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1. 发明公开

EP1309569A2 NITROGENOUS HETEROCYCLIC COMPOUNDS 有权
标题翻译： N-芳基 - {4- [7-（烷氧基）喹唑啉-4-基]哌嗪基}甲酰胺化合物作为PDGF受体阻断剂
公开(公告)号：EP1309569A2
公开(公告)日：2003-05-14
申请号：EP01973654.5
申请日：2001-08-17
申请人： Millennium Pharmaceuticals, Inc. , KYOWA HAKKO KOGYO CO., LTD. , Pandey, Anjali , Scarborough, Robert M. , Matsuno, Kenji , Ichimura, Michio , Nomoto, Yugi , Fujiwara, Shigeki , Ide, Shinichi , Tsukuda, Eiji , Irie, Junko , Oda, Shoji
发明人： PANDEY, Anjali , SCARBOROUGH, Robert, M. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , FUJIWARA, Shigeki , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
IPC分类号： C07D239/94 , C07D401/12 , C07D403/12 , A61K31/517 , A61P35/00
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

2. 发明公开

EP1315715A1 QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS 有权
标题翻译：喹唑啉衍生物作为激酶抑制剂的
公开(公告)号：EP1315715A1
公开(公告)日：2003-06-04
申请号：EP01964612.4
申请日：2001-08-17
申请人： Millennium Pharmaceuticals, Inc. , Kyowa Hakko Kogyo Co., Ltd , Pandey, Anjali , Scarborough, Robert M. , Matsuno, Kenji , Ichimura, Michio , Nomoto, Yugi , Ide, Shinichi , Tsukuda, Eiji , Irie, Junko , Oda, Shoji
发明人： PANDEY, Anjali , SCARBOROUGH, Robert, M. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
IPC分类号： C07D403/12 , C07D239/94 , C07D401/12
CPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

4. 发明专利

AU8544901A Quinazoline derivatives as kinase inhibitors 未知
公开(公告)号：AU8544901A
公开(公告)日：2002-03-04
申请号：AU8544901
申请日：2001-08-17
申请人： COR THERAPEUTICS INC , KYOWA HAKKO KOGYO KK , PANDEY ANJALI , SCARBOROUGH ROBERT M JR , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
发明人： PANDEY ANJALI , SCARBOROUGH ROBERT M JR , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
IPC分类号： A61K31/517 , A61K31/5377 , A61K31/541 , A61P9/08 , A61P9/10 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/94 , C07D401/12 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinase and treating disese states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

5. 发明申请

WO0216360A3 NITROGENOUS HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：硝基杂环化合物
公开(公告)号：WO0216360A3
公开(公告)日：2002-06-13
申请号：PCT/US0141749
申请日：2001-08-17
申请人： COR THERAPEUTICS INC , KYOWA HAKKO KOGYO KK , PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
发明人： PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
IPC分类号： A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , A61K31/517 , C07D405/12 , C07D409/12 , C07D417/12
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管重建，癌症和肾小球硬化症。

6. 发明申请

WO0216361A2 NITROGENOUS HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：非活性杂环化合物
公开(公告)号：WO0216361A2
公开(公告)日：2002-02-28
申请号：PCT/US0141750
申请日：2001-08-17
申请人： COR THERAPEUTICS INC , KYOWA HAKKO KOGYO KK , PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUGI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKIDA EIJI , IRIE JUNKO , ODA SHOJI
发明人： PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUGI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKIDA EIJI , IRIE JUNKO , ODA SHOJI
IPC分类号： A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/00
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibitng kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对激酶的磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐，其抑制这些激酶的活性。本发明还涉及抑制激酶和通过抑制激酶的磷酸化来治疗哺乳动物的疾病状态的方法。本发明的一个特定方面提供了抑制PDGF受体的磷酸化以阻碍异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管性重建，癌症和肾小球硬化。

7. 发明申请

WO0216362A3 NITROGENOUS HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：非活性杂环化合物
公开(公告)号：WO0216362A3
公开(公告)日：2002-06-13
申请号：PCT/US0141751
申请日：2001-08-17
申请人： COR THERAPEUTICS INC , KYOWA HAKKO KOGYO KK , PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
发明人： PANDEY ANJALI , SCARBOROUGH ROBERT M , MATSUNO KENJI , ICHIMURA MICHIO , NOMOTO YUJI , FUJIWARA SHIGEKI , IDE SHINICHI , TSUKUDA EIJI , IRIE JUNKO , ODA SHOJI
IPC分类号： A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , A61K31/517
CPC分类号： C07D401/12 , C07D239/94 , C07D403/12
摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.
摘要翻译：本发明涉及对激酶的磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐，其抑制这些激酶的活性。本发明还涉及抑制激酶并通过抑制激酶的磷酸化来治疗哺乳动物的疾病状态的方法。本发明的一个特定方面提供了抑制PDGF受体的磷酸化以阻碍异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管性重建，癌症和肾小球硬化。

