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1. 发明专利

AU2001274459B2 Pharmaceutical compositions comprising cannabidiol derivatives 未知
公开(公告)号：AU2001274459B2
公开(公告)日：2005-07-07
申请号：AU2001274459
申请日：2001-06-12
申请人： YISSUM RES DEV CO
发明人： GALLILY RUTH , BREUER AVIVA , HANUS LUMIR , FRIDE ESTER , TCHILIBON SUSANA , MECHOULAM RAPHAEL
IPC分类号： A61K9/08 , A61K9/10 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/05 , A61K31/065 , A61K31/192 , A61K31/222 , A61K47/08 , A61K47/10 , A61K47/24 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/22 , A61P29/00 , A61P35/00 , A61P43/00 , C07C37/055 , C07C39/23 , C07C43/23 , C07C51/367 , C07C59/54 , C07C59/72 , C07C62/32 , C07C69/017 , A61K031/192 , A61P029/00 , A61P025/00 , A61P035/00 , A61K041/00 , C07C051/29 , C07C059/72 , C07C059/54 , C07C039/23 , C07C043/178 , C07C043/23 , A61K009/107 , A61K031/075 , A61K031/085 , A61K031/05
摘要： The present invention relates to cannabidiol derivatives and to pharmaceutical compositions comprising cannabidiol derivatives being antiinflammatory agents having analgesic, antianxiety, anticonvulsive, neuroprotective, antipsychotic and anticancer activity. The present invention also relates to a process for the preparation of cannabidiol derivatives. It also relates to the use of cannabidiol derivatives and of pharmaceutical compositions comprising same in the preparation of a medicament, in a method of the treatment of human beings with cannabidiol derivatives or with a pharmaceutical preparations comprising same.

2. 发明申请

US20040259958A1 Non-halogenated phenoxy and/or benzyloxy substituted phenols, antimicrobial compositions containing the same, and methods of using the same 审中-公开
标题翻译：非卤代苯氧基和/或苄氧基取代酚，含有它们的抗微生物组合物及其使用方法
公开(公告)号：US20040259958A1
公开(公告)日：2004-12-23
申请号：US10866854
申请日：2004-06-14
发明人： David Scott Harper , robert A. Coburn , Constantine Georgiades , Andre Soshinsky , Marianne D. Huntley
IPC分类号： A61K031/075 , C07C043/02 , C07C043/20
CPC分类号： A61K8/347 , A01N31/16 , A61Q11/00 , C07C43/23 , C07C43/295
摘要： Antimicrobial compounds, compositions containing the same, and methods of using of the same for reducing the presence of microorganisms on a substrate or in a fluid environment comprising an antimicrobial effective carrier and at least one antimicrobial compounds including non-halogenated phenoxy and/or benzyloxy substituted phenol compounds.
摘要翻译：抗微生物化合物，含有它们的组合物和使用它们的方法，用于减少在底物或流体环境中的微生物的存在，其包含抗微生物有效载体和至少一种抗微生物化合物，包括非卤代苯氧基和/或苄氧基取代的苯酚化合物。

3. 发明申请

US20040044084A1 Blockade of sodium channels by phenol derivatives 失效
标题翻译：苯酚衍生物阻断钠通道
公开(公告)号：US20040044084A1
公开(公告)日：2004-03-04
申请号：US10416632
申请日：2003-09-08
发明人： Gertrud Haeseler , Martin Leuwer
IPC分类号： A61K031/075 , A61K031/045
CPC分类号： A61K8/498 , A61K8/347 , A61K8/4973 , A61K31/05 , A61K31/055 , A61K31/35 , A61K31/352 , A61K2800/28 , A61Q19/00
摘要： The invention relates to a pharmaceutical composition comprising at least one phenol derivative represented by formula (I) 1 wherein R1 represents a hydrogen atom, a halogen atom or a hydrocarbon group containing up to 12 carbon atoms; R2 represents a hydrogen atom or a C1-C7 alkyl group; wherein R1 and R2 may optionally form a carbocyclic 5- or 6-membered ring; R3 represents a hydrogen atom, a halogen atom or a C1-C7 alkyl group; R4 represents a hydrogen atom, a C1-C7 alkyl group or a halogen atom; R5 represents hydrogen atom, a halogen atom or a C1-C7 alkyl group; and R6 represents a hydrogen atom, a C1-C7 alkyl group or a C2 or C3 alkenyl group, under the proviso that R2 and R4 can only both represent a hydrogen atom if both R1 and R5 represent a C1-C7 alkyl group and R3 represents a halogen atom. The composition is particularly useful for the blockade of sodium channels and/or influencing the kinetics of sodium channels and thus can be used as local anesthetic, antidysrhythmic, anticonvulsant/antiepilepticand spasmolytic.
摘要翻译：本发明涉及包含至少一种由式（I）表示的苯酚衍生物的药物组合物，其中R 1表示氢原子，卤素原子或含有至多12个碳原子的烃基; R 2表示氢原子或C 1 -C 7烷基; 其中R 1和R 2可任选地形成碳环5或6元环; R 3表示氢原子，卤原子或C 1 -C 7烷基; R 4表示氢原子，C 1 -C 7烷基或卤素原子; R 5表示氢原子，卤素原子或C 1 -C 7烷基; 并且R 6表示氢原子，C 1 -C 7烷基或C 2或C 3烯基，条件是R 2和R 4只有两个R 2均表示氢原子， R 5表示C 1 -C 7烷基，R 3表示卤素原子。该组合物特别可用于阻断钠通道和/或影响钠通道的动力学，因此可用作局部麻醉剂，抗心律失常药，抗惊厥药/抗癫痫药和解痉药。

