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81. 发明申请

US20040067255A1 Method of administering split doses of a vascular targeting agent 审中-公开
标题翻译：分配剂量的血管靶向剂的方法
公开(公告)号：US20040067255A1
公开(公告)日：2004-04-08
申请号：US10265820
申请日：2002-10-07
发明人： David J. Chaplin , Sally Hill
IPC分类号： A61K031/075 , A61K009/22
CPC分类号： A61K31/075
摘要： The present invention is directed to the use of vascular targeting agents or pharmaceutically acceptable salts thereof for administration in divided doses to a warm-blooded animal, such as a human. Also disclosed is a medicament comprising two or more fraction of doses of a vascular targeting agent, or a pharmaceutically acceptable salt thereof, which together add up to a total daily dose, or administration in divided doses for use in a method of treating a human or warm-blooded animal. A kit comprising two or more fractions of doses of a vascular targeting agent or a pharmaceutically acceptable salt thereof, which together add up to a total daily dose, for administration in divided doses is also disclosed.
摘要翻译：本发明涉及血管靶向剂或其药学上可接受的盐在分配剂量下给予温血动物如人的用途。还公开了一种药物，其包含两个或更多个剂量的血管靶向剂或其药学上可接受的盐，其总共加入总日剂量，或以分剂量施用用于治疗人的方法或温血动物还公开了一种试剂盒，其包含两个或更多个剂量的血管靶向剂或其药学上可接受的盐，其总共加入总日剂量，以分剂量施用。

82. 发明申请

US20040018958A1 Methods for therapy of radiation cutaneous syndrome 失效
公开(公告)号：US20040018958A1
公开(公告)日：2004-01-29
申请号：US10205738
申请日：2002-07-25
发明人： Yih-Lin Chung
IPC分类号： A61K038/16 , A61K031/545 , A61K009/127 , A61K031/19 , A61K031/165 , A61K031/075
CPC分类号： A61K31/545 , A61K9/06 , A61K9/127 , A61K31/075 , A61K31/165 , A61K31/19 , A61K38/15
摘要： Compounds of a histone deacetylase inhibitor. The compounds are capable of simultaneously stimulating epithelium regrowth, inhibiting cutaneous fibroblast proliferation, decreasing collagen deposit, suppressing fibrogenic growth factor and subsiding inflammatory cytokine, and are useful inhibiting the main features of radiation cutaneous syndrome. Results include a decrease in skin swelling, promotion of epithelium healing, and prevention of cutaneous fibrosis, ulceration and necrosis. The present invention provides methods of treating, preventing or ameliorating radiation-induced skin damage by administering a therapeutically effective amount of a histone deacetylase inhibitor.

83. 发明申请

US20040009227A1 Thermoplastic particles which comprise an antiviral or antimicrobial agent 审中-公开
标题翻译：包含抗病毒剂或抗微生物剂的热塑性颗粒
公开(公告)号：US20040009227A1
公开(公告)日：2004-01-15
申请号：US10408095
申请日：2003-04-08
申请人： Porex Corporation
发明人： Li Yao
IPC分类号： A61K033/38 , A61K009/14 , A61K031/17 , A61K031/075 , A61K031/155
CPC分类号： A61L9/042 , A01N25/10 , A01N25/34 , A01N31/16 , A61L2/23 , A01N2300/00
摘要： This invention relates to novel porous materials that possess antiviral and/or antimicrobial properties. The invention encompasses a porous material having antiviral or antimicrobial properties-which is comprised of a porous substrate and an antiviral or antimicrobial agent. The invention also encompasses a process for making porous materials that possess antiviral and/or antimicrobial properties and the products of the process.
摘要翻译：本发明涉及具有抗病毒和/或抗微生物特性的新型多孔材料。本发明包括具有抗病毒或抗微生物性质的多孔材料，其由多孔底物和抗病毒或抗微生物剂组成。本发明还包括一种制备具有抗病毒和/或抗微生物特性的多孔材料和该方法的产物的方法。

84. 发明申请

US20030215532A1 New sensate composition imparting initial sensation upon contact 有权
标题翻译：新的感觉组合在接触时赋予最初的感觉
公开(公告)号：US20030215532A1
公开(公告)日：2003-11-20
申请号：US10464149
申请日：2003-06-17
申请人： Takasago International Corporation
发明人： Tetsuo Nakatsu , Peter J. Mazeiko , Andrew T. Lupo JR. , Carter B. Green , Charles H. Manley , David J. Spence , Hideaki Ohta
IPC分类号： A61K035/78 , A61K031/335 , A61K047/00 , A61K031/075 , A61K031/11
CPC分类号： A61Q13/00 , A23G3/36 , A23G4/06 , A23L27/204 , A61K8/42 , A61K8/922 , A61K2800/244 , A61Q11/00 , C07C43/196 , C07C2601/14
摘要： The present invention is directed to a sensate composition including at least one cooling sensate, warming sensate and tingling sensate. The tingling sensate is at least one of Jambu Oleoresin and Spilanthol. The present invention is further directed to a method of using the sensate composition in a food, pharmaceutical or personal care product.
摘要翻译：本发明涉及包含至少一种冷却感，加温感和刺痛感的敏感组合物。刺痛的感觉是至少一种Jambu Oleoresin和Spilanthol。本发明还涉及在食品，药物或个人护理产品中使用感觉组合物的方法。

