , KYOWA HAKKO KOGYO CO., LTD , UNIVERSITE PARIS SUD 11 , BELIN, Pascal , GONDRY, Muriel , THAI, Robert , PERNODET, Jean-Luc , GENET, Roger
发明人： BELIN, Pascal , GONDRY, Muriel , THAI, Robert , PERNODET, Jean-Luc , GENET, Roger
IPC分类号： C07K14/35 , C12P21/00
CPC分类号： C12N9/93
摘要： Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides, in particular cyclo(Tyr-Xaa) cyclodipeptides, wherein Xaa is any amino acid and their derivatives and applications thereof.
摘要翻译：分离的，天然的或合成的多核苷酸和由所述多核苷酸编码的多肽，其参与环肽的合成，包含所述多核苷酸的重组载体或任何基本上同源的多核苷酸，用所述多核苷酸或所述重组载体修饰的宿主细胞，以及用于体外和体内合成环肽，特别是环（Tyr-Xaa）环二肽，其中Xaa是任何氨基酸及其衍生物和应用。

2. 发明申请

WO2006112556A1 METHOD FOR TREATING CANCER USING PREMEDICATION 审中-公开
标题翻译：使用预处理癌症的方法
公开(公告)号：WO2006112556A1
公开(公告)日：2006-10-26
申请号：PCT/JP2006/308931
申请日：2006-04-21
申请人： KYOWA HAKKO KOGYO CO., LTD. , FORERO, Andres , KOBAYASHI, Shigeru , TAMAOKA, Masami , TAOKA, Shose
发明人： FORERO, Andres , KOBAYASHI, Shigeru , TAMAOKA, Masami , TAOKA, Shose
IPC分类号： A61K45/00 , A61K31/138 , A61K31/341 , A61K31/47 , A61K31/573 , A61K39/395 , A61P35/00
CPC分类号： A61K31/138 , A61K31/341 , A61K31/47 , A61K31/573 , A61K45/06
摘要： The present invention relates to a method for treating cancer which comprises; administering to a patient in need thereof a therapeutically effective amount of at least two compounds selected from antihistamic agent, antiallergic agent and steroid, and then administering to the patient in need thereof a therapeutically effective amount of a humanized antibody or a human antibody which specifically binds to ganglioside GD3 or the antibody fragment thereof.
摘要翻译：本发明涉及一种治疗癌症的方法，包括：向有需要的患者施用治疗有效量的至少两种选自抗组胺剂，抗过敏剂和类固醇的化合物，然后向有需要的患者施用治疗有效量的特异性结合的人源化抗体或人抗体神经节苷脂GD3或其抗体片段。

3. 发明申请

WO2004108137A1 A METHOD OF TREATING AN ANXIETY DISORDER 审中-公开
标题翻译：一种治疗恶心病的方法
公开(公告)号：WO2004108137A1
公开(公告)日：2004-12-16
申请号：PCT/JP2004/008486
申请日：2004-06-10
申请人： KYOWA HAKKO KOGYO CO., LTD. , KASE, Hiroshi , SENO, Naoki , SHIOZAKI, Shizuo , KOBAYASHI, Minoru , KASE, Junya
发明人： KASE, Hiroshi , SENO, Naoki , SHIOZAKI, Shizuo , KOBAYASHI, Minoru , KASE, Junya
IPC分类号： A61K31/522
CPC分类号： A61K45/06 , A61K31/00 , A61K31/519 , A61K31/522 , A61K2300/00
摘要： Anxiety disorders, such as panic disorder, agoraphobia, obsessive-compulsive disorder, social phobia, post-traumatic stress disorder, generalized anxiety disorder, specific phobia, or the like, are treated by administering an effective amount of at least one adenosine A 2A receptor antagonist to a patient in need thereof, optionally in combination with an anxiolytic(s) other than the adenosine A 2A receptor antagonist.
摘要翻译：通过施用有效量的至少一种腺苷A2A受体拮抗剂来治疗焦虑症，例如恐慌症，广场恐怖症，强迫症，社交恐惧症，创伤后应激障碍，广泛性焦虑症，特异性恐惧症等。任选地与除了腺苷A2A受体拮抗剂之外的抗焦虑药组合。