4. 发明申请

US20040010047A1 Method and composition for inhibiting arteriosclerosis 审中-公开
标题翻译：抑制动脉硬化的方法和组合物
公开(公告)号：US20040010047A1
公开(公告)日：2004-01-15
申请号：US10275553
申请日：2003-07-30
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K031/075
CPC分类号： A61K45/06 , A61K31/09 , A61K31/22 , A61K2300/00
摘要： The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy. A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Q10 represented by the following formula (1), and a composition for inhibiting arteriosclerosis containing both a cholesterol-lowering agent and said reduced coenzyme Q10. 1
摘要翻译：本发明的目的是提供一种方法和组合物，其通过使用抗高脂血症或降胆固醇药物抑制血浆LDL的抗氧化活性或甚至增加，从而更有效地回收确保增强的抗动脉硬化功效。一种抑制动脉硬化的方法，其包括使用降胆固醇剂和由下式（1）表示的还原型辅酶Q10的组合以及含有降胆固醇降低剂和所述还原型辅酶Q10的抑制动脉硬化的组合物。

5. 发明申请

US20030228269A1 Use of stilbene derivatives for dandruff treatment 审中-公开
标题翻译：使用二苯乙烯衍生物进行头皮屑治疗
公开(公告)号：US20030228269A1
公开(公告)日：2003-12-11
申请号：US10296726
申请日：2003-05-16
发明人： Mario DeRosa , Mose Rossi
IPC分类号： A61K031/075 , A61K031/704 , A61K007/06 , A61K031/05
CPC分类号： A61Q5/006 , A61K8/347
摘要： The present invention relates to the use of resveratrol and its derivatives as active principles in antidandruff formulations.
摘要翻译：本发明涉及白藜芦醇及其衍生物在去头皮屑制剂中作为活性成分的用途。

6. 发明申请

US20030215508A1 Sustained release of guaifenesin combination drugs 有权
标题翻译：愈创甘油联合药物的持续释放
公开(公告)号：US20030215508A1
公开(公告)日：2003-11-20
申请号：US10413530
申请日：2003-04-15
发明人： Robert D. Davis , Ralph W. Blume , Donald Jeffrey Keyser
IPC分类号： A61K009/22 , A61K031/075
CPC分类号： A61K9/2027 , A61K9/2054 , A61K9/209 , A61K9/5084 , A61K31/09 , A61K31/137 , A61K31/485 , A61K31/495 , A61K2300/00
摘要： The invention relates to a novel pharmaceutical modified release formulation of guaifenesin and dextromethorphan. The formulation may comprise a hydrophilic polymer, preferably a hydroxypropyl methylcellulose, and a water-insoluble polymer, preferably an acrylic resin, in a ratio range of about one-to-one (1:1) to about nine-to-one (9:1), more preferably a range of about three-to-two (3:2) to about six-to-one (6:1), and most preferably in a range of about two-to-one (2:1) to about four-to-one (4:1) by weight. This formulation capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject. The invention also relates to a modified release product which has two portions: a first portion having an immediate release formulation of guaifenesin and a second portion having a sustained release formulation of guaifenesin, wherein one or both portions further comprises dextromethorphan. The modified release product has a maximum guaifenesin serum concentration equivalent to that of an immediate release guaifenesin tablet, and is capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject.
摘要翻译：本发明涉及愈创甘油醚和右美沙芬的新型药物改良释放制剂。制剂可包含亲水性聚合物，优选羟丙基甲基纤维素和水不溶性聚合物，优选丙烯酸树脂，其比例范围为约一对一（1：1）至约九对一（9 ：1），更优选约三至二（3:2）至约六对一（6:1）的范围，最优选在约二至一（2:1）的范围内）至约四对一（4:1）重量比。该制剂能够在给予人受试者后至少十二个小时提供愈创甘油的治疗有效的生物利用度。本发明还涉及一种具有两部分的改性释放产物：第一部分具有愈创甘油醚的立即释放制剂，第二部分具有愈创甘油醚的持续释放制剂，其中一个或两个部分还包含右美沙芬。改性释放产物具有与立即释放愈创甘油醚片剂相当的最大愈创甘油醚血清浓度，并且能够在给予人受试者后至少十二个小时提供愈创甘油的治疗有效的生物利用度。