85. 发明申请

US20030207945A1 Non-halogenated phenyl substituted phenols, antimicrobial compositions containing the same, and methods of using the same 审中-公开
公开(公告)号：US20030207945A1
公开(公告)日：2003-11-06
申请号：US10425085
申请日：2003-04-28
发明人： David Scott Harper , Robert A. Coburn , Constantine Georgiades , Andre Soshinsky , Marianne D. Huntley
IPC分类号： A61K031/075 , A61K031/05 , C07C039/06 , C07C043/205
CPC分类号： A61K31/05 , A61K31/075 , C07C39/15
摘要： A antimicrobial compound, compositions containing the same, and method of using the same for reducing the presence of microorganism on a substrate or in a fluid environment comprising an antimicrobial effective carrier and at least one antimicrobial compounds including non-halogenated phenyl substituted phenol compounds.

86. 发明申请

US20030158265A1 Orally administrable pharmaceutical formulation comprising pseudoephedrine hydrochloride and process for preparing the same 审中-公开
标题翻译：口服给药的药物制剂，其包含盐酸假麻黄碱及其制备方法
公开(公告)号：US20030158265A1
公开(公告)日：2003-08-21
申请号：US10096709
申请日：2002-03-13
发明人： Ramachandran Radhakrishnan , Nehru Babu Gaddipati
IPC分类号： A61K031/137 , A61K009/48 , A61K031/075
CPC分类号： A61K31/09 , A61K9/4858 , A61K31/075 , A61K31/137 , A61K2300/00
摘要： Disclosed are pharmaceutical formulations for oral administration through a soft gelatin capsule drug delivery device, wherein the pharmaceutical formulation, in a preferred embodiment, contains Pseudoephedrine HCl and an expectorant as the active ingredients. The active pharmaceutical ingredient is embedded into an oily matrix. The formulation also includes an expectorant; a surfactant; a suspending agent; and a suspension medium, wherein, in a preferred embodiment, the expectorant is guaifenesin, the surfactant is lecithin, the suspending agent is yellow beeswax, and the suspension medium is soybean oil. In a preferred embodiment, the formulation consists essentially of about 30.5 mg by weight of Pseudoephedrine HCl, about 200 mg by weight of guaifenesin, about 0.1-5.0 mg by weight of yellow beeswax, about 10-15 mg by weight of lecithin; and about 200-300 mg by weight of soybean oil. Also disclosed is a process for preparing the formulation.
摘要翻译：公开了通过软明胶胶囊药物递送装置口服给药的药物制剂，其中在优选实施方案中，药物制剂含有盐酸假麻黄碱和作为活性成分的祛痰剂。将活性药物成分嵌入油性基质中。该制剂还包括祛痰剂; 表面活性剂; 悬浮剂; 和悬浮介质，其中，在优选的实施方案中，祛痰剂是愈创甘油醚，表面活性剂是卵磷脂，悬浮剂是黄蜂蜡，悬浮液是大豆油。在优选的实施方案中，制剂基本上由约30.5mg重量的盐酸假麻黄碱，约200mg重量的愈创甘油醚，约0.1-5.0mg的黄蜂蜡，约10-15mg的卵磷脂; 和约200-300mg的大豆油。还公开了制备该制剂的方法。