4. 发明申请

WO1998029544A1 NOVEL PEPTIDE, NOVEL DNA, AND NOVEL ANTIBODY 审中-公开
标题翻译：新肽，新型DNA和新型抗体
公开(公告)号：WO1998029544A1
公开(公告)日：1998-07-09
申请号：PCT/JP1997004585
申请日：1997-12-12
申请人： KYOWA HAKKO KOGYO CO., LTD. , NABESHIMA, Youichi , KUROO, Makoto , SEKINE, Susumu , IIDA, Akihiro
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C12N15/12
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , A01K2267/0393 , A61K38/00 , A61K48/00 , C07K14/47 , C07K16/18 , C12N2799/026 , C12N2800/30
摘要： A polypeptide having the activity of retarding aging; a DNA encoding this polypeptide; a method for breeding livestock with the use of this DNA; a recombinant DNA obtained by integrating this DNA into a vector; a transformant containing this recombinant; a process for producing the above polypeptide by using the transformant; an antibody capable of recognizing the polypeptide; a ligand for the polypeptide; a compound inhibiting the specific bond between the polypeptide and this ligand; a compound promoting the expression of the aging-retarding gene encoding the aging-retarding polypeptide; an oligonucleotide having a sequence consisting of 10 to 50 bases in the base sequence of the above DNA; and remedies for early aging, remedies for adult diseases, and aging resistors prepared with the use of the same.
摘要翻译：具有延缓衰老活性的多肽; 编码该多肽的DNA; 使用该DNA繁殖家畜的方法; 通过将该DNA整合到载体中获得的重组DNA; 含有此重组体的转化体; 通过使用转化体生产上述多肽的方法; 能识别多肽的抗体; 多肽的配体; 抑制多肽与该配体之间的特异性键的化合物; 促进编码衰老多肽的衰老基因表达的化合物; 在上述DNA的碱基序列中具有由10〜50个碱基组成的序列的寡核苷酸; 以及早期老化的补救措施，成人疾病的补救措施，以及使用它们制备的老化电阻。

5. 发明申请

WO1998024815A1 NOVEL PROTEIN 审中-公开
标题翻译：新蛋白质
公开(公告)号：WO1998024815A1
公开(公告)日：1998-06-11
申请号：PCT/JP1997004469
申请日：1997-12-05
申请人： KYOWA HAKKO KOGYO CO., LTD. , KAZUSA DNA RESEARCH INSTUTITE FOUNDATION , ISHIWATA, Tetsuyoshi , SAKURADA, Mikiko , NISHIMURA, Ayako , NAKAGAWA, Satoshi , KUGA, Tetsuro , NISHI, Tatsunari , NOMURA, Nobuo , NAGASE, Takahiro , SAWADA, Shigemasa , TAKEI, Masami
发明人： KYOWA HAKKO KOGYO CO., LTD. , KAZUSA DNA RESEARCH INSTUTITE FOUNDATION
IPC分类号： C07K14/435
CPC分类号： C07K14/47
摘要： A novel protein isolated from leukocytes of patients with IgA nephropathy; a DNA sequence encoding this protein; oligonucleotides based on the base sequence complementary to this DNA; an antibody reacting specifically with the above protein; and diagnostic drugs and remedies for IgA nephropathy containing the same.
摘要翻译：从IgA肾病患者白细胞分离的新蛋白; 编码该蛋白质的DNA序列; 基于与该DNA互补的碱基序列的寡核苷酸; 与上述蛋白质特异性反应的抗体; 以及含有该IgA肾病的诊断药物和治疗方法。

6. 发明申请

WO1998020150A1 PROCESS FOR PREPARING CHOLESTEROL-LOWERING COMPOUND 审中-公开
标题翻译：制备胆固醇降低化合物的方法
公开(公告)号：WO1998020150A1
公开(公告)日：1998-05-14
申请号：PCT/JP1997004067
申请日：1997-11-07
申请人： KYOWA HAKKO KOGYO CO., LTD. , SAITOH, Chiaki , KUMAZAWA, Hideyo , AISAKA, Kazuo , MIZUKAMI, Toru , KATSUMATA, Ryoichi , ANDO, Katsuhiko , OCHIAI, Keiko , OUCHI, Kozo
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C12P33/00
CPC分类号： C12Y101/99001 , A23K20/189 , A23L5/25 , A23L13/48 , A23L15/25 , A23L17/65 , C12N9/0006 , C12P33/00
摘要： A process for preparing a practical cholesterol-lowering compound by converting the cholesterol contained in a food or feed to coprostanol having very low intestinal absorption by utilizing an enzymatic action. The content of cholesterol in cholesterol-containing materials such as meat, eggs, milk, fishery products, and cooked and processed foods containing these products, or feed for animals, poultry, fish culture and the like is lowered by treating these materials with three enzymes, i.e., a cholesterol dehydrogenase having an optimal pH value in a neutral pH range and a 4-cholesten-3-one dehydrogenase and a coprostan-3-one dehydrogenase both having an optimal pH value in a weakly acidic range, or cells containing these enzymes to convert cholesterol to coprostanol.
摘要翻译：通过利用酶作用将食物或饲料中所含的胆固醇转化为具有非常低肠吸收的coprostanol来制备实用的降胆固醇化合物的方法。通过用三种酶处理这些物质来降低含有含胆固醇的材料如肉，蛋，牛奶，渔业产品中含有这些产品的熟化和加工食品中的胆固醇含量，动物，家禽，鱼类培养物等的饲料即在中性pH范围内具有最佳pH值的胆固醇脱氢酶和在弱酸性范围内具有最佳pH值的4-胆甾烯-3-酮脱氢酶和副雄甾-3-酮脱氢酶，或含有这些的细胞将胆固醇转化为coprostanol的酶。