8. 发明申请

WO1998014431A1 NITROGENOUS HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：硝基杂环化合物
公开(公告)号：WO1998014431A1
公开(公告)日：1998-04-09
申请号：PCT/JP1997003510
申请日：1997-10-01
申请人： KYOWA HAKKO KOGYO CO., LTD. , MATSUNO, Kenji , ICHIMURA, Michio , NOMOTO, Yuji , FUJIWARA, Shigeki , IDE, Shinichi , TSUKUDA, Eiji , IRIE, Junko , ODA, Shoji
发明人： KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C07D215/46
CPC分类号： C07D401/12 , A61K31/496 , A61K31/502 , A61K31/517 , C07D215/46 , C07D217/22 , C07D237/34 , C07D239/94 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要： Nitrogenous heterocyclic compounds of general formula (I) and pharmacologically acceptable salts thereof, which hinder the phosphorylation of PDGF acceptors and the abnormal proliferation or migration of cells and so are effective in preventing or treating cell proliferative diseases such as arterial sclerosis, vascular reocclusion diseases, cancer and glomerulosclerosis, wherein V is oxygen or sulfur; W is 1,4-piperazinediyl or 1,4-homopiperazinediyl which may be substituted with unsubstituted alkyl on the ring; X is nitrogen or C-R , Y is nitrogen or C-R and Z is nitrogen or C-R , with at least one of X, Y and Z being nitrogen; R is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like; R is substituted alkyl, substituted or unsubstituted cycloalkyl or the like; R , R , R and R are each independently hydrogen, halogeno, substituted or unsubstituted alkyl, nitro, cyano, -OR , -NR R or the like; R is halogeno or the like; R is the same as defined above for R ; and R is hydrogen or -COR .
摘要翻译：通式（I）的氮杂环化合物及其药理学上可接受的盐阻碍PDGF受体的磷酸化和细胞的异常增殖或迁移等，有效预防或治疗细胞增殖性疾病如动脉硬化，血管再闭塞疾病，癌症和肾小球硬化，其中V是氧或硫; W是可以在环上被未取代的烷基取代的1,4-哌嗪二基或1,4-高哌嗪二基; X是氮或C-R 9，Y是氮或C-R 8，Z是氮或C-R 7，X，Y和Z中的至少一个是氮; R 1是氢，取代或未取代的烷基，取代或未取代的环烷基等; R 2是取代的烷基，取代或未取代的环烷基等; R 3，R 4，R 5和R 6各自独立地为氢，卤素，取代或未取代的烷基，硝基，氰基，-OR 12，-NR 15 R 16，或类似物; R 7是卤代等; R 8与上述R 7相同; R 9为氢或-COR 41。

9. 发明申请

WO1996023069A1 RECOMBINANT DNA PREPARED BY INTEGRATING DNA THAT CODES FOR MYOSIN HEAVY-CHAIN SM1 ISOFORM PROTEIN INTO VECTOR DNA, AND MICROORGANISM AND ARTERIOSCLEROSIS REMEDY BOTH CONTAINING THE RECOMBINANT DNA 审中-公开
标题翻译：通过将含有MYOSIN重链SM1蛋白质的蛋白质的DNA整合到载体DNA中制备的重组DNA，以及含有重组DNA的微生物和二孢子体病毒
公开(公告)号：WO1996023069A1
公开(公告)日：1996-08-01
申请号：PCT/JP1996000134
申请日：1996-01-25
申请人： VESSEL RESEARCH LABORATORY CO., LTD. , OSAKA PREFECTURAL GOVERNMENT , HASEGAWA, Kazuhide , ARAKAWA, Emi , ODA, Shoji , MATSUDA, Yuzuru , TAKAHASHI, Katsuhito , SUGAWARA, Michihiro , ISHIYAMA, Haruo
发明人： VESSEL RESEARCH LABORATORY CO., LTD. , OSAKA PREFECTURAL GOVERNMENT
IPC分类号： C12N15/12
CPC分类号： C07K14/4716 , A61K38/00
摘要： A recombinant DNA prepared by integrating a DNA that codes for a smooth-muscle myosin heavy-chain SM1 isoform protein into a vector DNA; and a microorganism and arteriosclerosis remedy both containing the recombinant DNA. The DNA is utilizable as a gene remedy for post-PTCA reconstriction.
摘要翻译：将编码平滑肌肌球蛋白重链SM1同种型蛋白质的DNA整合到载体DNA中而制备的重组DNA; 以及含有重组DNA的微生物和动脉硬化症。该DNA可用作PTCA复发后的基因治疗方法。

10. 发明专利

JPH02198796A SLICING DEVICE 失效
公开(公告)号：JPH02198796A
公开(公告)日：1990-08-07
申请号：JP1401489
申请日：1989-01-25
申请人： ODA SHOJI CO LTD
发明人： KOBAYASHI YUZO , ODA MITSUO
IPC分类号： B26D3/28
摘要： PURPOSE:To obtain wide pieces of meat by slicing an object to be sliced diagonally by providing a work-table capable of turning round its base end part close to one face of a circular cutter, being tilted in a specified range of inclination from horizontal to vertical, and reciprocating horizontally along one face of the circular cutter. CONSTITUTION:A smoked salmon A with temperature of -6 to -10 deg.C is set on a work-table 3. In setting operation, setting of a pressing means 5 is released to place the smoked salmon A on the work-table 3, and an operating layer 11 of a chucking means 4 is operated to chuck the tail part of the smoked salmon A. After the completion of the chucking, the pressing means 5 is returned to the original position, and the setting is thus completed. A supporting rod 8 is operated to move an arm 9 connected to the work-table to adjust the inclination of the work-table 3, and a circular cutter 2 starts, a reciprocating table 6 is reciprocated, and slicing operation is thus performed. In this case, after checking of the width of meat and adjusting of the inclination of the work-table 3, the salmon A is cut diagonally to obtain pieces of meat with the desired width.

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