87. 发明申请

US20030152644A1 Gentle-acting skin-disinfectants 有权
标题翻译：温和的皮肤消毒剂
公开(公告)号：US20030152644A1
公开(公告)日：2003-08-14
申请号：US10047631
申请日：2001-10-23
发明人： Shanta Modak , Trupti A. Gaonkar , Lester Sampath
IPC分类号： A61K033/36 , A61K031/155 , A61K031/14 , A61K031/075
CPC分类号： A61K8/042 , A61K8/347 , A61K8/416 , A61K8/43 , A61K31/79 , A61K2800/75 , A61Q17/005
摘要： Antimicrobial compositions having synergistic combinations of octoxyglycerin and at least one other antimicrobial agent in formulations which are more effective than prior art compositions without causing increased irritation to the skin of the average user. In certain embodiments, skin irritation may be minimized by low concentrations of antimicrobials and/or the presence of soothing compounds such as zinc. Preferred embodiments include combinations of octoxyglycerin, a quaternary compound, and at least one other antimicrobial agent. Without being bound to any particular theory, it is hypothesized that the unexpected antimicrobial effectiveness of combinations of octoxyglycerin may result from an enhancement of the permeability of microbes to antimicrobials caused by octoxyglycerin.
摘要翻译：在制剂中具有协同组合的辛氧基甘油和至少一种其它抗微生物剂的抗微生物组合物比现有技术组合物更有效，而不会对一般使用者的皮肤造成更大的刺激。在某些实施方案中，皮肤刺激可以通过低浓度的抗微生物剂和/或舒缓化合物如锌的存在来最小化。优选的实施方案包括辛氧基甘油，季化合物和至少一种其它抗微生物剂的组合。不受任何特定理论的约束，假设辛氧基甘油组合的意想不到的抗菌效果可能是由于由辛氧基甘油引起的微生物对抗微生物剂的渗透性的提高。

88. 发明申请

US20030124157A1 Compositions containing aromatic aldehydes and their use in treatments 有权
标题翻译：含芳香醛的组合物及其在处理中的应用
公开(公告)号：US20030124157A1
公开(公告)日：2003-07-03
申请号：US10223073
申请日：2002-08-15
发明人： Charles R. Engles , Bryan Fuller , Brian Keith Pilcher
IPC分类号： A61K031/11 , A61K031/075 , A61K031/045 , A61K009/70
CPC分类号： A61K31/455 , A61K8/33 , A61K8/4926 , A61K9/06 , A61K31/11 , A61K2800/596 , A61K2800/70 , A61Q13/00 , A61Q19/00 , A61Q19/004 , A61Q19/08
摘要： Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.
摘要翻译：公开了含有芳族醛化合物的药物和化妆品组合物。所公开的组合物中的一些可用作治疗炎性皮肤病学条件的局部治疗剂。一些组合物可用于治疗哺乳动物中其它炎性病症的透皮和其它全身剂型。

89. 发明申请

US20030069309A1 6-Methoxy-2-naphthylacetic acid prodrugs 审中-公开
标题翻译： 6-甲氧基-2-萘基乙酸前药
公开(公告)号：US20030069309A1
公开(公告)日：2003-04-10
申请号：US10170800
申请日：2002-06-12
发明人： Nnochiri Nkem Ekwuribe , Tatyana A. Dyakonov
IPC分类号： A61K031/235 , A61K031/075
CPC分类号： A61K31/16 , A61K31/085 , A61K31/167 , A61K31/21 , A61K31/216 , A61K31/235 , A61K31/265
摘要： The present invention provides therapeutically effective amounts of 6MNA prodrugs. The pharmaceutical composition comprises 1 wherein R is H or CORnull, wherein Rnull is selected from the group consisting of C1 to C6 alkyl, (CH2)mO(CH2)n, (CH2)m(OC2H4)pO(CH2)n, (CH2)m(OC2H4)p, (OCH2H4)pONO2 and (OCH2H4)pO(CH2)n wherein m is an integer from 2 to 4, and n and p are integers from 1 to 4. Alternatively, R is a therapeutic moiety.
摘要翻译：本发明提供治疗有效量的6MNA前药。药物组合物包含其中R是H或COR'，其中R'选自C1-C6烷基，（CH2）mO（CH2）n，（CH2）m（OC2H4）pO（CH2）n，（ CH 2）m（OC 2 H 4）p，（OCH 2 H 4）pONO 2和（OCH 2 H 4）p O（CH 2）n，其中m是2至4的整数，n和p是1至4的整数。或者，R是治疗部分。

90. 发明申请

US20030060515A1 Protein tyrosine kinase inhibitors for treating osteoarthritis 审中-公开
标题翻译：用于治疗骨关节炎的蛋白酪氨酸激酶抑制剂
公开(公告)号：US20030060515A1
公开(公告)日：2003-03-27
申请号：US10252999
申请日：2002-09-23
申请人： The Osteoarthritis Sciences, Inc. Liquidating Trust
发明人： Thomas R. Sharpe , George W. Vasios , R. Nelson Campbell
IPC分类号： A61K031/045 , A61K031/075
CPC分类号： A61K31/472 , A61K31/00 , A61K31/165 , A61K31/277 , A61K31/352 , A61K31/395 , A61K31/4035 , A61K31/47 , A61K31/4725 , A61K31/517
摘要： Disclosed is a method of treating an individual or animal with osteoarthritis. The method comprises administering to the individual or animal a therapeutically effective amount of a protein tyrosine kinase inhibitor.
摘要翻译：公开了一种用骨关节炎治疗个体或动物的方法。该方法包括向个体或动物施用治疗有效量的蛋白酪氨酸激酶抑制剂。

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