7. 发明申请

WO1998014431A1 NITROGENOUS HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：硝基杂环化合物
公开(公告)号：WO1998014431A1
公开(公告)日：1998-04-09
申请号：PCT/JP1997003510
申请日：1997-10-01
申请人： KYOWA HAKKO KOGYO CO., LTD. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , FUJIWARA, Shigeki , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D215/46
CPC分类号： C07D401/12 , A61K31/496 , A61K31/502 , A61K31/517 , C07D215/46 , C07D217/22 , C07D237/34 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要： Nitrogenous heterocyclic compounds of general formula (I) and pharmacologically acceptable salts thereof, which hinder the phosphorylation of PDGF acceptors and the abnormal proliferation or migration of cells and so are effective in preventing or treating cell proliferative diseases such as arterial sclerosis, vascular reocclusion diseases, cancer and glomerulosclerosis, wherein V is oxygen or sulfur; W is 1,4-piperazinediyl or 1,4-homopiperazinediyl which may be substituted with unsubstituted alkyl on the ring; X is nitrogen or C-R , Y is nitrogen or C-R and Z is nitrogen or C-R , with at least one of X, Y and Z being nitrogen; R is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like; R is substituted alkyl, substituted or unsubstituted cycloalkyl or the like; R , R , R and R are each independently hydrogen, halogeno, substituted or unsubstituted alkyl, nitro, cyano, -OR , -NR R or the like; R is halogeno or the like; R is the same as defined above for R ; and R is hydrogen or -COR .
摘要翻译：通式（I）的氮杂环化合物及其药理学上可接受的盐阻碍PDGF受体的磷酸化和细胞的异常增殖或迁移等，有效预防或治疗细胞增殖性疾病如动脉硬化，血管再闭塞疾病，癌症和肾小球硬化，其中V是氧或硫; W是可以在环上被未取代的烷基取代的1,4-哌嗪二基或1,4-高哌嗪二基; X是氮或C-R 9，Y是氮或C-R 8，Z是氮或C-R 7，X，Y和Z中的至少一个是氮; R 1是氢，取代或未取代的烷基，取代或未取代的环烷基等; R 2是取代的烷基，取代或未取代的环烷基等; R 3，R 4，R 5和R 6各自独立地为氢，卤素，取代或未取代的烷基，硝基，氰基，-OR 12，-NR 15 R 16，或类似物; R 7是卤代等; R 8与上述R 7相同; R 9为氢或-COR 41。