7. 发明申请

US20030195259A1 Triaromatic vitamin D analogues 失效
标题翻译：色氨酸维生素D类似物
公开(公告)号：US20030195259A1
公开(公告)日：2003-10-16
申请号：US10315121
申请日：2002-12-10
发明人： Jean-Michel Bernardon , Thibaud Biadatti
IPC分类号： A61K031/135 , A61K031/075 , A61K031/045 , C07C033/38 , C07C043/02
CPC分类号： C07C43/23 , C07C33/26 , C07C215/68
摘要： The invention relates, as novel and useful industrial products, to triaromatic compounds, which are vitamin D analogues, of general formula (I): 1 and also to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic compositions.
摘要翻译：本发明作为新颖有用的工业产品涉及作为通式（I）的维生素D类似物的三芳族化合物：还涉及其制备方法及其用于人或兽用药物组合物中的用途药物，或者在化妆品组合物中。

8. 发明申请

US20030171441A1 Antiviral therapy 失效
标题翻译：抗病毒治疗
公开(公告)号：US20030171441A1
公开(公告)日：2003-09-11
申请号：US10099542
申请日：2002-03-14
发明人： Johannes Servatius Leonardus Maria Nottet
IPC分类号： A61K031/10 , A61K031/075
CPC分类号： A61K45/06 , A61K31/216 , A61K2300/00
摘要： The invention relates to the field of antiviral agents, and more specifically to antiviral therapy. The invention provides use of at least one compound or mixture of compounds of the general formula 1 or a functional equivalent or pharmaceutically acceptable salt or hydrate thereof for the production of a pharmaceutical composition for the treatment of a viral infection.
摘要翻译：本发明涉及抗病毒剂领域，更具体地涉及抗病毒治疗领域。本发明提供至少一种通式化合物或其功能等同物或药学上可接受的盐或水合物的化合物或其混合物用于生产用于治疗病毒感染的药物组合物的用途。

9. 发明申请

US20030162836A1 Hydroxydiphenyl ether compounds 审中-公开
标题翻译：羟基二苯醚化合物
公开(公告)号：US20030162836A1
公开(公告)日：2003-08-28
申请号：US10281011
申请日：2002-10-25
发明人： Werner Holzl , Wolfgang Haap , Dietmar Ochs , Karin Puchtler , Marcel Schnyder , Surendra Umesh Kulkarni , Arakali Srinivasarao Radhakrishna , Mangesh Shivram Sawant , Asawari Bhikaji Mahtre
IPC分类号： A61K031/192 , A61K031/075
CPC分类号： A01N31/16 , A01N35/04 , A61K8/347 , A61K8/35 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/005 , A61Q19/10 , C07C43/295 , C07C45/46 , C07C45/54 , C07C45/673 , C07C47/575 , C07C49/84 , C11D3/48 , C11D7/263 , C11D7/3227 , Y10S514/88 , Y10S514/881 , Y10S514/901
摘要： The present invention relates to the use of hydroxydiphenyl ether compounds as antimicrobially active substances, to certain new compounds of this type and to processes for the preparation of these compounds.
摘要翻译：本发明涉及羟基二苯醚化合物作为抗微生物活性物质的某些新型化合物和这些化合物的制备方法。

10. 发明申请

US20030157204A1 Novel synergistic compositions containing aromatic compounds and terpenoids present in Alpinia galanga 有权
标题翻译：含有芳香化合物和萜类化合物的新型协同组合物存在于高粱中
公开(公告)号：US20030157204A1
公开(公告)日：2003-08-21
申请号：US10336303
申请日：2003-01-02
申请人： Enrovita A/S
发明人： Morten Sloth Weidner , Morten Just Petersen , Nina Worm Jensen
IPC分类号： A61K035/78 , A61K031/366 , A61K031/22 , A61K031/225 , A61K031/075
CPC分类号： A61K8/97 , A61K36/48 , A61K36/9062 , A61K36/9068 , A61Q19/00 , A61K2300/00
摘要： Novel compositions of matter containing aromatic compounds and terpenoids which are present in and may preferably be derived from the plant Alpinia galanga (Zingiberaceae) show synergistic effects with respect to immunomodulation, and they significantly suppress hypersensitivity reactions. Thus they are used for preparing medicaments for these purposes and, more specifically, for the treatment or prevention of IgE mediated allergic reactions and conditions, such as asthma, allergic rhinitis, atopic eczema or anaphylaxis, and autoimmune disorders, such as Crohn's disease, ulcerative colitis, rheumatoid arthritis or psoriasis, as well as for the alleviation of pain. They can for example be formulated into pharmaceuticals, cosmetics or dietary supplements. A method of preparing such compositions from Alpinia galanga is also described.
摘要翻译：含有芳族化合物和萜类化合物的新型组合物存在于并且可优选衍生自植物高甘蓝（姜黄科），显示出相对于免疫调节的协同效应，并且它们显着抑制超敏反应。因此，它们用于制备用于这些目的的药物，更具体地，用于治疗或预防IgE介导的过敏反应和病症，例如哮喘，过敏性鼻炎，特应性湿疹或过敏反应，以及自身免疫性疾病如克罗恩病，溃疡性溃疡结肠炎，类风湿关节炎或牛皮癣，以及缓解疼痛。它们可以例如配制成药物，化妆品或膳食补充剂。还描述了从高山甘蓝制备这种组合物的方法。

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