8. 发明申请

WO1998011247A1 PROCESSES FOR PRODUCING SUGAR NUCLEOTIDES AND COMPLEX CARBOHYDRATES 审中-公开
标题翻译：生产蔗糖核糖体和复合碳水化合物的方法
公开(公告)号：WO1998011247A1
公开(公告)日：1998-03-19
申请号：PCT/JP1997003225
申请日：1997-09-12
申请人： KYOWA HAKKO KOGYO CO., LTD. , KOIZUMI, Satoshi , KAWANO, Hisaji , KINO, Kuniki , OZAKI, Akio
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C12P19/00
CPC分类号： C12P19/305 , C12N9/1051 , C12P19/02 , C12P19/18 , C12P19/26 , C12P19/30
摘要： A process for producing a sugar nucleotide characterized by using as an enzyme source an optionally processed culture of a microorganism capable of producing the sugar nucleotide from a nucleotide precursor and a sugar, effecting an enzymatic reaction in an aqueous medium containing the enzyme source, the nucleotide precursor and the sugar to thereby accumulate the sugar nucleotide in the medium, and taking up the sugar nucleotide from the medium; and a process for producing a complex carbohydrate characterized by using as enzyme sources an optionally processed culture of a microorganism capable of producing a sugar nucleotide from a nucleotide precursor and a sugar, and an optionally processed culture of a microorganism or animal cells capable of producing the complex carbohydrate from the sugar nucleotide and a complex carbohydrate precursor, effecting enzymatic reactions in an aqueous medium containing these enzyme sources, the nucleotide precursor, the sugar and the complex carbohydrate precursor to thereby accumulate the complex carbohydrate in the medium, and taking up the complex carbohydrate from the medium.
摘要翻译：一种制备糖核苷酸的方法，其特征在于使用能够从含有酶源的水性介质中进行酶反应的核苷酸前体和糖产生糖核苷酸的微生物任选加工的培养物作为酶源，核苷酸前体和糖，从而在培养基中积聚糖核苷酸，并从培养基中摄取糖核苷酸; 其特征在于使用能够从核苷酸前体和糖产生糖核苷酸的微生物任选加工的培养物，以及能够生产所述微生物或动物细胞的任选加工的培养物作为酶源的复合碳水化合物的生产方法来自糖核苷酸的复合碳水化合物和复合碳水化合物前体，在含有这些酶源的水性介质，核苷酸前体，糖和复合碳水化合物前体中进行酶促反应，从而在培养基中积聚复合碳水化合物，并吸收复合物碳水化合物从培养基中。

9. 发明申请

WO1998009966A1 DC-89 DERIVATIVES 审中-公开
标题翻译： DC-89衍生物
公开(公告)号：WO1998009966A1
公开(公告)日：1998-03-12
申请号：PCT/JP1997003089
申请日：1997-09-03
申请人： KYOWA HAKKO KOGYO CO., LTD. , AMISHIRO, Nobuyoshi , SAITO, Hiromitsu , OKAMOTO, Akihiko , OKABE, Masami
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： DC-89 derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein (a) represents (b) or (c); Y represents hydrogen, halogeno, optionally substituted lower alkyl, COR , CH=NR or (d); Z represents hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted aryl, optionally substituted heterocycle or COR (wherein R represents hydrogen, COR or R R R Si; and V represents hydrogen, halogeno, nitro or COR ); W represents hydrogen, (e), (f), (g) or (h); and X represents Cl or Br, provided that when Y is hydrogen or CO2R (wherein R is hydrogen, linear or branched C1-4 alkyl, aryl or benzyl), then Z and V do not represent hydrogen at the same time. These compounds have excellent antitumor activities, which makes them useful as antitumor agents.
摘要翻译：由通式（I）表示的DC-89衍生物或其药理学上可接受的盐，其中（a）表示（b）或（c）; Y表示氢，卤代，任选取代的低级烷基，COR 1，CH = NR 8或（d）; Z表示氢，任选取代的低级烷基，任选取代的低级烯基，任选取代的芳基，任选取代的杂环或COR 9（其中R表示氢，COR 12或R 16 R 17 R 18 ;和V表示氢，卤代，硝基或COR 11）; W表示氢，（e），（f），（g）或（h）; 并且X表示Cl或Br，条件是当Y是氢或CO 2 R 2（其中R 2是氢，直链或支链C 1-4烷基，芳基或苄基）时，则Z和V在同时。这些化合物具有优异的抗肿瘤活性，使其成为抗肿瘤剂。

10. 发明申请

WO1998005334A1 FAT EMULSION CONTAINING XANTHINE DERIVATIVE 审中-公开
标题翻译：含有XANTHINE衍生物的脂肪乳剂
公开(公告)号：WO1998005334A1
公开(公告)日：1998-02-12
申请号：PCT/JP1997002773
申请日：1997-08-07
申请人： KYOWA HAKKO KOGYO CO., LTD. , HOSOKAWA, Toshihito , IWATA, Kenji , KAWAGUCHI, Yuji , KATO, Yasuki , ITO, Kunio
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： A61K31/52
CPC分类号： A61K31/522 , A61K9/1075 , C07D473/06 , Y10S514/938
摘要： A fat emulsion comprising a xanthine derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R and R represent each independently substituted or unsubstituted lower alkyl, and Q represents hydrogen, hydroxyl or substituted hydroxyl.
摘要翻译：包含由通式（I）表示的黄嘌呤衍生物或其药学上可接受的盐的脂肪乳剂，其中R 1和R 2各自独立地为取代或未取代的低级烷基，Q表示氢，羟基或取代的羟基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式